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Veterinary research2004; 35(2); 163-187; doi: 10.1051/vetres:2004002

Application of acute phase protein measurements in veterinary clinical chemistry.

Abstract: The body's early defence in response to trauma, inflammation or infection, the acute phase response, is a complex set of systemic reactions seen shortly after exposure to a triggering event. One of the many components is an acute phase protein response in which increased hepatic synthesis leads to increased serum concentration of positive acute phase proteins. The serum concentration of these acute phase proteins returns to base levels when the triggering factor is no longer present. This paper provides a review of the acute phase proteins haptoglobin, C-reactive protein and serum amyloid A and their possible use as non-specific indicators of health in large animal veterinary medicine such as in the health status surveillance of pigs at the herd level, for the detection of mastitis in dairy cattle and for the prognosis of respiratory diseases in horses.
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Publication Date: 2004-04-22 PubMed ID: 15099494DOI: 10.1051/vetres:2004002Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article primarily discusses how the measurement of acute phase proteins can be applied in veterinary clinical chemistry, and their potential use as general health indicators in large animals like pigs, cows, and horses.

Main Objective

The principal objective of this research paper is to analyze the functioning of acute phase proteins, specifically haptoglobin, C-reactive protein, and serum amyloid A. The aim is to study their role as non-specific indicators of health in veterinary clinical chemistry, and accordingly, assess their utility in the health surveillance of large animals including pigs, cows, and horses.

Acute Phase Response

  • The research introduces the concept of the ‘acute phase response’, which is part of the body’s immediate response system against trauma, inflammation, or infection.
  • This reaction involves an increase in the synthesis of certain proteins in the liver, leading to a higher concentration of these proteins in the bloodstream, collectively referred to as ‘acute phase proteins’.
  • Once the triggering factor for the trauma, infection or inflammation disappears, the concentration of these proteins in the serum returns to their base levels.

Specific Acute Phase Proteins Discussed

  • The primary focus is on three specific acute phase proteins – haptoglobin, C-reactive protein, and serum amyloid A.
  • These proteins are released in response to inflammation and infection, thereby potentially serving as non-specific indicators of health.

Application in Veterinary Clinical Chemistry

  • The paper mentions the possible use of these proteins in the health status surveillance of pigs at the herd level. The levels of these proteins could potentially indicate the overall health status of the herd.
  • Measurement of these proteins may also help detect mastitis (inflammation of mammary glands) in dairy cattle. An increased level of these proteins could suggest the presence of this condition.
  • Lastly, the paper suggests that these proteins could also be used for prognosticating respiratory diseases in horses, potentially aiding in early detection and treatment.

Cite This Article

APA
Petersen HH, Nielsen JP, Heegaard PM. (2004). Application of acute phase protein measurements in veterinary clinical chemistry. Vet Res, 35(2), 163-187. https://doi.org/10.1051/vetres:2004002

Publication

Veterinary research
ISSN: 0928-4249
NlmUniqueID: 9309551
Country: England
Language: English
Volume: 35
Issue: 2
Pages: 163-187

Researcher Affiliations

Petersen, Henrik Hagbard
  • The Royal Veterinary and Agricultural University, Department of Clinical Studies, Swine Medicine, Dyrlaegevej 88, DK-1870 Frederiksberg C, Denmark. hhp@kvl.dk
Nielsen, Jens Peter
    Heegaard, Peter Mikael Helweg

      MeSH Terms

      • Acute-Phase Proteins / metabolism
      • Animals
      • Apolipoproteins / blood
      • C-Reactive Protein / metabolism
      • Cattle
      • Female
      • Haptoglobins / metabolism
      • Horse Diseases / blood
      • Horses
      • Mastitis, Bovine / blood
      • Respiratory Tract Infections / blood
      • Respiratory Tract Infections / veterinary
      • Serum Amyloid A Protein
      • Swine
      • Swine Diseases / blood

