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Home / Equine Research Bank / BMC Vet Res / Assessment of left ventricular function in horses with aorti...
BMC veterinary research2020; 16(1); 93; doi: 10.1186/s12917-020-02307-5

Assessment of left ventricular function in horses with aortic regurgitation by 2D speckle tracking.

Abstract: Aortic regurgitation (AR) may lead to left ventricular (LV) dilatation, cardiac arrhythmias and heart failure. Close follow-up of horses with AR is therefore paramount to detect onset of cardiac decompensation. The aim of this study was to examine whether two-dimensional speckle tracking (2DST) can be used to detect altered myocardial function in horses with chronic AR compared to control horses. Speckle tracking was performed on short axis and long axis images of the LV in 29 healthy Warmblood horses and 57 Warmblood horses with AR. Radial, circumferential and longitudinal strain, strain rate and displacement were measured for each segment separately and the average was calculated over all segments. Data generated from the apical segments were not included in the analysis. Results: Radial (SR) and circumferential (SC) strain were significantly higher in horses with moderate AR (average SR 75.5 ± 24.3%, SC 19.3 ± 3.2%) but not in horses with severe AR (SR 65.5 ± 26.2%, SC 16.3 ± 3.5%), compared to control horses (SR 54.5 ± 18.0%, SC 16.8 ± 3.0%). Longitudinal strain did not show significant differences, but longitudinal displacement (DL) was larger in horses with moderate (average DL 29.5 ± 4.1 cm) and severe AR (DL 32.4 ± 6.1 cm) compared to control horses (DL 25.7 ± 4.0 cm), especially in the interventricular septum. Diastolic longitudinal strain rate was lower in early diastole in horses with severe AR (0.93 ± 0.18/s) compared to controls (1.13 ± 0.13/s). Conclusions: 2DST is able to detect altered myocardial motion in horses with AR, which showed significantly higher radial and circumferential strain. Further research is needed to determine whether these findings contribute to a more accurate diagnosis and prognosis in clinical cases.
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Publication Date: 2020-03-20 PubMed ID: 32197611PubMed Central: PMC7085189DOI: 10.1186/s12917-020-02307-5Google Scholar: Lookup
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  • Journal Article
  • Observational Study
  • Veterinary

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study investigates whether two-dimensional speckle tracking (2DST) can be used to assess changes in heart function in horses with a chronic heart condition called aortic regurgitation (AR). It compared healthy horses to those with AR and found that horses with AR demonstrated significantly higher radial and circumferential strain, implying that 2DST could be a useful tool in diagnosing and monitoring the condition.

Objective of the Study

  • The aim of the study was to determine if two-dimensional speckle tracking (2DST) could be used to detect alterations in myocardial function, otherwise referred to as the muscular wall of the heart, in horses with chronic aortic regurgitation (AR).

Methodology

  • A comparison was made between 29 healthy Warmblood horses and 57 Warmblood horses that suffer from AR.
  • The method used for comparison was 2DST which involves monitoring the motion of patterns, of speckles, in ultrasound images over time.
  • This technique allowed them to measure radial, circumferential and longitudinal strain, strain rates, as well as displacement along the short axis and long axis images of the left ventricle (LV).
  • Data derived from the apical segments was not used in the analysis.

Results of the Analysis

  • Horses with moderate AR demonstrated significantly higher radial and circumferential strain, but the same was not true for horses with severe AR, in comparison to control horses.
  • No significant differences were observed in the longitudinal strain; however, the longitudinal displacement was larger in AR-affected horses, especially in the interventricular septum.
  • Diastolic longitudinal strain rate was lower in horses with severe AR in early diastole compared to control horses.

Conclusion

  • The study found that 2DST was able to detect altered myocardial motion in horses with AR.
  • This suggests that the technique could potentially be used for more accurate diagnosis and prognosis of horses with AR in future.
  • However, it was noted that further research is necessary to confirm these findings.

