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Home / Equine Research Bank / Pharmaceuticals (Basel) / Bee-Inspired Healing: Apitherapy in Veterinary Medicine for ...
Pharmaceuticals (Basel, Switzerland)2024; 17(8); doi: 10.3390/ph17081050

Bee-Inspired Healing: Apitherapy in Veterinary Medicine for Maintenance and Improvement Animal Health and Well-Being.

Abstract: This review aims to present current knowledge on the effects of honey bee products on animals based on in vivo studies, focusing on their application in clinical veterinary practice. Honey's best-proven effectiveness is in treating wounds, including those infected with antibiotic-resistant microorganisms, as evidenced in horses, cats, dogs, mice, and rats. Propolis manifested a healing effect in numerous inflammatory and painful conditions in mice, rats, dogs, and pigs and also helped in oncological cases in mice and rats. Bee venom is best known for its effectiveness in treating neuropathy and arthritis, as shown in dogs, mice, and rats. Besides, bee venom improved reproductive performance, immune response, and general health in rabbits, chickens, and pigs. Pollen was effective in stimulating growth and improving intestinal microflora in chickens. Royal jelly might be used in the management of animal reproduction due to its efficiency in improving fertility, as shown in rats, rabbits, and mice. Drone larvae are primarily valued for their androgenic effects and stimulation of reproductive function, as evidenced in sheep, chickens, pigs, and rats. Further research is warranted to determine the dose and method of application of honey bee products in animals.
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Publication Date: 2024-08-09 PubMed ID: 39204155PubMed Central: PMC11357515DOI: 10.3390/ph17081050Google Scholar: Lookup
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  • Journal Article
  • Review

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article is about exploring the impact of honey bee products on the health and wellbeing of animals, specifically looking at their use in veterinary medicine.

Introduction and Aim

  • The review aims to present current knowledge on the health effects of honey bee products on animals.
  • The study is based on in vivo experiments, focusing on the application of these natural products in clinical veterinary practice.

Honey’s Effects

  • Honey has been found effective in treating wounds, including those infected with antibiotic-resistant microorganisms.
  • Various species including horses, cats, dogs, mice, and rats have benefitted from the healing properties of honey.

Propolis’ Effects

  • Propolis, another bee product, has manifested healing effects on several inflammatory and painful conditions in mice, rats, dogs, and pigs.
  • It was also reported to be beneficial in oncological cases in mice and rats.

Bee Venom’s Effects

  • Bee venom has shown effectiveness in treating ailments like neuropathy and arthritis in dogs, mice, and rats.
  • Beyond these, bee venom has also improved reproductive performance, immune response, and the general health of rabbits, chickens, and pigs.

Pollen and Royal Jelly’s Effects

  • Pollen from bees has proved effective in stimulating growth and improving intestinal microflora in chickens.
  • Royal jelly seems to have a positive impact on animal reproduction due to its effectiveness in enhancing fertility, shown in studies involving rats, rabbits, and mice.

Drone Larvae’s Effects

  • Drone larvae are particularly valued for their androgenic effects and for stimulating reproductive function as demonstrated in sheep, chickens, pigs, and rats.

Future Research

  • Despite encouraging results, further research is necessary to determine the optimal dose and method of application of honey bee products in animals.

Cite This Article

APA
Stevanović J, Glavinić U, Ristanić M, Erjavec V, Denk B, Dolašević S, Stanimirović Z. (2024). Bee-Inspired Healing: Apitherapy in Veterinary Medicine for Maintenance and Improvement Animal Health and Well-Being. Pharmaceuticals (Basel), 17(8). https://doi.org/10.3390/ph17081050

Publication

Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
NlmUniqueID: 101238453
Country: Switzerland
Language: English
Volume: 17
Issue: 8

Researcher Affiliations

Stevanović, Jevrosima
  • Department of Biology, Faculty of Veterinary Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Glavinić, Uroš
  • Department of Biology, Faculty of Veterinary Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Ristanić, Marko
  • Department of Biology, Faculty of Veterinary Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Erjavec, Vladimira
  • Small Animal Clinic, Veterinary Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.
Denk, Barış
  • Department of Biochemistry, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar 03204, Turkey.
Dolašević, Slobodan
  • Institute for Animal Husbandry, Zemun, 11080 Belgrade, Serbia.
Stanimirović, Zoran
  • Department of Biology, Faculty of Veterinary Medicine, University of Belgrade, 11000 Belgrade, Serbia.

Grant Funding

  • project no. 5455 / Science Fund of the Republic of Serbia
  • contract number 451-03-66/2024-03/200143 / Utilization of the food industry waste for improving honey bee health and protecting the environment - Waste2ProtectBees and by the Ministry of Science, Technological Development and Innovation of the Republic of Serbia

Conflict of Interest Statement

The authors declare no conflict of interest.

