Cardiopulmonary effects of dopamine hydrochloride in anaesthetised horses.
Abstract: Dopamine hydrochloride was infused intravenously into six horses anaesthetised with halothane. Three dose rates; 0.5, 2.5 and 5.0 micrograms/kg/min, were evaluated in each horse. The cardiac output was significantly increased at 15 and 30 mins following administration of dopamine at 2.5 and 5.0 micrograms/kg/min. The heart rate, facial artery pressure and pulmonary artery pressure remained unchanged. Total peripheral resistance was significantly decreased at 30 mins with 2.5 micrograms/kg/min and at 15 and 30 mins with 5.0 micrograms/kg/min. No significant change was produced in packed cell volume, total protein, white blood cell count, platelets, glucose or lactate at any infusion rate. Supraventricular premature contractions occurred in one horse and episodes of tachycardia occurred in two horses during infusion of dopamine at 5.0 micrograms/kg/min. The results of the investigation demonstrated that dopamine administered at 2.5 and 5.0 micrograms/kg/min effectively increased the cardiac output of halothane anaesthetised horses and that dopamine at the high dosage may cause dysrhythmias.
Publication Date: 1985-01-01 PubMed ID: 3979372DOI: 10.1111/j.2042-3306.1985.tb02038.xGoogle Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research investigates the effects of a dopamine hydrochloride infusion on the heart and lungs of horses under anesthesia, discovering that certain doses of dopamine significantly increased cardiac output, while possibly producing irregular heart rhythms at higher doses.
Objective and Methodology
- The main aim of this research study was to explore the effects of dopamine hydrochloride on the cardiopulmonary responses in horses that were anaesthetised with halothane.
- The research was conducted by administering intravenous dopamine hydrochloride to six horses. The researchers used three different dosage rates: 0.5, 2.5, and 5.0 micrograms/kg/minute.
Results
- The findings demonstrated that dopamine deliveries at the rates of 2.5 and 5.0 micrograms/kg/min significantly boosted the cardiac output (the quantity of blood the heart pumps) of the horses at 15 and 30 minutes following their administration.
- It was observed that the rate of heartbeat, arterial pressure across the face, and pulmonary artery pressure did not alter during the experiment.
- The total peripheral resistance, which refers to the resistance that the circulatory system presents to blood flow, was significantly diminished at 30 minutes following the administration of 2.5 micrograms/kg/min of dopamine and at 15 and 30 minutes post the administration of 5.0 micrograms/kg/min.
- The researchers found no significant changes in packed cell volume, total protein, the count of white blood cells, platelets, glucose, or lactate levels across any of the infusion rates.
- The team recorded supraventricular premature contractions (a type of irregular heart rhythm) in one horse and instances of tachycardia (an abnormal rapid heart rate) in two horses during the infusion of dopamine at 5.0 micrograms/kg/min.
Conclusions
- The study concluded that dopamine hydrochloride, when administered at 2.5 and 5.0 micrograms/kg/min, effectively amped up the cardiac output in horses anaesthetised with halothane.
- The researchers also noted that higher dosages might induce dysrhythmias — irregular patterns in the heartbeat rhythm.
Cite This Article
APA
Trim CM, Moore JN, White NA.
(1985).
Cardiopulmonary effects of dopamine hydrochloride in anaesthetised horses.
Equine Vet J, 17(1), 41-44.
https://doi.org/10.1111/j.2042-3306.1985.tb02038.x Publication
Researcher Affiliations
MeSH Terms
- Anesthesia, Inhalation / veterinary
- Animals
- Cardiovascular System / drug effects
- Dopamine / administration & dosage
- Dose-Response Relationship, Drug
- Halothane
- Hemodynamics / drug effects
- Horses / physiology
- Male
- Pulmonary Artery / drug effects
- Time Factors
Citations
This article has been cited 1 times.- Gasthuys F, Vandamme R, De Moor A, De Meurichy W. Haemodynamic, metabolic and physical responses to a neuroleptanalgesic-glyceryl guaiacolate combination in the horse. Vet Res Commun 1989;13(2):113-26.
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