Cite This Article

APA
Decloedt A, Ven S, De Clercq D, Rademakers F, van Loon G. (2020). Assessment of left ventricular function in horses with aortic regurgitation by 2D speckle tracking. BMC Vet Res, 16(1), 93. https://doi.org/10.1186/s12917-020-02307-5

Publication

BMC veterinary research
ISSN: 1746-6148
NlmUniqueID: 101249759
Country: England
Language: English
Volume: 16
Issue: 1
Pages: 93
PII: 93

Researcher Affiliations

Decloedt, A
  • Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium. Annelies.Decloedt@ugent.be.
Ven, S
  • Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.
De Clercq, D
  • Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.
Rademakers, F
  • Division of Cardiovascular Imaging and Dynamics, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
van Loon, G
  • Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.

MeSH Terms

  • Animals
  • Aortic Valve Insufficiency / diagnostic imaging
  • Aortic Valve Insufficiency / veterinary
  • Case-Control Studies
  • Cross-Sectional Studies
  • Echocardiography / methods
  • Echocardiography / veterinary
  • Female
  • Horse Diseases / diagnostic imaging
  • Horses
  • Male
  • Ventricular Function, Left

Conflict of Interest Statement

The authors declare that they have no competing interests.

References

This article includes 26 references
  1. Young LE, Rogers K, Wood JL. Heart murmurs and valvular regurgitation in thoroughbred racehorses: epidemiology and associations with athletic performance.. J Vet Intern Med 2008 Mar-Apr;22(2):418-26.
    doi: 10.1111/j.1939-1676.2008.0053.xpubmed: 18346144google scholar: lookup
  2. Stevens KB, Marr CM, Horn JN, Pfeiffer DU, Perkins JD, Bowen IM, Allan EJ, Campbell J, Elliott J. Effect of left-sided valvular regurgitation on mortality and causes of death among a population of middle-aged and older horses.. Vet Rec 2009 Jan 3;164(1):6-10.
    doi: 10.1136/vr.164.1.6pubmed: 19122214google scholar: lookup
  3. Reef VB, Bonagura J, Buhl R, McGurrin MK, Schwarzwald CC, van Loon G, Young LE. Recommendations for management of equine athletes with cardiovascular abnormalities.. J Vet Intern Med 2014 May-Jun;28(3):749-61.
    doi: 10.1111/jvim.12340pmc: PMC4895474pubmed: 24628586google scholar: lookup
  4. Ven S, Decloedt A, Van Der Vekens N, De Clercq D, van Loon G. Assessing aortic regurgitation severity from 2D, M-mode and pulsed wave Doppler echocardiographic measurements in horses.. Vet J 2016 Apr;210:34-8.
    doi: 10.1016/j.tvjl.2016.01.011pubmed: 26900009google scholar: lookup
  5. Bonow RO, Lakatos E, Maron BJ, Epstein SE. Serial long-term assessment of the natural history of asymptomatic patients with chronic aortic regurgitation and normal left ventricular systolic function.. Circulation 1991 Oct;84(4):1625-35.
    doi: 10.1161/01.CIR.84.4.1625pubmed: 1914102google scholar: lookup
  6. Decloedt A, Verheyen T, Sys S, De Clercq D, van Loon G. Evaluation of tissue Doppler imaging for regional quantification of radial left ventricular wall motion in healthy horses.. Am J Vet Res 2013 Jan;74(1):53-61.
    doi: 10.2460/ajvr.74.1.53pubmed: 23270346google scholar: lookup
  7. Ven S, Decloedt A, De Clercq D, Vera L, Rademakers F, van Loon G. Detection of subclinical left ventricular dysfunction by tissue Doppler imaging in horses with aortic regurgitation.. Equine Vet J 2018 Sep;50(5):587-593.