References

This article includes 159 references
  1. Weis W.A., Ripari N., Conte F.L., da Silva Honorio M., Sartori A.A., Matucci R.H., Sforcin J.M.. An overview about apitherapy and its clinical applications.. Phytomedicine Plus 2022;2:100239.
    doi: 10.1016/j.phyplu.2022.100239google scholar: lookup
  2. Sawczuk R., Karpinska J., Miltyk W.. What do we need to know about drone brood homogenate and what is known.. J. Ethnopharmacol. 2019;245:111581.
    doi: 10.1016/j.jep.2018.10.042pubmed: 30391708google scholar: lookup
  3. Vogt N.A., Vriezen E., Nwosu A., Sargeant J.M.. A scoping review of the evidence for the medicinal use of natural honey in animals.. Front. Vet. Sci. 2021;7:618301.
    doi: 10.3389/fvets.2020.618301pmc: PMC7847899pubmed: 33537356google scholar: lookup
  4. Chatzimisios K., Tsioli V., Brellou G.D., Apostolopoulou E.P., Angelou V., Pratsinakis E.D., Cremers N.A.J., Papazoglou L.G.. Evaluation of the effectiveness of medical-grade honey and Hypericum perforatum ointment on second-intention healing of full-thickness skin wounds in cats.. Animals 2023;14:36.
    doi: 10.3390/ani14010036pmc: PMC10778018pubmed: 38200767google scholar: lookup
  5. Bischofberger A.S., Dart C.M., Horadagoda N., Perkins N.R., Jeffcott L.B., Little C.B., Dart A.J.. Effect of Manuka honey gel on the transforming growth factor β1 and β3 concentrations, bacterial counts and histomorphology of contaminated full-thickness skin wounds in equine distal limbs.. Aust. Vet. J. 2016;94:27–34.
    doi: 10.1111/avj.12405pubmed: 26814159google scholar: lookup
  6. Lukanc B., Potokar T., Erjavec V.. Complete skin regeneration with medical honey after skin loss on the entire circumference of a leg in a cat.. J. Tissue Viability 2020;29:148–152.
    doi: 10.1016/j.jtv.2020.03.007pubmed: 32247653google scholar: lookup
  7. Budak Ö., Çakıroğlu H.. Examination the effects of chestnut and Manuka honey for wound healing on mice experimental model.. Med. Sci. Discov. 2022;9:170–174.
    doi: 10.36472/msd.v9i3.700google scholar: lookup
  8. Blair S.E., Cokcetin N.N., Harry E.J., Carter D.A.. The unusual antibacterial activity of medical-grade Leptospermum honey: Antibacterial spectrum, resistance and transcriptome analysis.. Eur. J. Clin. Microbiol. Infect. Dis. 2009;28:1199–1208.
    doi: 10.1007/s10096-009-0763-zpubmed: 19513768google scholar: lookup
  9. Kwakman P.H., Zaat S.A.. Antibacterial components of honey.. IUBMB Life 2012;64:48–55.
    doi: 10.1002/iub.578pubmed: 22095907google scholar: lookup
  10. Majtan J., Bohova J., Prochazka E., Klaudiny J.. Methylglyoxal may affect hydrogen peroxide accumulation in manuka honey through the inhibition of glucose oxidase.. J. Med. Food 2014;17:290–293.
    doi: 10.1089/jmf.2012.0201pmc: PMC3929242pubmed: 24192110google scholar: lookup
  11. Majtan J., Klaudiny J., Bohova J., Kohutova L., Dzurova M., Sediva M., Bartosova M., Majtan V.. Methylglyoxal-induced modifications of significant honeybee proteinous components in manuka honey: Possible therapeutic implications.. Fitoterapia 2012;83:671–677.
    doi: 10.1016/j.fitote.2012.02.002pubmed: 22366273google scholar: lookup
  12. Unique Mānuka Factor, the Golden Standard in Mānuka Honey, the Rating System. [(accessed on 29 April 2024)]. Available online: https://www.umf.org.nz/unique-manuka-factor/
  13. Lu J., Carter D.A., Turnbull L., Rosendale D., Hedderley D., Stephens J., Gannabathula S., Steinhorn G., Schlothauer R.C., Whitchurch C.B.. The effect of New Zealand kanuka, manuka and clover honeys on bacterial growth dynamics and cellular morphology varies according to the species.. PLoS ONE 2013;8:e55898.
    doi: 10.1371/journal.pone.0055898pmc: PMC3572166pubmed: 23418472google scholar: lookup
  14. Lu J., Turnbull L., Burke C.M., Liu M., Carter D.A., Schlothauer R.C., Whitchurch C.B., Harry E.J.. Manuka-type honeys can eradicate biofilms produced by Staphylococcus aureus strains with different biofilm-forming abilities.. PeerJ 2014;2:e326.
    doi: 10.7717/peerj.326pmc: PMC3970805pubmed: 24711974google scholar: lookup
  15. Lu J., Cokcetin N.N., Burke C.M., Turnbull L., Liu M., Carter D.A., Whitchurch C.B., Harry E.J.. Honey can inhibit and eliminate biofilms produced by Pseudomonas aeruginosa.. Sci. Rep. 2019;9:18160.
    doi: 10.1038/s41598-019-54576-2pmc: PMC6890799pubmed: 31796774google scholar: lookup
  16. Bouzo D., Cokcetin N.N., Li L., Ballerin G., Bottomley A.L., Lazenby J., Whitchurch C.B., Paulsen I.T., Hassan K.A., Harry E.J.. Characterizing the mechanism of action of an ancient antimicrobial, Manuka honey, against Pseudomonas aeruginosa using modern transcriptomics.. MSystems 2020;5:e00106-20.
    doi: 10.1128/mSystems.00106-20pmc: PMC7329319pubmed: 32606022google scholar: lookup
  17. Green K.J., Lawag I.L., Locher C., Hammer K.A.. Correlation of the antibacterial activity of commercial manuka and Leptospermum honeys from Australia and New Zealand with methylglyoxal content and other physicochemical characteristics.. PLoS ONE 2022;17:e0272376.
    doi: 10.1371/journal.pone.0272376pmc: PMC9333225pubmed: 35901185google scholar: lookup
  18. Girma A., Seo W., She R.C.. Antibacterial activity of varying UMF-graded Manuka honeys.. PLoS ONE 2019;14:e0224495.
    doi: 10.1371/journal.pone.0224495pmc: PMC6814216pubmed: 31652284google scholar: lookup
  19. Lukanc B., Potokar T., Erjavec V.. Observational study of the effect of L-mesitran® medical honey on wound healing in cats.. Vet. Arhiv. 2018;88:59–74.
    doi: 10.24099/vet.arhiv.160905agoogle scholar: lookup
  20. Peteoaca A., Istrate A., Goanta A., Girdan G., Stefanescu A., Tanase A.. Therapeutic approach in managing degloving injuries of the front limbs in a dog—A case report.. Sci. Work. Ser. C Vet. Med. 2019;65:70–78.
  21. Lukanc B., Šteh T., Erjavec V.. The effect of medical honey on second intention wound healing in dogs.. Vet. Arh. 2023;93:569–580.
    doi: 10.24099/vet.arhiv.1865google scholar: lookup
  22. Yalcınkaya E., Basaran M.M., Tunckasık M.E., Yazici G.N., Elmas Ç., Kocaturk S.. Efficiency of Hypericum perforatum, povidone iodine, tincture benzoin and tretinoin on wound healing.. Food Chem. Toxicol. 2022;166:113209.
    doi: 10.1016/j.fct.2022.113209pubmed: 35688269google scholar: lookup
  23. Vatnikov Y., Shabunin S., Kulikov E., Karamyan A., Lenchenko E., Sachivkina N., Bobkova N., Bokov D., Zhilkina V., Tokar A.. Effectiveness of biologically active substances from Hypericum perforatum L. in the complex treatment of purulent wounds.. Int. J. Pharm. Res. 2020;12:1108–1117.
