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Reproduction in domestic animals = Zuchthygiene2021; 57(3); 262-268; doi: 10.1111/rda.14048

Assessment of serum amyloid A concentrations and biochemical profiles in lactating jennies and newborn Ragusano donkey foals around parturition and one month after foaling in Sicily.

Abstract: A proper knowledge of biochemical parameters and inflammatory markers like serum amyloid A (SAA) is crucial in the monitoring of the first post-partum period in equids. Since no information is available on SAA for donkeys at this stage, 50 animals including jennies (n.10) and newborn foals (n.10) within 48 hr from foaling, and jennies (n.10) and foals (n.20) after 30 days from parturition were enrolled in the study to assess routine biochemical profile including SAA. Jennies showed higher alkaline phosphatase and lower bilirubins and cholesterol at 30 days of lactation compared to post-partum. Neonatal donkey foals showed significant higher concentrations of sodium, alkaline phosphatase, lactic dehydrogenase, blood urea nitrogen, creatinine and albumin within 48 hr of age, whilst higher values of phosphate and triglycerides were observed in older foals of 30 days of age. Significant higher SAA concentrations were recorded during the peripartum period in both jennies (25.95 ± 14.98 μg/ml) and newborn donkey foals (37.44 ± 19.75 μg/ml) compared to SAA values recorded in lactating jennies (2.38 ± 1.78 μg/ml) and in donkey foals (16.04 ± 18.14 μg/ml) at 30 days after parturition. The assessment of SAA in jennies and donkey foals around parturition and one month after foaling represents a valuable tool for the monitoring of health status during this stage when animals have to face with new challenges like the peak of lactation and extrauterine life adaptation respectively.
© 2021 The Authors. Reproduction in Domestic Animals published by Wiley-VCH GmbH.
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Publication Date: 2021-11-29 PubMed ID: 34816505PubMed Central: PMC9300177DOI: 10.1111/rda.14048Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article is about a study conducted to understand the levels of serum amyloid A (SAA) and other biochemical parameters in lactating jennies and newborn donkey foals during and a month after birth. The results provide valuable insights for monitoring the health of these animals, particularly during the post-partum period.

Objective of the Study

  • The aim of this research was to investigate biochemical values and the concentrations of an inflammatory marker known as serum amyloid A (SAA) in lactating jennies and newborn Ragusano donkey foals both around the time of birth and a month afterwards.

Methodology

  • For this study, 50 donkeys were selected. This included ten lactating jennies and ten newborn foals less than 48 hours old, as well as ten jennies and twenty foals who were 30 days post-partum.
  • The researchers conducted a biochemical examination that included measuring SAA levels.

Results

  • The study found that lactating donkey mothers exhibited higher levels of an enzyme called alkaline phosphatase, along with lower bilirubin and cholesterol levels, 30 days post-partum compared to immediately after childbirth.
  • Newborn donkeys exhibited higher sodium, alkaline phosphatase, lactic dehydrogenase, blood urea nitrogen, creatinine, and albumin levels during the first 48 hours of life. However, by the time they reached 30 days of age, they showed higher levels of phosphate and triglycerides.
  • Both lactating jennies and newborn foals showed significantly higher SAA levels around the time of birth compared to 30 days post-partum.

Conclusion

  • The study discovered that measuring SAA levels in lactating jennies and donkey foals during and after childbirth can provide useful information regarding their health status. This testing is particularly valuable during this stage of their lives as they adapt to lactation and life outside the uterus.

Cite This Article

APA
Bazzano M, Bonfili L, Eleuteri AM, Serri E, Scollo C, Yaosen Y, Tesei B, Laus F. (2021). Assessment of serum amyloid A concentrations and biochemical profiles in lactating jennies and newborn Ragusano donkey foals around parturition and one month after foaling in Sicily. Reprod Domest Anim, 57(3), 262-268. https://doi.org/10.1111/rda.14048

Publication

Reproduction in domestic animals = Zuchthygiene
ISSN: 1439-0531
NlmUniqueID: 9015668
Country: Germany
Language: English
Volume: 57
Issue: 3
Pages: 262-268

Researcher Affiliations

Bazzano, Marilena
  • School of Biosciences and Veterinary Medicine, University of Camerino, Matelica, Italy.
Bonfili, Laura
  • School of Biosciences and Veterinary Medicine, University of Camerino, Matelica, Italy.
Eleuteri, Anna Maria
  • School of Biosciences and Veterinary Medicine, University of Camerino, Matelica, Italy.
Serri, Evelina
  • School of Biosciences and Veterinary Medicine, University of Camerino, Matelica, Italy.
Scollo, Carmela
  • Private Practitioner, Catania, Italy.
Yaosen, Yang
  • School of Biosciences and Veterinary Medicine, University of Camerino, Matelica, Italy.
Tesei, Beniamino
  • School of Biosciences and Veterinary Medicine, University of Camerino, Matelica, Italy.
Laus, Fulvio
  • School of Biosciences and Veterinary Medicine, University of Camerino, Matelica, Italy.

