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Home / Equine Research Bank / Vet Immunol Immunopathol / Association between equine leucocyte antigens (ELA) and equi...
Veterinary immunology and immunopathology1988; 19(3-4); 215-223; doi: 10.1016/0165-2427(88)90109-2

Association between equine leucocyte antigens (ELA) and equine sarcoid tumors in the population of Swedish halfbreds and some of their families.

Abstract: The distribution of equine leucocyte antigens (ELA) in Swedish Halfbreds affected by sarcoid tumors was determined and compared with that of control horses of the same breed. ELA-haplotype A3W13 appeared more frequently in affected horses, resulting in a chi 2 value of 4.45 (P = 0.034) for A3 and 9.05 (P = 0.0026) for W13, respectively. The relative risk factor (RR) could be estimated to 2.13 and 3.00 for A3 and W13, respectively. The etiology fraction (EF) was calculated to 28% and 37% for A3 and W13, respectively. Thus, in the population of Swedish Halfbreds approximately 40% (at least) of the disease appeared to be associated with the genetic background of the affected horse. Family studies established that ELA are codominantly expressed and inherited as simple Mendelian traits and that sarcoids among offspring are significantly associated with one of the parental haplotypes (P = 0.00942). This parental haplotype does not always include A3W13. These results confirm and extend previous results from other breeds and strongly suggest the existence of a predisposition for sarcoids among horses, that is due to an autosomal, dominant, ELA-linked gene with incomplete penetrance. In extension, this indicates a multifactorial etiology of equine sarcoids (additional non-MHC gene(s) and/or environmental factors).
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Publication Date: 1988-10-01 PubMed ID: 3252614DOI: 10.1016/0165-2427(88)90109-2Google Scholar: Lookup
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Summary

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This research article investigates the relationship between Equine Leucocyte Antigens (ELA) and the development of sarcoid tumors in Swedish Halfbred horses. The study identifies a greater frequency of specific ELA-haplotypes in horses affected by these tumors, suggesting a genetic predisposition linked to these antigens.

Understanding Equine Leucocyte Antigens and Sarcoid Tumors

  • The research focuses on equine leucocyte antigens (ELAs), which are important components of the horse’s immune system, responsible for identifying and neutralizing foreign substances.
  • The study also discusses sarcoid tumors, which are common skin tumors in horses, often considered benign but can become malignant.

Investigating ELA Distribution in Swedish Halfbreds

  • The research compares the distribution of ELAs in Swedish Halfbreds, a breed of horse, affected by sarcoid tumors with a control group of the same breed.
  • It was found that ELA-haplotype A3W13 appeared more frequently in horses with sarcoid tumors.
  • The results demonstrate a significant statistical correlation, with chi-square values of 4.45 for A3 and 9.05 for W13.
  • The relative risk factor was determined at 2.13 and 3.00 for A3 and W13, respectively, suggesting horses with these ELA-haplotypes have an increased risk of developing sarcoid tumors.

Genetic and Family Traits

  • In terms of family traits, it was found that ELAs show codominant expression and inherit as simple Mendelian traits, i.e., one copy of the gene is inherited from each parent.
  • The study also found a significant association between sarcoids among offspring and one of the parental haplotypes.
  • The specific parental haplotype associated with sarcoids, however, does not always include A3W13.

Etiology of Equine Sarcoids

  • The study concludes that about 40% of sarcoid disease occurrence in Swedish Halfbreds is associated with the genetic background of the horse.
  • These results support the existence of a predisposition for developing sarcoids, likely linked to an autosomal dominant ELA-linked gene with incomplete penetrance.
  • This finding suggests that the etiology of equine sarcoids is likely multifactorial, involving both additional non-MHC genes and environmental factors.

Cite This Article

APA
Broström H, Fahlbrink E, Dubath ML, Lazary S. (1988). Association between equine leucocyte antigens (ELA) and equine sarcoid tumors in the population of Swedish halfbreds and some of their families. Vet Immunol Immunopathol, 19(3-4), 215-223. https://doi.org/10.1016/0165-2427(88)90109-2

Publication

Veterinary immunology and immunopathology
ISSN: 0165-2427
NlmUniqueID: 8002006
Country: Netherlands
Language: English
Volume: 19
Issue: 3-4
Pages: 215-223

Researcher Affiliations

Broström, H
  • Department of Medicine and Surgery, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala.
Fahlbrink, E
    Dubath, M L
      Lazary, S

        MeSH Terms

        • Animals
        • Antigens, Surface / genetics
        • Biomarkers, Tumor / genetics
        • Biomarkers, Tumor / immunology
        • Female
        • Genes, Dominant
        • Genetic Linkage
        • Horse Diseases / genetics
        • Horse Diseases / immunology
        • Horses
        • Male
        • Skin Neoplasms / genetics
        • Skin Neoplasms / immunology
        • Skin Neoplasms / veterinary
        • Species Specificity

        Citations

        This article has been cited 5 times.
        1. Jindra C, Hainisch EK, Brandt S. Immunotherapy of Equine Sarcoids-From Early Approaches to Innovative Vaccines.. Vaccines (Basel) 2023 Mar 30;11(4).
          doi: 10.3390/vaccines11040769pubmed: 37112681google scholar: lookup
        2. Cappelli K, Ciucis CG, Mecocci S, Nervo T, Crescio MI, Pepe M, Gialletti R, Pietrucci D, Migone LF, Turco S, Mechelli L, Passamonti F, Drago C, Donato GG, Varello K, Modesto P, Chillemi G, Ghelardi A, Razzuoli E. Detection of Equus Caballus Papillomavirus Type-2 in Asymptomatic Italian Horses.. Viruses 2022 Jul 31;14(8).
          doi: 10.3390/v14081696pubmed: 36016317google scholar: lookup
        3. Unger L, Jagannathan V, Pacholewska A, Leeb T, Gerber V. Differences in miRNA differential expression in whole blood between horses with sarcoid regression and progression.. J Vet Intern Med 2019 Jan;33(1):241-250.
          doi: 10.1111/jvim.15375pubmed: 30506726google scholar: lookup
        4. Hägglund S, Hu K, Vargmar K, Poré L, Olofson AS, Blodörn K, Anderson J, Ahooghalandari P, Pringle J, Taylor G, Valarcher JF. Bovine respiratory syncytial virus ISCOMs-Immunity, protection and safety in young conventional calves.. Vaccine 2011 Nov 3;29(47):8719-30.
          doi: 10.1016/j.vaccine.2011.07.146pubmed: 21864616google scholar: lookup
        5. Broström H. Equine sarcoids. A clinical and epidemiological study in relation to equine leucocyte antigens (ELA).. Acta Vet Scand 1995;36(2):223-36.
          doi: 10.1186/BF03547691pubmed: 7484549google scholar: lookup
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