  24. Sotirova Y., Kiselova-Kaneva Y., Vankova D., Tasinov O., Ivanova D., Popov H., Hristova M., Nikolova K., Andonova V.. Tissue regeneration and remodeling in rat models after application of Hypericum perforatum L. extract-loaded bigels.. Gels 2024;10:341.
    doi: 10.3390/gels10050341pmc: PMC11121646pubmed: 38786258google scholar: lookup
  25. Bukhari M.H., Khalil J., Qamar S., Qamar Z., Zahid M., Ansari N., Bakhshi I.M.. Comparative gastroprotective effects of natural honey, Nigella sativa and cimetidine against acetylsalicylic acid induced gastric ulcer in albino rats.. JCPSP J. Coll. Physici. 2011;21:151–156.
    pubmed: 21419021
  26. Almasaudi S.B., El-Shitany N.A., Abbas A.T., Abdel-Dayem U.A., Ali S.S., Al Jaouni S.K., Harakeh S.. Antioxidant, anti-inflammatory, and antiulcer potential of manuka honey against gastric ulcer in rats.. Oxid. Med. Cell Longev. 2016;2016:3643824.
    doi: 10.1155/2016/3643824pmc: PMC4685122pubmed: 26770649google scholar: lookup
  27. Almasaudi S.B., Abbas A.T., Al-Hindi R.R., El-Shitany N.A., Abdel-Dayem U.A., Ali S.S., Saleh R.M., Al Jaouni S.K., Kamal M.A., Harakeh S.M.. Manuka honey exerts antioxidant and anti-inflammatory activities that promote healing of acetic acid-induced gastric ulcer in rats.. J. Evid. Based Complement. Altern. Med. 2017;2017:5413917.
    doi: 10.1155/2017/5413917pmc: PMC5307292pubmed: 28250794google scholar: lookup
  28. Harakeh S., Saber S.H., Akefe I.O., Shaker S., Hussain M.B., Almasaudi A.S., Saleh S.M., Almasaudi S.. Saudi honey alleviates indomethacin-induced gastric ulcer via improving antioxidant and anti-inflammatory responses in male albino rats.. Saudi. J. Biol. Sci. 2022;29:3040–3050.
    doi: 10.1016/j.sjbs.2022.01.031pmc: PMC9073134pubmed: 35531174google scholar: lookup
  29. Erejuwa O.O., Gurtu S., Sulaiman S.A., Wahab M.S., Sirajudeen K.N., Salleh M.S.. Hypoglycemic and antioxidant effects of honey supplementation in streptozotocin-induced diabetic rats.. Int. J. Vitam. Nutr. Res. 2010;80:74.
    pubmed: 20533247
  30. Erejuwa O.O., Sulaiman S.A., Wahab M.S., Sirajudeen K.N., Salleh M.M., Gurtu S.. Antioxidant protection of Malaysian tualang honey in pancreas of normal and streptozotocin-induced diabetic rats.. Ann. Endocrinol. Paris. 2010;71:291–296.
    doi: 10.1016/j.ando.2010.03.003pubmed: 20398890google scholar: lookup
  31. Erejuwa O.O., Nwobodo N.N., Akpan J.L., Okorie U.A., Ezeonu C.T., Ezeokpo B.C., Nwadike K.I., Erhiano E., Abdul Wahab M.S., Sulaiman S.A.. Nigerian honey ameliorates hyperglycemia and dyslipidemia in alloxan-induced diabetic rats.. Nutrients 2016;8:95.
    doi: 10.3390/n耰095pmc: PMC4808836pubmed: 26927161google scholar: lookup
  32. Arabmoazzen S., Sarkaki A.. Antidiabetic effect of honey feeding in noise induced hyperglycemic rat: Involvement of oxidative stress.. Iran. J. Basic Med. Sci. 2015;18:745–751.
    pmc: PMC4633456pubmed: 26557962
  33. Hemmati M., Karamian M., Malekaneh M.. Anti-atherogenic potential of natural honey: Anti-diabetic and antioxidant approaches.. J. Pharm. Pharmacol. 2015;3:278–284.
    doi: 10.17265/2328-2150/2015.06.004google scholar: lookup
  34. Berretta A.A., de Castro P.A., Cavalheiro A.H., Fortes V.S., Bom V.P., Nascimento A.P., Marquele-Oliveira F., Pedrazzi V., Ramalho L.N., Goldman G.H.. Evaluation of mucoadhesive gels with propolis (EPP-AF) in preclinical treatment of candidiasis vulvovaginal infection.. J. Evid. Based Complement. Altern. Med. 2013;2013:641480.
    doi: 10.1155/2013/641480pmc: PMC3749595pubmed: 23997797google scholar: lookup
  35. Bonfim A.P., Sakita K.M., Faria D.R., Arita G.S., Vendramini F.A., Capoci I.R., Braga A.G., Dos Santos R.S., Bruschi M.L., Becker T.C.. Preclinical approaches in vulvovaginal candidiasis treatment with mucoadhesive thermoresponsive systems containing propolis.. PLoS ONE 2020;15:e0243197.
    doi: 10.1371/journal.pone.0243197pmc: PMC7732059pubmed: 33306677google scholar: lookup
  36. Fiordalisi S.A., Honorato L.A., Loiko M.R., Avancini C.A., Veleirinho M.B., Machado Filho L.C., Kuhnen S.. The effects of Brazilian propolis on etiological agents of mastitis and the viability of bovine mammary gland explants.. J. Dairy. Sci. 2016;99:2308–2318.
    doi: 10.3168/jds.2015-9777pubmed: 26723111google scholar: lookup
  37. Santana H.F., Barbosa A.A., Ferreira S.O., Mantovani H.C.. Bactericidal activity of ethanolic extracts of propolis against Staphylococcus aureus isolated from mastitic cows.. World J. Microbiol. Biotechnol. 2012;28:485–491.
    doi: 10.1007/s11274-011-0839-7pubmed: 22806843google scholar: lookup
  38. Wang K., Jin X.L., Shen X.G., Sun L.P., Wu L.M., Wei J.Q., Marcucci M.C., Hu F.L., Liu J.X.. Effects of Chinese propolis in protecting bovine mammary epithelial cells against mastitis pathogens-induced cell damage.. Mediat. Inflamm. 2016;2016:8028291.
    doi: 10.1155/2016/8028291pmc: PMC4940570pubmed: 27433029google scholar: lookup
  39. Shimizu T., Takeshita Y., Takamori Y., Kai H., Sawamura R., Yoshida H., Watanabe W., Tsutsumi A., Park Y.K., Yasukawa K.. Efficacy of Brazilian propolis against herpes simplex virus type 1 infection in mice and their modes of antiherpetic efficacies.. J. Evid. Based Complement. Altern. Med. 2011;2011:976196.
    doi: 10.1155/2011/976196pmc: PMC3118910pubmed: 21716710google scholar: lookup
  40. Sartori G., Pesarico A.P., Pinton S., Dobrachinski F., Roman S.S., Pauletto F., Rodrigues L.C., Prigol M.. Protective effect of brown Brazilian propolis against acute vaginal lesions caused by herpes simplex virus type 2 in mice: Involvement of antioxidant and anti-inflammatory mechanisms.. Cell Biochem. Funct. 2012;30:1–10.
    doi: 10.1002/cbf.1810pubmed: 22025285google scholar: lookup
  41. Arismendi N., Vargas M., López M.D., Barría Y., Zapata N.. Promising antimicrobial activity against the honey bee parasite Nosema ceranae by methanolic extracts from Chilean native plants and propolis.. J. Apicult. Res. 2018;57:522–535.
    doi: 10.1080/00218839.2018.1453006google scholar: lookup
  42. Burnham A.J., De Jong E., Jones J.A., Lehman H.K.. North American propolis extracts from upstate New York decrease Nosema ceranae (Microsporidia) spore levels in honey bees (Apis mellifera). Front. Microbiol. 2020;11:1719.
    doi: 10.3389/fmicb.2020.01719pmc: PMC7387503pubmed: 32793168google scholar: lookup
  43. Naree S., Ellis J.D., Benbow M.E., Suwannapong G.. The use of propolis for preventing and treating Nosema ceranae infection in western honey bee (Apis mellifera Linnaeus, 1787) workers.. J. Apicult. Res. 2021;60:686–696.
