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Veterinary clinical pathology2013; 42(4); 424-436; doi: 10.1111/vcp.12101

ASVCP guidelines: allowable total error guidelines for biochemistry.

Abstract: As all laboratory equipment ages and contains components that may degrade with time, initial and periodically scheduled performance assessment is required to verify accurate and precise results over the life of the instrument. As veterinary patients may present to general practitioners and then to referral hospitals (both of which may each perform in-clinic laboratory analyses using different instruments), and given that general practitioners may send samples to reference laboratories, there is a need for comparability of results across instruments and methods. Allowable total error (TEa ) is a simple comparative quality concept used to define acceptable analytical performance. These guidelines are recommendations for determination and interpretation of TEa for commonly measured biochemical analytes in cats, dogs, and horses for equipment commonly used in veterinary diagnostic medicine. TEa values recommended herein are aimed at all veterinary settings, both private in-clinic laboratories using point-of-care analyzers and larger reference laboratories using more complex equipment. They represent the largest TEa possible without generating laboratory variation that would impact clinical decision making. TEa can be used for (1) assessment of an individual instrument's analytical performance, which is of benefit if one uses this information during instrument selection or assessment of in-clinic instrument performance, (2) Quality Control validation, and (3) as a measure of agreement or comparability of results from different laboratories (eg, between the in-clinic analyzer and the reference laboratory). These guidelines define a straightforward approach to assessment of instrument analytical performance.
© 2013 American Society for Veterinary Clinical Pathology and European Society for Veterinary Clinical Pathology.
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Publication Date: 2013-12-11 PubMed ID: 24320779DOI: 10.1111/vcp.12101Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research presents guidelines for determining and interpreting allowable total error (TEa) – that represents the acceptable variation in laboratory results without impacting clinical decisions – for biochemical analytes in cats, dogs, and horses. These guidelines are applicable for both small private in-clinic labs using point-of-care analyzers and larger reference labs using more complicated equipment.

Details of Research

  • The research focuses on the issues faced due to the degradation of laboratory equipment over time. This degradation could impair the accuracy and precision of the results, thus necessitating periodic performance assessments.
  • The problem is more pronounced due to the variation in lab equipment across different types of clinics and hospitals. Veterinary patients could see a general practitioner or be referred to a specialist hospital, each using different laboratory instruments. Moreover, samples sent to reference labs by general practitioners only add to the variability.
  • To cater for the aforementioned issue, the Allowable Total Error (TEa) concept is used to define what level of analytical performance is acceptable. The concept of TEa is quite straightforward – it defines the maximum possible error that could be allowed before it impacts clinical decision-making.

Guidelines and Recommendations

  • The guidelines generated for TEa mainly cater to commonly measured biochemical analytes in cats, dogs, and horses. It should be noted that these guidelines take into account the equipment used both by private in-clinic labs and larger reference labs.
  • Among the applications of these guidelines is aiding in the assessment of an individual instrument’s analytical performance. This can be instrumental during selection of equipment or while evaluating the performance of existing in-house lab equipment.
  • The guidelines also help in validation of quality control processes and to determine the level of agreement or comparability between outputs from different labs. For example, these can be useful in comparing results from an in-house analyzer with those from a reference lab.

Impact of Research

  • The guidelines provided for TEa could serve as a significant tool in improving the accuracy and precision of lab results by defining clear targets for equipment performance.
  • They help in ensuring the comparability of lab results across healthcare facilities and thereby ensuring effective patient treatment.
  • Quality control processes could also stand to gain from these guidelines by having a clear benchmark to measure performance against.
  • Overall, the impact of the research is on improving the effectiveness of diagnostic services in veterinary medicine.

Cite This Article

APA
Harr KE, Flatland B, Nabity M, Freeman KP. (2013). ASVCP guidelines: allowable total error guidelines for biochemistry. Vet Clin Pathol, 42(4), 424-436. https://doi.org/10.1111/vcp.12101

Publication

Veterinary clinical pathology
ISSN: 1939-165X
NlmUniqueID: 9880575
Country: United States
Language: English
Volume: 42
Issue: 4
Pages: 424-436

Researcher Affiliations

Harr, Kendal E
  • URIKA, LLC, Mukilteo, WA, USA.
Flatland, Bente
    Nabity, Mary
      Freeman, Kathleen P

        MeSH Terms

        • Animals
        • Blood Chemical Analysis / instrumentation
        • Blood Chemical Analysis / standards
        • Blood Chemical Analysis / veterinary
        • Cats
        • Clinical Laboratory Techniques / instrumentation
        • Clinical Laboratory Techniques / standards
        • Clinical Laboratory Techniques / veterinary
        • Diagnostic Errors
        • Dogs
        • Horses
        • Hospitals, Animal / standards
        • Laboratories / standards
        • Pathology, Veterinary / standards
        • Point-of-Care Systems / standards
        • Quality Assurance, Health Care
        • Quality Control
        • Societies, Medical
        • Veterinary Medicine / standards

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