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Archives of virology1991; 121(1-4); 179-197; doi: 10.1007/BF01316753

Antigenic relationships among the 47 human adenoviruses determined in reference horse antisera.

Abstract: Reference equine antisera to all 47 serotypes of human adenoviruses presently described have been prepared and evaluated by reciprocal neutralization and hemagglutination-inhibition tests. All tests were carried to endpoint dilutions a minimum of five times in each direction to give accurate values for homologous and heterologous antibody titers. Significant cross-reactions in the horse antisera were compared to similar data obtained from rabbit antisera. Using this analysis, major antigenic relationships exist among types 12-18-31 of subgenus A, types 7-11-14 and 34-35 of subgenus B, types 8-9-10, 10-19-37, 13-38-39, 15-22-42, 20-47, 24-32-33-46, and 29-45 of subgenus D, types 16-4 between subgenera B and E, and types 40-41 of subgenus F. Across all subgenera, types 8, 10, 13, 15, 17, 19, 26, 29, 39, 40, and 43 have antigenic moieties found most frequently in other types, averaging 12 heterologous reactions per type when summing both tests in both directions. Types 20, 30, 32, and 45 exhibit shared determinants slightly less often, with a mean of 8 heterologous reactions per type.
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Publication Date: 1991-01-01 PubMed ID: 1759904DOI: 10.1007/BF01316753Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research paper discusses the results of tests conducted using horse antibodies to identify antigenic relationships among the 47 recognized serotypes of human adenoviruses.

Research Overview

In this study, the scientists prepared and evaluated horse antisera against all 47 types of human adenoviruses. The antisera were tested through reciprocal neutralization and hemagglutination-inhibition tests, which were conducted multiple times to obtain accurate measurements. The cross-reactions in the horse antisera were compared with data from rabbit antisera.

Major Antigenic Relationships

  • The researchers discovered significant antigenic relationships in several adenovirus subgenera including A, B, D, E, and F. This suggests the presence of shared antigenic markers among viruses within these same subgroups.
  • For instance, within the A, B, and D subgenus, significant antigenic relationships were found among types 12-18-31, 7-11-14, 34-35, 8-9-10, 10-19-37, 13-38-39, 15-22-42, 20-47, 24-32-33-46, and 29-45 respectively.
  • Between subgenera B and E, types 16-4 showcased a major antigenic relationship, as did the types 40-41 in the F subgenus.

Virus Types with the Most Antigenic Relations Across All Subgenera

  • Virus types 8, 10, 13, 15, 17, 19, 26, 29, 39, 40, and 43 exhibited the greatest numbers of antigenic relations with other types, averaging 12 heterologous reactions per type.
  • This means these adenovirus types share antigenic features with a higher-than-average number of other types.

Virus Types with Fewer Antigenic Relations

  • The adenovirus types 20, 30, 32, and 45 had comparatively fewer antigenic relations, with an average of 8 heterologous reactions per type.
  • This indicates that these types share fewer antigenic properties with other types, making them potentially unique in their antigenic configurations.

In conclusion, this study provides invaluable insights into the antigenic relationships among the various serotypes of human adenoviruses, which could further contribute to the development of more effective vaccines and therapies.

Cite This Article

APA
Hierholzer JC, Stone YO, Broderson JR. (1991). Antigenic relationships among the 47 human adenoviruses determined in reference horse antisera. Arch Virol, 121(1-4), 179-197. https://doi.org/10.1007/BF01316753

Publication

Archives of virology
ISSN: 0304-8608
NlmUniqueID: 7506870
Country: Austria
Language: English
Volume: 121
Issue: 1-4
Pages: 179-197

Researcher Affiliations

Hierholzer, J C
  • Division of Viral Diseases, Centers for Disease Control, Atlanta, Georgia.
Stone, Y O
    Broderson, J R

      MeSH Terms

      • Adenoviruses, Human / classification
      • Animals
      • Antibodies, Viral / blood
      • Antibodies, Viral / immunology
      • Antigens, Viral / immunology
      • Cell Line
      • Cross Reactions
      • Hemagglutination Inhibition Tests
      • Hemagglutination Tests
      • Horses
      • Humans
      • Immune Sera
      • Immunization
      • Neutralization Tests
      • Rabbits
      • Serotyping

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