    doi: 10.1080/00218839.2021.1905374google scholar: lookup
  44. Nweze N.E., Okoro H.O., Al Robaian M., Omar R.M., Tor-Anyiin T.A., Watson D.G., Igoli J.O.. Effects of Nigerian red propolis in rats infected with.. Comp. Clin. Pathol. 2017;26:1129–1133.
    doi: 10.1007/s00580-017-2497-0google scholar: lookup
  45. Afrouzan H., Zakeri S., Mehrizi A.A., Molasalehi S., Tahghighi A., Shokrgozar M.A., Es-Haghi A., Djadid N.D.. Anti-plasmodial assessment of four different Iranian propolis extracts.. Arch. Iran. Med. 2017;20:270–281.
    pubmed: 28510462
  46. AlGabbani Q., Mansour L., Elnakady Y.A., Al-Quraishy S., Alomar S., Al-Shaebi E.M., Abdel-Baki A.A.. In vivo assessment of the antimalarial and spleen-protective activities of the Saudi propolis methanolic extract.. Parasitol. Res. 2017;116:539–547.
    doi: 10.1007/s00436-016-5318-5pubmed: 27822584google scholar: lookup
  47. Silva M.P., Silva T.M., Mengarda A.C., Salvadori M.C., Teixeira F.S., Alencar S.M., Luz Filho G.C., Bueno-Silva B., de Moraes J.. Brazilian red propolis exhibits antiparasitic properties in vitro and reduces worm burden and egg production in an mouse model harboring either early or chronic Schistosoma mansoni infection.. J. Ethnopharmacol. 2021;264:113387.
    doi: 10.1016/j.jep.2020.113387pubmed: 32918996google scholar: lookup
  48. Oryan A., Alemzadeh E., Moshiri A.. Potential role of propolis in wound healing: Biological properties and therapeutic activities.. Biomed. Pharmacother. 2018;98:469–483.
    doi: 10.1016/j.biopha.2017.12.069pubmed: 29287194google scholar: lookup
  49. Berretta A.A., Nascimento A.P., Bueno P.C., Leite M.M., Marchetti J.M.. Propolis standardized extract (EPP-AF®), an innovative chemically and biologically reproducible pharmaceutical compound for treating wounds.. Int. J. Biol. Sci. 2012;8:512–521.
    doi: 10.7150/ijbs.3641pmc: PMC3314192pubmed: 22457606google scholar: lookup
  50. Abu-Seida A.M.. Effect of propolis on experimental cutaneous wound healing in dogs.. Vet. Med. Int. 2015;2015:672643.
    doi: 10.1155/2015/672643pmc: PMC4691486pubmed: 26783495google scholar: lookup
  51. Olczyk P., Komosinska-Vassev K., Wisowski G., Mencner L., Stojko J., Kozma E.M.. Propolis modulates fibronectin expression in the matrix of thermal injury.. BioMed Res. Int. 2014;2014:748101.
    doi: 10.1155/2014/748101pmc: PMC3967494pubmed: 24738072google scholar: lookup
  52. Staniczek J., Jastrzębska-Stojko Ż., Stojko R.. Biological activity of propolis ointment with the addition of 1% nanosilver in the treatment of experimentally-evoked burn wounds.. Polymers 2021;13:2312.
    doi: 10.3390/polym13142312pmc: PMC8309302pubmed: 34301074google scholar: lookup
  53. Ma X., Guo Z., Shen Z., Wang J., Hu Y., Wang D.. The immune enhancement of propolis adjuvant on inactivated porcine parvovirus vaccine in guinea pig.. Cell Immunol. 2011;270:13–18.
    doi: 10.1016/j.cellimm.2011.03.020pubmed: 21482422google scholar: lookup
  54. Ferreira L.N., Fonseca F.P., Caetano de Castro C., Sica Siedler B., Silveira Munhoz L., D’Avila Vargas G., Fischer G., Oliveira Hubner S.. Effect of the etanolic extract from green propolis on production of antibodies after immunization against Canine Parvovirus (CPV) and Canine Coronavirus (CCoV). Braz. J. Vet. Res. Anim. Sci. 2012;49:116–122.
    doi: 10.11606/issn.2318-3659.v49i2p116-121google scholar: lookup
  55. Liu S., Wang D., Cao Y., Lu T., Liu H., Li S.. Effects of propolis on the immune enhancement of the formalin-inactivated Aeromonas salmonicida vaccine.. Aquac. Res. 2020;51:4759–4770.
    doi: 10.1111/are.14822google scholar: lookup
  56. de Mendonça M.A.A., Ribeiro A.R.S., de Lima A.K., Bezerra G.B., Pinheiro M.S., de Albuquerque-Júnior R.L.C., Gomes M.Z., Padilha F.F., Thomazzi S.M., Novellino E.. Red propolis and its dyslipidemic regulator formononetin: Evaluation of antioxidant activity and gastroprotective effects in rat model of gastric ulcer.. Nutrients 2020;12:2951.
    doi: 10.3390/nሐ2951pmc: PMC7600383pubmed: 32993069google scholar: lookup
  57. Babińska I., Kleczek K., Makowski W., Szarek J.. Effect of feed supplementation with propolis on liver and kidney morphology in broiler chickens.. Pak. Vet. J. 2013;33:1–4.
  58. Salehi A., Hosseini S.M., Kazemi S.. Antioxidant and anticarcinogenic potentials of propolis for dimethylhydrazine-induced colorectal cancer in Wistar rats.. BioMed Res. Int. 2022;2022:8497562.
    doi: 10.1155/2022/8497562pmc: PMC9246617pubmed: 35782078google scholar: lookup
  59. Rizk S.M., Zaki H.F., Mina M.A.. Propolis attenuates doxorubicin-induced testicular toxicity in rats.. Food Chem. Toxicol. 2014;67:176–186.
    doi: 10.1016/j.fct.2014.02.031pubmed: 24593989google scholar: lookup
  60. Sameni H.R., Yosefi S., Alipour M., Pakdel A., Torabizadeh N., Semnani V., Bandegi A.R.. Co-administration of 5FU and propolis on AOM/DSS induced colorectal cancer in BALB-c mice.. Life Sci. 2021;276:119390.
    doi: 10.1016/j.lfs.2021.119390pubmed: 33794252google scholar: lookup
  61. Cavalcante D.R.R., de Oliveira P.S., Góis S.M., Soares A.F., Cardoso J.C., Padilha F.F., de Albuquerque Júnior R.L.C.. Effect of green propolis on oral epithelial dysplasia in rats.. Rev. Bras. Otorrinolaringol. 2011;77:278–284.
    doi: 10.1590/S1808-86942011000300002pmc: PMC9443718pubmed: 21738999google scholar: lookup
  62. Arslan S., Silici S., Percin D., Koç A.N., Er Ö.. Antimicrobial activity of poplar propolis on mutans streptococci and caries development in rats.. Turk. J. Biol. 2012;36:65–73.
    doi: 10.3906/biy-1101-180google scholar: lookup
  63. Bueno-Silva B., Koo H., Falsetta M.L., Alencar S.M., Ikegaki M., Rosalen P.L.. Effect of neovestitol–vestitol containing Brazilian red propolis on accumulation of biofilm in vitro and development of dental caries in vivo.. Biofouling 2013;29:1233–1242.
    doi: 10.1080/08927014.2013.834050pmc: PMC3855307pubmed: 24099330google scholar: lookup
  64. Ribeiro D.R., Alves A.V., dos Santos E.P., Padilha F.F., Gomes M.Z., Rabelo A.S., Cardoso J.C., Massarioli A.P., de Alencar S.M., de Albuquerque-Junior R.L.. Inhibition of DMBA-induced oral squamous cells carcinoma growth by Brazilian red propolis in rodent model.. Basic. Clin. Physiol. Pharmacol. 2015;117:85–95.
    doi: 10.1111/bcpt.12374pubmed: 25556639google scholar: lookup
  65. Darweesh F.A., Zaher A.R., Zaghlool A.E., Helal M.E., El-Sabaa H.M.. Honey bee propolis as a storage medium on teeth replantation in dogs (histological, histochemical and radiographic study). Mansoura J. Dent. 2014;1:1–6.
