[Aspergillus oryzae as a cause of keratomycosis in the horse].

The study presents a case of a horse with an ocular infection of a specific fungal strain, Aspergillus oryzae, which follows corneal injury. Despite initial treatments, a more comprehensive solution was found with the use of iodine-based therapies.

Research subject and problem

• The research investigates a case of ocular infection in a horse: mycokeratitis.
• The infection was a result of a previously damaged cornea, and was caused by the fungus Aspergillus oryzae.
• Fungal keratitis in horses is rare and hard to diagnose, hence the significance of this single-case study.

Initial findings and treatment

• Following application of Chloramphenicol, an antibiotic ophthalmic ointment, the researchers observed a clearly defined, circular corneal clouding in the center of eye.
• Subsequent usage of Dexamethasone-Neomycin (an anti-inflammatory and antibiotic respectively) eye drops led to the spread of infection, turning the clouded cornea into a purulent keratitis – inflammation of the cornea caused by bacterial or fungal infection.

Alternative treatments and outcomes

• The team then shifted to try different treatment approaches.
• Their first attempt involved the application of a tincture of iodine. They saw considerable improvement in non-purulent (not pus-filled) mycotic (fungal) lesions.
• However, it was a prolonged treatment with Lugol’s solution, another iodine-based remedy, that completely cured the purulent keratitis. The solution, named after French physician Jean Lugol, often used as a disinfectant and antiseptic, showing potential in mycotic infections in the eyes of horses.