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Veterinary sciences2021; 8(7); 124; doi: 10.3390/vetsci8070124

Atopic Dermatitis in Domestic Animals: What Our Current Understanding Is and How This Applies to Clinical Practice.

Abstract: Atopic dermatitis is a clinical syndrome that affects both people and animals. Dogs closely mimic the complexity of the human skin disease, and much progress has been made in recent years in terms of our understanding of the role of skin impairment and the identification of new treatments. Cats and horses also develop atopic syndromes which include both cutaneous and respiratory signs, yet studies in these species are lagging. It is now recognized that atopic dermatitis is not a single disease but a multifaceted clinical syndrome with different pathways in various subgroups of patients. Appreciating this complexity is clinically relevant as we develop more targeted treatments which may work well in some patients but not in others. Different phenotypes of atopic dermatitis have been described in dogs, and it is possible that phenotypes related to breed and age may exist in other animals similar to how they are described in people. The awareness of different mechanisms of disease leads to the desire to correlate different phenotypes with specific biomarkers and responses to treatment. In this review, the current understanding and updated information on atopic syndrome in animals are described, highlighting opportunities for further studies in the future.
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Publication Date: 2021-07-02 PubMed ID: 34357916PubMed Central: PMC8310319DOI: 10.3390/vetsci8070124Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses the progress made in understanding atopic dermatitis in domestic animals, such as dogs, cats, and horses, and how this knowledge can influence clinical practices. It emphasizes that atopic dermatitis is a complex disease with different pathways in various patient subgroups and the possibility of breed and age-related phenotypes.

Research Overview

The article primarily focuses on the clinical syndrome of atopic dermatitis, a condition affecting both people and animals. This study draws attention to the similarities of the disease progression in dogs to their human counterparts, highlighting the complexity involved. The researchers have explored significant advancements in understanding the effects of dermatitis, particularly skin impairment, and identifying new treatments.

Atopic Syndromes in Cats and Horses

  • The study recognizes that, like dogs, cats and horses also develop atopic syndromes. These syndromes encompass both cutaneous (skin-related) and respiratory signs.
  • Despite these implications, the research in these species hasn’t progressed at the same rate as that in canine counterparts. The article suggests opportunities for further studies to understand these complex syndromes better in cats and horses.

Complexity of Atopic Dermatitis

  • The article emphasizes that atopic dermatitis is not a simple, singular disease. Instead, it’s a multifaceted clinical syndrome affecting different subgroups of patients differently.
  • Understanding this nuance is crucial in clinical practice, as some treatments developed might work effectively for certain patients but not for others. This differential effectiveness is attributed to varying disease pathways among different patient groups.

Atopic Dermatitis Phenotypes

  • Various phenotypes (observable characteristics) of atopic dermatitis have been identified in dogs by the researchers. They also suggest the possibility of similar, breed, and age-related phenotypes existing in other animals, something commonly observed in people.
  • The researchers indicate a growing desire to connect different disease phenotypes with unique biomarkers (biological markers) and treatment responses, thereby personalizing the treatment strategies based on specific patient categories.

Conclusion

This research review presents an updated perspective on our understanding of atopic syndromes in animals. The authors hope that their study will cast light on promising areas for future investigation and contribute to more targeted and effective treatment strategies in veterinary medicine.

Cite This Article

APA
Marsella R. (2021). Atopic Dermatitis in Domestic Animals: What Our Current Understanding Is and How This Applies to Clinical Practice. Vet Sci, 8(7), 124. https://doi.org/10.3390/vetsci8070124

Publication

Veterinary sciences
ISSN: 2306-7381
NlmUniqueID: 101680127
Country: Switzerland
Language: English
Volume: 8
Issue: 7
PII: 124

Researcher Affiliations

Marsella, Rosanna
  • Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, 2015 SW 16th Avenue, Gainesville, FL 32610, USA.

Conflict of Interest Statement

Marsella has received multiple pharma research funding.

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