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Veterinary surgery : VS1987; 16(3); 245-250; doi: 10.1111/j.1532-950x.1987.tb00947.x

Cardiovascular effects of intravenous sodium penicillin, sodium cefazolin, and sodium citrate in awake and anesthetized horses.

Abstract: Sodium penicillin, sodium cefazolin, and sodium citrate were administered to six adult horses on separate occasions, when awake and during anesthesia. The order of administration was randomized and studies were separated by a minimum of 7 days. Arterial blood pressure decreased significantly (less than 0.05) from control 5 minutes after intravenous (IV) sodium penicillin in awake and anesthetized horses. Systolic arterial blood pressure remained significantly (less than 0.05) decreased 10 minutes after IV sodium penicillin in anesthetized horses. Sodium cefazolin and sodium citrate did not significantly affect any of the measured cardiovascular variables. Although the changes in arterial blood pressure were small (8-15 mm Hg), monitoring of arterial blood pressure is advised when sodium penicillin is administered IV to anesthetized horses.
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Publication Date: 1987-05-01 PubMed ID: 3507151DOI: 10.1111/j.1532-950x.1987.tb00947.xGoogle Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses the cardiovascular effects of intravenous sodium penicillin, sodium cefazolin, and sodium citrate on awake and anaesthetized horses. The study found that sodium penicillin significantly decreased arterial blood pressure in these animals, while sodium cefazolin and sodium citrate did not have any significant effect on cardiovascular variables.

Study Design

  • The research involved the administration of sodium penicillin, sodium cefazolin, and sodium citrate to six adult horses.
  • These compounds were administered separately, and the horses were both awake and under anesthesia during administration.
  • To ensure a fair test, the order of administration was randomized and each administration was separated by a minimum of seven days.

Observations and Results

  • In the case of intravenous sodium penicillin, it was observed that arterial blood pressure decreased significantly five minutes after administration. This was observed in both awake and anesthetized horses.
  • Further, it was noted that systolic arterial blood pressure still remained significantly diminished ten minutes after intravenous sodium penicillin was given to anesthetized horses.
  • On the other hand, neither sodium cefazolin nor sodium citrate significantly impacted any of the measured cardiovascular variables.

Discussion

  • Although the decrease in arterial blood pressure post administration of sodium penicillin was small (between 8 and 15 mm Hg), the researchers advise monitoring of arterial blood pressure during intravenous administration of the medication to anesthetized horses.
  • This precaution ensures the safety and well-being of the horses, particularly during surgical procedures or other medical procedures requiring anesthesia.

Conclusions

  • The findings indicate that sodium penicillin can cause a significant decrease in arterial blood pressure in horses, both awake and anesthetized, warranting monitoring of these animals during intravenous administration of this antibiotic.
  • In contrast, sodium cefazolin and sodium citrate do not appear to have a marked effect on the cardiovascular system.

Cite This Article

APA
Hubbell JA, Muir WW, Robertson JT, Sams RA. (1987). Cardiovascular effects of intravenous sodium penicillin, sodium cefazolin, and sodium citrate in awake and anesthetized horses. Vet Surg, 16(3), 245-250. https://doi.org/10.1111/j.1532-950x.1987.tb00947.x

Publication

Veterinary surgery : VS
ISSN: 0161-3499
NlmUniqueID: 8113214
Country: United States
Language: English
Volume: 16
Issue: 3
Pages: 245-250

Researcher Affiliations

Hubbell, J A
  • Department of Veterinary Clinical Sciences, Ohio State University, College of Veterinary Medicine, Columbus.
Muir, W W
    Robertson, J T
      Sams, R A

        MeSH Terms

        • Anesthesia, General / veterinary
        • Animals
        • Blood Gas Analysis / veterinary
        • Blood Pressure / drug effects
        • Cardiac Output / drug effects
        • Cefazolin / pharmacology
        • Central Venous Pressure / drug effects
        • Citrates / pharmacology
        • Citric Acid
        • Female
        • Heart Rate / drug effects
        • Horses / physiology
        • Injections, Intravenous / veterinary
        • Male
        • Penicillins / administration & dosage
        • Penicillins / pharmacology
        • Random Allocation
        • Respiration / drug effects

        Citations

        This article has been cited 7 times.
        1. Rockow M, Griffenhagen G, Landolt G, Hendrickson D, Pezzanite L. Current Antimicrobial Use in Horses Undergoing Exploratory Celiotomy: A Survey of Board-Certified Equine Specialists. Animals (Basel) 2023 Apr 22;13(9).
          doi: 10.3390/ani13091433pubmed: 37174470google scholar: lookup
        2. Gandini M, Cerullo A, Franci P, Giusto G. Changes in Perioperative Antimicrobial and Anti-Inflammatory Drugs Regimens for Colic Surgery in Horses: A Single Center Report. Vet Sci 2022 Oct 4;9(10).
          doi: 10.3390/vetsci9100546pubmed: 36288159google scholar: lookup
        3. Gomez DE, Li L, Goetz H, MacNicol J, Gamsjaeger L, Renaud DL. Calf Diarrhea Is Associated With a Shift From Obligated to Facultative Anaerobes and Expansion of Lactate-Producing Bacteria. Front Vet Sci 2022;9:846383.
          doi: 10.3389/fvets.2022.846383pubmed: 35392114google scholar: lookup
        4. Ceriotti S, Westerfeld R, Bonilla AG, Pang DSJ. Use of Clinical Audits to Evaluate Timing of Preoperative Antimicrobials in Equine Surgery at a Veterinary Teaching Hospital. Front Vet Sci 2021;8:630111.
          doi: 10.3389/fvets.2021.630111pubmed: 33842572google scholar: lookup
        5. Weese JS, Cruz A. Retrospective study of perioperative antimicrobial use practices in horses undergoing elective arthroscopic surgery at a veterinary teaching hospital. Can Vet J 2009 Feb;50(2):185-8.
          pubmed: 19412399
        6. Hardefeldt L, Thomas K, Page S, Norris J, Browning G, El Hage C, Stewart A, Gilkerson J, Muscatello G, Verwilghen D, van Galen G, Bauquier J, Cuming R, Reynolds B, Whittaker C, Wilkes E, Clulow J, Burden C, Begg L. Antimicrobial prescribing guidelines for horses in Australia. Aust Vet J 2025 Dec;103(12):781-889.
          doi: 10.1111/avj.70003pubmed: 40903020google scholar: lookup
        7. Recchi L, Cribb N, Côté N, Dubois MS, Koenig J, Valverde A, Monteith G. Retrospective study of perioperative antimicrobial use in horses undergoing elective laparoscopy at a single institution. Can J Vet Res 2024 Jan;88(1):24-29.
          pubmed: 38222072
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