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Veterinary dermatology2008; 19(5); 243-254; doi: 10.1111/j.1365-3164.2008.00683.x

Bovine papillomaviruses: their role in the aetiology of cutaneous tumours of bovids and equids.

Abstract: Bovine papillomavirus (BPV) is perhaps the most extensively studied animal papillomavirus. In cattle BPVs induce benign tumours of cutaneous or mucosal epithelia, called papillomas or warts. Cattle papillomas are benign tumours and generally regress without eliciting any serious clinical problems in the host, but occasionally persist and provide the focus for malignant transformation to squamous cell carcinoma, as in the case of cancer of the urinary bladder and cancer of the upper alimentary canal. BPV is the only papillomavirus that jumps species: the virus also infects equids, and gives rise to fibroblastic tumours called sarcoids. Sarcoids very rarely regress, more often they persist and can be locally aggressive. These tumours are the most common dermatological tumour of equids worldwide. The purpose of this review is to discuss the biology of BPV, the biology of bovine tumours and equine sarcoids, and present the current understanding of BPV in tumour pathogenesis in its natural host, cattle, and in its heterologous host, equids. Finally, the use of anti-BPV vaccines as a therapy for equine sarcoids will be discussed. Only limited information on the clinical or pathological aspects of either bovine or equine tumours will be provided as this subject has been extensively addressed previously.
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Publication Date: 2008-10-18 PubMed ID: 18927950DOI: 10.1111/j.1365-3164.2008.00683.xGoogle Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't
  • Review

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research focuses on bovine papillomavirus (BPV), a virus extensively studied due to its role in causing benign skin and mucosal tumors, known as papillomas or warts, in animals like cattle and horses. The study further delves into BPV’s ability to affect different species, its role in the malignant transformation of benign tumors, and how potential vaccines against BPV could be used as a treatment for equine sarcoids.

Bovine Papillomavirus (BPV) and its Effect on Cattle

  • The study initially concentrates on the impact of BPV in cattle, wherein it leads to the development of benign tumors, or papillomas, in the skin and in the inner lining of body cavities or mucosal epithelia of the animals.
  • Normally, these benign tumors regress naturally without causing any serious health implications. However, there are cases when BPV becomes a contributing factor for these benign tumors to progress into malignant ones, specifically squamous cell carcinoma.
  • Examples of such progression can be seen in cancers of the urinary bladder and the upper alimentary canal of cattle.

Bovine Papillomavirus (BPV) and its Cross-Species Impact

  • One of the unique features of BPV, as pointed out in the study, is its ability to ‘jump species’. This means BPV also has the capacity to infect equids, or members of the horse family.
  • In equids, BPV results in the formation of fibroblastic tumors known as sarcoids, which differ from the papillomas seen in cattle. These sarcoids typically don’t regress and can sometimes become locally invasive.
  • According to the research, such tumors are the most prevalent dermatological tumors in equids globally.

Role of Vaccines in Treating BPV-Related Tumors

  • The review also touched upon potential treatments for such BPV-related conditions, particularly focusing on the use of anti-BPV vaccines.
  • Such vaccines could potentially be used as a form of therapy for equine sarcoids, offering a promising avenue for future investigations and practical applications.

Although the review does not thoroughly discuss the clinical or pathological aspects of bovine or equine tumors, it acknowledges the extensive previous research in these areas. Its main focus stays on the biology of BPV, its role in inducing tumors in its natural and heterologous hosts, and potential therapeutic interventions using vaccines.

Cite This Article

APA
Nasir L, Campo MS. (2008). Bovine papillomaviruses: their role in the aetiology of cutaneous tumours of bovids and equids. Vet Dermatol, 19(5), 243-254. https://doi.org/10.1111/j.1365-3164.2008.00683.x

Publication

Veterinary dermatology
ISSN: 1365-3164
NlmUniqueID: 9426187
Country: England
Language: English
Volume: 19
Issue: 5
Pages: 243-254

Researcher Affiliations

Nasir, Lubna
  • Division of Pathological Sciences, Institute of Comparative Medicine, University of Glasgow, Garscube Estate, Glasgow G61 1QH. l.nasir@vet.gla.ac.uk
Campo, M Saveria

    MeSH Terms

    • Animals
    • Cattle
    • Cattle Diseases / virology
    • Horse Diseases / virology
    • Horses
    • Papillomaviridae
    • Papillomavirus Infections / etiology
    • Papillomavirus Infections / veterinary
    • Skin Neoplasms / veterinary
    • Skin Neoplasms / virology

    Grant Funding

    • Cancer Research UK
    • Medical Research Council

    Citations

    This article has been cited 69 times.
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