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Pathogens (Basel, Switzerland)2023; 12(8); 1059; doi: 10.3390/pathogens12081059

Bovine Papillomavirus Type 1 Infection in an Equine Congenital Papilloma.

Abstract: Papillomas are benign epithelial lesions protruding on the epithelial surfaces as finger-like or warty projections. These lesions are often caused by papillomavirus (PV) infection. Congenital papillomas have been reported in foals. However, to date, no evidence of PV infection has been provided. In the present paper, we describe the main clinical-pathological features of a congenital papilloma observed in a foal. In addition, biomolecular tests demonstrated BPV1 infection in the case under study. Such data stimulate further investigations, even on archived samples, aiming to clarifying the etiology of equine congenital papilloma and the clinical relevance, if any, of BPV1 vertical transmission in horses.
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Publication Date: 2023-08-18 PubMed ID: 37624019PubMed Central: PMC10458069DOI: 10.3390/pathogens12081059Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research explores a case where Bovine Papillomavirus Type 1 (BPV1) is discovered in a congenital papilloma in a foal, sparking further research into the origins and clinical impact of BPV1 transmission in horses.

Research Objective

  • The purpose of this research is to investigate the manifestation of a congenital papilloma in a foal and reveal the apparent connection with Bovine Papillomavirus Type 1 (BPV1) infection. The researchers strive to stimulate more inquiries into the etiology of equine congenital papilloma and the potential clinical consequences of BPV1 vertical transmission in horses.

Background Information

  • The entry provides background knowledge about papillomas, which are benign epithelial lesions that project like fingers or warts on the outer surfaces of epithelial cells. These typically occur due to a papillomavirus (PV) infection.
  • The text also points out that congenital papillomas have been reported in foals before, but no PV infection had been conclusively identified in any of those cases.

The Case Study

  • The researchers present a specific clinical case of a congenital papilloma seen in a foal. They provide details regarding the major clinical and pathological attributes of this particular instance.
  • Biomolecular studies were also conducted that confirmed BPV1 infection in the case under observation. This is noteworthy because it’s the first documented link between PV infection and foal congenital papillomas.

Implications of the Findings

  • The identification of BPV1 in this case could lead to a clearer understanding of the etiology, or cause and development, of congenital papillomas in horses.
  • Researchers also propose further investigation into potential implications of vertical (from parent to offspring) transmission of BPV1. If present, it could significantly impact the clinical treatment, prevention strategies, and overall disease management in horses.

Cite This Article

APA
Maggi R, De Paolis L, De Santis D, Vellone VG, De Ciucis CG, Fruscione F, Mazzocco K, Ghelardi A, Marruchella G, Razzuoli E. (2023). Bovine Papillomavirus Type 1 Infection in an Equine Congenital Papilloma. Pathogens, 12(8), 1059. https://doi.org/10.3390/pathogens12081059

Publication

Pathogens (Basel, Switzerland)
ISSN: 2076-0817
NlmUniqueID: 101596317
Country: Switzerland
Language: English
Volume: 12
Issue: 8
PII: 1059

Researcher Affiliations

Maggi, Raffaella
  • Veterinary Practitioner, Via Cassia 829, 00189 Rome, Italy.
De Paolis, Livia
  • Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, National Reference Center of Veterinary and Comparative Oncology (CEROVEC), Piazza Borgo Pila 29/34, 16129 Genova, Italy.
De Santis, Daria
  • Veterinary Practitioner, Via San Manno 19, 03024 Cepranno, Italy.
Vellone, Valerio Gaetano
  • U.O.C. Anatomia Patologica, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.
De Ciucis, Chiara Grazia
  • Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, National Reference Center of Veterinary and Comparative Oncology (CEROVEC), Piazza Borgo Pila 29/34, 16129 Genova, Italy.
Fruscione, Floriana
  • Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, National Reference Center of Veterinary and Comparative Oncology (CEROVEC), Piazza Borgo Pila 29/34, 16129 Genova, Italy.
Mazzocco, Katia
  • U.O.C. Anatomia Patologica, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.
Ghelardi, Alessandro
  • Azienda Usl Toscana-Ovest, UOC Ostetricia e Ginecologia, Ospedale Apuane, 54100 Massa, Italy.
Marruchella, Giuseppe
  • Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy.
Razzuoli, Elisabetta
  • Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, National Reference Center of Veterinary and Comparative Oncology (CEROVEC), Piazza Borgo Pila 29/34, 16129 Genova, Italy.

Grant Funding

  • 12/19 IZS PLV / Governo Italiano

Conflict of Interest Statement

The authors declare no conflict of interest.

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Citations

This article has been cited 2 times.
  1. Rapezzano G, Foote A, Petrini F, Pereira R, Marcatili M. Fetal rhabdomyoma in a Thoroughbred filly. Vet Med Sci 2024 Jul;10(4):e1534.
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  2. Pontes NE, Carrazzoni PG, Pessoa-Junior ME, Tibúrcio Júnior E, Freitas AC, Silva MARD. Bovine papillomavirus vertical transmission: BPV diversity and expression in maternal and fetal tissues. Braz J Microbiol 2024 Sep;55(3):2879-2884.
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