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Home / Equine Research Bank / J Vet Intern Med / Cardiovascular, colloid osmotic pressure, and hemostatic eff...
Journal of veterinary internal medicine2013; 28(1); 223-233; doi: 10.1111/jvim.12245

Cardiovascular, colloid osmotic pressure, and hemostatic effects of 2 formulations of hydroxyethyl starch in healthy horses.

Abstract: Lower molecular weight and molar substitution formulations of hydroxyethyl starch (HES) solutions might maximize cardiovascular function and colloid osmotic pressure (COP) and minimize adverse effects on coagulation. Objective: To compare effects of 1 low and 1 high molecular weight and molar substitution HES solution on cardiovascular variables, COP, and hemostasis in normal horses. Methods: Eight healthy adult horses. Methods: Randomized, crossover designed study: 10 mL/kg bolus of 6% HES (600/0.75) (hetastarch) (HS), 6% HES (130/0.4) tetrastarch (TS), and 0.9% NaCl (NS). Variables recorded included central venous pressure (CVP), noninvasive arterial blood pressure, packed cell volume (PCV), COP, and automated platelet analysis (CT). Results: Central venous pressure was increased for 8 hours after all treatment (baseline = 8.4 ± 3.8; 8 hours = 10.3 ± 3.5 cm H2 O; P < .001). HS and TS produced an increase in systolic arterial pressure (HS = 109.1 ± 11.9; TS = 109.5 ± 10.9 mmHg) and mean arterial pressure (HS = 80.4 ± 13.0; TS = 82.3 ± 10.1 mmHg) compared to NS (SAP = 103.2 ± 13.2 [P = .023]; MAP = 74.2 ± 11.4 mmHg [P = .048]). PCV decreased transiently with HS (baseline = 37.1 ± 4.4%; 1.5 hours = 31.6 ± 3.9%) and TS (baseline = 38.4 ± 3.9%; 1.5 hours = 32.2 ± 3.3%), but not NS (P = .007). COP was greater with HS (1 hour; 24.0 ± 2.1 mmHg) and TS (8 hours; 25.9 ± 2.1 mmHg) than NS (1 hour = 20.8 ± 2.6; 8 hours = 22.9 ± 3.1 mmHg; P < .001). CT was greater at 8 (HS = 178.6 ± 36.9; TS = 121.9 ± 33.3; NS = 108.3 ± 23.6 seconds) and 24 hours (HS = 174.2 ± 41.7; TS = 100.8 ± 26.0; NS = 118.7 ± 38.7 seconds; P < .001) in horses receiving HS than TS or NS. Conclusions: Both TS and HS resulted in more effective volume expansion and arterial pressure support than NS. TS produced a more sustained effect on COP with shorter duration of adverse effects on platelet function than HS.
Copyright © 2013 by the American College of Veterinary Internal Medicine.
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Publication Date: 2013-11-13 PubMed ID: 24428324PubMed Central: PMC4895541DOI: 10.1111/jvim.12245Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research examines the cardiovascular, colloid osmotic pressure, and hemostatic effects of two different forms of hydroxyethyl starch (HES) in healthy horses. The study findings suggest that both high and low molecular weight HES can effectively enhance volume expansion and arterial pressure, with the tetrastarch (TS) version proving more effective in sustaining colloid osmotic pressure and having less adverse impact on platelet function.

Research Objectives and Methods

  • The main objective of the study was to analyse and compare the effects of two HES solutions differing in molecular weight and molar substitution on equine cardiovascular parameters, colloid osmotic pressure (COP), and hemostasis.
  • The research model involved eight healthy adult horses, which were subjected to a randomized crossover study design. Each horse received boluses of high molecular weight HES (named hetastarch or HS), lower molecular weight HES (called tetrastarch or TS), and a saline solution (designated as NS).
  • Several physiological parameters were measured, including central venous pressure (CVP), arterial blood pressure, packed cell volume (PCV), COP, and coagulation times, which were assessed using automated platelet analysis (CT).

Results of the Study

  • The results showed that CVP was elevated for 8 hours following all treatments. Both HS and TS caused an increase in systolic (SAP) and mean arterial pressure (MAP) compared to the saline solution.
  • PCV temporarily dropped with HS and TS, but this was not observed with NS. The COP was higher for both HS (at 1 hour) and TS (at 8 hours) than the saline solution.
  • Coagulation times were lengthier at 8 and 24 hours in horses given HS rather than TS or saline, indicating a more prolonged adverse effect on platelet function.

Conclusions

  • The research concluded that both HS and TS were more efficient than saline at facilitating volume expansion and supporting arterial pressure in horses.
  • When compared to HS, TS demonstrated a more lasting effect on COP and showed a shorter duration of adverse effects on platelet function, making it potentially the more desirable option for this application.

Cite This Article

APA
Epstein KL, Bergren A, Giguère S, Brainard BM. (2013). Cardiovascular, colloid osmotic pressure, and hemostatic effects of 2 formulations of hydroxyethyl starch in healthy horses. J Vet Intern Med, 28(1), 223-233. https://doi.org/10.1111/jvim.12245

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 28
Issue: 1
Pages: 223-233

Researcher Affiliations

Epstein, K L
  • Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA.
Bergren, A
    Giguère, S
      Brainard, B M

        MeSH Terms

        • Animals
        • Blood Pressure / physiology
        • Cross-Over Studies
        • Female
        • Hemostasis
        • Horses / physiology
        • Hydroxyethyl Starch Derivatives / administration & dosage
        • Hydroxyethyl Starch Derivatives / pharmacology
        • Infusions, Intravenous / veterinary
        • Male
        • Osmotic Pressure / physiology
        • Partial Thromboplastin Time / veterinary
        • Plasma Substitutes / administration & dosage
        • Plasma Substitutes / pharmacology
        • Platelet Aggregation / physiology
        • Prothrombin Time / veterinary
        • Random Allocation

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        Citations

        This article has been cited 8 times.
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