      References

      This article includes 196 references

      Citations

      This article has been cited 238 times.
      1. Martins MM, Gheller LS, Noronha BL, Cassiano GA, Figueiredo MB, Meira CM, Simili FF, Salles MSV, Netto AS. Effects of Sodium Butyrate and Organic Zinc Supplementation on Performance, Mineral Metabolism, and Intestinal Health of Dairy Calves. Animals (Basel) 2026 Jan 13;16(2).
        doi: 10.3390/ani16020230pubmed: 41594419google scholar: lookup
      2. Nalpadan AA, Reyer H, Oster M, Trakooljul N, Ponsuksili S, Kozera W, Karpiesiuk K, Kępka-Borkowska K, Chałaśkiewicz K, Pierzchała M, Taniguchi H, Lepczyński A, Ślaska B, Asediya V, Pareek CS, Wimmers K. Transcriptional insights into aflatoxin B1 induced hepatotoxicity and comparative effects of medicinal herbs in pigs. BMC Vet Res 2026 Jan 15;22(1):53.
        doi: 10.1186/s12917-025-05270-1pubmed: 41535828google scholar: lookup
      3. Ortín A, Villanueva-Saz S, Lacasta D, Windsor PA, Fernández A, Quilez P, Ruiz H, Gómez A, Guallar D, Ruiz de Arcaute M. The Treatment of Contagious Ecthyma in Lambs with a Local Anaesthetic/Antiseptic Wound Formulation Lowers Serum Amyloid A Responses. Animals (Basel) 2025 Dec 20;16(1).
        doi: 10.3390/ani16010017pubmed: 41514705google scholar: lookup
      4. Hotomi S, Ochi M, Fujitani N, Hata A. Analytical comparison of three canine C-reactive protein assays in clinical use in Japan. J Vet Med Sci 2025 Dec 3;87(12):1480-1483.
        doi: 10.1292/jvms.25-0299pubmed: 41125394google scholar: lookup
      5. Alharbi YM. Phenotype- and age-associated variations in non-specific agglutinins and complement components (C3 and C5a) in camels: Implications for transfusion compatibility and immune function. Vet World 2025 Sep;18(9):2811-2822.
        doi: 10.14202/vetworld.2025.2811-2822pubmed: 41113229google scholar: lookup
      6. Friend MM, McGaffigan EM, Hall SM, Staniar WB, Smarsh DN. Changes in equine complete blood count parameters and inflammatory indices with inflammation. J Equine Vet Sci 2025 Dec;155:105705.
        doi: 10.1016/j.jevs.2025.105705pubmed: 41043566google scholar: lookup
      7. Oikonomidis IL, Kavarnos I, Papadimitriou S, Ceron JJ, Kouki M, Adamama-Moraitou KK, Soubasis N. Serum Amyloid A and Haptoglobin as Markers in Cats with Gingivitis-Preliminary Study. Vet Med Sci 2025 Sep;11(5):e70606.
        doi: 10.1002/vms3.70606pubmed: 40944939google scholar: lookup
      8. Yaghoobpour T, Sheikhi Z, Nazifi S. The impact of stress in domestic animals: roles of heat shock proteins and acute-phase proteins. Vet Res Commun 2025 Jul 17;49(5):258.
        doi: 10.1007/s11259-025-10802-zpubmed: 40673978google scholar: lookup
      9. Eder K, Ringseis R, Gessner DK. Effects of Grape By-Products on Oxidative Stress and Inflammation in Farm Animals: An Overview of Studies Performed in Pigs, Chickens, and Cattle. Animals (Basel) 2025 May 23;15(11).
        doi: 10.3390/ani15111536pubmed: 40509002google scholar: lookup
      10. Evans D, Bowring B, Collins A, Clarke J, Kim JC, Mansfield J, Pluske JR. A comparison of feeding acetylated high-amylose maize starch and zinc oxide in weaned pigs experimentally inoculated with an enterotoxigenic strain of Escherichia coli. J Anim Sci 2025 Jan 4;103.
        doi: 10.1093/jas/skaf181pubmed: 40411481google scholar: lookup
      11. Yuan D, Huang Y, Cai Y, Zhang C, Wang JJ, Zhou JG. Orosomucoid 1 is a Potential Prognostic Biomarker for Uterine Sarcoma. Technol Cancer Res Treat 2025 Jan-Dec;24:15330338251343487.
        doi: 10.1177/15330338251343487pubmed: 40388709google scholar: lookup
      12. Khattab MSA, Haiqiang L, Shaoxun T, Qiongxian Y, Yong L, Zhiliang T, Qi L. Immunological response enhancement in cows with subclinical mastitis fed diet supplemented with Macleaya cordata. Front Vet Sci 2025;12:1503487.
        doi: 10.3389/fvets.2025.1503487pubmed: 40303387google scholar: lookup
      13. Souto PC, Santos MR, Orozco AMO, Bento LD, Ramirez-Lopez CJ, Girardi FM, Machado JCA, de Oliveira LL, da Fonseca LA. Enzyme-Linked Immunosorbent Assay (ELISA) Development for Equine Serum Amyloid A (SAA) Determination Using Recombinant Proteins. Methods Protoc 2025 Apr 7;8(2).
        doi: 10.3390/mps8020037pubmed: 40278511google scholar: lookup
      14. Ali AA, Salama SM, Darwish WS, Abdelazim AM. Acute phase proteins as potent early biomarkers for the detection of Escherichia coli infection in white New Zealand rabbits. Open Vet J 2025 Feb;15(2):977-982.
        doi: 10.5455/OVJ.2025.v15.i2.46pubmed: 40201835google scholar: lookup
      15. Marteles D, Lebrero ME, Fernández A, Ortín A, González A, Morell C, Villanueva MJ, Schäfer I, Quílez P, Verde M, Gómez A, Villanueva-Saz S. Impact of single versus multiple infection on serum protein fractions in cats. Vet Res Commun 2025 Apr 4;49(3):158.
        doi: 10.1007/s11259-025-10724-wpubmed: 40183830google scholar: lookup
      16. Fabà L, Martín-Orúe SM, Hulshof TG, Pérez JF, Wellington MO, Van Hees HMJ. Impact of initial postweaning feed intake on weanling piglet metabolism, gut health, and immunity. J Anim Sci 2025 Jan 4;103.
        doi: 10.1093/jas/skaf099pubmed: 40159791google scholar: lookup
      17. Ozcan U, Tutuncu M. The Effect of Florfenicol Given by Nebulization in the Treatment of Naturally Infected Calves With Bovine Respiratory Disease Complex: Randomized Clinical Study. Vet Med Sci 2025 Mar;11(2):e70238.
        doi: 10.1002/vms3.70238pubmed: 39918544google scholar: lookup
      18. Nanas I, Giannoulis T, Dovolou E, Giannenas I, Amiridis GS. Impact of Low Inclusion Rate of Olive Cake in Dairy Cow Rations on Uterine Health and Fertility Indices During Early Lactation. Animals (Basel) 2025 Jan 19;15(2).
        doi: 10.3390/ani15020269pubmed: 39858269google scholar: lookup
      19. Ciliberti MG, Santillo A, Caroprese M, Albenzio M. Buffalo Immune Competence Under Infectious and Non-Infectious Stressors. Animals (Basel) 2025 Jan 10;15(2).
        doi: 10.3390/ani15020163pubmed: 39858163google scholar: lookup
      20. Gerhards K, Becker S, Kuehling J, Lechner M, Willems H, Ringseis R, Reiner G. Screening for transcriptomic associations with Swine Inflammation and Necrosis Syndrome. BMC Vet Res 2025 Jan 17;21(1):26.
        doi: 10.1186/s12917-024-04469-ypubmed: 39825377google scholar: lookup
      21. Hassaneen ASA, Anis A, Nour SY, Mohamed RS, Wassif IM, El-Kattan AM, Abdelgawad HA, Mohamed RH. Poor semen quality is associated with impaired antioxidant response and acute phase proteins and is likely mediated by high cortisol levels in Brucella-seropositive dromedary camel bulls. Sci Rep 2024 Nov 13;14(1):27816.
        doi: 10.1038/s41598-024-74018-ypubmed: 39537650google scholar: lookup
      22. Sidwell AE, Duz M, Khan A, Bodnàr R, Hole SL. Effect of Simple Oral Dental Extraction on Systemic Serum Amyloid A Concentrations in Horses. Vet Med Sci 2024 Nov;10(6):e70104.
        doi: 10.1002/vms3.70104pubmed: 39508719google scholar: lookup
      23. Rispoli LA, Wojtusik J, Roth TL. Exploring Serum Ferritin's Connection to the Acute Phase Response in Zoo-Managed African Rhinoceroses. Zoo Biol 2025 Jan-Feb;44(1):16-23.
        doi: 10.1002/zoo.21873pubmed: 39478097google scholar: lookup
      24. Darwish A, Ebissy E, Hafez A, Ateya A, El-Sayed A. Nucleotide sequence variants, gene expression and serum profile of immune and antioxidant markers associated with bacterial diarrhea susceptibility in Barki lambs. BMC Vet Res 2024 Oct 11;20(1):462.
        doi: 10.1186/s12917-024-04288-1pubmed: 39394128google scholar: lookup
      25. Loch M, Dorbek-Sundström E, Husso A, Pessa-Morikawa T, Niine T, Kaart T, Mõtus K, Niku M, Orro T. Associations of Neonatal Dairy Calf Faecal Microbiota with Inflammatory Markers and Future Performance. Animals (Basel) 2024 Aug 31;14(17).
        doi: 10.3390/ani14172533pubmed: 39272317google scholar: lookup
      26. Rhim H, Kwag C, Han JI. A preliminary study on effects of storage time and repeated freezing-thawing on the stability of avian serum amyloid A. Acta Vet Scand 2024 Sep 2;66(1):42.
        doi: 10.1186/s13028-024-00764-8pubmed: 39223651google scholar: lookup
      27. Dana A, Allymehr M, Talebi A, Asri-Rezaei S. Cytokine and acute-phase proteins response following vaccination against infectious bronchitis in broilers. Vet Med Sci 2024 Sep;10(5):e1586.
        doi: 10.1002/vms3.1586pubmed: 39171612google scholar: lookup
      28. Arrigo F, Aragona F, Faggio C, Giudice E, Giannetto C, Piccione G, Rizzo M, Arfuso F. Monitoring the physiological inflammatory alertness in horse after road transport. Vet Res Commun 2024 Oct;48(5):3331-3338.
        doi: 10.1007/s11259-024-10459-0pubmed: 38965174google scholar: lookup
      29. Trefz FM, Balmer M, Peters LM, Bruckmaier RM, Meylan M. Association of results of the glutaraldehyde coagulation test with plasma acute phase protein concentrations and hematologic findings in hospitalized cows. Front Vet Sci 2024;11:1404809.
        doi: 10.3389/fvets.2024.1404809pubmed: 38962710google scholar: lookup
      30. Heegaard PMH, Starbæk SMR, Lelli D, Skovgaard K. Pig Acute Phase Proteins as Non-Antibody Systemic Biomarkers of Intracellular Infections. Methods Mol Biol 2024;2813:145-165.
        doi: 10.1007/978-1-0716-3890-3_11pubmed: 38888777google scholar: lookup
      31. Augustyniak A, Czyżewska-Dors E, Pomorska-Mól M. Concentrations of selected immunological parameters in the serum and processing fluid of suckling piglets and the serum and colostrum of their mothers. BMC Vet Res 2024 May 3;20(1):170.
        doi: 10.1186/s12917-024-04024-9pubmed: 38702674google scholar: lookup
      32. El-Sayed A, Refaai M, Ateya A. Doppler ultrasonographic scan, gene expression and serum profile of immune, APPs and antioxidant markers in Egyptian buffalo-cows with clinical endometritis. Sci Rep 2024 Mar 8;14(1):5698.
        doi: 10.1038/s41598-024-56258-0pubmed: 38459095google scholar: lookup
      33. Kamel MS, Davidson JL, Verma MS. Strategies for Bovine Respiratory Disease (BRD) Diagnosis and Prognosis: A Comprehensive Overview. Animals (Basel) 2024 Feb 16;14(4).
        doi: 10.3390/ani14040627pubmed: 38396598google scholar: lookup
      34. Rhim H, Kim M, Gim S, Han JI. Diagnostic value of serum amyloid A in differentiating the inflammatory disorders in wild birds. Front Vet Sci 2024;11:1284113.
        doi: 10.3389/fvets.2024.1284113pubmed: 38379926google scholar: lookup
