Assessment of the effect and safety of salacinol in horses.
Abstract: We report a study that examined the effect and safety of salacinol from Salacia reticulata extract (SRE) for the intestinal microbiota of horses. We administered SRE to healthy horses and evaluated their intestinal microbiota before and after the test period for changes in composition. Horses that received the SRE showed notable differences in intestinal microbiota composition between before and after administration, with a substantial increase in bacteria of the order Lactobacillales at the end of the test period. Moreover, the Firmicutes-to-Bacteroidetes ratio was elevated. Salacinol was administered as a supplement for 28 days. Physiological and blood tests were conducted in the presence of a veterinarian, and a safety assessment was performed. These evaluations revealed no detrimental findings.
©2019 The Japanese Society of Equine Science.
Publication Date: 2019-12-18 PubMed ID: 31871413PubMed Central: PMC6920057DOI: 10.1294/jes.30.105Google Scholar: Lookup
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- Journal Article
Summary
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This research article presents a study on the impact and safety of salacinol, extracted from Salacia reticulata, on the intestinal microbiota in horses.
Study Overview
- This study sought to ascertain the effect and safety level of Salacia reticulata extract (SRE), particularly a component known as salacinol, on the intestinal microbiota of horses. The administration was done on healthy horses. The objective was to investigate any major shift in the composition of the intestinal microbiota before and after salacinol administration.
Findings on Intestinal Microbiota Composition
- It was found that horses that were given the SRE showed clear changes in the composition of the intestinal microbiota before and after the salacinol was administered.
- One of the remarkable findings included a substantial increase in bacteria from the order Lactobacillales towards the conclusion of the test period.
- Additionally, the scientists observed a rise in the ratio of Firmicutes to Bacteroidetes – two significant groups of bacteria in the gut. However, the article does not elaborate on the relative implications of the noted increase.
Administration and Safety Assessments
- Salacinol was given as a supplement for 28 consecutive days to validate its impact on the horses’ intestinal microbiota.
- To ensure safety and maintain the highest ethical considerations during the study, physiological and blood tests were conducted throughout the administration period under the watchful eye of a qualified veterinarian.
- A safety evaluation was also carried out after the test period. Importantly, the evaluations showed no adverse results, thereby indicating that the administration of salacinol did not trigger any harmful effects in the horses.
Implications and Further Research
- Despite the researchers concluding that salacinol is safe for use in horses, the functional or health implications of the shift in microbiota composition due to salacinol administration are not detailed in the abstract.
- Therefore, further studies could aim to explore how salacinol might benefit or affect the overall health and well-being of horses, particularly considering the changes observed in microbiota composition.
Cite This Article
APA
Ueda F, Iida A, Saito H, Seki S, Amao A, Yamate H.
(2019).
Assessment of the effect and safety of salacinol in horses.
J Equine Sci, 30(4), 105-111.
https://doi.org/10.1294/jes.30.105 Publication
Researcher Affiliations
- Bio Science & Engineering Laboratory, Research & Development Management Headquarters, FUJIFILM Corporation, Kanagawa 258-8577, Japan.
- Bio Science & Engineering Laboratory, Research & Development Management Headquarters, FUJIFILM Corporation, Kanagawa 258-8577, Japan.
- Bio Science & Engineering Laboratory, Research & Development Management Headquarters, FUJIFILM Corporation, Kanagawa 258-8577, Japan.
- Bio Science & Engineering Laboratory, Research & Development Management Headquarters, FUJIFILM Corporation, Kanagawa 258-8577, Japan.
- Highly Functional Materials Business Development Headquarters, FUJIFILM Corporation, Tokyo 107-0052, Japan.
- Yamate Racehorse Clinic, Iwate 020-0103, Japan.
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Citations
This article has been cited 1 times.- Morikawa T, Ninomiya K, Tanabe G, Matsuda H, Yoshikawa M, Muraoka O. A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia. J Nat Med 2021 Jun;75(3):449-466.
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