Assessment of the effect of three treatments to remove intrauterine fluid on pregnancy rate in the mare.
Abstract: The effects on pregnancy rate of three different treatments to remove intrauterine fluid were assessed in 1267 mares. The mares were mated and allocated, in strict rotation, to four treatment groups: 1) untreated controls, 2) intrauterine infusion of broad spectrum antibiotics, 3) intravenous injection of oxytocin, 4) intravenous injection of oxytocin followed by intrauterine antibiotics. The pregnancy status of the mares was determined 13 to 15 days and 27 to 30 days after ovulation by transrectal ultrasonography. The pregnancy rate of group 4 (72 per cent) was higher than that of group 2 (64 per cent, P < 0.01) or group 3 (63 per cent, P < 0.01). The pregnancy rates of groups 2 and 3 were higher than that of group 1 (56 per cent, P < 0.01). The treatment with antibiotics and oxytocin appeared to have an additive beneficial effect which suggested two different modes of action of the combination treatment, namely antibacterial activity and fluid drainage. In the untreated mares more fluid accumulated in the uterine lumen after mating, and this was the most likely reason for their lower pregnancy rate.
Publication Date: 1996-04-06 PubMed ID: 8730672DOI: 10.1136/vr.138.14.320Google Scholar: Lookup
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- Clinical Trial
- Controlled Clinical Trial
- Journal Article
Summary
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The research investigates how different treatments to remove intrauterine fluid impact the pregnancy rate in mares. The study found that a combination of oxytocin and antibiotics treatment resulted in the highest pregnancy rate.
Objective of the Research
- The research aimed to determine the effects of three different treatments used to clear out intrauterine fluid in mares on their chances of getting pregnant.
Methodology
- The researchers divided a total of 1267 mares into four groups, each receiving a different treatment after being mated.
- Group 1 was the control, receiving no treatment. The mares in Group 2 were treated with intrauterine infusion of broad-spectrum antibiotics. Group 3 received an intravenous injection of oxytocin. Group 4 was subjected to both oxytocin and antibiotics.
- Throughout the study, the pregnancy status of the mares was tracked by using transrectal ultrasonography 13 to 15 days and 27 to 30 days after ovulation.
Results and Conclusion
- The mares treated with both oxytocin and antibiotics (Group 4) exhibited the highest pregnancy rate of 72%, significantly higher than the rates of Group 2 (64%) and Group 3 (63%).
- The pregnancy rates of mares in Groups 2 and 3 were also found to be higher than that of the untreated control group (56%).
- The findings suggested that oxytocin and antibiotics treatments work together in two distinct ways to increase pregnancy rates: the antibiotics kill harmful bacteria while the oxytocin aids in draining the fluid.
- The researchers infer that the accumulation of more fluid in the uterine lumen after mating in the untreated mares is the most likely cause of their lower pregnancy rate.
Significance of the Study
- This research provides valuable insights for equine breeding processes by shedding light on the significant role of combined antibiotics and oxytocin treatments for improving pregnancy rates in mares.
Cite This Article
APA
Pycock JF, Newcombe JR.
(1996).
Assessment of the effect of three treatments to remove intrauterine fluid on pregnancy rate in the mare.
Vet Rec, 138(14), 320-323.
https://doi.org/10.1136/vr.138.14.320 Publication
Researcher Affiliations
- Department of Herd Health and Reproduction, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.
MeSH Terms
- Animals
- Anti-Bacterial Agents / therapeutic use
- Drug Therapy, Combination
- Endometritis / drug therapy
- Endometritis / veterinary
- Female
- Horse Diseases / drug therapy
- Horses
- Infusions, Parenteral
- Injections, Intravenous
- Oxytocin / therapeutic use
- Pregnancy
- Pregnancy Rate
- Ultrasonography
- Uterus / diagnostic imaging
Citations
This article has been cited 4 times.- Scarlet D, Malama E, Fischer S, Knutti B, Bollwein H. Relationship between Clinical Uterine Findings, Therapy, and Fertility in the Mare.. Vet Sci 2023 Mar 29;10(4).
- Katila T, Ferreira-Dias G. Evolution of the Concepts of Endometrosis, Post Breeding Endometritis, and Susceptibility of Mares.. Animals (Basel) 2022 Mar 19;12(6).
- Díaz-Bertrana ML, Deleuze S, Pitti Rios L, Yeste M, Morales Fariña I, Rivera Del Alamo MM. Microbial Prevalence and Antimicrobial Sensitivity in Equine Endometritis in Field Conditions.. Animals (Basel) 2021 May 20;11(5).
- Köhne M, Kuhlmann M, Tönißen A, Martinsson G, Sieme H. Diagnostic and Treatment Practices of Equine Endometritis-A Questionnaire.. Front Vet Sci 2020;7:547.
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