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Transboundary and emerging diseases2011; 58(3); 206-212; doi: 10.1111/j.1865-1682.2010.01197.x

Antibody response in horses following experimental infection with West Nile Virus lineages 1 and 2.

Abstract: West Nile virus (WNV) has re-emerged as an important pathogen for humans and horses, which are considered to be incidental 'dead-end' hosts. We have demonstrated that horses are susceptible to experimental infection with WNV and that horses infected with either WNV lineage 1 or lineage 2 elicit a similar antibody profile in serum samples. These data suggest that virus-neutralizing antibody responses persist for longer than WNV-specific IgM levels in serum and that there are not any notable differences in the antibody profile following experimental infection of horses with either WNV lineage 1 and lineage 2 viruses. Furthermore, the duration of IgM appears to be short-lived in horses and may be useful for identifying and differentiating recent infections from previously exposed animals.
© 2011 Crown copyright.
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Publication Date: 2011-01-12 PubMed ID: 21223533DOI: 10.1111/j.1865-1682.2010.01197.xGoogle Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research explores how horses respond, specifically in terms of antibody production, to experimental infection with West Nile Virus lineages 1 and 2, demonstrating that both strains of the virus elicit a similar antibody response.

Antibody Response to West Nile Virus Infection

The very core of this research was to determine and analyze how horses, categorized as incidental ‘dead-end’ hosts, react upon being experimentally infected with either lineage 1 or 2 of the West Nile Virus (WNV). The objective was to understand the similarities or differences in the antibody profiles produced as a response to these infections. Through their experiments:

  • The researchers proved that horses are susceptible to WNV infections.
  • They found that irrespective of the strain of the virus (lineage 1 or 2), the infected horses exhibited a similar antibody profile.

Persistence and Duration of Antibody Responses

The study also delved into the duration and persistence of different types of antibody responses. The conclusions drawn were:

  • The study showed that virus-neutralizing antibody responses seem to endure longer than virus-specific IgM levels.
  • They found that WNV-specific IgM levels in the serum of the horses were short-lived.

Implications and Applications

Research findings hold significance for diagnostics and disease management in the context of West Nile Virus. Application of these observations include:

  • The observations regarding the duration and persistence of different antibody responses could be used for differentiating recent infections from previous exposures in the horses.
  • The short-lived nature of IgM may be helpful in identifying and distinguishing recently infected horses from those that were exposed to the virus earlier.

Cite This Article

APA
Castillo-Olivares J, Mansfield KL, Phipps LP, Johnson N, Tearle J, Fooks AR. (2011). Antibody response in horses following experimental infection with West Nile Virus lineages 1 and 2. Transbound Emerg Dis, 58(3), 206-212. https://doi.org/10.1111/j.1865-1682.2010.01197.x

Publication

Transboundary and emerging diseases
ISSN: 1865-1682
NlmUniqueID: 101319538
Country: Germany
Language: English
Volume: 58
Issue: 3
Pages: 206-212

Researcher Affiliations

Castillo-Olivares, J
  • Centre for Preventative Medicine, Animal Health Trust, Newmarket, Suffolk, UK.
Mansfield, K L
    Phipps, L P
      Johnson, N
        Tearle, J
          Fooks, A R

            MeSH Terms

            • Animals
            • Antibodies, Viral / blood
            • Asymptomatic Diseases
            • Disease Models, Animal
            • Enzyme-Linked Immunosorbent Assay / veterinary
            • Horse Diseases / blood
            • Horse Diseases / virology
            • Horses
            • Immunoglobulin M
            • West Nile Fever / blood
            • West Nile Fever / veterinary
            • West Nile virus / classification
            • West Nile virus / immunology