    pubmed: 29341213doi: 10.1111/evj.12805google scholar: lookup
  8. Marciniak A, Sutherland GR, Marciniak M, Claus P, Bijnens B, Jahangiri M. Myocardial deformation abnormalities in patients with aortic regurgitation: a strain rate imaging study.. Eur J Echocardiogr 2009 Jan;10(1):112-9.
    doi: 10.1093/ejechocard/jen185pubmed: 18579501google scholar: lookup
  9. Lancellotti P, Cosyns B, Zacharakis D, Attena E, Van Camp G, Gach O, Radermecker M, Piérard LA. Importance of left ventricular longitudinal function and functional reserve in patients with degenerative mitral regurgitation: assessment by two-dimensional speckle tracking.. J Am Soc Echocardiogr 2008 Dec;21(12):1331-6.
    doi: 10.1016/j.echo.2008.09.023pubmed: 19041577google scholar: lookup
  10. Decloedt A, Verheyen T, Sys S, De Clercq D, van Loon G. Two-dimensional speckle tracking for quantification of left ventricular circumferential and radial wall motion in horses.. Equine Vet J 2013 Jan;45(1):47-55.
    doi: 10.1111/j.2042-3306.2012.00549.xpubmed: 22339797google scholar: lookup
  11. Decloedt A, Verheyen T, Sys S, De Clercq D, van Loon G. Quantification of left ventricular longitudinal strain, strain rate, velocity, and displacement in healthy horses by 2-dimensional speckle tracking.. J Vet Intern Med 2011 Mar-Apr;25(2):330-8.
    doi: 10.1111/j.1939-1676.2010.0663.xpubmed: 21382074google scholar: lookup
  12. Schwarzwald CC, Schober KE, Berli AS, Bonagura JD. Left ventricular radial and circumferential wall motion analysis in horses using strain, strain rate, and displacement by 2D speckle tracking.. J Vet Intern Med 2009 Jul-Aug;23(4):890-900.
    doi: 10.1111/j.1939-1676.2009.0321.xpubmed: 19496916google scholar: lookup
  13. Decloedt A, Verheyen T, Sys S, De Clercq D, van Loon G. Tissue Doppler imaging and 2-dimensional speckle tracking of left ventricular function in horses exposed to lasalocid.. J Vet Intern Med 2012 Sep-Oct;26(5):1209-16.
    doi: 10.1111/j.1939-1676.2012.00972.xpubmed: 22845660google scholar: lookup
  14. Gehlen H, Neukirch S. Tissue Doppler imaging and two-dimensional speckle tracking of left ventricular function in healthy horses after Clenbuterol application. J Equine Vet Sci 2013;33(12):1076–1081.
    doi: 10.1016/j.jevs.2013.04.005google scholar: lookup
  15. Gehlen H, Nagel D. Myocardial function of horses under sedation with Romifidine using two-dimensional speckle tracking. J Equine Vet Sci 2014;34(5):656–661.
    doi: 10.1016/j.jevs.2013.12.006google scholar: lookup
  16. Flethøj M, Schwarzwald CC, Haugaard MM, Carstensen H, Kanters JK, Olsen LH, Buhl R. Left Ventricular Function After Prolonged Exercise in Equine Endurance Athletes.. J Vet Intern Med 2016 Jul;30(4):1260-9.
    doi: 10.1111/jvim.13982pmc: PMC5094507pubmed: 27305095google scholar: lookup
  17. Ewe SH, Haeck ML, Ng AC, Witkowski TG, Auger D, Leong DP, Abate E, Ajmone Marsan N, Holman ER, Schalij MJ, Bax JJ, Delgado V. Detection of subtle left ventricular systolic dysfunction in patients with significant aortic regurgitation and preserved left ventricular ejection fraction: speckle tracking echocardiographic analysis.. Eur Heart J Cardiovasc Imaging 2015 Sep;16(9):992-9.
    pubmed: 25733208doi: 10.1093/ehjci/jev019google scholar: lookup