      35. Uva A, Cavalera MA, Gusatoaia O, Donghia R, Gernone F, Silvestrino M, Zatelli A. Inflammatory Status and Chronic Kidney Disease in Cats: Old and New Inflammatory Markers-A Pilot Prospective Study. Animals (Basel) 2023 Nov 28;13(23).
        doi: 10.3390/ani13233674pubmed: 38067025google scholar: lookup
      36. Akyüz E, Merhan O, Aydın U, Sezer M, Atlı K, Büyük E, Batı YU, Saltık HS, Tanrıverdi E, Çelebi Ö, Kuru M, Cihan M, Otlu S, Gökce G. Pentraxin-3, endothelin-1, some biochemical parameters and hematology in bovine respiratory disease complex. Iran J Vet Res 2023;24(2):143-150.
        doi: 10.22099/IJVR.2023.46494.6674pubmed: 37790112google scholar: lookup
      37. Moriconi M, Pagliasso G, Fusi F, Vitale N, Guardone L, Vevey M, Dondo A, Razzuoli E, Bergagna S. Is the Introduction into a New Environment Stressful for Young Bulls?. Vet Sci 2023 Aug 30;10(9).
        doi: 10.3390/vetsci10090545pubmed: 37756067google scholar: lookup
      38. Yue L, Xu X, Dai S, Xu F, Zhao W, Gu J, Dai X, Qian X. Orosomucoid 1 promotes colorectal cancer progression and liver metastasis by affecting PI3K/AKT pathway and inducing macrophage M2 polarization. Sci Rep 2023 Aug 28;13(1):14092.
        doi: 10.1038/s41598-023-40404-1pubmed: 37640741google scholar: lookup
      39. Shinya U, Yamato O, Iwamura Y, Kato T, Hamada Y, Widodo OS, Taniguchi M, Takagi M. Usefulness of Measuring Serum Amyloid A Concentration in Japanese Black Cattle in Clinical Practice. Vet Sci 2023 Aug 17;10(8).
        doi: 10.3390/vetsci10080528pubmed: 37624315google scholar: lookup
      40. Isik Uslu N, Derinbay Ekici O, Ceylan O. Evaluation of Oxidative Status, Cytokines, Acute Phase Proteins and Cardiac Damage Markers in Sheep Naturally Infected with Babesia ovis. Acta Parasitol 2023 Dec;68(4):762-768.
        doi: 10.1007/s11686-023-00708-8pubmed: 37589881google scholar: lookup
      41. Gerhards K, Becker S, Kuehling J, Lechner M, Bathke J, Willems H, Reiner G. GWAS reveals genomic associations with swine inflammation and necrosis syndrome. Mamm Genome 2023 Dec;34(4):586-601.
        doi: 10.1007/s00335-023-10011-6pubmed: 37526658google scholar: lookup
      42. Di Luca A, Bennato F, Ianni A, Grotta L, Henry M, Meleady P, Martino G. Comparative Label-Free Liquid Chromatography-Mass Spectrometry Milk Proteomic Profiles Highlight Putative Differences between the Autochthon Teramana and Saanen Goat Breeds. Animals (Basel) 2023 Jul 10;13(14).
        doi: 10.3390/ani13142263pubmed: 37508040google scholar: lookup
      43. Ali A, Rehman MU, Mushtaq S, Ahmad SB, Khan A, Karan A, Bashir Wani A, Ganie SA, Mir MUR. Biochemical and Computational Assessment of Acute Phase Proteins in Dairy Cows Affected with Subclinical Mastitis. Curr Issues Mol Biol 2023 Jun 26;45(7):5317-5346.
        doi: 10.3390/cimb45070338pubmed: 37504254google scholar: lookup
      44. Miller I, Gianazza E. Proteomic methods for the study of porcine acute phase proteins - anything new to detect?. Vet Res Commun 2023 Dec;47(4):1801-1815.
        doi: 10.1007/s11259-023-10170-6pubmed: 37452983google scholar: lookup
      45. Alwan GF, Al Saad KM. Investigation of the Clinical and Diagnostic Aspects of Peste des Petits Ruminants (PPR) in Sheep from the Southern Region of Iraq. Arch Razi Inst 2023 Apr;78(2):561-570.
        doi: 10.22092/ARI.2022.359291.2396pubmed: 37396745google scholar: lookup
      46. Cheng Z, Ferris C, Crowe MA, Ingvartsen KL, Grelet C, Vanlierde A, Foldager L, Becker F, Wathes DC, The GplusE Consortium. Hepatic Global Transcriptomic Profiles of Holstein Cows According to Parity Reveal Age-Related Changes in Early Lactation. Int J Mol Sci 2023 Jun 8;24(12).
        doi: 10.3390/ijms24129906pubmed: 37373054google scholar: lookup
      47. Rivadeneira-Barreiro P, Montes-de-Oca-Jiménez R, Zambrano-Rodríguez P, Vázquez-Chagoyán JC, Gutiérrez-Castillo ADC, Pardo-Marin L, Franco-Martínez L, Cerón JJ, Martínez-Subiela S. Acute Phase Proteins in Dogs with Natural Infection by Trypanosoma cruzi. Trop Med Infect Dis 2023 May 31;8(6).
        doi: 10.3390/tropicalmed8060299pubmed: 37368717google scholar: lookup
      48. Akiyoshi M, Hisasue M, Neo S, Akiyoshi M. Serum amyloid A (SAA) concentration in cats with gastrointestinal lymphoma. J Vet Med Sci 2023 Aug 1;85(8):867-875.
        doi: 10.1292/jvms.23-0043pubmed: 37357392google scholar: lookup
      49. Valldeperes M, Yerro PP, López-Olvera JR, Fandos P, Lavín S, Escofet RCS, Mentaberre G, León FJC, Espinosa J, Ráez-Bravo A, Pérez JM, Tampach S, Estruch J, Velarde R, Granados JE. Diseases of Iberian ibex (Capra pyrenaica). Eur J Wildl Res 2023;69(3):63.
        doi: 10.1007/s10344-023-01684-0pubmed: 37274486google scholar: lookup
      50. Moratorio M, Carriquiry M, Ungerfeld R, Fiol C. Frequent social regroupings affect corporal and reproductive development, metabolic status, and behavioral time budget in dairy heifers. Trop Anim Health Prod 2023 Jun 5;55(4):231.
        doi: 10.1007/s11250-023-03648-7pubmed: 37273090google scholar: lookup
      51. Grzędzicka J, Dąbrowska I, Malin K, Witkowska-Piłaszewicz O. Exercise-related changes in the anabolic index (testosterone to cortisol ratio) and serum amyloid A concentration in endurance and racehorses at different fitness levels. Front Vet Sci 2023;10:1148990.
        doi: 10.3389/fvets.2023.1148990pubmed: 37138908google scholar: lookup
      52. Smock TM, Rand Broadway P, Burdick Sanchez NC, Carroll JA, Theurer ME, Hales KE. An updated profile of the bovine acute phase response following an intravenous lipopolysaccharide challenge. J Anim Sci 2023 Jan 3;101.
        doi: 10.1093/jas/skad133pubmed: 37115605google scholar: lookup
      53. Brodzki P, Marczuk J, Lisiecka U, Krakowski L, Szczubiał M, Dąbrowski R, Bochniarz M, Kulpa K, Brodzki N, Wolniaczyk K. Assessment of Selected Immunological Parameters in Dairy Cows with Naturally Occurring Mycotoxicosis before and after the Application of a Mycotoxin Deactivator. J Vet Res 2023 Mar;67(1):105-113.
        doi: 10.2478/jvetres-2023-0002pubmed: 37008772google scholar: lookup
      54. Palmisano M, Javsicas L, McNaughten J, Gamsjäger L, Renaud DL, Gomez DE. Effect of plasma transfusion on serum amyloid A concentration in healthy neonatal foals and foals with failure of transfer of passive immunity. J Vet Intern Med 2023 Mar;37(2):697-702.
        doi: 10.1111/jvim.16647pubmed: 36825688google scholar: lookup
      55. Ledoux D, Veissier I, Meunier B, Gelin V, Richard C, Kiefer H, Jammes H, Foucras G, de Boyer des Roches A. Combining accelerometers and direct visual observations to detect sickness and pain in cows of different ages submitted to systemic inflammation. Sci Rep 2023 Feb 3;13(1):1977.
        doi: 10.1038/s41598-023-27884-xpubmed: 36737469google scholar: lookup
      56. Seveljevic-Jaran D, Antolic M, Ognjenovic A, Kalliokoski O, Abelson KSP, Hau J. Effects of Multimodal Therapy, Blinding, and Multi-laboratory Protocol Conduct on the Robustness of the Rat Model of Adjuvant Induced Arthritis. In Vivo 2023 Jan-Feb;37(1):115-123.
        doi: 10.21873/invivo.13060pubmed: 36593032google scholar: lookup
      57. Meléndez DM, Marti S, Haley DB, Schwinghamer TD, Yang X, Schwartzkopf-Genswein KS. Effect of rest, post-rest transport duration, and conditioning on performance, behavioural, and physiological welfare indicators of beef calves. PLoS One 2022;17(12):e0278768.
        doi: 10.1371/journal.pone.0278768pubmed: 36454988google scholar: lookup
      58. D'Alessandro E, Arfuso F, Floridia V, Tardiolo G, Fazio F, Giannetto C, Piccione G, Zumbo A. Different genotype and a liquid whey-supplemented diet influence the resilience of pigs through immune-modulation and anti-inflammatory response. Front Vet Sci 2022;9:1046101.
        doi: 10.3389/fvets.2022.1046101pubmed: 36439344google scholar: lookup
      59. Dória RGS, Reginato GM, Hayasaka YB, Fantinato Neto P, Passarelli D, Arantes JA. Complications following transcutaneous cecal trocarization in horses with a cattle trocar and a cecal needle. PLoS One 2022;17(11):e0277468.
        doi: 10.1371/journal.pone.0277468pubmed: 36417417google scholar: lookup
      60. Liu H, Wang S, Zhang D, Wang J, Zhang W, Wang Y, Ji H. Effects of dietary supplementation with Pediococcus acidilactici ZPA017 on reproductive performance, fecal microbial flora and serum indices in sows during late gestation and lactation. Asian-Australas J Anim Sci 2020 Jan;33(1):120-126.
        doi: 10.5713/ajas.18.0764pubmed: 36379222google scholar: lookup
      61. Fazio E, Bionda A, Liotta L, Amato A, Chiofalo V, Crepaldi P, Satué K, Lopreiato V. Changes of acute-phase proteins, glucose, and lipid metabolism during pregnancy in lactating dairy cows. Arch Anim Breed 2022;65(3):329-339.
        doi: 10.5194/aab-65-329-2022pubmed: 36267480google scholar: lookup
      62. Ramos MGDSN, Campos SDE, Strauch MA, Ott LC, Macieira DB, de Alencar NX, Lessa DAB. Serum proteins and electrophoretic profile in horses undergoing crotalid venom hyperimmunization. J Equine Sci 2022 Sep;33(3):31-35.
        doi: 10.1294/jes.33.31pubmed: 36196141google scholar: lookup
      63. Cappellozza BI, Cooke RF. Administering an Appeasing Substance to Improve Performance, Neuroendocrine Stress Response, and Health of Ruminants. Animals (Basel) 2022 Sep 15;12(18).
        doi: 10.3390/ani12182432pubmed: 36139292google scholar: lookup
      64. Oreiby A, Seada AS, Abou Elazab MF, Abdo W, Kassab M, Hegazy Y, Khalifa HO, Matsumoto T. Emergency Vaccination as a Control Strategy against Sheeppox Outbreak in a Highly Susceptible Population. Animals (Basel) 2022 Aug 15;12(16).
        doi: 10.3390/ani12162084pubmed: 36009674google scholar: lookup
      65. Kubota T, Tateishi N, Toita H, Kanaki N, Hata A, Fujitani N. Development of a canine blood C-reactive protein-measuring device using a flow-type immunosensor. Anal Sci 2022 Oct;38(10):1269-1276.
        doi: 10.1007/s44211-022-00173-9pubmed: 35931913google scholar: lookup
      66. Pirkkalainen H, Talvio I, Kujala-Wirth M, Soveri T, Orro T. Acute phase response of sole ulcer, white line disease and digital dermatitis in dairy cows. Vet Anim Sci 2022 Sep;17:100253.
        doi: 10.1016/j.vas.2022.100253pubmed: 35669246google scholar: lookup
      67. Crawford DM, Richeson JT, Perkins TL, Samuelson KL. Feeding a high-energy finishing diet upon arrival to high-risk feedlot calves: effects on health, performance, ruminal pH, rumination, serum metabolites, and carcass traits. J Anim Sci 2022 Sep 1;100(9).
        doi: 10.1093/jas/skac194pubmed: 35639878google scholar: lookup
