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The Journal of veterinary medical science2017; 79(3); 579-583; doi: 10.1292/jvms.16-0537

Blindness associated with nasal/paranasal lymphoma in a stallion.

Abstract: A 29-year-old stallion presented with bilateral blindness following the chronic purulent nasal drainage. The mass occupied the right caudal nasal cavity and right paranasal sinuses including maxillary, palatine and sphenoidal sinuses, and the right-side turbinal and paranasal septal bones, and cribriform plate of ethmoid bone were destructively replaced by the mass growth. The right optic nerve was invaded and involved by the mass, and the left optic nerve and optic chiasm were compressed by the mass which was extended and invaded the skull base. Histologically, the optic nerves and optic chiasm were degenerated, and the mass was diagnosed as lymphoma which was morphologically and immunohistochemically classified as a diffuse large B-cell lymphoma. Based on these findings, the cause of the blindness in the stallion was concluded to be due to the degeneration of the optic nerves and chiasm associated with lymphoma occurring in the nasal and paranasal cavities. To the best of our knowledge, this is the first report of the equine blindness with optic nerve degeneration accompanied by lymphoma.
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Publication Date: 2017-02-05 PubMed ID: 28163275PubMed Central: PMC5383180DOI: 10.1292/jvms.16-0537Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study documents the case of a 29-year-old stallion that went blind due to a large tumor identified as diffuse large B-cell lymphoma located in the nasal and paranasal cavities. The growth and expansion of this tumor led to significant damage to the optic nerves, resulting in blindness.

Case Presentation

  • This research focuses on a 29-year-old stallion that developed blindness in both eyes. The stallion had suffered from chronic purulent nasal discharge prior to this development.
  • On examination, it was discovered that a mass was occupying regions in the stallion’s right caudal nasal cavity and right paranasal sinuses, inclusive of the maxillary, palatine and sphenoidal sinuses.
  • The destructive growth of this mass resulted in the displacement of the right-side turbinal and paranasal septal bones, along with the cribriform plate of the ethmoid bone.

Progression and Impact of the Lymphoma

  • The tumor grew to the extent of invading and implicating the right optic nerve.
  • Furthermore, the mass extended to compress the left optic nerve and optic chiasm, intensifying its invasion to the base of the skull.
  • Both the optic nerves and optic chiasm showed signs of degeneration under histological examination.

Diagnosis and Classification

  • The mass was identified as a lymphoma, which is a type of cancer developing from lymphocytes, a kind of white blood cell.
  • Both morphological and immunohistochemical classification recognized the lymphoma as a diffuse large B-cell lymphoma, one of the most common subtypes of non-Hodgkin’s lymphoma in adults.

Conclusion and Significance of the Case

  • This case established that the cause of the stallion’s blindness was the degeneration of the optic nerves and chiasm. These degenerations were consequences of the lymphoma in the nasal and paranasal cavities.
  • According to researchers, this is the first reported occurrence of equine blindness due to optic nerve degeneration in the presence of lymphoma.

Cite This Article

APA
Sano Y, Okamoto M, Ootsuka Y, Matsuda K, Yusa S, Taniyama H. (2017). Blindness associated with nasal/paranasal lymphoma in a stallion. J Vet Med Sci, 79(3), 579-583. https://doi.org/10.1292/jvms.16-0537

Publication

The Journal of veterinary medical science
ISSN: 1347-7439
NlmUniqueID: 9105360
Country: Japan
Language: English
Volume: 79
Issue: 3
Pages: 579-583

Researcher Affiliations

Sano, Yuto
  • Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan.
Okamoto, Minoru
    Ootsuka, Youhei
      Matsuda, Kazuya
        Yusa, Shigeki
          Taniyama, Hiroyuki

            MeSH Terms

            • Animals
            • Blindness / etiology
            • Blindness / pathology
            • Blindness / veterinary
            • Horse Diseases / pathology
            • Horses
            • Lymphoma, B-Cell / complications
            • Lymphoma, B-Cell / veterinary
            • Male
            • Nose Neoplasms / complications
            • Nose Neoplasms / pathology
            • Nose Neoplasms / veterinary
            • Optic Chiasm / pathology
            • Optic Nerve Neoplasms / complications
            • Optic Nerve Neoplasms / pathology
            • Optic Nerve Neoplasms / veterinary
            • Paranasal Sinus Neoplasms / complications
            • Paranasal Sinus Neoplasms / pathology
            • Paranasal Sinus Neoplasms / veterinary
            • Skull Neoplasms / complications
            • Skull Neoplasms / pathology
            • Skull Neoplasms / veterinary

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            Citations

            This article has been cited 2 times.
            1. Holz N, Suárez J, Hetzel U, Rampazzo A, Stoppini R. Mycotic Sphenopalatine Sinusitis With Concurrent Compression of the Optic Nerves and Chiasm and Severe Visual Impairment in A Horse. Vet Ophthalmol 2026 Jan;29(1):e70003.
              doi: 10.1111/vop.70003pubmed: 40055139google scholar: lookup
            2. Peretti JC, Dos Santos AB, Davi Dos Santos E, Machado TP, Pescador CA, Quillas LJA, Milani VM, Picetti TS, da Motta AC. Oral T-cell-rich large B-cell lymphoma in a horse. Vet Res Commun 2024 Dec;48(6):4067-4071.
              doi: 10.1007/s11259-024-10476-zpubmed: 39190130google scholar: lookup
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