  18. Smith DN, Bonagura JD, Culwell NM, Schober KE. Left ventricular function quantified by myocardial strain imaging in small-breed dogs with chronic mitral regurgitation.. J Vet Cardiol 2012 Mar;14(1):231-42.
    doi: 10.1016/j.jvc.2011.11.002pubmed: 22361170google scholar: lookup
  19. Olsen NT, Sogaard P, Larsson HB, Goetze JP, Jons C, Mogelvang R, Nielsen OW, Fritz-Hansen T. Speckle-tracking echocardiography for predicting outcome in chronic aortic regurgitation during conservative management and after surgery.. JACC Cardiovasc Imaging 2011 Mar;4(3):223-30.
    doi: 10.1016/j.jcmg.2010.11.016pubmed: 21414568google scholar: lookup
  20. Koenig TR, Mitchell KJ, Schwarzwald CC. Echocardiographic Assessment of Left Ventricular Function in Healthy Horses and in Horses with Heart Disease Using Pulsed-Wave Tissue Doppler Imaging.. J Vet Intern Med 2017 Mar;31(2):556-567.
    doi: 10.1111/jvim.14641pmc: PMC5354014pubmed: 28109132google scholar: lookup
  21. Chetboul V, Sampedrano CC, Concordet D, Tissier R, Lamour T, Ginesta J, Gouni V, Nicolle AP, Pouchelon JL, Lefebvre HP. Use of quantitative two-dimensional color tissue Doppler imaging for assessment of left ventricular radial and longitudinal myocardial velocities in dogs.. Am J Vet Res 2005 Jun;66(6):953-61.
    doi: 10.2460/ajvr.2005.66.953pubmed: 16008215google scholar: lookup
  22. Edner M, Jarnert C, Müller-Brunotte R, Malmqvist K, Ring M, Kjerr AC, Lind L, Kahan T. Influence of age and cardiovascular factors on regional pulsed wave Doppler myocardial imaging indices.. Eur J Echocardiogr 2000 Jun;1(2):87-95.
    doi: 10.1053/euje.2000.0013pubmed: 12086213google scholar: lookup
  23. Suzuki R, Matsumoto H, Teshima T, Koyama H. Effect of age on myocardial function assessed by two-dimensional speckle-tracking echocardiography in healthy beagle dogs.. J Vet Cardiol 2013 Dec;15(4):243-52.
    pubmed: 24054982doi: 10.1016/j.jvc.2013.07.001google scholar: lookup
  24. Gehlen H, Bildheim LM. Speckle-tracking analysis of myocardial deformation in correlation to age in healthy horses.. J Vet Sci 2018 Sep 30;19(5):676-682.
    doi: 10.4142/jvs.2018.19.5.676pmc: PMC6167342pubmed: 29695144google scholar: lookup
  25. McKeever KH, Eaton TL, Geiser S, Kearns CF, Lehnhard RA. Age related decreases in thermoregulation and cardiovascular function in horses.. Equine Vet J Suppl 2010 Nov;(38):220-7.
    doi: 10.1111/j.2042-3306.2010.00259.xpubmed: 21059010google scholar: lookup
  26. Blessberger H, Binder T. Two dimensional speckle tracking echocardiography: clinical applications.. Heart 2010 Dec;96(24):2032-40.
    doi: 10.1136/hrt.2010.199885pubmed: 21088126google scholar: lookup

Citations

This article has been cited 2 times.
  1. Gehlen H, Fisch J, Merle R, Trachsel DS. Preliminary study on the effects of pergolide on left ventricular function in the horses with pituitary pars intermedia dysfunction. J Vet Sci 2021 Sep;22(5):e64.
    doi: 10.4142/jvs.2021.22.e64pubmed: 34553515google scholar: lookup
  2. Dufourni A, Demeyere M, Vernemmen I, Van Steenkiste G, Verhaeghe LM, van Loon G, Decloedt A. Effect of N-Butylscopolammonium Bromide and Metamizol Sodium on Heart Rate, Blood Pressure, and Echocardiographic Measurements in Warmblood Horses With Aortic and Mitral Valve Regurgitation. J Vet Intern Med 2025 Nov-Dec;39(6):e70254.
    doi: 10.1111/jvim.70254pubmed: 41070729google scholar: lookup
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