MeSH Terms

  • Animals
  • Animals, Newborn
  • Equidae
  • Female
  • Horses
  • Lactation
  • Parturition
  • Pregnancy
  • Serum Amyloid A Protein
  • Sicily

Conflict of Interest Statement

Authors declare no conflict of interest.

References

This article includes 23 references
  1. Bazzano M, Giannetto C, Fazio F, Arfuso F, Giudice E, Piccione G. Metabolic profile of broodmares during late pregnancy and early post-partum.. Reprod Domest Anim 2014 Dec;49(6):947-53.
    doi: 10.1111/RDA.12411pubmed: 25251226google scholar: lookup
  2. Bonelli F, Rota A, Corazza M, Serio D, Sgorbini M. Hematological and biochemical findings in pregnant, postfoaling, and lactating jennies.. Theriogenology 2016 Apr 15;85(7):1233-8.
    doi: 10.1016/J.THERIOGENOLOGY.2015.12.004pubmed: 26792379google scholar: lookup
  3. Bordonaro S, Dimauro C, Criscione A, Marletta D, Macciotta NP. The mathematical modeling of the lactation curve for dairy traits of the donkey (Equus asinus).. J Dairy Sci 2013 Jun;96(6):4005-14.
    doi: 10.3168/JDS.2012-6180pubmed: 23587386google scholar: lookup
  4. Chavatte PM, Pepys MB, Roberts B, Ousey JC, McGladdery AJ. Measurement of serum amyloid A protein (SAA) as an aid to differential diagnosis of infection in newborn foals. Equine Infectious Disease 4, 33–38.
  5. Coutinho da Silva MA, Canisso IF, MacPherson ML, Johnson AE, Divers TJ. Serum amyloid A concentration in healthy periparturient mares and mares with ascending placentitis.. Equine Vet J 2013 Sep;45(5):619-24.
    doi: 10.1111/evj.12034pubmed: 23432049google scholar: lookup
  6. Evans L, Crane M. The clinical companion of the donkey. 1st ed..
  7. Gan XW, Wang WS, Lu JW, Ling LJ, Zhou Q, Zhang HJ, Ying H, Sun K. De novo Synthesis of SAA1 in the Placenta Participates in Parturition.. Front Immunol 2020;11:1038.
    doi: 10.3389/fimmu.2020.01038pmc: PMC7297131pubmed: 32582166google scholar: lookup
  8. Jerele S, Davis E, Mapes S, Pusterla N, Navas González FJ, Iglesias Pastrana C, Abdelfattah EM, McLean A. Survey of Serum Amyloid A and Bacterial and Viral Frequency Using qPCR Levels in Recently Captured Feral Donkeys from Death Valley National Park (California).. Animals (Basel) 2020 Jun 23;10(6).
    doi: 10.3390/ani10061086pmc: PMC7341296pubmed: 32585994google scholar: lookup
  9. Kay G, Tligui N, Semmate N, Azrib R, González FJN, Brizgys L, McLean A. Determining factors and interspecific modeling for serum amyloid a concentrations in working horses, donkeys, and mules.. Res Vet Sci 2019 Aug;125:256-265.
    doi: 10.1016/J.RVSC.2019.07.004pubmed: 31325640google scholar: lookup
  10. Krakowski L, Brodzki P, Krakowska I, Opielak G, Marczuk J, Piech T. The Level of Prolactin, Serum Amyloid A, and Selected Biochemical Markers in Mares Before and After Parturition and Foal Heat.. J Equine Vet Sci 2020 Jan;84:102854.
    doi: 10.1016/J.JEVS.2019.102854pubmed: 31864459google scholar: lookup
  11. Long A, Nolen-Walston R. Equine Inflammatory Markers in the Twenty-First Century: A Focus on Serum Amyloid A.. Vet Clin North Am Equine Pract 2020 Apr;36(1):147-160.
    doi: 10.1016/j.cveq.2019.12.005pmc: PMC7135104pubmed: 32007299google scholar: lookup
  12. Mariella J, Pirrone A, Gentilini F, Castagnetti C. Hematologic and biochemical profiles in Standardbred mares during peripartum.. Theriogenology 2014 Mar 1;81(4):526-34.
    doi: 10.1016/J.THERIOGENOLOGY.2013.11.001pubmed: 24361129google scholar: lookup
  13. McDonald TL, Weber A, Smith JW. A monoclonal antibody sandwich immunoassay for serum amyloid A (SAA) protein.. J Immunol Methods 1991 Nov 22;144(2):149-55.
    doi: 10.1016/0022-1759(91)90081-Ppubmed: 1720442google scholar: lookup
  14. McLean AK, Wang W, Navas‐Gonzalez FJ, Rodrigues JB. Reference intervals for hematological and blood biochemistry reference values in healthy mules and hinnies. Comparative Clinical Pathology 25(4), 871–878.
    doi: 10.1007/s00580-016-2276-3google scholar: lookup
  15. Milonis E, Polidori P. Aggiornamenti sull’allevamento dell’asina da Latte. 1st ed..
  16. Nolen‐Walston R. How to interpret serum amyloid a concentrations. AAEP Proceedings 61, 130–137.
  17. Piccione G, Bazzano M, Bruschetta D, Giannetto C, Arfuso F, Giudice E. Omega‐3 fatty acid food enrichment influences some serum acute phase proteins concentration and white blood cell count in athlete horses. Journal of Equine Veterinary Science 39, 90–96.
    doi: 10.1016/J.JEVS.2015.11.007google scholar: lookup
  18. Sato J, Kanata M, Yasuda J, Sato R, Okada K, Seimiya Y, Naito Y. Changes of serum alkaline phosphatase activity in dry and lactational cows.. J Vet Med Sci 2005 Aug;67(8):813-5.
    doi: 10.1292/JVMS.67.813pubmed: 16141669google scholar: lookup
  19. Sgorbini M, Bonelli F, Rota A, Baragli P, Marchetti V, Corazza M. Hematology and clinical chemistry in amiata donkey foals from birth to 2 months of age. Journal of Equine Veterinary Science 33(1), 35–39.
    doi: 10.1016/J.JEVS.2012.04.010google scholar: lookup
  20. Stoneham SJ, Palmer L, Cash R, Rossdale PD. Measurement of serum amyloid A in the neonatal foal using a latex agglutination immunoturbidimetric assay: determination of the normal range, variation with age and response to disease.. Equine Vet J 2001 Nov;33(6):599-603.
    doi: 10.2746/042516401776563472pubmed: 11720032google scholar: lookup
  21. Veronesi MC, Gloria A, Panzani S, Sfirro MP, Carluccio A, Contri A. Blood analysis in newborn donkeys: hematology, biochemistry, and blood gases analysis.. Theriogenology 2014 Jul 15;82(2):294-303.
    doi: 10.1016/J.THERIOGENOLOGY.2014.04.004pubmed: 24831574google scholar: lookup
  22. Witkowska-Piłaszewicz O, Bąska P, Czopowicz M, Żmigrodzka M, Szczepaniak J, Szarska E, Winnicka A, Cywińska A. Changes in Serum Amyloid A (SAA) Concentration in Arabian Endurance Horses During First Training Season.. Animals (Basel) 2019 Jun 8;9(6).
    doi: 10.3390/ANI9060330pmc: PMC6616404pubmed: 31181740google scholar: lookup
  23. Witkowska-Piłaszewicz OD, Żmigrodzka M, Winnicka A, Miśkiewicz A, Strzelec K, Cywińska A. Serum amyloid A in equine health and disease.. Equine Vet J 2019 May;51(3):293-298.
    doi: 10.1111/evj.13062pmc: PMC7163734pubmed: 30565319google scholar: lookup

