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Home / Equine Research Bank / J Vet Diagn Invest / Assessment of the CoaguChek-XS portable prothrombin time poi...
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc2019; 31(3); 448-452; doi: 10.1177/1040638719832340

Assessment of the CoaguChek-XS portable prothrombin time point-of-care analyzer for horses.

Abstract: Coagulopathies in horses are common and potentially life-threatening. In equine field medicine, a portable point-of-care (POC) prothrombin time (PT) testing device could be useful to identify early changes in extrinsic clotting. The CoaguChek-XS (Roche Diagnostics) is a small, portable POC PT analyzer used in human medicine. Our preliminary study assessed the suitability of CoaguChek-XS for testing PT in horses and established the PT reference interval (PT RI) in healthy horses using this instrument. Blood samples collected from 102 healthy and ill horses were analyzed with the CoaguChek-XS and compared to a semi-automated coagulometric analyzer (SACA) as the gold standard. There was a significant positive correlation between the 2 measurement methods ( r = 0.765, p < 0.01), and very good agreement, with 97% of the samples falling within limits of agreement. The mean CoaguChek-XS PT coefficient of variation was 0.8%, indicating high precision. With high precision and good agreement with the coagulometric PT, the CoaguChek-XS should be further validated for PT measurement in horses.
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Publication Date: 2019-03-11 PubMed ID: 30852982PubMed Central: PMC6838704DOI: 10.1177/1040638719832340Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article examines the effectiveness of the CoaguChek-XS, a point-of-care testing device, in assessing the prothrombin time (PT) in horses, which may aid in early detection of clotting disorders. The study shows a significant correlation with the standard method of measurement and suggests the CoaguChek-XS might be a valuable tool in horse health management.

About the Research

  • The study revolves around CoaguChek-XS, a portable device commonly used in human medicine to measure prothrombin time or PT, a test that measures how quickly the blood clots.
  • The researchers wanted to see if this device could also work effectively for horses, as blood clotting problems can be common and serious in equines.

Methodology

  • The scientists tested the CoaguChek-XS on blood samples drawn from 102 horses, both healthy and ill.
  • They then compared the results from the CoaguCheck-XS to those obtained using a semi-automated coagulometric analyzer (SACA), considered the “gold standard” for such tests.

Results and Interpretation

  • Analysis showed a significant positive correlation between the measurements obtained from the two methods. This means that as the PT values increased in the SACA measurements, they also increased in the CoaguChek-XS measurements, and vice versa.
  • In fact, 97% of the samples’ results aligned with each other regarding the limits of agreement, suggesting that the CoaguChek-XS can yield results highly consistent with those from the SACA.
  • The study also found that the CoaguChek-XS shows high precision (as indicated by the coefficient of variation being only 0.8%). This means the CoaguChek-XS provides very consistent measurements for the same samples.

Conclusions and Future Directions

  • The research concludes that the portable CoaguChek-XS device could be a useful tool in equine medicine for assessing PT in the field.
  • Given its demonstrated high precision and agreement with the gold standard coagulometric PT measurement, the researchers recommend that the CoaguChek-XS be further validated for PT measurement in horses.

Cite This Article

APA
Berlin N, Kelmer E, Segev G, Aroch I, Kelmer G. (2019). Assessment of the CoaguChek-XS portable prothrombin time point-of-care analyzer for horses. J Vet Diagn Invest, 31(3), 448-452. https://doi.org/10.1177/1040638719832340

Publication

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
ISSN: 1943-4936
NlmUniqueID: 9011490
Country: United States
Language: English
Volume: 31
Issue: 3
Pages: 448-452

Researcher Affiliations

Berlin, Noa
  • Departments of Small Animal Emergency and Critical Care (Berlin, E Kelmer).
  • Small Animal Internal Medicine (Segev, Aroch).
  • Large Animal Medicine and Surgery (G Kelmer).
  • The Hebrew University Veterinary Teaching Hospital, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Kelmer, Efrat
  • Departments of Small Animal Emergency and Critical Care (Berlin, E Kelmer).
  • Small Animal Internal Medicine (Segev, Aroch).
  • Large Animal Medicine and Surgery (G Kelmer).
  • The Hebrew University Veterinary Teaching Hospital, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Segev, Gilad
  • Departments of Small Animal Emergency and Critical Care (Berlin, E Kelmer).
  • Small Animal Internal Medicine (Segev, Aroch).
  • Large Animal Medicine and Surgery (G Kelmer).
  • The Hebrew University Veterinary Teaching Hospital, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Aroch, Itamar
  • Departments of Small Animal Emergency and Critical Care (Berlin, E Kelmer).
  • Small Animal Internal Medicine (Segev, Aroch).
  • Large Animal Medicine and Surgery (G Kelmer).
  • The Hebrew University Veterinary Teaching Hospital, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Kelmer, Gal
  • Departments of Small Animal Emergency and Critical Care (Berlin, E Kelmer).
  • Small Animal Internal Medicine (Segev, Aroch).
  • Large Animal Medicine and Surgery (G Kelmer).
  • The Hebrew University Veterinary Teaching Hospital, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.

MeSH Terms

  • Animals
  • Disseminated Intravascular Coagulation / diagnosis
  • Disseminated Intravascular Coagulation / veterinary
  • Female
  • Horse Diseases / diagnosis
  • Horses
  • Male
  • Point-of-Care Systems
  • Prothrombin Time / methods
  • Prothrombin Time / veterinary
  • Sensitivity and Specificity

Conflict of Interest Statement

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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Citations

This article has been cited 1 times.
  1. Tonthong S, Rungpupradit J. Coagulation testing: Comparison of portable (CoaguChek(®) XS) and automated coagulation analyzer in healthy cats.. Vet World 2020 Nov;13(11):2541-2545.
    doi: 10.14202/vetworld.2020.2541-2545pubmed: 33363352google scholar: lookup
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