      68. Shinya U, Iwamura Y, Yamato O, Pambudi D, Widodo OS, Taniguchi M, Takagi M. Serum Amyloid A Concentrations of Healthy and Clinically Diseased Japanese Black Breeding Cattle-Preliminary Measurements for Determining the Cut-Off Concentrations. Vet Sci 2022 Apr 21;9(5).
        doi: 10.3390/vetsci9050198pubmed: 35622726google scholar: lookup
      69. Hu C, Dai Z, Xu J, Zhao L, Xu Y, Li M, Yu J, Zhang L, Deng H, Liu L, Zhang M, Huang J, Wu L, Chen G. Proteome Profiling Identifies Serum Biomarkers in Rheumatoid Arthritis. Front Immunol 2022;13:865425.
        doi: 10.3389/fimmu.2022.865425pubmed: 35603148google scholar: lookup
      70. Han P, Hou C, Zheng X, Cao L, Shi X, Zhang X, Ye H, Pan H, Liu L, Li T, Hu F, Li Z. Serum Antigenome Profiling Reveals Diagnostic Models for Rheumatoid Arthritis. Front Immunol 2022;13:884462.
        doi: 10.3389/fimmu.2022.884462pubmed: 35514972google scholar: lookup
      71. Gautreaux MA, Tucker LJ, Person XJ, Zetterholm HK, Priddy LB. Review of immunological plasma markers for longitudinal analysis of inflammation and infection in rat models. J Orthop Res 2022 Jun;40(6):1251-1262.
        doi: 10.1002/jor.25330pubmed: 35315119google scholar: lookup
      72. Kromann S, Olsen RH, Bojesen AM, Jensen HE, Thøfner I. Assessment of automated assays for serum amyloid A, haptoglobin (PIT54) and basic biochemistry in broiler breeders experimentally infected with Escherichia coli. Vet Res 2022 Mar 21;53(1):25.
        doi: 10.1186/s13567-022-01040-1pubmed: 35313963google scholar: lookup
      73. Bazzano M, Marchegiani A, Troisi A, McLean A, Laus F. Serum Amyloid A as a Promising Biomarker in Domestic Animals' Reproduction: Current Knowledge and Future Perspective. Animals (Basel) 2022 Feb 25;12(5).
        doi: 10.3390/ani12050589pubmed: 35268158google scholar: lookup
      74. Seveljevic-Jaran D, Kalliokoski O, Abelson KSP, Hau J. Antidepressant Fluoxetine Does Not Appear to Interfere With Key Translational Parameters in the Rat Adjuvant-induced Arthritis Model. In Vivo 2022 Mar-Apr;36(2):635-642.
        doi: 10.21873/invivo.12747pubmed: 35241516google scholar: lookup
      75. Wollanke B, Gerhards H, Ackermann K. Infectious Uveitis in Horses and New Insights in Its Leptospiral Biofilm-Related Pathogenesis. Microorganisms 2022 Feb 7;10(2).
        doi: 10.3390/microorganisms10020387pubmed: 35208842google scholar: lookup
      76. Loewenstein F, Becker S, Kuehling J, Schrade H, Lechner M, Ringseis R, Eder K, Moritz A, Reiner G. Inflammation and necrosis syndrome is associated with alterations in blood and metabolism in pigs. BMC Vet Res 2022 Jan 19;18(1):50.
        doi: 10.1186/s12917-021-03107-1pubmed: 35045844google scholar: lookup
      77. Pomorska-Mól M, Libera K, Larska M, Krzysiak MK. Acute-phase protein concentrations in serum of clinically healthy and diseased European bison (Bison bonasus) - preliminary study. BMC Vet Res 2022 Jan 10;18(1):28.
        doi: 10.1186/s12917-021-03133-zpubmed: 35012560google scholar: lookup
      78. Martin MS, Kleinhenz MD, White BJ, Johnson BT, Montgomery SR, Curtis AK, Weeder MM, Blasi DA, Almes KM, Amachawadi RG, Salih HM, Miesner MD, Baysinger AK, Nickell JS, Coetzee JF. Assessment of pain associated with bovine respiratory disease and its mitigation with flunixin meglumine in cattle with induced bacterial pneumonia. J Anim Sci 2022 Feb 1;100(2).
        doi: 10.1093/jas/skab373pubmed: 34932121google scholar: lookup
      79. Meyer M, Montero L, Meckelmann SW, Schmitz OJ. Comparative study for analysis of carbohydrates in biological samples. Anal Bioanal Chem 2022 Mar;414(6):2117-2130.
        doi: 10.1007/s00216-021-03845-zpubmed: 34928405google scholar: lookup
      80. Chovanová F, Tóthová C, Klein R, Nagy O. Changes in the Serum Protein Fractions in Goats after Treatment of Natural Gastrointestinal Parasite Infections. Vet Med Int 2021;2021:9946519.
        doi: 10.1155/2021/9946519pubmed: 34888029google scholar: lookup
      81. Farschtschi S, Mattes M, Hildebrandt A, Chiang D, Kirchner B, Kliem H, Pfaffl MW. Development of an advanced flow cytometry based high-resolution immunophenotyping method to benchmark early immune response in dairy cows. Sci Rep 2021 Nov 24;11(1):22896.
        doi: 10.1038/s41598-021-02405-wpubmed: 34819614google scholar: lookup
      82. Barcellos J, Alves WJ, Arnaut PR, Fonseca L, Muniz JCL, Dorigam JCP, Campos PHRF, Silva FFE, Dilger RN, Hannas MI. Assessment of digestible lysine requirements in lipopolysaccharide-challenged pigs. J Anim Sci 2021 Dec 1;99(12).
        doi: 10.1093/jas/skab336pubmed: 34752613google scholar: lookup
      83. Golshan N, Toosi BK, Heidarpour M. The relationship of metabolic parameters and milk acute-phase protein with the outcome of treatment of Staphylococcus aureus subclinical mastitis in dairy cows. Trop Anim Health Prod 2021 Oct 1;53(5):489.
        doi: 10.1007/s11250-021-02942-6pubmed: 34596781google scholar: lookup
      84. Dänicke S, Saltzmann J, Liermann W, Glatter M, Hüther L, Kersten S, Zeyner A, Feige K, Warnken T. Evaluation of Inner Exposure of Horses to Zearalenone (ZEN), Deoxynivalenol (DON) and Their Metabolites in Relation to Colic and Health-Related Clinical-Chemical Traits. Toxins (Basel) 2021 Aug 23;13(8).
        doi: 10.3390/toxins13080588pubmed: 34437459google scholar: lookup
      85. Brodzki P, Marczuk J, Lisiecka U, Szczubiał M, Brodzki A, Gorzkoś H, Kulpa K. Comparative evaluation of cytokine and acute-phase protein concentrations in sera of dairy cows with subclinical and clinical ketosis as a different view of the causes of the disease. Vet World 2021 Jun;14(6):1572-1578.
        doi: 10.14202/vetworld.2021.1572-1578pubmed: 34316205google scholar: lookup
      86. Keany KM, Fosgate GT, Perry SM, Stroup ST, Steiner JM. Serum concentrations of canine pancreatic lipase immunoreactivity and C-reactive protein for monitoring disease progression in dogs with acute pancreatitis. J Vet Intern Med 2021 Sep;35(5):2187-2195.
        doi: 10.1111/jvim.16218pubmed: 34250650google scholar: lookup
      87. Wegener B, Behnke M, Milz S, Jansson V, Redlich C, Hermanns W, Birkenmaier C, Pieper K, Weißgärber T, Quadbeck P. Local and systemic inflammation after implantation of a novel iron based porous degradable bone replacement material in sheep model. Sci Rep 2021 Jun 8;11(1):12035.
        doi: 10.1038/s41598-021-91296-ypubmed: 34103567google scholar: lookup
      88. Lora I, Massignani M, Stefani A, Gottardo F. Potential Benefits to Dairy Cow Welfare of Using a Ceftiofur-Ketoprofen Combination Drug for the Treatment of Inflammatory Disease Associated with Pyrexia: A Field Clinical Trial on Acute Puerperal Metritis. Animals (Basel) 2021 May 28;11(6).
        doi: 10.3390/ani11061597pubmed: 34071561google scholar: lookup
      89. Mohamed RH, Abo El-Maaty AM, Abd El Hameed AR, Ali AH. Impact of travel by walk and road on testicular hormones, oxidants, traces minerals, and acute phase response biomarkers of dromedary camels. Heliyon 2021 Apr;7(4):e06879.
        doi: 10.1016/j.heliyon.2021.e06879pubmed: 34007918google scholar: lookup
      90. Bartlett SL, Lamberski N, Arheart KL, Cray C. Protein Electrophoresis and Haptoglobin Values for Captive Bongo (Tragelaphus eurycerus). Front Vet Sci 2021;8:646500.
        doi: 10.3389/fvets.2021.646500pubmed: 33996975google scholar: lookup
      91. Le Floc'h N, Gondret F, Resmond R. Identification of blood immune and metabolic indicators explaining the variability of growth of pigs under contrasted sanitary conditions. BMC Vet Res 2021 Apr 15;17(1):166.
        doi: 10.1186/s12917-021-02872-3pubmed: 33858408google scholar: lookup
      92. Windria S, Salasia SIO, Nugroho W, Widayanti R, Indarjulianto S. Development of ELISA against milk haptoglobin for diagnosis of subclinical mastitis in goats. Heliyon 2021 Feb;7(2):e06314.
        doi: 10.1016/j.heliyon.2021.e06314pubmed: 33665459google scholar: lookup
      93. Meléndez DM, Marti S, Haley DB, Schwinghamer TD, Schwartzkopf-Genswein KS. Effects of conditioning, source, and rest on indicators of stress in beef cattle transported by road. PLoS One 2021;16(1):e0244854.
        doi: 10.1371/journal.pone.0244854pubmed: 33434915google scholar: lookup
      94. Wu H, Wang Y, Dong L, Hu H, Meng L, Liu H, Zheng N, Wang J. Microbial Characteristics and Safety of Dairy Manure ComPosting for Reuse as Dairy Bedding. Biology (Basel) 2020 Dec 28;10(1).
        doi: 10.3390/biology10010013pubmed: 33379325google scholar: lookup
      95. Perez-Ecija A, Buzon-Cuevas A, Aguilera-Aguilera R, Gonzalez-De Cara C, Mendoza Garcia FJ. Reference intervals of acute phase proteins in healthy Andalusian donkeys and response to experimentally induced endotoxemia. J Vet Intern Med 2021 Jan;35(1):580-589.
        doi: 10.1111/jvim.16015pubmed: 33336874google scholar: lookup
      96. Bassis S, Fischer S, Köhler H, Reinhold P. Acid-base variables in acute and chronic form of nontuberculous mycobacterial infection in growing goats experimentally inoculated with Mycobacterium avium subsp. hominissuis or Mycobacterium avium subsp. paratuberculosis. PLoS One 2020;15(12):e0243892.
        doi: 10.1371/journal.pone.0243892pubmed: 33315933google scholar: lookup
      97. Fernandez-Novo A, Pérez-Garnelo SS, Villagrá A, Pérez-Villalobos N, Astiz S. The Effect of Stress on Reproduction and Reproductive Technologies in Beef Cattle-A Review. Animals (Basel) 2020 Nov 11;10(11).
        doi: 10.3390/ani10112096pubmed: 33187308google scholar: lookup
      98. Smock TM, Samuelson KL, Wells JE, Hales KE, Hergenreder JE, Rounds PW, Richeson JT. Effects of Bacillus subtilis PB6 and/or chromium propionate supplementation on serum chemistry, complete blood count, and fecal Salmonella spp. count in high-risk cattle during the feedlot receiving and finishing periods(). Transl Anim Sci 2020 Jul;4(3):txaa164.
        doi: 10.1093/tas/txaa164pubmed: 33134874google scholar: lookup
      99. Espinosa J, de la Morena R, Benavides J, García-Pariente C, Fernández M, Tesouro M, Arteche N, Vallejo R, Ferreras MC, Pérez V. Assessment of Acute-Phase Protein Response Associated with the Different Pathological Forms of Bovine Paratuberculosis. Animals (Basel) 2020 Oct 20;10(10).
        doi: 10.3390/ani10101925pubmed: 33092108google scholar: lookup
      100. Navarro T, González JM, Ramos JJ, Marca MC, Figliola L, de Arcaute MR, Borobia M, Ortín A. Impact of Stress on Health and Final Weight in Fattening Lambs. Animals (Basel) 2020 Jul 25;10(8).
