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The Veterinary record2024; 195(3); e4395; doi: 10.1002/vetr.4395

Antinociceptive and wound healing effects of a commercial formulation of lidocaine, bupivacaine, adrenaline and cetrimide applied topically to superficial skin wounds in horses.

Abstract: Post-traumatic distal limb wounds cause discomfort and heal gradually by second intention. The topical application of Tri-Solfen (lidocaine hydrochloride, bupivacaine hydrochloride, adrenaline acid tartrate and cetrimide [LBAC]) produces effective postsurgical cutaneous analgesia in lambs, calves and piglets; however, its effect on wounds in horses is unknown. The antinociceptive effect, measured by mechanical threshold (MT), and the wound healing impacts of LBAC compared with saline were investigated on surgically created 20 × 20 mm distal limb wounds in 10 horses. Treatment was applied once daily for 7 days following wounding on day 0. Mechanical thresholds were measured after treatment on days 1, 2 and 3. Healing was observed for 25 days. The topical application of LBAC immediately following wounding and its reapplication 24 hours later increased the average MT on the first post-traumatic day by 3 Newtons. However, no antinociceptive benefit was observed on days 2 or 3. Treatment with LBAC did not adversely affect wound healing when compared with saline. Methodological differences preclude absolute MT comparisons between studies. The experimental design did not include a model of contaminated or naturally occurring wounds. LBAC may provide an early antinociceptive benefit when applied to uncontaminated surgically created wounds without compromising healing.
© 2024 The Authors. Veterinary Record published by John Wiley & Sons Ltd on behalf of British Veterinary Association.
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Publication Date: 2024-07-08 PubMed ID: 38975630DOI: 10.1002/vetr.4395Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper explores the pain relief and wound healing effects of using a commercial mixture of lidocaine, bupivacaine, adrenaline, and cetrimide (LBAC) on superficial skin wounds in horses. The experiment, conducted on surgically created wounds, showed that the treatment increased the pain tolerance on the first day post-wound, however, did not affect wound healing as compared to saline.

Methods:

  • The experiment was conducted on 10 horses, where 20 x 20 mm distal limb wounds were surgically created.
  • The LBAC treatment was applied once daily for a week since the wounding.
  • The pain reducing effect or antinociceptive effect was measured by calculating the mechanical threshold (MT) after treatment on day 1, 2, and 3.
  • Wound healing process was observed for a duration of 25 days.

Results:

  • Application of LBAC increased the average mechanical threshold on the first day after the wounding by 3 Newtons, showing relief in pain.
  • However, this antinociceptive effect was not evident on the second or third day of the treatment.
  • The rate of wound healing under LBAC treatment was roughly similar to when saline was applied instead, indicating that LPAC treatment didn’t affect the wound healing process.

Conclusions:

  • The researchers implied that the difference in methods across various studies does not allow for a direct comparison of mechanical thresholds between them.
  • It’s worthy to note that the experimentation was done on clean, surgically created wounds, and may not reflect the same results for naturally occurring or contaminated wounds.
  • The conclusions drawn suggest that LBAC could offer initial pain relief when applied to uncontaminated surgical wounds without negatively affecting the wound healing process.

Cite This Article

APA
Pratt S, Sole-Guitart A, de Klerk K, Evans E, Hume J, Palmieri C, Rainger J, Goodwin W. (2024). Antinociceptive and wound healing effects of a commercial formulation of lidocaine, bupivacaine, adrenaline and cetrimide applied topically to superficial skin wounds in horses. Vet Rec, 195(3), e4395. https://doi.org/10.1002/vetr.4395

Publication

The Veterinary record
ISSN: 2042-7670
NlmUniqueID: 0031164
Country: England
Language: English
Volume: 195
Issue: 3
Pages: e4395

Researcher Affiliations

Pratt, Shaun
  • School of Veterinary Science, University of Queensland, Gatton, Queensland, Australia.
Sole-Guitart, Albert
  • School of Veterinary Science, University of Queensland, Gatton, Queensland, Australia.
de Klerk, Karla
  • School of Veterinary Science, University of Queensland, Gatton, Queensland, Australia.
Evans, Elizabeth
  • Invetus, Casino, New South Wales, Australia.
  • Bioproperties, Glenorie, New South Wales, Australia.
Hume, Jane
  • Invetus, Casino, New South Wales, Australia.
  • Vetoquinol, Hamilton, Queensland, Australia.
Palmieri, Chiara
  • School of Veterinary Science, University of Queensland, Gatton, Queensland, Australia.
Rainger, Joanne
  • School of Veterinary Science, University of Queensland, Gatton, Queensland, Australia.
Goodwin, Wendy
  • School of Veterinary Science, University of Queensland, Gatton, Queensland, Australia.

MeSH Terms

  • Animals
  • Lidocaine / administration & dosage
  • Lidocaine / therapeutic use
  • Lidocaine / pharmacology
  • Wound Healing / drug effects
  • Horses
  • Epinephrine / administration & dosage
  • Bupivacaine / administration & dosage
  • Male
  • Cetrimonium
  • Administration, Topical
  • Female
  • Analgesics / therapeutic use
  • Analgesics / administration & dosage
  • Treatment Outcome
  • Wounds and Injuries / veterinary
  • Wounds and Injuries / drug therapy
  • Anesthetics, Local / administration & dosage
  • Anesthetics, Local / therapeutic use
  • Anesthetics, Local / pharmacology
  • Skin / injuries
  • Skin / drug effects
  • Drug Combinations

Grant Funding

  • 2018002127 / Invetus

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