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Veterinary research2004; 35(2); 163-187; doi: 10.1051/vetres:2004002

Application of acute phase protein measurements in veterinary clinical chemistry.

Abstract: The body's early defence in response to trauma, inflammation or infection, the acute phase response, is a complex set of systemic reactions seen shortly after exposure to a triggering event. One of the many components is an acute phase protein response in which increased hepatic synthesis leads to increased serum concentration of positive acute phase proteins. The serum concentration of these acute phase proteins returns to base levels when the triggering factor is no longer present. This paper provides a review of the acute phase proteins haptoglobin, C-reactive protein and serum amyloid A and their possible use as non-specific indicators of health in large animal veterinary medicine such as in the health status surveillance of pigs at the herd level, for the detection of mastitis in dairy cattle and for the prognosis of respiratory diseases in horses.
Publication Date: 2004-04-22 PubMed ID: 15099494DOI: 10.1051/vetres:2004002Google Scholar: Lookup
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Summary

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The research article primarily discusses how the measurement of acute phase proteins can be applied in veterinary clinical chemistry, and their potential use as general health indicators in large animals like pigs, cows, and horses.

Main Objective

The principal objective of this research paper is to analyze the functioning of acute phase proteins, specifically haptoglobin, C-reactive protein, and serum amyloid A. The aim is to study their role as non-specific indicators of health in veterinary clinical chemistry, and accordingly, assess their utility in the health surveillance of large animals including pigs, cows, and horses.

Acute Phase Response

  • The research introduces the concept of the ‘acute phase response’, which is part of the body’s immediate response system against trauma, inflammation, or infection.
  • This reaction involves an increase in the synthesis of certain proteins in the liver, leading to a higher concentration of these proteins in the bloodstream, collectively referred to as ‘acute phase proteins’.
  • Once the triggering factor for the trauma, infection or inflammation disappears, the concentration of these proteins in the serum returns to their base levels.

Specific Acute Phase Proteins Discussed

  • The primary focus is on three specific acute phase proteins – haptoglobin, C-reactive protein, and serum amyloid A.
  • These proteins are released in response to inflammation and infection, thereby potentially serving as non-specific indicators of health.

Application in Veterinary Clinical Chemistry

  • The paper mentions the possible use of these proteins in the health status surveillance of pigs at the herd level. The levels of these proteins could potentially indicate the overall health status of the herd.
  • Measurement of these proteins may also help detect mastitis (inflammation of mammary glands) in dairy cattle. An increased level of these proteins could suggest the presence of this condition.
  • Lastly, the paper suggests that these proteins could also be used for prognosticating respiratory diseases in horses, potentially aiding in early detection and treatment.

Cite This Article

APA
Petersen HH, Nielsen JP, Heegaard PM. (2004). Application of acute phase protein measurements in veterinary clinical chemistry. Vet Res, 35(2), 163-187. https://doi.org/10.1051/vetres:2004002

Publication

ISSN: 0928-4249
NlmUniqueID: 9309551
Country: England
Language: English
Volume: 35
Issue: 2
Pages: 163-187

Researcher Affiliations

Petersen, Henrik Hagbard
  • The Royal Veterinary and Agricultural University, Department of Clinical Studies, Swine Medicine, Dyrlaegevej 88, DK-1870 Frederiksberg C, Denmark. hhp@kvl.dk
Nielsen, Jens Peter
    Heegaard, Peter Mikael Helweg

      MeSH Terms

      • Acute-Phase Proteins / metabolism
      • Animals
      • Apolipoproteins / blood
      • C-Reactive Protein / metabolism
      • Cattle
      • Female
      • Haptoglobins / metabolism
      • Horse Diseases / blood
      • Horses
      • Mastitis, Bovine / blood
      • Respiratory Tract Infections / blood
      • Respiratory Tract Infections / veterinary
      • Serum Amyloid A Protein
      • Swine
      • Swine Diseases / blood

      References

      This article includes 196 references