        doi: 10.3390/ani10081274pubmed: 32722490google scholar: lookup
      101. Ferrer LM, Lacasta D, Ortín A, Ramos JJ, Tejedor MT, Borobia M, Pérez M, Castells E, Ruiz de Arcaute M, Ruiz H, Windsor PA. Impact of a Topical Anaesthesia Wound Management Formulation on Pain, Inflammation and Reduction of Secondary Infections after Tail Docking in Lambs. Animals (Basel) 2020 Jul 24;10(8).
        doi: 10.3390/ani10081255pubmed: 32722010google scholar: lookup
      102. Daniel JA, Crane A, Krawczel PD, Coetzee JF, Whitlock BK. Effect of oral meloxicam administration on growth performance and behavior of pre-weaning age calves following band castration. Transl Anim Sci 2020 Apr;4(2):txaa021.
        doi: 10.1093/tas/txaa021pubmed: 32705021google scholar: lookup
      103. Dänicke S, Bannert E, Tesch T, Kersten S, Frahm J, Bühler S, Sauerwein H, Görs S, Kahlert S, Rothkötter HJ, Metges CC, Kluess J. Oral exposure of pigs to the mycotoxin deoxynivalenol does not modulate the hepatic albumin synthesis during a LPS-induced acute-phase reaction. Innate Immun 2020 Nov;26(8):716-732.
        doi: 10.1177/1753425920937778pubmed: 32703050google scholar: lookup
      104. Fadl SE, El-Gammal GA, Sakr OA, Salah AABS, Atia AA, Prince AM, Hegazy AM. Impact of dietary Mannan-oligosaccharide and β-Glucan supplementation on growth, histopathology, E-coli colonization and hepatic transcripts of TNF-α and NF- ϰB of broiler challenged with E. coli O(78). BMC Vet Res 2020 Jun 19;16(1):204.
        doi: 10.1186/s12917-020-02423-2pubmed: 32560684google scholar: lookup
      105. Adamovicz L, Baker SJ, Kessler E, Kelly M, Johnson S, Winter J, Phillips CA, Allender MC. Erythrocyte sedimentation rate and hemoglobin-binding protein in free-living box turtles (Terrapene spp.). PLoS One 2020;15(6):e0234805.
        doi: 10.1371/journal.pone.0234805pubmed: 32555669google scholar: lookup
      106. Otsuka M, Nishi Y, Tsukano K, Tsuchiya M, Lakritz J, Suzuki K. Sequential changes in hepatic mRNA abundance and serum concentration of serum amyloid A in cattle with acute inflammation caused by endotoxin. J Vet Med Sci 2020 Jul 31;82(7):1006-1011.
        doi: 10.1292/jvms.19-0629pubmed: 32493888google scholar: lookup
      107. Proverbio D, Perego R, Baggiani L, Ravasio G, Giambellini D, Spada E. Serum Protein Gel Agarose Electrophoresis in Captive Tigers. Animals (Basel) 2020 Apr 20;10(4).
        doi: 10.3390/ani10040716pubmed: 32325948google scholar: lookup
      108. Seppä-Lassila L, Eerola U, Orro T, Härtel H, Simojoki H, Autio T, Pelkonen S, Soveri T. Health and growth of Finnish beef calves and the relation to acute phase response. Livest Sci 2017 Feb;196:7-13.
        doi: 10.1016/j.livsci.2016.12.007pubmed: 32288871google scholar: lookup
      109. Atmaca HT, Gazyagci AN, Terzi OS, Dincel GC, Sumer T. Tracking acute phase protein response during acute and chronic Toxoplasma gondii infection. Lab Anim Res 2019;35:6.
        doi: 10.1186/s42826-019-0007-zpubmed: 32257894google scholar: lookup
      110. Hajimohammadi A, Nazifi S, Ansari-Lari M, Khoshmanzar MR, Bigdeli SM. Identifying relationships among acute phase proteins (haptoglobin, serum amyloid A, fibrinogen, ceruloplasmin) and clinical findings in dairy calf diarrhea. Comp Clin Path 2013;22(2):227-232.
        doi: 10.1007/s00580-011-1390-5pubmed: 32214972google scholar: lookup
      111. Meléndez DM, Marti S, Haley DB, Schwinghamer TD, Schwartzkopf-Genswein KS. Effect of transport and rest stop duration on the welfare of conditioned cattle transported by road. PLoS One 2020;15(3):e0228492.
        doi: 10.1371/journal.pone.0228492pubmed: 32120382google scholar: lookup
      112. Sinovich M, Villarino NF, Singer E, Robinson CS, Rubio-Martínez LM. Can blood serum amyloid A concentrations in horses differentiate synovial sepsis from extrasynovial inflammation and determine response to treatment?. Vet Rec 2020 Sep 19;187(6):235.
        doi: 10.1136/vr.105153pubmed: 32098906google scholar: lookup
      113. Long A, Nolen-Walston R. Equine Inflammatory Markers in the Twenty-First Century: A Focus on Serum Amyloid A. Vet Clin North Am Equine Pract 2020 Apr;36(1):147-160.
        doi: 10.1016/j.cveq.2019.12.005pubmed: 32007299google scholar: lookup
      114. Kayser WC, Carstens GE, Parsons IL, Washburn KE, Lawhon SD, Pinchak WE, Chevaux E, Skidmore AL. Efficacy of statistical process control procedures to identify deviations in continuously measured physiologic and behavioral variables in beef steers experimentally challenged with Mannheimia haemolytica. J Anim Sci 2020 Feb 1;98(2).
        doi: 10.1093/jas/skaa009pubmed: 31930309google scholar: lookup
      115. Huang J, Wang Q, Hu Y, Qi Z, Lin Z, Ying W, Zhou M. Proteomic Profiling for Serum Biomarkers in Mice Exposed to Ionizing Radiation. Dose Response 2019 Oct-Dec;17(4):1559325819894794.
        doi: 10.1177/1559325819894794pubmed: 31853238google scholar: lookup
      116. Dhama K, Latheef SK, Dadar M, Samad HA, Munjal A, Khandia R, Karthik K, Tiwari R, Yatoo MI, Bhatt P, Chakraborty S, Singh KP, Iqbal HMN, Chaicumpa W, Joshi SK. Biomarkers in Stress Related Diseases/Disorders: Diagnostic, Prognostic, and Therapeutic Values. Front Mol Biosci 2019;6:91.
        doi: 10.3389/fmolb.2019.00091pubmed: 31750312google scholar: lookup
      117. Tothova C, Novotny J, Nagy O, Hornakova P, Zert Z, Varga M, Medvecky L, Vdoviakova K, Danko J, Petrovova E. Changes in the Acute-Phase Protein Concentrations and Activities of Some Enzymes in Pigs Following the Repair of Experimentally Induced Articular Cartilage Defects Using Two Types of Biocement Powder. Animals (Basel) 2019 Nov 7;9(11).
        doi: 10.3390/ani9110931pubmed: 31703315google scholar: lookup
      118. Gregg BA, Parker PA, Waller KM, Schneider LG, Garcia M, Bradford B, Daniel JA, Whitlock BK. Effects of central and peripheral administration of an acute-phase protein, α-1-acid-glycoprotein, on feed intake and rectal temperature in sheep. J Anim Sci 2019 Dec 17;97(12):4783-4791.
        doi: 10.1093/jas/skz336pubmed: 31679022google scholar: lookup
      119. Assunção P, Barbosa T, Yonezawa L, Barbosa L, Watanabe M, Kohayagawa A, Schmidt E. Acute-phase protein profile in horses subjected to different exercise protocols. Can J Vet Res 2019 Oct;83(4):272-278.
        pubmed: 31571727
      120. Bergeron N, Guay F. Impact of zinc and arginine on antioxidant status of weanling piglets raised under commercial conditions. Anim Nutr 2019 Sep;5(3):227-233.
        doi: 10.1016/j.aninu.2019.03.001pubmed: 31528723google scholar: lookup
      121. Witkowska-Piłaszewicz O, Bąska P, Czopowicz M, Żmigrodzka M, Szarska E, Szczepaniak J, Nowak Z, Winnicka A, Cywińska A. Anti-Inflammatory State in Arabian Horses Introduced to the Endurance Training. Animals (Basel) 2019 Aug 27;9(9).
        doi: 10.3390/ani9090616pubmed: 31462005google scholar: lookup
      122. Baccili CC, Martin CC, Decaris N, Madureira KM, Chase C, Gomes V. Effects of 3 Different Commercial Vaccines Formulations against BVDV and BHV-1 on the Inflammatory Response of Holstein Heifers. Vet Sci 2019 Aug 26;6(3).
        doi: 10.3390/vetsci6030069pubmed: 31455017google scholar: lookup
      123. Izumiyama T, Mori Y, Mori S, Mori N, Kodama T, Itoi E. The effect of anti-IL-6 receptor antibody for the treatment of McH-lpr/lpr-RA1 mice that spontaneously developed destructive arthritis and enthesitis. BMC Musculoskelet Disord 2019 Jun 15;20(1):286.
        doi: 10.1186/s12891-019-2664-3pubmed: 31200688google scholar: lookup
      124. Gelain ME, Bonsembiante F. Acute Phase Proteins in Marine Mammals: State of Art, Perspectives and Challenges. Front Immunol 2019;10:1220.
        doi: 10.3389/fimmu.2019.01220pubmed: 31191557google scholar: lookup
      125. Witkowska-Piłaszewicz O, Bąska P, Czopowicz M, Żmigrodzka M, Szczepaniak J, Szarska E, Winnicka A, Cywińska A. Changes in Serum Amyloid A (SAA) Concentration in Arabian Endurance Horses During First Training Season. Animals (Basel) 2019 Jun 8;9(6).
        doi: 10.3390/ani9060330pubmed: 31181740google scholar: lookup
      126. Hennig-Pauka I, Menzel A, Boehme TR, Schierbaum H, Ganter M, Schulz J. Haptoglobin and C-Reactive Protein-Non-specific Markers for Nursery Conditions in Swine. Front Vet Sci 2019;6:92.
        doi: 10.3389/fvets.2019.00092pubmed: 31001544google scholar: lookup
      127. Boswell M, Lu Y, Boswell W, Savage M, Hildreth K, Salinas R, Walter CA, Walter RB. Fluorescent Light Incites a Conserved Immune and Inflammatory Genetic Response within Vertebrate Organs (Danio Rerio, Oryzias Latipes and Mus Musculus). Genes (Basel) 2019 Apr 3;10(4).
        doi: 10.3390/genes10040271pubmed: 30987199google scholar: lookup
      128. Yakan S, Aydin T, Gulmez C, Ozden O, Eren Erdogan K, Daglioglu YK, Andic F, Atakisi O, Cakir A. The protective role of jervine against radiation-induced gastrointestinal toxicity. J Enzyme Inhib Med Chem 2019 Dec;34(1):789-798.
        doi: 10.1080/14756366.2019.1586681pubmed: 30871382google scholar: lookup
      129. Piñeiro C, Manso A, Manzanilla EG, Morales J. Influence of sows' parity on performance and humoral immune response of the offspring. Porcine Health Manag 2019;5:1.
        doi: 10.1186/s40813-018-0111-8pubmed: 30783536google scholar: lookup
      130. Nakov D, Hristov S, Stankovic B, Pol F, Dimitrov I, Ilieski V, Mormede P, Hervé J, Terenina E, Lieubeau B, Papanastasiou DK, Bartzanas T, Norton T, Piette D, Tullo E, van Dixhoorn IDE. Methodologies for Assessing Disease Tolerance in Pigs. Front Vet Sci 2018;5:329.
        doi: 10.3389/fvets.2018.00329pubmed: 30687721google scholar: lookup
      131. Tothova C, Mihajlovicova X, Novotny J, Nagy O, Giretova M, Kresakova L, Tomco M, Zert Z, Vilhanova Z, Varga M, Medvecky L, Petrovova E. The Serum Protein Profile and Acute Phase Proteins in the Postoperative Period in Sheep after Induced Articular Cartilage Defect. Materials (Basel) 2019 Jan 3;12(1).
        doi: 10.3390/ma12010142pubmed: 30609876google scholar: lookup
      132. Kayser WC, Carstens GE, Washburn KE, Welsh TH, Lawhon SD, Reddy SM, Pinchak WE, Chevaux E, Skidmore AL. Effects of combined viral-bacterial challenge with or without supplementation of Saccharomyces cerevisiae boulardii strain CNCM I-1079 on immune upregulation and DMI in beef heifers. J Anim Sci 2019 Mar 1;97(3):1171-1184.
        doi: 10.1093/jas/sky483pubmed: 30597005google scholar: lookup
