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Frontiers in veterinary science2024; 11; 1329054; doi: 10.3389/fvets.2024.1329054

Application of the HRE-S to 140 horses with trigeminal-mediated headshaking and the association of clinical signs with diagnosis, therapy, and outcome.

Abstract: Horses with trigeminal-mediated headshaking (TMHS) exhibit different headshaking patterns (HSPs), electric shock-like jerking, signs of nasal irritation, and painful facial expressions. The History Rest and Exercise Score (HRE-S) was developed to objectively clarify the severity of the condition in affected horses. This score considers the history and severity of clinical signs at rest and exercise. This study aimed to assess the frequency of different clinical signs and their individual associations with diagnosis, treatment, and outcome in horses diagnosed with TMHS.The clinical records of horses presented with headshaking (HS) at the Clinic for Horses, University of Veterinary Medicine Hannover, between 2006 and 2021 were assessed retrospectively for clinical signs, diagnosis, and treatment. A total of 140 horses were included in the study. Video recordings were evaluated using the HRE-S and compared to the score described by Talbot. Following discharge, owners were interviewed via telephone about the outcome. Correlations between the presence and severity of clinical signs, diagnosis, and outcome were evaluated. Unassigned: The following clinical signs were significantly correlated with a higher HRE-S and grade by Talbot: HS at walk (independently of HSP) (52.9%, 74/140), increased total number of demonstrated HSP (independent of the dominant HSP) (more than one HSP per horse in 91.4%, 128/140), signs of nasal irritation (75.9%, 104/137), painful facial expression (67.8%, 80/118), and electric shock-like jerking (77.5%, 107/138). Diagnosis and outcome do not correlate with the presence of the above-mentioned clinical signs. Unassigned: The HRE-S was confirmed as a valid tool to evaluate disease severity in a cohort of 140 horses with HS. Additionally, clinical signs identified as indicators for higher disease severity may have a stronger negative effect on patient welfare, but they do not correlate with diagnosis or outcome.
Copyright © 2024 Kloock, Hellige, Kloock, Feige and Niebuhr.
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Publication Date: 2024-04-05 PubMed ID: 38645651PubMed Central: PMC11027008DOI: 10.3389/fvets.2024.1329054Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research studies the application of the History Rest and Exercise Score (HRE-S) on 140 horses that exhibit symptoms of trigeminal-mediated headshaking (TMHS), and explores the correlation of clinical signs with diagnosis, treatment, and ultimate outcome. Despite identifying certain symptoms of higher severity, these were found not to bear correlation with diagnosis or outcome.

Study Methodology

  • The study drew upon the clinical records of horses presented with headshaking (HS) symptoms at the Clinic for Horses, University of Veterinary Medicine Hannover, from 2006 to 2021.
  • A total of 140 horses were included in the retrospective study, and clinical signs, diagnosis, and treatment records were assessed.
  • Video recordings of these horses were evaluated with the HRE-S metric — a score assessing the severity of TMHS condition in horses based on the history and severity of clinical signs and behavior both at rest and exercise.
  • The researchers also interviewed the horses’ owners via telephone about the outcomes post-treatment.

Key Research Findings

  • Significant clinical signs correlating with a higher HRE-S were identified. These included HS at walk irrespective of HSP (52.9%, 74/140), increased total number of demonstrated HSPs (more than one HSP per horse in 91.4%, 128/140), signs of nasal irritation (75.9%, 104/137), painful facial expression (67.8%, 80/118), and electric shock-like jerking (77.5%, 107/138).
  • Interestingly, though these signs were strong indicators of higher disease severity, possibly leading to a stronger negative impact on the patient’s welfare, they were not found to correlate with diagnosis or outcome.

Conclusion of the Study

  • The study affirmed the utility of the HRE-S as a valid tool to quantify disease severity in horses exhibiting TMHS, demonstrating its value in assessing and managing horse welfare in this context.
  • The study also emphasized the complexity of TMHS without any clear correlation between the presence of certain clinical signs and the prognosis, enhancing the understanding of the disease and its management.

Cite This Article

APA
Kloock T, Hellige M, Kloock A, Feige K, Niebuhr T. (2024). Application of the HRE-S to 140 horses with trigeminal-mediated headshaking and the association of clinical signs with diagnosis, therapy, and outcome. Front Vet Sci, 11, 1329054. https://doi.org/10.3389/fvets.2024.1329054

Publication

Frontiers in veterinary science
ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 11
Pages: 1329054

Researcher Affiliations

Kloock, Tanja
  • Clinic for Horses, University of Veterinary Medicine Hannover, Hanover, Germany.
Hellige, Maren
  • Clinic for Horses, University of Veterinary Medicine Hannover, Hanover, Germany.
Kloock, Anke
  • Department of Cell Biology, NYU Langone Medical Center, New York City, NY, United States.
Feige, Karsten
  • Clinic for Horses, University of Veterinary Medicine Hannover, Hanover, Germany.
Niebuhr, Tobias
  • Clinic for Horses, University of Veterinary Medicine Hannover, Hanover, Germany.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Citations

This article has been cited 1 times.
  1. Franzen V, Gruber NA, Klußmann S, Schoster A, May A. Effect of repetitive transcranial magnetic stimulation on trigeminal-mediated headshaking in 17 horses. J Vet Intern Med 2024 Sep-Oct;38(5):2758-2765.
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