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Home / Equine Research Bank / Transbound Emerg Dis / Antibody response in horses following experimental infection...
Transboundary and emerging diseases2011; 58(3); 206-212; doi: 10.1111/j.1865-1682.2010.01197.x

Antibody response in horses following experimental infection with West Nile Virus lineages 1 and 2.

Abstract: West Nile virus (WNV) has re-emerged as an important pathogen for humans and horses, which are considered to be incidental 'dead-end' hosts. We have demonstrated that horses are susceptible to experimental infection with WNV and that horses infected with either WNV lineage 1 or lineage 2 elicit a similar antibody profile in serum samples. These data suggest that virus-neutralizing antibody responses persist for longer than WNV-specific IgM levels in serum and that there are not any notable differences in the antibody profile following experimental infection of horses with either WNV lineage 1 and lineage 2 viruses. Furthermore, the duration of IgM appears to be short-lived in horses and may be useful for identifying and differentiating recent infections from previously exposed animals.
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Publication Date: 2011-01-12 PubMed ID: 21223533DOI: 10.1111/j.1865-1682.2010.01197.xGoogle Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research explores how horses respond, specifically in terms of antibody production, to experimental infection with West Nile Virus lineages 1 and 2, demonstrating that both strains of the virus elicit a similar antibody response.

Antibody Response to West Nile Virus Infection

The very core of this research was to determine and analyze how horses, categorized as incidental ‘dead-end’ hosts, react upon being experimentally infected with either lineage 1 or 2 of the West Nile Virus (WNV). The objective was to understand the similarities or differences in the antibody profiles produced as a response to these infections. Through their experiments:

  • The researchers proved that horses are susceptible to WNV infections.
  • They found that irrespective of the strain of the virus (lineage 1 or 2), the infected horses exhibited a similar antibody profile.

Persistence and Duration of Antibody Responses

The study also delved into the duration and persistence of different types of antibody responses. The conclusions drawn were:

  • The study showed that virus-neutralizing antibody responses seem to endure longer than virus-specific IgM levels.
  • They found that WNV-specific IgM levels in the serum of the horses were short-lived.

Implications and Applications

Research findings hold significance for diagnostics and disease management in the context of West Nile Virus. Application of these observations include:

  • The observations regarding the duration and persistence of different antibody responses could be used for differentiating recent infections from previous exposures in the horses.
  • The short-lived nature of IgM may be helpful in identifying and distinguishing recently infected horses from those that were exposed to the virus earlier.

Cite This Article

APA
Castillo-Olivares J, Mansfield KL, Phipps LP, Johnson N, Tearle J, Fooks AR. (2011). Antibody response in horses following experimental infection with West Nile Virus lineages 1 and 2. Transbound Emerg Dis, 58(3), 206-212. https://doi.org/10.1111/j.1865-1682.2010.01197.x

Publication

Transboundary and emerging diseases
ISSN: 1865-1682
NlmUniqueID: 101319538
Country: Germany
Language: English
Volume: 58
Issue: 3
Pages: 206-212

Researcher Affiliations

Castillo-Olivares, J
  • Centre for Preventative Medicine, Animal Health Trust, Newmarket, Suffolk, UK.
Mansfield, K L
    Phipps, L P
      Johnson, N
        Tearle, J
          Fooks, A R

            MeSH Terms

            • Animals
            • Antibodies, Viral / blood
            • Asymptomatic Diseases
            • Disease Models, Animal
            • Enzyme-Linked Immunosorbent Assay / veterinary
            • Horse Diseases / blood
            • Horse Diseases / virology
            • Horses
            • Immunoglobulin M
            • West Nile Fever / blood
            • West Nile Fever / veterinary
            • West Nile virus / classification
            • West Nile virus / immunology

            Citations

            This article has been cited 11 times.
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