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Frontiers in endocrinology2024; 15; 1382844; doi: 10.3389/fendo.2024.1382844

Arthrospira platensis enriched with Cr(III), Mg(II), and Mn(II) ions improves insulin sensitivity and reduces systemic inflammation in equine metabolic affected horses.

Abstract: Equine metabolic syndrome (EMS) is a critical endocrine condition in horses, characterized by hyperinsulinemia, hyperlipidemia, and insulin resistance, posing a significant threat to their health. This study investigates the efficacy of supplementing EMS-affected horses with Arthrospira platensis enriched with Cr(III), Mg(II), and Mn(II) ions using biosorption process in improving insulin sensitivity and glucose tolerance, reducing inflammation, and mitigating obesity-related fat accumulation. Our results demonstrate that Arthrospira supplementation reduces baseline insulin and glucose levels, contributing to decreased adipose tissue inflammation. Furthermore, Arthrospira supplementation results in a decrease in body weight and improvements in overall body condition scores and cresty neck scores. Additionally, administration of Arthrospira leads to reduced levels of triglycerides and aspartate aminotransferase, indicating a decrease in hepatic adiposity and inflammation. These findings suggest that Arthrospira, enriched with essential micro- and macroelements, can be an advanced feed additive to enhance insulin sensitivity, promote weight reduction, and alleviate inflammatory processes, thereby improving the overall condition of horses affected by EMS. The use of Arthrospira as a feed additive has the potential to complement conventional management strategies for EMS.
Copyright © 2024 Tomal, Szłapka-Kosarzewska, Mironiuk, Michalak and Marycz.
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Publication Date: 2024-04-16 PubMed ID: 38689728PubMed Central: PMC11058661DOI: 10.3389/fendo.2024.1382844Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article explores the impact of supplementing the diet of horses with Equine Metabolic Syndrome (EMS) with Arthrospira platensis enriched with Chromium(III), Magnesium(II), and Manganese (II) ions. The results provide evidence that this nutritional supplement can mitigate elements of the syndrome, such as insulin resistance and inflammation, and potentially improve the horse’s overall health.

Research Scope and Methodology

  • The main purpose of this study was to assess the potential benefits of adding Arthrospira platensis, an algae rich in essential nutrients and further enriched with Chromium(III), Magnesium(II), and Manganese(II) ions, into the feed for horses diagnosed with Equine Metabolic Syndrome (EMS).
  • EMS is a common endocrine disorder observed in horses. It results in excess insulin and lipid levels, resistance to insulin, inflammation, and obesity, affecting the horse’s overall well-being considerably.
  • The study aims to ascertain whether the supplement could enhance insulin sensitivity, reduce inflammation, help control glucose levels, and decrease obesity rates in affected horses.

Key Findings

  • Results indicate that this nutritional enrichment of the horse’s typical feed contributes substantially to lowering insulin and glucose levels. This reduction subsequently leads to decreased inflammation in adipose tissues, thereby diminishing one of the key symptoms associated with EMS.
  • Beyond just reducing inflammation and enhancing insulin sensitivity, adding the enriched Arthrospira platensis to the horse’s feed resulted in a noticeable decrease in weight, along with visible improvements in overall body condition scores and cresty neck scores, a common marker for EMS.
  • Another observed benefit was the reduced levels of triglycerides and aspartate aminotransferase in the horses, indicating a decrease in both liver fat accumulation and inflammation.

Implications and Future Prospects

  • The research findings propose enriched Arthrospira platensis as a potentially highly effective feed supplement for horses affected by EMS. By enhancing insulin sensitivity, promoting weight reduction, and alleviating harmful inflammatory processes, it could significantly improve the horse’s overall condition.
  • This enriched supplement could complement the existing management strategies for EMS, providing a more holistic and efficient approach to treating this common endocrine disorder in horses.
  • However, this research serves as a preliminary investigation, and further studies are required to fully understand the supplement’s long-term impact and potential side effects, if any exist.

Cite This Article

APA
Tomal A, Szłapka-Kosarzewska J, Mironiuk M, Michalak I, Marycz K. (2024). Arthrospira platensis enriched with Cr(III), Mg(II), and Mn(II) ions improves insulin sensitivity and reduces systemic inflammation in equine metabolic affected horses. Front Endocrinol (Lausanne), 15, 1382844. https://doi.org/10.3389/fendo.2024.1382844

Publication

Frontiers in endocrinology
ISSN: 1664-2392
NlmUniqueID: 101555782
Country: Switzerland
Language: English
Volume: 15
Pages: 1382844

Researcher Affiliations

Tomal, Artur
  • International Institute of Translational Medicine, Wisznia Mała, Poland.
Szłapka-Kosarzewska, Jolanta
  • International Institute of Translational Medicine, Wisznia Mała, Poland.
Mironiuk, Małgorzata
  • Department of Advanced Material Technologies, Faculty of Chemistry, Wrocław University of Science and Technology, Wrocław, Poland.
Michalak, Izabela
  • Department of Advanced Material Technologies, Faculty of Chemistry, Wrocław University of Science and Technology, Wrocław, Poland.
Marycz, Krzysztof
  • International Institute of Translational Medicine, Wisznia Mała, Poland.
  • Department of Experimental Biology, Faculty of Biology and Animal Science, Wrocław University of Environmental and Life Sciences, Wrocław, Poland.

MeSH Terms

  • Animals
  • Spirulina
  • Insulin Resistance
  • Horses
  • Chromium
  • Inflammation / metabolism
  • Manganese
  • Dietary Supplements
  • Metabolic Syndrome / veterinary
  • Metabolic Syndrome / metabolism
  • Horse Diseases / metabolism
  • Horse Diseases / prevention & control
  • Animal Feed / analysis
  • Magnesium / metabolism
  • Male
  • Female

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Citations

This article has been cited 1 times.
  1. Loos C, Castelein A, Vanzant E, Adam E, McLeod KR. Nutraceutical Supplement Mitigates Insulin Resistance in Horses with a History of Insulin Dysregulation During a Challenge with a High-Starch Diet. Animals (Basel) 2024 Nov 25;14(23).
    doi: 10.3390/ani14233385pubmed: 39682351google scholar: lookup
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