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Antiparasitic activity of an ivermectin and praziquantel combination paste in horses.

Abstract: Modern anthelmintic use in horses has decreased the prevalence of the large strongyles, which has in turn shifted the focus of parasitologists to the pathogenic importance of the small strongyles, tapeworms, and other parasites. These studies show that a combination product containing ivermectin and praziquantel allowed efficacious treatment of horses for nematode, cestode, and bot infections. The use of this combination product may be of special benefit to horses that are mainly kept outdoors and on grazing pastures.
Publication Date: 2004-10-07 PubMed ID: 15468008
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

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This study explores the use of a mix of ivermectin and praziquantel in treating horses infected with nematode, cestode, and bot infections, suggesting that it could be particularly beneficial for horses living outdoors and on pastures.

Research Background and Purpose

  • The research undertakes the contemporary challenges of de-worming horses, especially as there has been a decrease in the prevalence of large strongyles. This has shifted attention to the impact of small strongyles, tapeworms and various other parasites.
  • The aim of this study was to assess the efficiency of a joint product composed of ivermectin and praziquantel for treating horses infected with a range of parasites.

Research Methodology and Findings

  • The research utilized a mixture of ivermectin and praziquantel, employed to cure horses of nematodes, cestodes, and bot infections.
  • The results indicate that the combination product is effective in eradicating these parasites. Therefore, this suggests that the product facilitates a broad spectrum and efficient treatment for horses.

Practical Implications and Future Research

  • This research highlights that the combined product of ivermectin and praziquantel might deliver particular benefits to horses predominantly kept outdoors and on grazing pasture.
  • Hence, it encourages further investigation and application of this combined therapy, enriching current de-worming practices. It is especially relevant for more effective and integrated parasitic management in equine health settings.

Cite This Article

APA
Marley SE, Hutchens DE, Reinemeyer CR, Holste JE, Paul AJ, Rehbein S. (2004). Antiparasitic activity of an ivermectin and praziquantel combination paste in horses. Vet Ther, 5(2), 105-119.

Publication

ISSN: 1528-3593
NlmUniqueID: 100936368
Country: United States
Language: English
Volume: 5
Issue: 2
Pages: 105-119

Researcher Affiliations

Marley, Sara E
  • Merial Limited, Duluth, GA, USA.
Hutchens, Doug E
    Reinemeyer, Craig R
      Holste, John E
        Paul, Allan J
          Rehbein, Steffen

            MeSH Terms

            • Administration, Oral
            • Animals
            • Anthelmintics / therapeutic use
            • Anticestodal Agents / therapeutic use
            • Antinematodal Agents / therapeutic use
            • Cestode Infections / drug therapy
            • Cestode Infections / veterinary
            • Dose-Response Relationship, Drug
            • Drug Therapy, Combination
            • Female
            • Helminthiasis, Animal / drug therapy
            • Horse Diseases / drug therapy
            • Horse Diseases / parasitology
            • Horses
            • Ivermectin / therapeutic use
            • Male
            • Nematode Infections / drug therapy
            • Nematode Infections / veterinary
            • Praziquantel / therapeutic use
            • Random Allocation
            • Strongyle Infections, Equine / drug therapy
            • Strongylida / drug effects
            • Treatment Outcome

            Citations

            This article has been cited 4 times.