[Antimicrobial susceptibility and resistance genes among Salmonella enterica Serovar Weltevreden isolates from humans, farm animals, and the environment in Okinawa Prefecture between 1992 and 2007].
Abstract: Between 1992 and 2007, a total of 86 isolates of Salmonella enterica Weltevreden were obtained from clinical human samples (n = 41), 45 farm animals and their environment on 20 farms, including poultry (n = 25), beef cattle (n = 5), swine (n = 5), dairy cattle (n = 3), mice (n = 2), pony (n = 1), fly (n = 1) and feed samples (n = 3), in Okinawa Prefecture, Japan. Only seven isolates (8.1%) of the isolates were resistance to one or more antimicrobial agents tested; six streptomycin (7.0%), six oxytetracycline (7.0%), two ampicillin (2.3%), two kanamycin, (2.3%), two chloramphenicol (2.3%), two suffamethoxazole/trimethoprim (2.3%), whereas all isolates were susceptible to gentamicin, sefuroxime, colistin, nalidixic acid, fosfomycin and ofloxacin. Drug resistance patterns showed six patterns; ABPC-SM-KM-OTC-CP-ST, ABPC-SM-ST, SM-KM-OTC, SM-OTC-CP, SM-OTC, OTC. Two ampicillin-resistant isolates harbored the blaTEM genes, streptomycin-resistant isolates (four aadA, two strA), tetracycline-resistant isolates (two tetA, three tetB), chloramphenicol-resistant isolates (two catA1), respectively.
Publication Date: 2010-02-23 PubMed ID: 20170010DOI: 10.11150/kansenshogakuzasshi.84.24Google Scholar: Lookup
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- Journal Article
Summary
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This study analyzed 86 samples of Salmonella enterica Weltevreden, collected over 15 years from both humans and various farm animals in Okinawa, Japan, in order to determine their susceptibility to certain antibiotics. Only a small percentage showed resistance, with most appearing susceptible to all tested treatments. Antibiotic-resistant samples contained resistance genes for their respective medications.
Examining the Samples
- Over a period of 15 years between 1992 and 2007, 86 total samples of a bacterium called Salmonella enterica Weltevreden were collected. This bacterium is known for causing gastrointestinal illness in both humans and animals.
- These samples came from a number of sources in the Okinawa Prefecture in Japan. A little under half (41) were derived from humans, while the rest came from various farm animals and their environments.
Testing for Antimicrobial Resistance
- The samples were then tested for their resistance to a variety of antimicrobial substances. This was done to measure the level of drug resistance among these bacteria, which is an important factor in treating potential infections.
- Only a small fraction (8.1%) of these samples proved resistant to one or more of the tested drugs.
- The rest of the samples were susceptible to all the substances, including gentamicin, sefuroxime, colistin, nalidixic acid, fosfomycin and ofloxacin.
Identifying Resistance Patterns
- Among the resistant samples, six distinct drug resistance patterns were identified, potentially due to combining various antibiotics during treatment.
- Specific samples showed resistance to streptomycin, ampicillin, kanamycin, oxytetracycline, chloramphenicol, and suffamethoxazole/trimethoprim.
Identifying Resistance Genes
- Investigation into the DNA of the resistant strains revealed that each contained specific genes that are known to provide resistance to certain drugs.
- These included two ampicillin-resistant bacteria samples that contained the blaTEM gene, four streptomycin-resistant samples with the aadA gene, two streptomycin-resistant samples with the strA gene, two tetracycline-resistant samples with the tetA gene, three tetracycline-resistant samples with the tetB gene, and two chloramphenicol-resistant samples with the catA1 gene.
Cite This Article
APA
Matayoshi M, Kudaka J.
(2010).
[Antimicrobial susceptibility and resistance genes among Salmonella enterica Serovar Weltevreden isolates from humans, farm animals, and the environment in Okinawa Prefecture between 1992 and 2007].
Kansenshogaku Zasshi, 84(1), 24-27.
https://doi.org/10.11150/kansenshogakuzasshi.84.24 Publication
Researcher Affiliations
- Yaeyama Livestock Hygiene Service Center, Okinawa Prefectual Insititute of Health and Environment.
MeSH Terms
- Animals
- Animals, Domestic / microbiology
- Cattle / microbiology
- Chickens / microbiology
- Diptera / microbiology
- Drug Resistance, Bacterial / genetics
- Drug Resistance, Bacterial / physiology
- Humans
- Japan
- Mice / microbiology
- Salmonella enterica / drug effects
- Salmonella enterica / genetics
- Salmonella enterica / isolation & purification
- Swine / microbiology
Citations
This article has been cited 1 times.- Sumiyama D, Shimizu A, Kanazawa T, Anzai H, Murata K. Prevalence of Salmonella in green anoles (Anolis Carolinensis), an invasive alien species in Naha and Tomigusuku Cities, Okinawa Main Island, Japan.. J Vet Med Sci 2020 May 20;82(5):678-680.
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