            Citations

            This article has been cited 11 times.
            1. Björnström A, Blomström AL, Singh MC, Hesson JC. Sindbis virus neutralising antibodies detected in Swedish horses. One Health 2021 Jun;12:100242.
              doi: 10.1016/j.onehlt.2021.100242pubmed: 33851003google scholar: lookup
            2. Pérez-Ramírez E, Cano-Gómez C, Llorente F, Vodica A, Veljović L, Toklikishvilli N, Sherifi K, Sghaier S, Omani A, Kustura A, Krstevski K, Karayel-Hacioglu I, Hagag NM, El Hage J, Davdyan H, Bintarif MS, Adzic B, Abouchoaib N, Jiménez-Clavero MÁ, Fernández-Pinero J. Evaluation of West Nile Virus Diagnostic Capacities in Veterinary Laboratories of the Mediterranean and Black Sea Regions. Pathogens 2020 Dec 11;9(12).
              doi: 10.3390/pathogens9121038pubmed: 33322276google scholar: lookup
            3. More S, Bøtner A, Butterworth A, Calistri P, Depner K, Edwards S, Garin-Bastuji B, Good M, Gortázar Schmidt C, Michel V, Miranda MA, Nielsen SS, Raj M, Sihvonen L, Spoolder H, Stegeman JA, Thulke HH, Velarde A, Willeberg P, Winckler C, Baldinelli F, Broglia A, Dhollander S, Beltrán-Beck B, Kohnle L, Morgado J, Bicout D. Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): West Nile fever. EFSA J 2017 Aug;15(8):e04955.
              doi: 10.2903/j.efsa.2017.4955pubmed: 32625621google scholar: lookup
            4. Byas AD, Ebel GD. Comparative Pathology of West Nile Virus in Humans and Non-Human Animals. Pathogens 2020 Jan 7;9(1).
              doi: 10.3390/pathogens9010048pubmed: 31935992google scholar: lookup
            5. de Heus P, Kolodziejek J, Camp JV, Dimmel K, Bagó Z, Hubálek Z, van den Hoven R, Cavalleri JV, Nowotny N. Emergence of West Nile virus lineage 2 in Europe: Characteristics of the first seven cases of West Nile neuroinvasive disease in horses in Austria. Transbound Emerg Dis 2020 May;67(3):1189-1197.
              doi: 10.1111/tbed.13452pubmed: 31840920google scholar: lookup
            6. Beck C, Lowenski S, Durand B, Bahuon C, Zientara S, Lecollinet S. Improved reliability of serological tools for the diagnosis of West Nile fever in horses within Europe. PLoS Negl Trop Dis 2017 Sep;11(9):e0005936.
              doi: 10.1371/journal.pntd.0005936pubmed: 28915240google scholar: lookup
            7. Suen WW, Uddin MJ, Wang W, Brown V, Adney DR, Broad N, Prow NA, Bowen RA, Hall RA, Bielefeldt-Ohmann H. Experimental West Nile Virus Infection in Rabbits: An Alternative Model for Studying Induction of Disease and Virus Control. Pathogens 2015 Jul 14;4(3):529-58.
              doi: 10.3390/pathogens4030529pubmed: 26184326google scholar: lookup
            8. Angenvoort J, Brault AC, Bowen RA, Groschup MH. West Nile viral infection of equids. Vet Microbiol 2013 Nov 29;167(1-2):168-80.
              doi: 10.1016/j.vetmic.2013.08.013pubmed: 24035480google scholar: lookup
            9. Zaayman D, Venter M. West Nile virus neurologic disease in humans, South Africa, September 2008-may 2009. Emerg Infect Dis 2012 Dec;18(12):2051-4.
              doi: 10.3201/eid1812.111208pubmed: 23171668google scholar: lookup
            10. Williams RAJ, Criollo Valencia HA, López Márquez I, González González F, Llorente F, Jiménez-Clavero MÁ, Busquets N, Mateo Barrientos M, Ortiz-Díez G, Ayllón Santiago T. West Nile Virus Seroprevalence in Wild Birds and Equines in Madrid Province, Spain. Vet Sci 2024 Jun 7;11(6).
              doi: 10.3390/vetsci11060259pubmed: 38922006google scholar: lookup
            11. Naveed A, Eertink LG, Wang D, Li F. Lessons Learned from West Nile Virus Infection:Vaccinations in Equines and Their Implications for One Health Approaches. Viruses 2024 May 14;16(5).
              doi: 10.3390/v16050781pubmed: 38793662google scholar: lookup
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