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Acta veterinaria Scandinavica2012; 54(1); 63; doi: 10.1186/1751-0147-54-63

Antibody response in vaccinated pregnant mares to recent G3BP[12] and G14P[12] equine rotaviruses.

Abstract: Both the G3P[12] and the G14P[12] type of equine group A rotavirus (RVA) have recently become predominant in many countries, including Japan. G3 types are classified further into G3A and G3B. The G3A viruses have been circulating in Europe, Australia, and Argentina, and the G3B viruses have been circulating in Japan. However, only an inactivated vaccine containing a single G3BP[12] strain is commercially available in Japan. To assess the efficacy of the current vaccine against recently circulating equine RVA strains, we examined antibody responses in pregnant mares to recent G3BP[12] and G14P[12] strains by virus neutralization test. Results: After vaccination in five pregnant mares, the geometric mean serum titers of virus-neutralizing antibody to recent G3BP[12] strains increased 5.3- to 7.0-fold and were similar to that against homologous vaccine strain. Moreover, antibody titers to recent G14P[12] strains were also increased 3.0- to 3.5-fold. Conclusions: These results suggest that inoculation of mares with the current vaccine should provide foals with virus-neutralizing antibodies against not only the G3BP[12] but also the G14P[12] RVA strain via the colostrum.
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Publication Date: 2012-11-06 PubMed ID: 23130609PubMed Central: PMC3523035DOI: 10.1186/1751-0147-54-63Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research paper investigates the effectiveness of a particular vaccine in pregnant horses against two prevalent types of equine A rotavirus. The study found that vaccination led to a significant increase in virus-neutralizing antibodies against both kinds of the virus, suggesting that the vaccine can also provide newly born foals with immunity through the mother’s colostrum.

Context and Objectives of the Research

  • Two types of Group A Rotavirus (G3P[12] and G14P[12]) have become dominant in many nations, including Japan, causing concern in the equine industry.
  • The variants of G3 are further classified into two categories: The G3A type is prevalent in Europe, Australia, and Argentina, whereas the G3B type is common in Japan. Unfortunately, the only commercially available vaccine in Japan contains a single G3BP[12] strain.
  • Given this situation, the goal of the researchers was to determine whether this vaccine could effectively counteract the recently active strains of Equine RVA, thus providing the necessary information to make an informed decision regarding horse health management.

Methodology

  • The researchers used a virus neutralization test to measure the antibody responses in five pregnant mares to recent G3BP[12] and G14P[12] strains following vaccination.

Results

  • The results indicated a significant increase in the average virus-neutralizing antibody levels against the recent G3BP[12] strains, ranging from 5.3 to 7.0-fold. These results were comparable to the response against the specific strain in the vaccine.
  • The antibody responses against recent G14P[12] strains also showed a notable rise, between 3.0- to 3.5-fold, indicating the vaccine’s potential efficacy against this strain.

Conclusions

  • Based on these promising results, the researchers suggest that vaccinating mares with the current vaccine could provide not only protection against the G3BP[12] strain but also the G14P[12] RVA strain.
  • Moreover, the immunity could potentially be passed on to foals via the colostrum, the first form of milk produced by the mother after birth which is rich in antibodies. This transfer of immunity from the mother to the offspring could help in preventing rotavirus infection in young horses which are particularly vulnerable to the disease.

Cite This Article

APA
Nemoto M, Tsunemitsu H, Murase H, Nambo Y, Sato S, Orita Y, Imagawa H, Bannai H, Tsujimura K, Yamanaka T, Matsumura T, Kondo T. (2012). Antibody response in vaccinated pregnant mares to recent G3BP[12] and G14P[12] equine rotaviruses. Acta Vet Scand, 54(1), 63. https://doi.org/10.1186/1751-0147-54-63

Publication

Acta veterinaria Scandinavica
ISSN: 1751-0147
NlmUniqueID: 0370400
Country: England
Language: English
Volume: 54
Issue: 1
Pages: 63

Researcher Affiliations

Nemoto, Manabu
  • Epizootic Research Center, Equine Research Institute, Japan Racing Association, 1400-4 Shiba, Shimotsuke, Tochigi 329-0412, Japan. nemoto_manabu@epizoo.equinst.go.jp
Tsunemitsu, Hiroshi
    Murase, Harutaka
      Nambo, Yasuo
        Sato, Shinsuke
          Orita, Yasuhiro
            Imagawa, Hiroshi
              Bannai, Hiroshi
                Tsujimura, Koji
                  Yamanaka, Takashi
                    Matsumura, Tomio
                      Kondo, Takashi

                        MeSH Terms

                        • Animals
                        • Antibodies, Viral / blood
                        • Antibodies, Viral / immunology
                        • Female
                        • Horse Diseases / immunology
                        • Horse Diseases / virology
                        • Horses
                        • Molecular Sequence Data
                        • Neutralization Tests / veterinary
                        • Phylogeny
                        • Polymerase Chain Reaction / veterinary
                        • Pregnancy
                        • Rotavirus / immunology
                        • Rotavirus Infections / immunology
                        • Rotavirus Infections / veterinary
                        • Rotavirus Infections / virology
                        • Rotavirus Vaccines / immunology
                        • Sequence Analysis, DNA / veterinary
                        • Vaccines, Inactivated / immunology

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                        Citations

                        This article has been cited 10 times.
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