      133. Radaković M, Borozan S, Djelić N, Ivanović S, Miladinović DĆ, Ristanić M, Spremo-Potparević B, Stanimirović Z. Nitroso-Oxidative Stress, Acute Phase Response, and Cytogenetic Damage in Wistar Rats Treated with Adrenaline. Oxid Med Cell Longev 2018;2018:1805354.
        doi: 10.1155/2018/1805354pubmed: 30584458google scholar: lookup
      134. Witkowska-Piłaszewicz OD, Żmigrodzka M, Winnicka A, Miśkiewicz A, Strzelec K, Cywińska A. Serum amyloid A in equine health and disease. Equine Vet J 2019 May;51(3):293-298.
        doi: 10.1111/evj.13062pubmed: 30565319google scholar: lookup
      135. Meléndez DM, Marti S, Pajor EA, Sidhu PK, Gellatly D, Moya D, Janzen ED, Coetzee JF, Schwartzkopf-Genswein KS. Effect of meloxicam and lidocaine administered alone or in combination on indicators of pain and distress during and after knife castration in weaned beef calves. PLoS One 2018;13(11):e0207289.
        doi: 10.1371/journal.pone.0207289pubmed: 30500846google scholar: lookup
      136. Abuajamieh M, Kvidera SK, Mayorga EJ, Kaiser A, Lei S, Seibert JT, Horst EA, Sanz Fernandez MV, Ross JW, Selsby JT, Keating AF, Rhoads RP, Baumgard LH. The effect of recovery from heat stress on circulating bioenergetics and inflammatory biomarkers. J Anim Sci 2018 Nov 21;96(11):4599-4610.
        doi: 10.1093/jas/sky345pubmed: 30476152google scholar: lookup
      137. Sabes AF, Girardi AM, Fagliari JJ, de Oliveira JA, Marques LC. Serum proteinogram in sheep with acute ruminal lactic acidosis. Int J Vet Sci Med 2017 Jun;5(1):35-40.
        doi: 10.1016/j.ijvsm.2017.04.003pubmed: 30255046google scholar: lookup
      138. Bozukluhan K, Merhan O, Ogun M, Kurt B, Cihan M, Erkilic EE, Gokce G, Aydin U, Ozcan A. Investigation of haptoglobin, serum amyloid A, and some biochemical parameters in calves with omphalitis. Vet World 2018 Aug;11(8):1055-1058.
        doi: 10.14202/vetworld.2018.1055-1058pubmed: 30250363google scholar: lookup
      139. Meling S, Skovgaard K, Bårdsen K, Helweg Heegaard PM, Ulvund MJ. Expression of selected genes isolated from whole blood, liver and obex in lambs with experimental classical scrapie and healthy controls, showing a systemic innate immune response at the clinical end-stage. BMC Vet Res 2018 Sep 12;14(1):281.
        doi: 10.1186/s12917-018-1607-9pubmed: 30208891google scholar: lookup
      140. Adnane M, Meade KG, O'Farrelly C. Cervico-vaginal mucus (CVM) - an accessible source of immunologically informative biomolecules. Vet Res Commun 2018 Dec;42(4):255-263.
        doi: 10.1007/s11259-018-9734-0pubmed: 30117040google scholar: lookup
      141. Mathiesen R, Birch JM, Chriél M, Jensen HE, Agger JF, Heegaard PMH, Struve T. Mink (Neovison vison) kits with pre-weaning diarrhea have elevated serum amyloid A levels and intestinal pathomorphological similarities with New Neonatal Porcine Diarrhea Syndrome. Acta Vet Scand 2018 Aug 15;60(1):48.
        doi: 10.1186/s13028-018-0403-7pubmed: 30111375google scholar: lookup
      142. Marcato F, van den Brand H, Kemp B, van Reenen K. Evaluating Potential Biomarkers of Health and Performance in Veal Calves. Front Vet Sci 2018;5:133.
        doi: 10.3389/fvets.2018.00133pubmed: 29977895google scholar: lookup
      143. Ison SH, Jarvis S, Hall SA, Ashworth CJ, Rutherford KMD. Periparturient Behavior and Physiology: Further Insight Into the Farrowing Process for Primiparous and Multiparous Sows. Front Vet Sci 2018;5:122.
        doi: 10.3389/fvets.2018.00122pubmed: 29946552google scholar: lookup
      144. Meléndez DM, Marti S, Pajor EA, Moya D, Gellatly D, Janzen ED, Schwartzkopf-Genswein KS. Effect of subcutaneous meloxicam on indicators of acute pain and distress after castration and branding in 2-mo-old beef calves1,2. J Anim Sci 2018 Sep 7;96(9):3606-3621.
        doi: 10.1093/jas/sky245pubmed: 29912457google scholar: lookup
      145. Bergeron N, Robert C, Guay F. Feed supplementation with arginine and zinc on antioxidant status and inflammatory response in challenged weanling piglets. Anim Nutr 2017 Sep;3(3):236-246.
        doi: 10.1016/j.aninu.2017.06.009pubmed: 29767161google scholar: lookup
      146. Váradyová Z, Mravčáková D, Babják M, Bryszak M, Grešáková Ľ, Čobanová K, Kišidayová S, Plachá I, Königová A, Cieslak A, Slusarczyk S, Pecio L, Kowalczyk M, Várady M. Effects of herbal nutraceuticals and/or zinc against Haemonchus contortus in lambs experimentally infected. BMC Vet Res 2018 Mar 9;14(1):78.
        doi: 10.1186/s12917-018-1405-4pubmed: 29523134google scholar: lookup
      147. Meléndez DM, Marti S, Pajor EA, Moya D, Gellatly D, Janzen ED, Schwartzkopf-Genswein KS. Effect of a single dose of meloxicam prior to band or knife castration in 1-wk-old beef calves: I. Acute pain. J Anim Sci 2018 Apr 14;96(4):1268-1280.
        doi: 10.1093/jas/sky034pubmed: 29506258google scholar: lookup
      148. Roberts SL, Powell JG, Hughes HD, Richeson JT. Effect of castration method and analgesia on inflammation, behavior, growth performance, and carcass traits in feedlot cattle. J Anim Sci 2018 Feb 15;96(1):66-75.
        doi: 10.1093/jas/skx022pubmed: 29432545google scholar: lookup
      149. El-Malky OM, Mostafa TH, Abd El-Salaam AM, Ayyat MS. Effect of reproductive disorders on productivity and reproductive efficiency of dromedary she-camels in relation to cytokine concentration. Trop Anim Health Prod 2018 Jun;50(5):1079-1087.
        doi: 10.1007/s11250-018-1533-7pubmed: 29423707google scholar: lookup
      150. Silva GM, Poore MH, Ranches J, Santos GS, Moriel P. Effects of gradual reduction in frequency of energy supplementation on growth and immunity of beef steers. J Anim Sci 2018 Feb 15;96(1):273-283.
        doi: 10.1093/jas/skx047pubmed: 29385600google scholar: lookup
      151. Silva GM, Poore MH, Ranches J, Moriel P. Effects of timing of vaccination relative to weaning and post-weaning frequency of energy supplementation on growth and immunity of beef calves. J Anim Sci 2018 Feb 15;96(1):318-330.
        doi: 10.1093/jas/skx021pubmed: 29378006google scholar: lookup
      152. Meléndez DM, Marti S, Pajor EA, Moya D, Gellatly D, Janzen ED, Schwartzkopf-Genswein KS. Effect of timing of subcutaneous meloxicam administration on indicators of pain after knife castration of weaned calves. J Anim Sci 2017 Dec;95(12):5218-5229.
        doi: 10.2527/jas2017.1978pubmed: 29293785google scholar: lookup
      153. Kim WS, Lee JS, Jeon SW, Peng DQ, Kim YS, Bae MH, Jo YH, Lee HG. Correlation between blood, physiological and behavioral parameters in beef calves under heat stress. Asian-Australas J Anim Sci 2018 Jun;31(6):919-925.
        doi: 10.5713/ajas.17.0545pubmed: 29268589google scholar: lookup
      154. Upadhyaya I, Thanislass J, Veerapandyan A, Badami S, Antony PX. Characterization of Haptoglobin Isotype in Milk of Mastitis-Affected Cows. Vet Sci 2016 Oct 13;3(4).
        doi: 10.3390/vetsci3040029pubmed: 29056737google scholar: lookup
      155. Musk GC, Jacobsen S, Hyndman TH, Lehmann HS, Tuke SJ, Collins T, Gleerup KB, Johnson CB, Laurence M. Objective Measures for the Assessment of Post-Operative Pain in Bos indicus Bull Calves Following Castration. Animals (Basel) 2017 Sep 28;7(10).
        doi: 10.3390/ani7100076pubmed: 28956843google scholar: lookup
      156. Haltmayer E, Schwendenwein I, Licka TF. Course of serum amyloid A (SAA) plasma concentrations in horses undergoing surgery for injuries penetrating synovial structures, an observational clinical study. BMC Vet Res 2017 May 22;13(1):137.
        doi: 10.1186/s12917-017-1057-9pubmed: 28532514google scholar: lookup
      157. Ferreira RS Jr, de Barros LC, Abbade LPF, Barraviera SRCS, Silvares MRC, de Pontes LG, Dos Santos LD, Barraviera B. Heterologous fibrin sealant derived from snake venom: from bench to bedside - an overview. J Venom Anim Toxins Incl Trop Dis 2017;23:21.
        doi: 10.1186/s40409-017-0109-8pubmed: 28396682google scholar: lookup
      158. Jo M, Kim JH, Song GJ, Seo M, Hwang EM, Suk K. Astrocytic Orosomucoid-2 Modulates Microglial Activation and Neuroinflammation. J Neurosci 2017 Mar 15;37(11):2878-2894.
        doi: 10.1523/JNEUROSCI.2534-16.2017pubmed: 28193696google scholar: lookup
      159. Fazio F, Ferrantelli V, Cicero A, Casella S, Piccione G. Utility of Acute Phase Proteins as Biomarkers of Transport Stress in Ewes and Beef Cattle. Ital J Food Saf 2015 May 28;4(2):4210.
        doi: 10.4081/ijfs.2015.4210pubmed: 27800386google scholar: lookup
      160. Fazio F, Ferrantelli V, Cicero A, Casella S, Piccione G. Utility of Acute Phase Proteins as Biomarkers of Transport Stress in Ewes and Beef Cattle. Ital J Food Saf 2014 Dec 9;3(4):4210.
        doi: 10.4081/ijfs.2014.4210pubmed: 27800365google scholar: lookup
      161. Glushakov AV, Arias RA, Tolosano E, Doré S. Age-Dependent Effects of Haptoglobin Deletion in Neurobehavioral and Anatomical Outcomes Following Traumatic Brain Injury. Front Mol Biosci 2016;3:34.
        doi: 10.3389/fmolb.2016.00034pubmed: 27486583google scholar: lookup
      162. Moyes KM, Sørensen P, Bionaz M. The Impact of Intramammary Escherichia coli Challenge on Liver and Mammary Transcriptome and Cross-Talk in Dairy Cows during Early Lactation Using RNAseq. PLoS One 2016;11(6):e0157480.
        doi: 10.1371/journal.pone.0157480pubmed: 27336699google scholar: lookup
      163. Abdallah A, Hewson J, Francoz D, Selim H, Buczinski S. Systematic Review of the Diagnostic Accuracy of Haptoglobin, Serum Amyloid A, and Fibrinogen versus Clinical Reference Standards for the Diagnosis of Bovine Respiratory Disease. J Vet Intern Med 2016 Jul;30(4):1356-68.
        doi: 10.1111/jvim.13975pubmed: 27255433google scholar: lookup
      164. Vinther AM, Heegaard PM, Skovgaard K, Buhl R, Andreassen SM, Andersen PH. Characterization and differentiation of equine experimental local and early systemic inflammation by expression responses of inflammation-related genes in peripheral blood leukocytes. BMC Vet Res 2016 Jun 1;12:83.
        doi: 10.1186/s12917-016-0706-8pubmed: 27250718google scholar: lookup
      165. Balikci E, Al M. Some serum acute phase proteins and immunoglobulins concentrations in calves with rotavirus, coronavirus, E. coli F5 and Eimeria species. Iran J Vet Res 2014 Fall;15(4):397-401.
        pubmed: 27175138
      166. Samir M, Pessler F. Small Non-coding RNAs Associated with Viral Infectious Diseases of Veterinary Importance: Potential Clinical Applications. Front Vet Sci 2016;3:22.
        doi: 10.3389/fvets.2016.00022pubmed: 27092305google scholar: lookup
