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Home / Equine Research Bank / Can Vet J / Autologous vaccination for the treatment of equine sarcoids:...
The Canadian veterinary journal = La revue veterinaire canadienne2015; 56(7); 709-714;

Autologous vaccination for the treatment of equine sarcoids: 18 cases (2009-2014).

Abstract: The purpose of this retrospective case series was to assess the outcome of an autologous vaccination procedure on single and multiple sarcoid lesions, determine complication rate, and report owner satisfaction. Medical records (18 cases) from January 2009 through May 2014 were evaluated to identify horses undergoing the procedure. Signalment, number, size, anatomic location of lesions, and type of historical treatment were recorded. Follow-up was obtained via standardized owner survey, veterinary examination, and digital images. Data recorded and analyzed included ancillary therapies post-procedure, decrease in number and/or size of sarcoid lesions, sarcoid regrowth, complications, and owner satisfaction. There was a decrease in number of lesions observed by owners in 75% of cases and a decrease in size of sarcoids in 93.8% of cases. Clinical regression observed by owners was noted in 68.8% of cases. There were complications in 43.8% of cases and owner satisfaction in 75% of cases. Le but de cette série de cas rétrospectifs était d’évaluer le résultat d’une procédure de vaccination autologue sur des lésions de sarcoïdes simples et multiples, de déterminer le taux de complication et de signaler la satisfaction des propriétaires. Les dossiers médicaux (18 cas) datant de janvier 2009 à mai 2014 ont été évalués afin d’identifier les chevaux subissant l’intervention. Le signalement, le nombre, la taille, l’emplacement anatomique des lésions et le type de traitement historique ont été consignés. Le suivi a été obtenu par un sondage standard auprès des propriétaires, un examen vétérinaire et des images numériques. Les données consignées et analysées incluaient des traitements auxiliaires après l’intervention, une baisse du nombre et/ou de la taille des lésions des sarcoïdes, la repousse des sarcoïdes, les complications et la satisfaction des propriétaires. Il s’est produit une baisse du nombre des lésions observées par les propriétaires et de la taille des sarcoïdes dans 93,8 % des cas. La régression clinique observée par les propriétaires a été consignée dans 68,8 % des cas. Il y a eu des complications dans 43,8 % des cas et les propriétaires étaient satisfaits dans 75 % des cas.(Traduit par Isabelle Vallières).
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Publication Date: 2015-07-02 PubMed ID: 26130832PubMed Central: PMC4466821
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article examines the outcomes of an autologous vaccination procedure on equine sarcoid lesions. It looks at factors like changes in the size and number of lesions, possible post-procedure complications, and owner satisfaction.

Objective and Methodology

  • The primary objective of the study is to assess the outcome of autologous vaccination on equine sarcoid lesions. The researchers aim to understand the success rate of this procedure in reducing the number and size of such lesions.
  • The methodology involves a retrospective review of medical cases (18 cases) from 2009 to 2014.
  • Data including number, size, location of lesions, and initial treatment type were retrieved from these records.
  • Follow-up information was obtained via a standardized survey given to the owners, veterinary examinations, and digital images.

Data Analysis

  • The researchers recorded and analyzed data related to therapies provided following the vaccination procedure.
  • Information on the reduction in the number and size of sarcoid lesions after treatment, recurrence of the lesions, and complications encountered post-procedure were also gathered and analyzed.
  • Owner satisfaction was also recorded to evaluate the perceived effectiveness and general acceptance of the vaccination protocol.

Results

  • The results indicated a reduction in the number of lesions in 75% of horses, and a decrease in the size of sarcoid lesions in 93.8% of the cases.
  • Owners reported visible clinical regression of the sarcoids in 68.8% of the cases.
  • About 43.8% of the cases had complications after the procedure.
  • The procedure achieved a satisfaction rate of 75% among the owners.

Conclusion

  • This study provides evidence supporting the efficacy of autologous vaccinations for the treatment of equine sarcoid lesions.
  • Despite notable complications in some cases, the majority of horse owners expressed satisfaction with the procedure outcomes.
  • This indicates potential for further exploration and refinement of the autologous vaccination process in the battle against equine sarcoids.

Cite This Article

APA
Rothacker CC, Boyle AG, Levine DG. (2015). Autologous vaccination for the treatment of equine sarcoids: 18 cases (2009-2014). Can Vet J, 56(7), 709-714.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 56
Issue: 7
Pages: 709-714

Researcher Affiliations

Rothacker, Caitlin C
  • Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, 382 West Street Road, Kennett Square, Philadelphia, Pennsylvania 19348, USA.
Boyle, Ashley G
  • Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, 382 West Street Road, Kennett Square, Philadelphia, Pennsylvania 19348, USA.
Levine, David G
  • Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, 382 West Street Road, Kennett Square, Philadelphia, Pennsylvania 19348, USA.

MeSH Terms

  • Animals
  • Autoantigens / therapeutic use
  • Cancer Vaccines / therapeutic use
  • Female
  • Horse Diseases / therapy
  • Horses
  • Male
  • Retrospective Studies
  • Skin Neoplasms / therapy
  • Skin Neoplasms / veterinary

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Citations

This article has been cited 9 times.
  1. Jindra C, Hainisch EK, Brandt S. Immunotherapy of Equine Sarcoids-From Early Approaches to Innovative Vaccines. Vaccines (Basel) 2023 Mar 30;11(4).
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  2. Saba C, Eggleston R, Parks A, Peroni J, Sjoberg E, Rice S, Tyma J, Williams J, Grosenbaugh D, Leard AT. ALVAC-fIL2, a feline interleukin-2 immunomodulator, as a treatment for sarcoids in horses: A pilot study. J Vet Intern Med 2022 May;36(3):1179-1184.
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  3. Jindra C, Hainisch EK, Rümmele A, Wolschek M, Muster T, Brandt S. Influenza virus vector iNS1 expressing bovine papillomavirus 1 (BPV1) antigens efficiently induces tumour regression in equine sarcoid patients. PLoS One 2021;16(11):e0260155.
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  4. Pietersen I, van Zyl A, Rybicki E, Hitzeroth I. Novel Production of Bovine Papillomavirus Pseudovirions in Tobacco Plants. Pathogens 2020 Nov 28;9(12).
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