Bilateral congenital cystic eye with intraocular tissue differentiation in a horse.
Abstract: Congenital cystic eye (CCE) is a rare congenital ocular disease, which has been suggested to be caused by problems with optic vesicle invagination. This is characterized by the formation of intraorbital cystic lesions lined by undifferentiated neuroepithelium. However, cases involving ocular structures with varying degrees of differentiation have also been reported as CCE in humans and animals. In horses, CCE have only been reported as a case presenting as neuroepithelial-lined cysts without the formation of ocular structures. This paper describes large bilateral intraorbital cysts in a 1-day-old horse. The histopathological findings revealed that the cysts were covered by neuroepithelium with formation of the lens, ciliary body, and optic nerve, and it was diagnosed as CCE. This report provides further variations of CCE in horses.
Publication Date: 2024-11-19 PubMed ID: 39567001PubMed Central: PMC11735210DOI: 10.1292/jvms.24-0285Google Scholar: Lookup
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Summary
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This research paper discusses a unique case of bilateral congenital cystic eye disease in a newborn horse, with histopathological results suggesting the rare formation of ocular structures within the intraorbital cysts.
Introduction:
- The study introduces Congenital Cystic Eye (CCE), which is an uncommon birth defect affecting the eyes.
- CCE is believed to result from complications in the invagination of the optic vesicle during embryonic development.
- This disease is marked by the creation of cystic lesions within the orbits of the eye, which are lined by an underdeveloped type of nervous tissue known as neuroepithelium.
- Although these cysts primarily contain underdeveloped neuroepithelium, certain cases reported in humans and animals have presented cysts with various stages of differentiation within ocular structures.
Previous Reports of CCE in Horses:
- The study mentions that occurrences of CCE in horses have only been reported once before, and on that occasion, the cysts consisted solely of neuroepithelial tissue, without the formation of any ocular structures.
Current Case Study:
- This research discusses a novel occurrence of CCE in a one-day-old horse, where the cysts were remarkably large and bilateral, meaning they were present in both eyes.
Results and Diagnosis:
- Upon histopathological examination, it was found that besides the expected lining of neuroepithelium, these cysts also contained differentiated ocular structures such as the lens, ciliary body, and optic nerve.
- Based on these findings, the horse was diagnosed with CCE.
Conclusions:
- This report contributes to the understanding of the variations of CCE that can occur in horses.
- It highlights that CCE in horses can present with differentiated ocular structures within the cysts, rather than just the neuroepithelial lining widely reported within medical literature.
Cite This Article
APA
Sano Y, Miura C, Kinoshita Y, Kakimoto M, Tsuda T, Matsuda K.
(2024).
Bilateral congenital cystic eye with intraocular tissue differentiation in a horse.
J Vet Med Sci, 87(1), 52-56.
https://doi.org/10.1292/jvms.24-0285 Publication
Researcher Affiliations
- Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan.
- Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan.
- Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan.
- Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan.
- Northern Farm, Hokkaido, Japan.
- Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan.
MeSH Terms
- Horses
- Animals
- Horse Diseases / pathology
- Horse Diseases / congenital
- Cysts / veterinary
- Cysts / pathology
- Cysts / congenital
- Eye Diseases / veterinary
- Eye Diseases / pathology
- Eye Diseases / congenital
- Animals, Newborn
- Male
- Female
Conflict of Interest Statement
The authors declared no conflicts of interest to the research, authorship, and/or publication of this paper.
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