  66. Lozina L.A., Peichoto M.E., Boehringer S.I., Koscinczuk P., Granero G.E., Acosta O.C.. Efficacy of Argentine propolis formulation for topical treatment of canine otitis externa.. Arq. Bras. Med. Vet. Zootec. 2010;62:1359–1366.
    doi: 10.1590/S0102-09352010000600010google scholar: lookup
  67. Martin L.F., Rocha E.M., Garcia S.B., Paula J.S.. Topical Brazilian propolis improves corneal wound healing and inflammation in rats following alkali burns.. BMC Complement. Altern. Med. 2013;13:337.
    doi: 10.1186/1472-6882-13-337pmc: PMC4224050pubmed: 24279635google scholar: lookup
  68. Oršolić N., Sirovina D., Končić M.Z., Lacković G., Gregorović G.. Effect of Croatian propolis on diabetic nephropathy and liver toxicity in mice.. BMC Complement. Altern. Med. 2012;12:117.
    doi: 10.1186/1472-6882-12-117pmc: PMC3551731pubmed: 22866906google scholar: lookup
  69. Farooqui T., Farooqui A.A.. Molecular mechanism underlying the therapeutic activities of propolis: A critical review.. Curr. Nutr. Food Sci. 2010;6:186–199.
    doi: 10.2174/157340110792389136google scholar: lookup
  70. Araujo M.A., Libério S.A., Guerra R.N., Ribeiro M.N., Nascimento F.R.. Mechanisms of action underlying the anti-inflammatory and immunomodulatory effects of propolis: A brief review.. Rev. Bras. Farmacogn. 2012;22:208–219.
    doi: 10.1590/S0102-695X2011005000167google scholar: lookup
  71. Oršolić N., Jazvinšćak Jembrek M.. Molecular and cellular mechanisms of propolis and its polyphenolic compounds against cancer.. Int. J. Mol. Sci. 2022;23:10479.
    doi: 10.3390/ijms231810479pmc: PMC9499605pubmed: 36142391google scholar: lookup
  72. Zhang S., Liu Y., Ye Y., Wang X.R., Lin L.T., Xiao L.Y., Zhou P., Shi G.X., Liu C.Z.. Bee venom therapy: Potential mechanisms and therapeutic applications.. Toxicon 2018;148:64–73.
    doi: 10.1016/j.toxicon.2018.04.012pubmed: 29654868google scholar: lookup
  73. Kocyigit A., Guler E.M., Kaleli S., Kocyigit A., Guler E.M., Kaleli S.. Anti-inflammatory and antioxidative properties of honey bee venom on Freund’s Complete Adjuvant-induced arthritis model in rats.. Toxicon 2019;161:4–11.
    doi: 10.1016/j.toxicon.2019.02.016pubmed: 30825463google scholar: lookup
  74. Lin T.Y., Hsieh C.L.. Clinical applications of bee venom acupoint injection.. Toxins 2020;12:618.
    doi: 10.3390/toxins12100618pmc: PMC7601520pubmed: 32992601google scholar: lookup
  75. Oršolić N.. Bee venom in cancer therapy.. Cancer Metastasis Rev. 2012;31:173–194.
    doi: 10.1007/s10555-011-9339-3pubmed: 22109081google scholar: lookup
  76. Aufschnaiter A., Kohler V., Khalifa S., Abd El-Wahed A., Du M., El-Seedi H., Büttner S.. Apitoxin and its components against cancer, neurodegeneration and rheumatoid arthritis: Limitations and possibilities.. Toxins 2020;12:66.
    doi: 10.3390/toxins12020066pmc: PMC7076873pubmed: 31973181google scholar: lookup
  77. Tsai L.C., Lin Y.W., Hsieh C.L.. Effects of bee venom injections at acupoints on neurologic dysfunction induced by thoracolumbar intervertebral disc disorders in canines: A randomized, controlled prospective study.. BioMed Res. Int. 2015;2015:363801.
    doi: 10.1155/2015/363801pmc: PMC4676995pubmed: 26693480google scholar: lookup
  78. Alvarez-Fischer D., Noelker C., Vulinović F., Grünewald A., Chevarin C., Klein C., Oertel W.H., Hirsch E.C., Michel P.P., Hartmann A.. Bee venom and its component apamin as neuroprotective agents in a Parkinson disease mouse model.. PLoS ONE 2013;8:e61700.
    doi: 10.1371/journal.pone.0061700pmc: PMC3630120pubmed: 23637888google scholar: lookup
  79. Mohammadi-Rad M., Ghasemi N., Aliomrani M.. Evaluation of apamin effects on myelination process in C57BL/6 mice model of multiple sclerosis.. Res. Pharm. Sci. 2019;14:424.
    pmc: PMC6827192pubmed: 31798659
  80. Nguyen C.D., Lee G.. Neuroprotective activity of melittin—The main component of bee venom—Against oxidative stress induced by Aβ25–35 in in vitro and in vivo models.. Antioxidants 2021;10:1654.
    doi: 10.3390/antiox10111654pmc: PMC8614890pubmed: 34829525google scholar: lookup
  81. Khalil W.K., Assaf N., ElShebiney S.A., Salem N.A.. Neuroprotective effects of bee venom acupuncture therapy against rotenone-induced oxidative stress and apoptosis.. Neurochem. Int. 2015;80:79–86.
    doi: 10.1016/j.neuint.2014.11.008pubmed: 25481089google scholar: lookup
  82. Choi J., Jeon C., Lee J.H., Jang J.U., Quan F.S., Lee K., Kim W., Kim S.K.. Suppressive effects of bee venom acupuncture on paclitaxel-induced neuropathic pain in rats: Mediation by spinal α2-adrenergic receptor.. Toxins 2017;9:351.
    doi: 10.3390/toxins9110351pmc: PMC5705966pubmed: 29088102google scholar: lookup
  83. Li D., Chung G., Kim S.K.. The involvement of central noradrenergic pathway in the analgesic effect of bee venom acupuncture on vincristine-induced peripheral neuropathy in rats.. Toxins 2020;12:775.
    doi: 10.3390/toxins12120775pmc: PMC7762247pubmed: 33291335google scholar: lookup
  84. Sung H.J., Park H.M.. Therapeutic trial of bee venom acupuncture for idiopathic facial paralysis in a dog.. J. Vet. Clin. 2013;30:107–110.
  85. El-Hanoun A., El-Komy A., El-Sabrout K., Abdella M.. Effect of bee venom on reproductive performance and immune response of male rabbits.. Physiol. Behav. 2020;223:112987.
    doi: 10.1016/j.physbeh.2020.112987pubmed: 32492496google scholar: lookup
  86. Elkomy A., El-Hanoun A., Abdella M., El-Sabrout K.. Improving the reproductive, immunity and health status of rabbit does using honey bee venom.. J. Anim. Physiol. Anim. Nutr. 2021;105:975–983.
    doi: 10.1111/jpn.13552pubmed: 33856075google scholar: lookup
  87. Mohamed W.A., Abd-Elhakim Y.M., Ismail S.A.. Involvement of the anti-inflammatory, anti-apoptotic, and anti-secretory activity of bee venom in its therapeutic effects on acetylsalicylic acid-induced gastric ulceration in rats.. Toxicology 2019;419:11–23.
    doi: 10.1016/j.tox.2019.03.003pubmed: 30885738google scholar: lookup
  88. Han S.M., Lee K.G., Yeo J.H., Oh B.Y., Kim B.S., Lee W., Baek H.J., Kim S.T., Hwang S.J., Pak S.C.. Effects of honeybee venom supplementation in drinking water on growth performance of broiler chickens.. Poult. Sci. 2010;89:2396–2400.
    doi: 10.3382/ps.2010-00915pubmed: 20952702google scholar: lookup
  89. Kim D.H., Han S.M., Keum M.C., Lee S., An B.K., Lee S.R., Lee K.W.. Evaluation of bee venom as a novel feed additive in fast-growing broilers.. Brit. Poult. Sci. 2018;59:435–442.