Citations

This article has been cited 5 times.
  1. Bazzano M, Arfuso F, Bonfili L, Eleuteri AM, McLean A, Serri E, Spaterna A, Laus F. Measuring Biochemical Variables and Serum Amyloid A (SAA) in Working Mules in Central Italy. Animals (Basel) 2022 Oct 16;12(20).
    doi: 10.3390/ani12202793pubmed: 36290179google scholar: lookup
  2. Hoeberg E, Sånge A, Saegerman C, Bohlin A, Nostell K, Durie I, Husted L, Öhman A, Jacobsen S, Berg L, Laursen SH, van Galen G. Serum amyloid A as a marker to detect sepsis and predict outcome in hospitalized neonatal foals. J Vet Intern Med 2022 Nov;36(6):2245-2253.
    doi: 10.1111/jvim.16550pubmed: 36239317google scholar: lookup
  3. Bazzano M, Marchegiani A, Troisi A, McLean A, Laus F. Serum Amyloid A as a Promising Biomarker in Domestic Animals' Reproduction: Current Knowledge and Future Perspective. Animals (Basel) 2022 Feb 25;12(5).
    doi: 10.3390/ani12050589pubmed: 35268158google scholar: lookup
  4. Lisuzzo A, Bonelli F, Sgorbini M, Nocera I, Cento G, Mazzotta E, Turini L, Martini M, Salari F, Morgante M, Badon T, Fiore E. Differences of the Plasma Total Lipid Fraction from Pre-Foaling to Post-Foaling Period in Donkeys. Animals (Basel) 2022 Jan 26;12(3).
    doi: 10.3390/ani12030304pubmed: 35158628google scholar: lookup
  5. Accorroni L, Bazzano M, Marchegiani A, Spaterna A, Laus F. Abdominal Ultrasonography in Healthy Female Standard Donkeys. Animals (Basel) 2025 Jan 8;15(2).
    doi: 10.3390/ani15020129pubmed: 39858129google scholar: lookup
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