      167. Manimaran A, Kumaresan A, Jeyakumar S, Mohanty TK, Sejian V, Kumar N, Sreela L, Prakash MA, Mooventhan P, Anantharaj A, Das DN. Potential of acute phase proteins as predictor of postpartum uterine infections during transition period and its regulatory mechanism in dairy cattle. Vet World 2016 Jan;9(1):91-100.
        doi: 10.14202/vetworld.2016.91-100pubmed: 27051191google scholar: lookup
      168. Jeber ZK, MohdJin Z, Jesse FF, Saharee AA, Sabri J, Yusoff R, Wahid H. Influence of Corynebacterium pseudotuberculosis infection on level of acute phase proteins in goats. BMC Vet Res 2016 Mar 9;12:48.
        doi: 10.1186/s12917-016-0675-ypubmed: 26961495google scholar: lookup
      169. Riera Romo M, Pérez-Martínez D, Castillo Ferrer C. Innate immunity in vertebrates: an overview. Immunology 2016 Jun;148(2):125-39.
        doi: 10.1111/imm.12597pubmed: 26878338google scholar: lookup
      170. Hesselager MO, Codrea MC, Sun Z, Deutsch EW, Bennike TB, Stensballe A, Bundgaard L, Moritz RL, Bendixen E. The Pig PeptideAtlas: A resource for systems biology in animal production and biomedicine. Proteomics 2016 Feb;16(4):634-44.
        doi: 10.1002/pmic.201500195pubmed: 26699206google scholar: lookup
      171. El-Deeb WM, Buczinski S. The diagnostic and prognostic importance of oxidative stress biomarkers and acute phase proteins in Urinary Tract Infection (UTI) in camels. PeerJ 2015;3:e1363.
        doi: 10.7717/peerj.1363pubmed: 26587339google scholar: lookup
      172. Haas M, Kaup FJ, Neumann S. Canine pyometra: a model for the analysis of serum CXCL8 in inflammation. J Vet Med Sci 2016 Mar;78(3):375-81.
        doi: 10.1292/jvms.15-0415pubmed: 26522810google scholar: lookup
      173. Christensen MB, Eriksen T, Kjelgaard-Hansen M. C-reactive protein: quantitative marker of surgical trauma and post-surgical complications in dogs: a systematic review. Acta Vet Scand 2015 Oct 20;57:71.
        doi: 10.1186/s13028-015-0164-5pubmed: 26483038google scholar: lookup
      174. Zhang G, Hailemariam D, Dervishi E, Deng Q, Goldansaz SA, Dunn SM, Ametaj BN. Alterations of Innate Immunity Reactants in Transition Dairy Cows before Clinical Signs of Lameness. Animals (Basel) 2015 Aug 14;5(3):717-47.
        doi: 10.3390/ani5030381pubmed: 26479383google scholar: lookup
      175. Christoffersen BØ, Jensen SJ, Ludvigsen TP, Nilsson SK, Grossi AB, Heegaard PM. Age- and Sex-Associated Effects on Acute-Phase Proteins in Göttingen Minipigs. Comp Med 2015 Aug;65(4):333-41.
        pubmed: 26310463
      176. Seppä-Lassila L, Orro T, Lassen B, Lasonen R, Autio T, Pelkonen S, Soveri T. Intestinal pathogens, diarrhoea and acute phase proteins in naturally infected dairy calves. Comp Immunol Microbiol Infect Dis 2015 Aug;41:10-6.
        doi: 10.1016/j.cimid.2015.05.004pubmed: 26264522google scholar: lookup
      177. Ráez-Bravo A, Granados JE, Cerón JJ, Cano-Manuel FJ, Fandos P, Pérez JM, Espinosa J, Soriguer RC, López-Olvera JR. Acute phase proteins increase with sarcoptic mange status and severity in Iberian ibex (Capra pyrenaica, Schinz 1838). Parasitol Res 2015 Nov;114(11):4005-10.
        doi: 10.1007/s00436-015-4628-3pubmed: 26227139google scholar: lookup
      178. Lassen B, Bangoura B, Lepik T, Orro T. Systemic acute phase proteins response in calves experimentally infected with Eimeria zuernii. Vet Parasitol 2015 Sep 15;212(3-4):140-6.
        doi: 10.1016/j.vetpar.2015.06.024pubmed: 26215927google scholar: lookup
      179. Prohl A, Schroedl W, Rhode H, Reinhold P. Acute phase proteins as local biomarkers of respiratory infection in calves. BMC Vet Res 2015 Jul 25;11:167.
        doi: 10.1186/s12917-015-0485-7pubmed: 26209015google scholar: lookup
      180. Sproull M, Kramp T, Tandle A, Shankavaram U, Camphausen K. Serum Amyloid A as a Biomarker for Radiation Exposure. Radiat Res 2015 Jul;184(1):14-23.
        doi: 10.1667/RR13927.1pubmed: 26114330google scholar: lookup
      181. Brodzki P, Kostro K, Krakowski L, Marczuk J. Inflammatory cytokine and acute phase protein concentrations in the peripheral blood and uterine washings of cows with subclinical endometritis in the late postpartum period. Vet Res Commun 2015 Jun;39(2):143-9.
        doi: 10.1007/s11259-015-9635-4pubmed: 25846950google scholar: lookup
      182. Raiten DJ, Sakr Ashour FA, Ross AC, Meydani SN, Dawson HD, Stephensen CB, Brabin BJ, Suchdev PS, van Ommen B. Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE). J Nutr 2015 May;145(5):1039S-1108S.
        doi: 10.3945/jn.114.194571pubmed: 25833893google scholar: lookup
      183. Leal RO, Gil S, Duarte A, McGahie D, Sepúlveda N, Niza MM, Tavares L. Evaluation of viremia, proviral load and cytokine profile in naturally feline immunodeficiency virus infected cats treated with two different protocols of recombinant feline interferon omega. Res Vet Sci 2015 Apr;99:87-95.
        doi: 10.1016/j.rvsc.2015.02.008pubmed: 25747956google scholar: lookup
      184. Luo Z, Lei H, Sun Y, Liu X, Su DF. Orosomucoid, an acute response protein with multiple modulating activities. J Physiol Biochem 2015 Jun;71(2):329-40.
        doi: 10.1007/s13105-015-0389-9pubmed: 25711902google scholar: lookup
      185. Colom-Cadena A, Velarde R, Salinas J, Borge C, García-Bocanegra I, Serrano E, Gassó D, Bach E, Casas-Díaz E, López-Olvera JR, Lavín S, León-Vizcaíno L, Mentaberre G. Management of a caseous lymphadenitis outbreak in a new Iberian ibex (Capra pyrenaica) stock reservoir. Acta Vet Scand 2014 Dec 10;56(1):83.
        doi: 10.1186/s13028-014-0083-xpubmed: 25492129google scholar: lookup
      186. Wegmann M, Voegeli B, Richner H. Parasites suppress immune-enhancing effect of methionine in nestling great tits. Oecologia 2015 Jan;177(1):213-21.
        doi: 10.1007/s00442-014-3138-9pubmed: 25395313google scholar: lookup
      187. Hinds CA, Niehaus AJ, Premanandan C, Rajala-Schultz PJ, Rings DM, Lakritz J. Characterization of the contributions of Hp-MMP 9 to the serum acute phase protein response of lipopolysaccharide challenged calves. BMC Vet Res 2014 Oct 30;10:261.
        doi: 10.1186/s12917-014-0261-0pubmed: 25358728google scholar: lookup
      188. Wang C, Gu C, Guo D, Gao J, Li C, Liu N, Geng Y, Su M, Wang X, Sun D. Preparation of monoclonal antibodies against bovine haptoglobin. Monoclon Antib Immunodiagn Immunother 2014 Oct;33(5):350-3.
        doi: 10.1089/mab.2014.0028pubmed: 25358005google scholar: lookup
      189. Song KD, Cho HW, Lee HK, Cho BW. Molecular Characterization and Expression Analysis of Equine Vascular Endothelial Growth Factor Alpha (VEGFα) Gene in Horse (Equus caballus). Asian-Australas J Anim Sci 2014 May;27(5):743-8.
        doi: 10.5713/ajas.2013.13821pubmed: 25050010google scholar: lookup
      190. Kumar De U, Mukherjee R, Nandi S, Patel BH, Dimri U, Ravishankar C, Verma AK. Alterations in oxidant/antioxidant balance, high-mobility group box 1 protein and acute phase response in cross-bred suckling piglets suffering from rotaviral enteritis. Trop Anim Health Prod 2014 Oct;46(7):1127-33.
        doi: 10.1007/s11250-014-0616-3pubmed: 24848720google scholar: lookup
      191. Dudek K, Bednarek D, Ayling RD, Szacawa E. Stimulation and analysis of the immune response in calves from vaccinated pregnant cows. Res Vet Sci 2014 Aug;97(1):32-7.
        doi: 10.1016/j.rvsc.2014.04.005pubmed: 24815344google scholar: lookup
      192. Bundgaard L, Jacobsen S, Sørensen MA, Sun Z, Deutsch EW, Moritz RL, Bendixen E. The Equine PeptideAtlas: a resource for developing proteomics-based veterinary research. Proteomics 2014 Mar;14(6):763-73.
        doi: 10.1002/pmic.201300398pubmed: 24436130google scholar: lookup
      193. Asuni AA, Gray B, Bailey J, Skipp P, Perry VH, O'Connor V. Analysis of the hippocampal proteome in ME7 prion disease reveals a predominant astrocytic signature and highlights the brain-restricted production of clusterin in chronic neurodegeneration. J Biol Chem 2014 Feb 14;289(7):4532-45.
        doi: 10.1074/jbc.M113.502690pubmed: 24366862google scholar: lookup
      194. Viitanen SJ, Laurila HP, Lilja-Maula LI, Melamies MA, Rantala M, Rajamäki MM. Serum C-reactive protein as a diagnostic biomarker in dogs with bacterial respiratory diseases. J Vet Intern Med 2014 Jan-Feb;28(1):84-91.
        doi: 10.1111/jvim.12262pubmed: 24351049google scholar: lookup
      195. Gil S, Leal RO, McGahie D, Sepúlveda N, Duarte A, Niza MM, Tavares L. Oral Recombinant Feline Interferon-Omega as an alternative immune modulation therapy in FIV positive cats: clinical and laboratory evaluation. Res Vet Sci 2014 Feb;96(1):79-85.
        doi: 10.1016/j.rvsc.2013.11.007pubmed: 24332273google scholar: lookup
      196. Guo D, Zhang H, Li C, Sun D. A polyclonal antibody against recombinant bovine haptoglobin expressed in Escherichia coli. Monoclon Antib Immunodiagn Immunother 2013 Dec;32(6):419-24.
        doi: 10.1089/mab.2013.0061pubmed: 24328747google scholar: lookup
      197. Leal RO, Gil S, Sepúlveda N, McGahie D, Duarte A, Niza MM, Tavares L. Monitoring acute phase proteins in retrovirus infected cats undergoing feline interferon-ω therapy. J Small Anim Pract 2014 Jan;55(1):39-45.
        doi: 10.1111/jsap.12160pubmed: 24279640google scholar: lookup
      198. Wells B, Innocent GT, Eckersall PD, McCulloch E, Nisbet AJ, Burgess ST. Two major ruminant acute phase proteins, haptoglobin and serum amyloid A, as serum biomarkers during active sheep scab infestation. Vet Res 2013 Oct 31;44(1):103.
        doi: 10.1186/1297-9716-44-103pubmed: 24176040google scholar: lookup
      199. Abbasi MH, Fatima S, Naz N, Malik IA, Sheikh N. Effect of Nerium oleander (N.O.) leaves extract on serum hepcidin, total iron, and infiltration of ED1 positive cells in albino rat. Biomed Res Int 2013;2013:125671.
        doi: 10.1155/2013/125671pubmed: 24069586google scholar: lookup
      200. Asasi K, Mohammadi A, Boroomand Z, Hosseinian SA, Nazifi S. Changes of several acute phase factors in broiler chickens in response to infectious bronchitis virus infection. Poult Sci 2013 Aug;92(8):1989-96.
        doi: 10.3382/ps.2012-02902pubmed: 23873545google scholar: lookup
      201. Müller S, Lehnert K, Seibel H, Driver J, Ronnenberg K, Teilmann J, van Elk C, Kristensen J, Everaarts E, Siebert U. Evaluation of immune and stress status in harbour porpoises (Phocoena phocoena): can hormones and mRNA expression levels serve as indicators to assess stress?. BMC Vet Res 2013 Jul 17;9:145.
        doi: 10.1186/1746-6148-9-145pubmed: 23866055google scholar: lookup