    doi: 10.1080/00071668.2018.1476675pubmed: 29774758google scholar: lookup
  90. Han S.M., Lee K.G., Yeo J.H., Hwang S.J., Jang C.H., Chenoweth P.J., Pak S.C.. Effects of bee venom treatment on growth performance of young pigs.. Am. J. Chin. Med. 2009;37:253–260.
    doi: 10.1142/S0192415X09006813pubmed: 19507270google scholar: lookup
  91. Shin J.C., Kim S.H., Park H.J., Seo K.W., Song K.H.. Effect of aromatherapy and apipuncture on Malassezia-related otitis externa in dogs.. J. Vet. Clin. 2012;29:470–473.
  92. Jung B.G., Lee J.A., Park S.B., Hyun P.M., Park J.K., Suh G.H., Lee B.J.. Immunoprophylactic effects of administering honeybee (Apis melifera) venom spray against Salmonella gallinarum in broiler chicks.. J. Vet. Med. Sci. 2013;75:1287–1295.
    doi: 10.1292/jvms.13-0045pmc: PMC3942925pubmed: 23719751google scholar: lookup
  93. Uddin M.B., Lee B.H., Nikapitiya C., Kim J.H., Kim T.H., Lee H.C., Kim C.G., Lee J.S., Kim C.J.. Inhibitory effects of bee venom and its components against viruses in vitro and in vivo.. J. Microbiol. 2016;54:853–866.
    doi: 10.1007/s12275-016-6376-1pmc: PMC7091203pubmed: 27888461google scholar: lookup
  94. Lee J., Kim Y.M., Kim J.H., Cho C.W., Jeon J.W., Park J.K., Lee S.H., Jung B.G., Lee B.J.. Nasal delivery of chitosan/alginate nanoparticle encapsulated bee (Apis mellifera) venom promotes antibody production and viral clearance during porcine reproductive and respiratory syndrome virus infection by modulating T cell related responses.. Vet. Immunol. Immunop. 2018;200:40–51.
    doi: 10.1016/j.vetimm.2018.04.006pubmed: 29776611google scholar: lookup
  95. Choi J.H., Jang A.Y., Lin S., Lim S., Kim D., Park K., Han S.M., Yeo J.H., Seo H.S.. Melittin, a honeybee venom derived antimicrobial peptide, may target methicillin resistant Staphylococcus aureus.. Mol. Med. Rep. 2015;12:6483–6490.
    doi: 10.3892/mmr.2015.4275pmc: PMC4626175pubmed: 26330195google scholar: lookup
  96. Mousavi S.M., Imani S., Haghighi S., Mousavi S.E., Karimi A.. Effect of Iranian honey bee (Apis mellifera) venom on blood glucose and insulin in diabetic rats.. J. Arthropod-Borne Dis. 2012;6:136–143.
    pmc: PMC3547303pubmed: 23378971
  97. Denk B., Fidan A.F.. Effects of honeybee (Apis mellifera) venom on redox balance, biochemical and hematological profile in diabetic rats: A preliminary study.. Turk. J. Vet. Anim. Sci. 2021;45:257–265.
  98. Denk B.. Exploring Apis mellifera L. venom’s antioxidant power in various solvents: Unveiling its in vitro potential.. Kocatepe Vet. J. 2023;16:420–431.
    doi: 10.30607/kvj.1343130google scholar: lookup
  99. Kostić A.Ž., Milinčić D.D., Barać M.B., Ali Shariati M., Tešić Ž.L., Pešić M.B.. The application of pollen as a functional food and feed ingredient—The present and perspectives.. Biomolecules 2020;10:84.
    doi: 10.3390/biom10010084pmc: PMC7023195pubmed: 31948037google scholar: lookup
  100. Kročko M., Čanigová M., Bezeková J., Lavová M., Haščík P., Ducková V.. Effect of nutrition with propolis and bee pollen supplements on bacteria colonization pattern in gastrointestinal tract of broiler chicken.. Sci. Pap. Anim. Sci. Biotechnol. 2012;45:63–67.
  101. Haščík P., Trembecká L., Tkáčová J., Kročko M., Čuboň J., Kačániová M.. Effect of bee pollen dietary supplementation on meat performance of Ross 308 broiler chickens.. J. Microb. Biotec. Food. 2015;4:55–58.
    doi: 10.15414/jmbfs.2015.4.special3.55-58google scholar: lookup
  102. Fazayeli-Rad A.R., Afzali N., Farhangfar S.H., Asghari M.R.. Effect of bee pollen on growth performance, intestinal morphometry and immune status of broiler chicks.. Eur. Poult. Sci. 2015;79:1–9.
    doi: 10.1399/eps.2015.86google scholar: lookup
  103. Abood S.S., Ezzat H.N.. Effect of adding different levels from bee pollen in diet on productive performance of broiler chickens.. Plant Arch. 2018;18:2435–2438.
  104. Petričević V., Lukić M., Škrbić Z., Rakonjac S., Stanojković A., Nikšić D., Živković V.. Production parameters, microbiological composition of intestines and slaughter performance of broilers fed with bee pollen.. Züchtungskunde 2022;94:36–46.
  105. Locatelli M., Macchione N., Ferrante C., Chiavaroli A., Recinella L., Carradori S., Zengin G., Cesa S., Leporini L., Leone S.. Graminex pollen: Phenolic pattern, colorimetric analysis and protective effects in immortalized prostate cells (PC3) and rat prostate challenged with LPS.. Molecules 2018;23:1145.
    doi: 10.3390/molecules23051145pmc: PMC6100541pubmed: 29751604google scholar: lookup
  106. Chen X., Wu R.Z., Zhu Y.Q., Ren Z.M., Tong Y.L., Yang F., Dai G.H.. Study on the inhibition of Mfn1 by plant-derived miR5338 mediating the treatment of BPH with rape bee pollen.. BMC Complement. Altern. Med. 2018;18:38.
    doi: 10.1186/s12906-018-2107-ypmc: PMC5791735pubmed: 29382326google scholar: lookup
  107. Chen X., Wu R.Z., Ren Z.M., Tong Y.L., Chen S., Yang F., Dai G.H.. Regulation of microRNAs by rape bee pollen on benign prostate hyperplasia in rats.. Andrologia 2020;52:e13386.
    doi: 10.1111/and.13386pubmed: 31733069google scholar: lookup
  108. Mohamed N.A., Ahmed O.M., Hozayen W.G., Ahmed M.A.. Ameliorative effects of bee pollen and date palm pollen on the glycemic state and male sexual dysfunctions in streptozotocin-induced diabetic Wistar rats.. Biomed. Pharmacother. 2018;97:9–18.
    doi: 10.1016/j.biopha.2017.10.117pubmed: 29080463google scholar: lookup
  109. Karadeniz A., Simsek N., Karakus E., Yildirim S., Kara A., Can I., Kisa F., Emre H., Turkeli M.. Royal jelly modulates oxidative stress and apoptosis in liver and kidneys of rats treated with cisplatin.. Oxid. Med. Cell Longev. 2011;2011:981793.
    doi: 10.1155/2011/981793pmc: PMC3166579pubmed: 21904651google scholar: lookup
  110. Ibrahim A., Eldaim M.A., Abdel-Daim M.M.. Nephroprotective effect of bee honey and royal jelly against subchronic cisplatin toxicity in rats.. Cytotechnology 2016;68:1039–1048.
    doi: 10.1007/s10616-015-9860-2pmc: PMC4960153pubmed: 25720368google scholar: lookup
  111. Zargar H.R., Hemmati A.A., Ghafourian M., Arzi A., Rezaie A., Javad-Moosavi S.A.. Long-term treatment with royal jelly improves bleomycin-induced pulmonary fibrosis in rats.. Can. J. Physiol. Pharm. 2017;95:23–31.
    doi: 10.1139/cjpp-2015-0451pubmed: 27841941google scholar: lookup
  112. Albalawi A.E., Althobaiti N.A., Alrdahe S.S., Alhasani R.H., Alaryani F.S., BinMowyna M.N.. Antitumor activity of royal jelly and its cellular mechanisms against Ehrlich solid tumor in mice.. BioMed Res. Int. 2022;2022:7233997.
