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Home / Equine Research Bank / Acta Vet Scand / Cardiovascular changes after administration of aerosolized s...
Acta veterinaria Scandinavica2014; 56(1); 49; doi: 10.1186/s13028-014-0049-z

Cardiovascular changes after administration of aerosolized salbutamol in horses: five cases.

Abstract: Prevention and treatment of intraoperative hypoxemia in horses is difficult and both efficacy and safety of therapeutic maneuvers have to be taken into account. Inhaled salbutamol has been suggested as treatment of hypoxia in horses during general anesthesia, due to safety and ease of the technique. The present report describes the occurrence of clinically relevant unwanted cardiovascular effects (i.e. tachycardia and blood pressure modifications) in 5 horses undergoing general anesthesia in dorsal recumbency after salbutamol inhalation. Balanced anesthesia based on inhalation of isoflurane in oxygen or oxygen and air and continuous rate infusion (CRI) of lidocaine, romifidine, or combination of lidocaine and guaifenesine and ketamine was provided. Supportive measures were necessary to restore normal cardiovascular function in all horses but no long-term adverse effects were noticed in any of the cases.
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Publication Date: 2014-08-14 PubMed ID: 25124268PubMed Central: PMC4236592DOI: 10.1186/s13028-014-0049-zGoogle Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article investigates the negative cardiovascular effects of administering aerosolized salbutamol to horses under general anesthesia. In spite of its benefits, the use of salbutamol caused tachycardia and blood pressure changes requiring supportive measures to restore normal functioning.

Research Background

  • The study focuses on the difficulties encountered in preventing and treating intraoperative hypoxemia in horses.
  • One proposed solution to these issues has been the use of inhaled salbutamol due to its user-friendly technique and perceived safety.
  • However, concerns were raised over some clinically significant unwanted cardiovascular effects.

Methodology

  • The research analyzes the cardiovascular effects of salbutamol in five horses undergoing general anesthesia in dorsal recumbency, a common position for surgeries on the ventral side.
  • A balanced anesthesia was provided, composed of isoflurane inhalation given in oxygen or a combination of oxygen and air, coupled with continuous rate infusion (CRI) of lidocaine, romifidene, or a combination of lidocaine, guaifenesine, and ketamine.

Findings

  • The inhalation of salbutamol caused significant negative cardiovascular side effects, specifically tachycardia (an abnormally rapid heart rate) and modifications to blood pressure.
  • These side effects necessitated the use of supportive measures in order to return the cardiovascular function of the horses to normal.
  • Despite these side effects, no lasting adverse consequences were observed in any of the study subjects.

Conclusion

  • While the study did not forget the beneficial aspects of salbutamol’s use in treating hypoxia during general anesthesia, it cautiously pointed out the occurrence of negative cardiovascular side effects.
  • The results thus made clear that, while salbutamol can be an effective treatment technique, its administration must be closely monitored to prevent possible cardiovascular issues.
  • Further research would be warranted to investigate these side effects and to develop safer treatment strategies.

Cite This Article

APA
Casoni D, Spadavecchia C, Adami C. (2014). Cardiovascular changes after administration of aerosolized salbutamol in horses: five cases. Acta Vet Scand, 56(1), 49. https://doi.org/10.1186/s13028-014-0049-z

Publication

Acta veterinaria Scandinavica
ISSN: 1751-0147
NlmUniqueID: 0370400
Country: England
Language: English
Volume: 56
Issue: 1
Pages: 49

Researcher Affiliations

Casoni, Daniela
    Spadavecchia, Claudia
      Adami, Chiara

        MeSH Terms

        • Adrenergic beta-2 Receptor Agonists / toxicity
        • Aerosols
        • Albuterol / toxicity
        • Anesthesia, General / veterinary
        • Animals
        • Cardiovascular System / drug effects
        • Female
        • Horse Diseases / chemically induced
        • Horses
        • Hypotension / chemically induced
        • Hypotension / veterinary
        • Male
        • Tachycardia / chemically induced
        • Tachycardia / veterinary
        • Ventricular Fibrillation / chemically induced
        • Ventricular Fibrillation / veterinary

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