      202. Heegaard PM, Miller I, Sorensen NS, Soerensen KE, Skovgaard K. Pig α1-acid glycoprotein: characterization and first description in any species as a negative acute phase protein. PLoS One 2013;8(7):e68110.
        doi: 10.1371/journal.pone.0068110pubmed: 23844161google scholar: lookup
      203. Addis MF, Pisanu S, Marogna G, Cubeddu T, Pagnozzi D, Cacciotto C, Campesi F, Schianchi G, Rocca S, Uzzau S. Production and release of antimicrobial and immune defense proteins by mammary epithelial cells following Streptococcus uberis infection of sheep. Infect Immun 2013 Sep;81(9):3182-97.
        doi: 10.1128/IAI.00291-13pubmed: 23774600google scholar: lookup
      204. Cywinska A, Witkowski L, Szarska E, Schollenberger A, Winnicka A. Serum amyloid A (SAA) concentration after training sessions in Arabian race and endurance horses. BMC Vet Res 2013 May 1;9:91.
        doi: 10.1186/1746-6148-9-91pubmed: 23634727google scholar: lookup
      205. Bennett D, Eckersall PD, Waterston M, Marchetti V, Rota A, McCulloch E, Sbrana S. The effect of robenacoxib on the concentration of C-reactive protein in synovial fluid from dogs with osteoarthritis. BMC Vet Res 2013 Mar 1;9:42.
        doi: 10.1186/1746-6148-9-42pubmed: 23452411google scholar: lookup
      206. Renson P, Le Dimna M, Keranflech A, Cariolet R, Koenen F, Le Potier MF. CP7_E2alf oral vaccination confers partial protection against early classical swine fever virus challenge and interferes with pathogeny-related cytokine responses. Vet Res 2013 Feb 11;44(1):9.
        doi: 10.1186/1297-9716-44-9pubmed: 23398967google scholar: lookup
      207. Gómez-Laguna J, Salguero FJ, Pallarés FJ, Carrasco L. Immunopathogenesis of porcine reproductive and respiratory syndrome in the respiratory tract of pigs. Vet J 2013 Feb;195(2):148-55.
        doi: 10.1016/j.tvjl.2012.11.012pubmed: 23265866google scholar: lookup
      208. Chalmeh A, Badiei K, Pourjafar M, Nazifi S. Anti-inflammatory effects of insulin regular and flunixin meglumine on endotoxemia experimentally induced by Escherichia coli serotype O55:B5 in an ovine model. Inflamm Res 2013 Jan;62(1):61-7.
        doi: 10.1007/s00011-012-0551-6pubmed: 22960692google scholar: lookup
      209. Lamprecht ED, Williams CA. Biomarkers of antioxidant status, inflammation, and cartilage metabolism are affected by acute intense exercise but not superoxide dismutase supplementation in horses. Oxid Med Cell Longev 2012;2012:920932.
        doi: 10.1155/2012/920932pubmed: 22919442google scholar: lookup
      210. Nazifi S, Esmailnezhad Z, Haghkhah M, Ghadirian S, Mirzaei A. Acute phase response in lame cattle with interdigital dermatitis. World J Microbiol Biotechnol 2012 Apr;28(4):1791-6.
        doi: 10.1007/s11274-011-0995-9pubmed: 22805961google scholar: lookup
      211. Meling S, Bårdsen K, Ulvund MJ. Presence of an acute phase response in sheep with clinical classical scrapie. BMC Vet Res 2012 Jul 17;8:113.
        doi: 10.1186/1746-6148-8-113pubmed: 22805457google scholar: lookup
      212. Che TM, Song M, Liu Y, Johnson RW, Kelley KW, Van Alstine WG, Dawson KA, Pettigrew JE. Mannan oligosaccharide increases serum concentrations of antibodies and inflammatory mediators in weanling pigs experimentally infected with porcine reproductive and respiratory syndrome virus. J Anim Sci 2012 Aug;90(8):2784-93.
        doi: 10.2527/jas.2011-4518pubmed: 22367071google scholar: lookup
      213. Cray C. Acute phase proteins in animals. Prog Mol Biol Transl Sci 2012;105:113-50.
        doi: 10.1016/B978-0-12-394596-9.00005-6pubmed: 22137431google scholar: lookup
      214. Hansson M, Lundeheim N, Nyman G, Johansson G. Effect of local anaesthesia and/or analgesia on pain responses induced by piglet castration. Acta Vet Scand 2011 May 31;53(1):34.
        doi: 10.1186/1751-0147-53-34pubmed: 21627797google scholar: lookup
      215. Stenfeldt C, Heegaard PM, Stockmarr A, Tjørnehøj K, Belsham GJ. Analysis of the acute phase responses of serum amyloid a, haptoglobin and type 1 interferon in cattle experimentally infected with foot-and-mouth disease virus serotype O. Vet Res 2011 May 18;42(1):66.
        doi: 10.1186/1297-9716-42-66pubmed: 21592356google scholar: lookup
      216. Jain S, Gautam V, Naseem S. Acute-phase proteins: As diagnostic tool. J Pharm Bioallied Sci 2011 Jan;3(1):118-27.
        doi: 10.4103/0975-7406.76489pubmed: 21430962google scholar: lookup
      217. Heegaard PM, Stockmarr A, Piñeiro M, Carpintero R, Lampreave F, Campbell FM, Eckersall PD, Toussaint MJ, Gruys E, Sorensen NS. Optimal combinations of acute phase proteins for detecting infectious disease in pigs. Vet Res 2011 Mar 17;42(1):50.
        doi: 10.1186/1297-9716-42-50pubmed: 21414190google scholar: lookup
      218. Collier CT, Williams PN, Carroll JA, Welsh TH Jr, Laurenz JC. Effect of maternal restraint stress during gestation on temporal lipopolysaccharide-induced neuroendocrine and immune responses of progeny. Domest Anim Endocrinol 2011 Jan;40(1):40-50.
        doi: 10.1016/j.domaniend.2010.08.005pubmed: 20932703google scholar: lookup
      219. Cray C, Besselsen DG, Hart JL, Yoon D, Rodriguez M, Zaias J, Altman NH. Quantitation of acute phase proteins and protein electrophoresis in monitoring the acute inflammatory process in experimentally and naturally infected mice. Comp Med 2010 Aug;60(4):263-71.
        pubmed: 20819375
      220. Earley B, Murray M. The effect of road and sea transport on inflammatory, adrenocortical, metabolic and behavioural responses of weanling heifers. BMC Vet Res 2010 Jul 20;6:36.
        doi: 10.1186/1746-6148-6-36pubmed: 20646267google scholar: lookup
      221. Barbé F, Atanasova K, Van Reeth K. Cytokines and acute phase proteins associated with acute swine influenza infection in pigs. Vet J 2011 Jan;187(1):48-53.
        doi: 10.1016/j.tvjl.2009.12.012pubmed: 20097110google scholar: lookup
      222. Cray C, Zaias J, Altman NH. Acute phase response in animals: a review. Comp Med 2009 Dec;59(6):517-26.
        pubmed: 20034426
      223. Janczyk P, Pieper R, Urubschurov V, Wendler KR, Souffrant WB. Investigations on the effects of dietary essential oils and different husbandry conditions on the gut ecology in piglets after weaning. Int J Microbiol 2009;2009:730809.
        doi: 10.1155/2009/730809pubmed: 20016670google scholar: lookup
      224. Zaias J, Mineau M, Cray C, Yoon D, Altman NH. Reference values for serum proteins of common laboratory rodent strains. J Am Assoc Lab Anim Sci 2009 Jul;48(4):387-90.
        pubmed: 19653947
      225. Nielsen OL, Iburg T, Aalbaek B, Leifsson PS, Agerholm JS, Heegaard P, Boye M, Simon S, Jensen KB, Christensen S, Melsen K, Bak AK, Backman ER, Jørgensen MH, Groegler DK, Jensen AL, Kjelgaard-Hansen M, Jensen HE. A pig model of acute Staphylococcus aureus induced pyemia. Acta Vet Scand 2009 Mar 27;51(1):14.
        doi: 10.1186/1751-0147-51-14pubmed: 19327150google scholar: lookup
      226. Skovgaard K, Mortensen S, Boye M, Poulsen KT, Campbell FM, Eckersall PD, Heegaard PM. Rapid and widely disseminated acute phase protein response after experimental bacterial infection of pigs. Vet Res 2009 May-Jun;40(3):23.
        doi: 10.1051/vetres/2009006pubmed: 19236838google scholar: lookup
      227. Lai IH, Tsao JH, Lu YP, Lee JW, Zhao X, Chien FL, Mao SJ. Neutrophils as one of the major haptoglobin sources in mastitis affected milk. Vet Res 2009 May-Jun;40(3):17.
        doi: 10.1051/vetres:2008055pubmed: 19094922google scholar: lookup
      228. Jiang L, Sørensen P, Røntved C, Vels L, Ingvartsen KL. Gene expression profiling of liver from dairy cows treated intra-mammary with lipopolysaccharide. BMC Genomics 2008 Sep 24;9:443.
        doi: 10.1186/1471-2164-9-443pubmed: 18816405google scholar: lookup
      229. Stolina M, Bolon B, Middleton S, Dwyer D, Brown H, Duryea D, Zhu L, Rohner A, Pretorius J, Kostenuik P, Feige U, Zack D. The evolving systemic and local biomarker milieu at different stages of disease progression in rat adjuvant-induced arthritis. J Clin Immunol 2009 Mar;29(2):158-74.
        doi: 10.1007/s10875-008-9238-8pubmed: 18726678google scholar: lookup
      230. Lomborg SR, Nielsen LR, Heegaard PM, Jacobsen S. Acute phase proteins in cattle after exposure to complex stress. Vet Res Commun 2008 Oct;32(7):575-82.
        doi: 10.1007/s11259-008-9057-7pubmed: 18461465google scholar: lookup
      231. Walsh RB, LeBlanc SJ, Vernooy E, Leslie KE. Safety of a progesterone-releasing intravaginal device as assessed from vaginal mucosal integrity and indicators of systemic inflammation in postpartum dairy cows. Can J Vet Res 2008 Jan;72(1):43-9.
        pubmed: 18214161
      232. Eckersall PD, Lawson FP, Kyle CE, Waterston M, Bence L, Stear MJ, Rhind SM. Maternal undernutrition and the ovine acute phase response to vaccination. BMC Vet Res 2008 Jan 15;4:1.
        doi: 10.1186/1746-6148-4-1pubmed: 18197966google scholar: lookup
      233. Eckersall PD, Lawson FP, Bence L, Waterston MM, Lang TL, Donachie W, Fontaine MC. Acute phase protein response in an experimental model of ovine caseous lymphadenitis. BMC Vet Res 2007 Dec 19;3:35.
        doi: 10.1186/1746-6148-3-35pubmed: 18093286google scholar: lookup
      234. Paltrinieri S. The feline acute phase reaction. Vet J 2008 Jul;177(1):26-35.
        doi: 10.1016/j.tvjl.2007.06.005pubmed: 17686640google scholar: lookup
      235. Gao WM, Chadha MS, Berger RP, Omenn GS, Allen DL, Pisano M, Adelson PD, Clark RS, Jenkins LW, Kochanek PM. A gel-based proteomic comparison of human cerebrospinal fluid between inflicted and non-inflicted pediatric traumatic brain injury. J Neurotrauma 2007 Jan;24(1):43-53.
        doi: 10.1089/neu.2006.0061pubmed: 17263669google scholar: lookup
      236. Gånheim C, Alenius S, Persson Waller K. Acute phase proteins as indicators of calf herd health. Vet J 2007 May;173(3):645-51.
        doi: 10.1016/j.tvjl.2006.01.011pubmed: 16546422google scholar: lookup
      237. Gruys E, Toussaint MJ, Niewold TA, Koopmans SJ. Acute phase reaction and acute phase proteins. J Zhejiang Univ Sci B 2005 Nov;6(11):1045-56.
        doi: 10.1631/jzus.2005.B1045pubmed: 16252337google scholar: lookup
      238. Gruys E, Toussaint MJ, Upragarin N, Van EA, Adewuyi AA, Candiani D, Nguyen TK, Sabeckiene J. Acute phase reactants, challenge in the near future of animal production and veterinary medicine. J Zhejiang Univ Sci B 2005 Oct;6(10):941-7.
        doi: 10.1631/jzus.2005.B0941pubmed: 16187407google scholar: lookup
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