    doi: 10.1155/2022/7233997pmc: PMC9071879pubmed: 35528154google scholar: lookup
  113. Zhang S., Shao Q., Geng H., Su S.. The effect of royal jelly on the growth of breast cancer in mice.. Oncol. Lett. 2017;14:7615–7621.
    doi: 10.3892/ol.2017.7078pmc: PMC5755229pubmed: 29344209google scholar: lookup
  114. Okumura N., Toda T., Ozawa Y., Watanabe K., Ikuta T., Tatefuji T., Hashimoto K., Shimizu T.. Royal jelly delays motor functional impairment during aging in genetically heterogeneous male mice.. Nutrients 2018;10:1191.
    doi: 10.3390/nဉ1191pmc: PMC6164577pubmed: 30200401google scholar: lookup
  115. Ghanbari E., Khazaei M.R., Khazaei M., Nejati V.. Royal jelly promotes ovarian follicles growth and increases steroid hormones in immature rats.. Int. J. Fertil. Steril. 2018;11:263–269.
    pmc: PMC5641457pubmed: 29043701
  116. Shimizu S., Matsushita H., Minami A., Kanazawa H., Suzuki T., Watanabe K., Wakatsuki A.. Royal jelly does not prevent bone loss but improves bone strength in ovariectomized rats.. Climacteric 2018;21:601–606.
    doi: 10.1080/13697137.2018.1517739pubmed: 30296854google scholar: lookup
  117. Hattori S., Omi N.. The effects of royal jelly protein on bone mineral density and strength in ovariectomized female rats.. Phys. Act. Nutr. 2021;25:33.
    doi: 10.20463/pan.2021.0013pmc: PMC8342184pubmed: 34315205google scholar: lookup
  118. Pan Y., Xu J., Jin P., Yang Q., Zhu K., You M., Hu F., Chen M.. Royal jelly ameliorates behavioral deficits, cholinergic system deficiency, and autonomic nervous dysfunction in ovariectomized cholesterol-fed rabbits.. Molecules 2019;24:1149.
    doi: 10.3390/molecules24061149pmc: PMC6470943pubmed: 30909491google scholar: lookup
  119. Hassan A.A.. Effect of royal jelly on sexual efficiency in adult male rats.. Iraqi J. Vet. Sci. 2009;23:155–160.
  120. Mahdivand N., Najafi G., Nejati V., Shalizar-Jalali A., Rahmani F.. Royal jelly protects male rats from heat stress-induced reproductive failure.. Andrologia 2019;51:e13213.
    doi: 10.1111/and.13213pubmed: 30548301google scholar: lookup
  121. Asadi N., Kheradmand A., Gholami M., Saidi S.H., Mirhadi S.A.. Effect of royal jelly on testicular antioxidant enzymes activity, MDA level and spermatogenesis in rat experimental Varicocele model.. Tissue Cell. 2019;57:70–77.
    doi: 10.1016/j.tice.2019.02.005pubmed: 30947966google scholar: lookup
  122. Zahmatkesh E., Najafi G., Nejati V., Heidari R.. Protective effect of royal jelly on the sperm parameters and testosterone level and lipid peroxidation in adult mice treated with oxymetholone.. Avicenna J. Phytomedi. 2014;4:43.
    pmc: PMC4103725pubmed: 25050300
  123. Azad F., Nejati V., Shalizar-Jalali A., Najafi G., Rahmani F.. Royal jelly protects male mice against nicotine-induced reproductive failure.. Vet. Res. Forum. 2018;9:231–238.
    pmc: PMC6198156pubmed: 30357078
  124. El-Hanoun A.M., Elkomy A.E., Fares W.A., Shahien E.H.. Impact of royal jelly to improve reproductive performance of male rabbits under hot summer conditions.. World Rabbit. Sci. 2014;22:241–248.
    doi: 10.4995/wrs.2014.1677google scholar: lookup
  125. Khadr A.H., Abdou A., El-Sherbiny A.M.. Age of puberty and fertility of male New Zealand white rabbits orally administered with royal jelly or/and bee honey.. J. Anim. Poult. Prod. Mansoura Univ. 2015;6:201–217.
    doi: 10.21608/jappmu.2016.52748google scholar: lookup
  126. Guo J., Wang Z., Chen Y., Cao J., Tian W., Ma B., Dong Y.. Active components and biological functions of royal jelly.. J. Funct. Foods. 2021;82:104514.
    doi: 10.1016/j.jff.2021.104514google scholar: lookup
  127. Ghosh S., Jung C., Meyer-Rochow V.B.. Nutritional value and chemical composition of larvae, pupae, and adults of worker honey bee, Apis mellifera ligustica as a sustainable food source.. J. Asia Pac. Entomol. 2016;19:487–495.
    doi: 10.1016/j.aspen.2016.03.008google scholar: lookup
  128. Odemer R., Odemer F., Liebig G., de Craigher D.. Temporal increase of Varroa mites in trap frames used for drone brood removal during the honey bee season.. J. Appl. Entomol. 2022;146:1207–1211.
    doi: 10.1111/jen.13046google scholar: lookup
  129. Shoinbayeva K.B., Omirzak T., Bigara T., Abubakirova A., Dauylbay A.. Biologically active preparation and reproductive function of stud rams.. Asian J. Pharm. 2017;11:184–191.
  130. Seres A.B., Ducza E., Báthori M., Hunyadi A., Béni Z., Dékány M., Hajagos-Tóth J., Verli J., Gáspár R.. Androgenic effect of honeybee drone milk in castrated rats: Roles of methyl palmitate and methyl oleate.. J. Ethnopharmacol. 2014;153:446–453.
    doi: 10.1016/j.jep.2014.02.050pubmed: 24607508google scholar: lookup
  131. Yucel B., Acikgoz Z., Bayraktar H., Seremet C.. The effect of apilarnil (drone bee larvae) administration on growth performance and secondary sex characteristics of male broilers.. J. Anim. Vet. Adv. 2011;10:2263–2266.
  132. Altan O., Yucel B., Açikgoz Z., Seremet C., Kosoglu M., Turgan N., Ozgonul A.M.. Apilarnil reduces fear and advances sexual development in male broilers but has no effect on growth.. Brit. Poult. Sci. 2013;54:355–361.
    doi: 10.1080/00071668.2013.791382pubmed: 23796118google scholar: lookup
  133. Zdorovjova J.V., Boryayev G.I., Nosov A.V., Katayev O.G., Meloyan G.M., Zemljanova J.V., Kistanova J.K.. Hormonal status and productive qualities of young pigs at inclusion in a diet feeding homogenate drone brood.. Agrar. Sci. J. 2018;2:3–7.
  134. Kistanova E., Zdoroveva E., Nevitov M., Nosov A., Vysokikh M., Sukhanova I., Vishnyakova P., Abadjieva D., Ankova D., Rashev P.. Drone brood fed supplement impacts on the folliculogenesis in growing gilts.. Vet. Arh. 2020;90:583–592.
    doi: 10.24099/vet.arhiv.0886google scholar: lookup
  135. Yemets Y.M.. Dietary effects of drone larves homogenate on the homeostatic constants and the reproductive capacity of Large White gilts.. Transl. Res. Vet. Sci. 2020;3:27–39.
    doi: 10.12775/TRVS.2020.008google scholar: lookup
  136. Hamamci M., Doganyigit Z., Silici S., Okan A., Kayma E., Yilmaz S., Tokpina A., Inan L.E.. Apilarnil: A novel neuroprotective candidate.. Acta Neurol. Taiwan. 2020;29:33–45.
    pubmed: 32436201
  137. Doğanyiğit Z., Okan A., Kaymak E., Pandır D., Silici S.. Investigation of protective effects of apilarnil against lipopolysaccharide induced liver injury in rats via TLR 4/HMGB-1/NF-κB pathway.. Biomed. Pharmacother. 2020;125:109967.
