Bovine colostrum as a biologic in clinical medicine: a review. Part I: biotechnological standards, pharmacodynamic and pharmacokinetic characteristics and principles of treatment.
Abstract: Mammals supply their newborn before birth, at birth or shortly after birth with antibodies, immunocytes and humoral constituents. This "borrowed immunity" is a form of passive immunization to protect the newborn against environmental pathogens until it establishes its own pathogen recognition and disposal systems. In cows, goats, horses and some other animal species, most immunoglobulins are obtained from the colostrum, the first milk after birth, via the gut but in humans the majority of immunoglobulins, and those of the IgG-class in particular, are acquired from the mother by placental transport in the weeks prior to parturition. It has long been known that the consumption of bovine colostrum by humans has therapeutic effects e.g. in gastrointestinal infections, but only since the second half of the last century has it been possible to prepare stable, standardized preparations of colostrum. These biologics are administered to patients in combination with standard therapies as so-called balanced supportive diets. Investigations with standardized colostrum preparations in animal models of human disease and estimates of bovine IgG activity in the human GI-tract, described in this review, have provided preclinical data supporting the use of bovine colostrum in human diseases. On the other hand, the number of bovine colostrum products with a sufficiently large and reliable database is limited and the precise nature of the therapeutic targets is still being evaluated.
Publication Date: 2007-05-04 PubMed ID: 17474538DOI: 10.5414/cpp45193Google Scholar: Lookup
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- Journal Article
- Review
Summary
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This research article focuses on the health benefits of bovine colostrum, the first milk produced after birth, particularly as a supportive treatment in human diseases. It also provides insights into the technological advances that have made possible stable, standardized preparations of colostrum.
Biotechnological Standards
- During the second half of the last century, advancements in technology laid the foundation for the production of stable, standardized colostrum preparations. These advancements enabled the extraction, preservation, and administration of bovine colostrum for clinical use.
- In accordance with biotechnological standards, these preparations are measured and standardized based on their biological and therapeutic properties to ensure their efficacy and safety in clinical application.
Pharmacodynamic and Pharmacokinetic Characteristics
- Pharmacodynamic characteristics pertain to the bioactive effects of colostrum in the human body, notably its immune-boosting properties. Bovine colostrum has long been observed to have therapeutic effects, particularly in gastrointestinal infections.
- Pharmacokinetic characteristics refer to how the human body processes bovine colostrum, encompassing absorption, distribution, metabolism, and excretion. The consumption of bovine colostrum is considered a form of passive immunization that mimics the process of newborns receiving antibodies from colostrum shortly after birth.
Principles of Treatment
- Traditional treatments are combined with the consumption of bovine colostrum as supportive and balanced diets for patients. This balance ensures that patients receive the health benefits of colostrum while maintaining standard medical treatment.
- The review outlines research from animal models that support its use in human diseases, solidifying bovine colostrum’s role in human disease treatment.
- However, the author notes that the number of bovine colostrum products with a robust and trustworthy data set is limited, and further understanding of their therapeutic targets is needed.
Cite This Article
APA
Struff WG, Sprotte G.
(2007).
Bovine colostrum as a biologic in clinical medicine: a review. Part I: biotechnological standards, pharmacodynamic and pharmacokinetic characteristics and principles of treatment.
Int J Clin Pharmacol Ther, 45(4), 193-202.
https://doi.org/10.5414/cpp45193 Publication
Researcher Affiliations
- Center for Transfusion Medicine, Münster, German Red Cross Blood Transfusion Service West gGmbH, Münster, Germany. w.struff@bsdwest.de
MeSH Terms
- Animals
- Anti-Infective Agents / pharmacokinetics
- Anti-Infective Agents / pharmacology
- Anti-Infective Agents / standards
- Bacteremia
- Cattle
- Colostrum / chemistry
- Communicable Diseases / drug therapy
- Dietary Supplements / standards
- Disease Models, Animal
- Humans
- Immune System / drug effects
- Immune System / metabolism
- Immune System Diseases / drug therapy
- Immunoglobulin G / pharmacology
- Immunologic Factors / pharmacokinetics
- Immunologic Factors / pharmacology
- Immunologic Factors / standards
- Quality Control
Citations
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- Rossi L, Lumbreras AEV, Vagni S, Dell'Anno M, Bontempo V. Nutritional and Functional Properties of Colostrum in Puppies and Kittens.. Animals (Basel) 2021 Nov 15;11(11).
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