Blood plasma concentrations of insulin-like growth factor-I (IGF-I) in resting standardbred horses.
Abstract: A survey of standardbred horses was conducted to build up a normal population profile for insulin like growth factor-I (IGF-I) concentrations in racing standardbreds and to ascertain how age, sex and geographic location affect IGF-I. Blood samples were drawn by jugular venepuncture from 202 racing standardbred horses aged one to eight years located in five different geographic regions of New Zealand. IGF-I concentrations were determined by insulin like growth factor-I binding protein (IGFBP)-blocked radioimmunoassay validated for the horse. As described in other species, age played a significant (P<0.05) role in IGF-I concentrations with the highest concentrations occurring in the younger horses. There was a significant (P<0.05) sex effect, intact males having significantly higher IGF-I concentrations compared of mares and/or geldings. Geographic location had a significant (P<0.05) influence on IGF-I. A significant (P<0.05) trainer effect also was noted both within and between geographic locations. We concluded that IGF-I concentrations in racing standardbred horses are affected by age, sex, trainer and geographic location.
Copyright 2002 Harcourt Publishers Ltd.
Publication Date: 2001-12-26 PubMed ID: 11749135DOI: 10.1053/tvjl.2001.0619Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The study examined levels of insulin-like growth factor-I (IGF-I) in racing standardbred horses and found that different ages, sexes, trainers, and geographical locations contribute to varied IGF-I concentrations.
Objective of the Study
- The purpose of the study was to establish a standard profile for the concentration of insulin-like growth factor-I (IGF-I) among standardbred horses, the racehorses featured in this research. The study paid attention to how different variables such as age, sex, the influence of trainers, and varying geographic circumstances affect IGF-I levels.
Methodology
- Researchers carried out a blood sample collection using jugular venipuncture from 202 standardbred racehorses aged between one and eight years old.
- The horses were spread across five diverse geographic regions within New Zealand to understand the effect of different geographic locations on IGF-I concentration.
- The concentration of IGF-I was determined through an IGFBP-blocked radioimmunoassay, a test that has been validated for use in horses.
Results
- As per the research findings, age was found to play a significant role in the concentration of IGF-I. Younger horses presented higher IGF-I concentrations, suggesting a link between youth and higher IGF-I levels.
- Research also indicated a significant sex effect, where intact males had higher IGF-I concentrations compared to mares and/or geldings, illustrating that sex too impacts IGF-I concentrations.
- The study revealed that geographic location significantly influenced the IGF-I levels. However, the specifics of this effect were not disclosed in the abstract.
- Finally, the study also noted a significant effect from horse trainers, varying both within and between geographic locations. The exact nature of this influence was not specified in the abstract.
Conclusion
- Based on the results, the researchers concluded that in standardbred racehorses, various factors – age, sex, trainer, and geographic location – influence the concentration of IGF-I.
Cite This Article
APA
Champion ZJ, Breier BH, Ewen WE, Tobin TT, Casey PJ.
(2001).
Blood plasma concentrations of insulin-like growth factor-I (IGF-I) in resting standardbred horses.
Vet J, 163(1), 45-50.
https://doi.org/10.1053/tvjl.2001.0619 Publication
Researcher Affiliations
- Research Centre in Reproductive Medicine, The University of Auckland, Private Bag, Auckland, New Zealand. z.champion@auckland.ac.nz
MeSH Terms
- Age Factors
- Animals
- Female
- Horses / blood
- Insulin-Like Growth Factor Binding Protein 1 / metabolism
- Insulin-Like Growth Factor I / analysis
- Insulin-Like Growth Factor I / metabolism
- Jugular Veins
- Male
- New Zealand
- Radioimmunoassay / veterinary
- Reference Values
- Sex Factors
Citations
This article has been cited 6 times.- Ishimaru M, Matsui A, Seki K, Korosue K, Akiyama K, Mizukami H, Yoshida T, Taya K. Effects of different winter climates in Japan on body composition of young Thoroughbreds in training. J Vet Med Sci 2022 Nov 18;84(12):1585-1594.
- Suzuki T, Mizukami H, Nambo Y, Ishimaru M, Miyata K, Akiyama K, Korosue K, Naito H, Nagaoka K, Watanabe G, Taya K. Different effects of an extended photoperiod treatment on growth, gonadal function, and condition of hair coats in Thoroughbred yearlings reared under different climate conditions. J Equine Sci 2015;26(4):113-24.
- Mizukami H, Suzuki T, Nambo Y, Ishimaru M, Naito H, Korosue K, Akiyama K, Miyata K, Yamanobe A, Nagaoka K, Watanabe G, Taya K. Comparison of growth and endocrine changes in Thoroughbred colts and fillies reared under different climate conditions. J Equine Sci 2015;26(2):49-56.
- Dhakal P, Tsunoda N, Nakai R, Kitaura T, Harada T, Ito M, Nagaoka K, Toishi Y, Taniyama H, Gen W, Taya K. Annual Changes in Day-length, Temperature, and Circulating Reproductive Hormones in Thoroughbred Stallions and Geldings. J Equine Sci 2011;22(2):29-36.
- Verwilghen DR, Vanderheyden L, Franck T, Busoni V, Enzerink E, Gangl M, Lejeune JP, van Galen G, Grulke S, Serteyn D. Variations of plasmatic concentrations of Insulin-like Growth Factor-I in post-pubescent horses affected with developmental osteochondral lesions. Vet Res Commun 2009 Oct;33(7):701-9.
- Lejeune JP, Franck T, Gangl M, Schneider N, Michaux C, Deby-Dupont G, Serteyn D. Plasma concentration of insulin-like growth factor I (IGF-I) in growing Ardenner horses suffering from juvenile digital degenerative osteoarthropathy. Vet Res Commun 2007 Feb;31(2):185-95.
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