    doi: 10.1016/j.biopha.2020.109967pubmed: 32018220google scholar: lookup
  138. Stevanovic J., Stanimirović Z., Aleksić N., Simeunović P., Vučićević M.. The influence of natural and synthetic substances applied in honey bee health care on the quality of bee products (invited paper); Proceedings of the Apimondia Symposium “Apiecotech Serbia 2012”; Belgrade, Serbia. 18–19 February 2012; pp. 9–34.. .
  139. Kasiotis K.M., Zafeiraki E., Manea-Karga E., Anastasiadou P., Machera K.. Pesticide residues and metabolites in Greek honey and pollen: Bees and human health risk assessment.. Foods 2023;12:706.
    doi: 10.3390/foods12040706pmc: PMC9955768pubmed: 36832781google scholar: lookup
  140. Végh R., Csóka M., Mednyánszky Z., Sipos L.. Pesticide residues in bee bread, propolis, beeswax and royal jelly–a review of the literature and dietary risk assessment.. Food Chem. Toxicol. 2023;176:113806.
    doi: 10.1016/j.fct.2023.113806pubmed: 37121430google scholar: lookup
  141. Simsek I., Kuzukiran O., Yurdakok-Dikmen B., Sireli U.T., Beykaya M., Filazi A.. Comparison of selected lipophilic compound residues in honey and propolis.. J. Food Compos. Anal. 2021;102:104068.
    doi: 10.1016/j.jfca.2021.104068google scholar: lookup
  142. Ilić D., Brkić B., Sekulić M.T.. Biomonitoring: Developing a beehive air volatiles profile as an indicator of environmental contamination using a sustainable in-field technique.. Sustainability 2024;16:1713.
    doi: 10.3390/sᘅ1713google scholar: lookup
  143. Stanimirović Z., Glavinić U., Lakić N., Radović D., Ristanić M., Tarić E., Stevanović J.. Efficacy of plant-derived formulation “Argus Ras” in control.. Acta Vet. Beogr. 2017;67:191–200.
    doi: 10.1515/acve-2017-0017google scholar: lookup
  144. Stanimirovic Z., Glavinic U., Jovanovic N.M., Ristanic M., Milojković-Opsenica D., Mutic J., Stevanovic J.. Preliminary trials on effects of lithium salts on Varroa destructor, honey and wax matrices.. J. Apicult. Res. 2022;61:375–391.
    doi: 10.1080/00218839.2021.1988277google scholar: lookup
  145. Stanimirović Z., Glavinić U., Ristanić M., Jelisić S., Vejnović B., Niketić M., Stevanović J.. Diet supplementation helps honey bee colonies in combat infections by enhancing their hygienic behaviour.. Acta Vet. Beogr. 2022;72:145–166.
    doi: 10.2478/acve-2022-0013google scholar: lookup
  146. Jovanovic N.M., Glavinic U., Delic B., Vejnovic B., Aleksic N., Mladjan V., Stanimirovic Z.. Plant-based supplement containing B-complex vitamins can improve bee health and increase colony performance.. Prev. Vet. Med. 2021;190:105322.
    doi: 10.1016/j.prevetmed.2021.105322pubmed: 33744676google scholar: lookup
  147. Jovanovic N.M., Glavinic U., Ristanic M., Vejnovic B., Stevanovic J., Cosic M., Stanimirovic Z.. Contact varroacidal efficacy of lithium citrate and its influence on viral loads, immune parameters and oxidative stress of honey bees in a field experiment.. Front. Physiol. 2022;13:1000944.
    doi: 10.3389/fphys.2022.1000944pmc: PMC9510912pubmed: 36171978google scholar: lookup
  148. Jovanovic N.M., Glavinic U., Ristanic M., Vejnovic B., Ilic T., Stevanovic J., Stanimirovic Z.. Effects of plant-based supplement on oxidative stress of honey bees (Apis mellifera) infected with Nosema ceranae.. Animals 2023;13:3543.
    doi: 10.3390/ani13223543pmc: PMC10668651pubmed: 38003159google scholar: lookup
  149. Dolasevic S., Stevanovic J., Aleksic N., Glavinic U., Deletic N., Mladenovic M., Stanimirovic Z.. The effect of diet types on some quality characteristics of artificially reared Apis mellifera queens.. J. Apicult. Res. 2020;59:115–123.
    doi: 10.1080/00218839.2019.1673965google scholar: lookup
  150. Glavinic U., Stankovic B., Draskovic V., Stevanovic J., Petrovic T., Lakic N., Stanimirovic Z.. Dietary amino acid and vitamin complex protects honey bee from immunosuppression caused by Nosema ceranae.. PLoS ONE 2017;12:e0187726.
    pmc: PMC5678887pubmed: 29117233
  151. Glavinic U., Stevanovic J., Ristanic M., Rajkovic M., Davitkov D., Lakic N., Stanimirovic Z.. Potential of fumagillin and Agaricus blazei mushroom extract to reduce Nosema ceranae in honey bees.. Insects 2021;12:282.
    doi: 10.3390/insects12040282pmc: PMC8064457pubmed: 33806001google scholar: lookup
  152. Glavinic U., Rajkovic M., Vunduk J., Vejnovic B., Stevanovic J., Milenkovic I., Stanimirovic Z.. Effects of Agaricus bisporus mushroom extract on honey bees infected with Nosema ceranae.. Insects 2021;12:915.
    doi: 10.3390/insects12100915pmc: PMC8541333pubmed: 34680684google scholar: lookup
  153. Glavinic U., Blagojevic J., Ristanic M., Stevanovic J., Lakic N., Mirilovic M., Stanimirovic Z.. Use of thymol in Nosema ceranae control and health improvement of infected honey bees.. Insects 2022;13:574.
    doi: 10.3390/insects13070574pmc: PMC9319372pubmed: 35886750google scholar: lookup
  154. Taric E., Glavinic U., Vejnovic B., Stanojkovic A., Aleksic N., Dimitrijevic V., Stanimirovic Z.. Oxidative stress, endoparasite prevalence and social immunity in bee colonies kept traditionally vs. those kept for commercial purposes.. Insects 2020;11:266.
    doi: 10.3390/insects11050266pmc: PMC7290330pubmed: 32349295google scholar: lookup
  155. Taric E., Glavinic U., Stevanovic J., Vejnovic B., Aleksic N., Dimitrijevic V., Stanimirovic Z.. Occurrence of honey bee (Apis mellifera L.) pathogens in commercial and traditional hives.. J. Apicult. Res. 2019;58:433–443.
    doi: 10.1080/00218839.2018.1554231google scholar: lookup
  156. Rostaher A., Mueller R.S., Meile L., Favrot C., Fischer N.M.. Venom immunotherapy for Hymenoptera allergy in a dog.. Vet. Dermatol. 2021;32:206-e52.
    doi: 10.1111/vde.12931pubmed: 33439532google scholar: lookup
  157. Moore A., Burrows A.K., Rosenkrantz W.S., Ghubash R.M., Hosgood G.. Modified rush venom immunotherapy in dogs with Hymenoptera hypersensitivity.. Vet. Dermatol. 2023;34:532–542.
    doi: 10.1111/vde.13189pubmed: 37395162google scholar: lookup
  158. Vazquez-Revuelta P., Madrigal-Burgaleta R.. Death due to live bee acupuncture apitherapy.. J. Investig. Allerg. Clin. 2018;28:45–46.
    doi: 10.18176/jiaci.0202pubmed: 29461208google scholar: lookup
  159. Chen J., Lariviere W.R.. The nociceptive and anti-nociceptive effects of bee venom injection and therapy: A double-edged sword.. Prog. Neurobiol. 2010;92:151–183.
    doi: 10.1016/j.pneurobio.2010.06.006pmc: PMC2946189pubmed: 20558236google scholar: lookup
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