Cartilage defect repair in horses: Current strategies and recent developments in regenerative medicine of the equine joint with emphasis on the surgical approach.
Abstract: Chondral and osteochondral lesions due to injury or other pathology are highly prevalent conditions in horses (and humans) and commonly result in the development of osteoarthritis and progression of joint deterioration. Regenerative medicine of articular cartilage is an emerging clinical treatment option for patients with articular cartilage injury or disease. Functional articular cartilage restoration, however, remains a major challenge, but the field is progressing rapidly and there is an increasing body of supportive clinical and scientific evidence. This review gives an overview of the established and emerging surgical techniques employed for cartilage repair in horses. Through a growing insight in surgical cartilage repair possibilities, surgeons might be more stimulated to explore novel techniques in a clinical setting.
Copyright © 2016 Elsevier Ltd. All rights reserved.
Publication Date: 2016-02-13 PubMed ID: 27387728DOI: 10.1016/j.tvjl.2016.02.005Google Scholar: Lookup
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- Journal Article
- Review
Summary
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The research article discusses current practices and advancements in the field of regenerative medicine, specifically concerning the repair of cartilage defects in horses’ joints and emphasizes the importance of the surgical approach.
Objective of the Research
- The primary objective of the research is to provide an overview of the current and emerging surgical techniques utilized for the repair of cartilage defects in horses. It gives a detailed account of the existing procedures and focuses on the advancements made in regenerative medicine to treat articular cartilage injury or disease.
Issues Addressed
- The article explains the prevalent conditions of chondral and osteochondral lesions in horses due to injury or other pathologic reasons. The research discusses these lesions as they often lead to the development of osteoarthritis and deteriorate the state of the joint further.
- The researchers also highlight the challenge of functional articular cartilage restoration, while noting that the area of study is progressing rapidly.
The Role of Regenerative Medicine
- Indicated as an emerging treatment option, regenerative medicine works towards treatment and recovery of cartilage injuries and related diseases. This field shows promise in providing new approaches and methods that can bring significant advancements to the conventional methods of treatment for such injuries in horses.
Significance of the Research
- The research is of considerable importance as it encourages surgeons to explore and utilize novel techniques in a clinical setting, through increased understanding of the possibilities of surgical cartilage repair.
- Furthermore, it adds to the growing body of scientific and clinical evidence supporting the use of regenerative medicine practices. It also underscores the potential benefits of these treatments for horses, and by extension, possibly for humans as well.
Cite This Article
APA
Cokelaere S, Malda J, van Weeren R.
(2016).
Cartilage defect repair in horses: Current strategies and recent developments in regenerative medicine of the equine joint with emphasis on the surgical approach.
Vet J, 214, 61-71.
https://doi.org/10.1016/j.tvjl.2016.02.005 Publication
Researcher Affiliations
- Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 112, 3584 CM Utrecht, NL, Netherlands. Electronic address: S.M.Cokelaere@uu.nl.
- Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 112, 3584 CM Utrecht, NL, Netherlands; Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, NL, Netherlands.
- Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 112, 3584 CM Utrecht, NL, Netherlands.
MeSH Terms
- Animals
- Cartilage Diseases / surgery
- Cartilage Diseases / veterinary
- Cartilage, Articular / pathology
- Cartilage, Articular / surgery
- Horse Diseases / surgery
- Horses
- Joint Diseases / surgery
- Joint Diseases / veterinary
- Joints / surgery
- Regenerative Medicine / methods
Citations
This article has been cited 7 times.- Honkanen MKM, Mohammadi A, Te Moller NCR, Ebrahimi M, Xu W, Plomp S, Pouran B, Lehto VP, Brommer H, van Weeren PR, Korhonen RK, Töyräs J, Mäkelä JTA. Dual-contrast micro-CT enables cartilage lesion detection and tissue condition evaluation ex vivo.. Equine Vet J 2023 Mar;55(2):315-324.
- Zayed M, Adair S, Dhar M. Effects of Normal Synovial Fluid and Interferon Gamma on Chondrogenic Capability and Immunomodulatory Potential Respectively on Equine Mesenchymal Stem Cells.. Int J Mol Sci 2021 Jun 15;22(12).
- Watkins A, Fasanello D, Stefanovski D, Schurer S, Caracappa K, D'Agostino A, Costello E, Freer H, Rollins A, Read C, Su J, Colville M, Paszek M, Wagner B, Reesink H. Investigation of synovial fluid lubricants and inflammatory cytokines in the horse: a comparison of recombinant equine interleukin 1 beta-induced synovitis and joint lavage models.. BMC Vet Res 2021 May 12;17(1):189.
- Ribitsch I, Oreff GL, Jenner F. Regenerative Medicine for Equine Musculoskeletal Diseases.. Animals (Basel) 2021 Jan 19;11(1).
- Bourebaba L, Michalak I, Baouche M, Kucharczyk K, Marycz K. Cladophora glomerata methanolic extract promotes chondrogenic gene expression and cartilage phenotype differentiation in equine adipose-derived mesenchymal stromal stem cells affected by metabolic syndrome.. Stem Cell Res Ther 2019 Dec 17;10(1):392.
- Viganò M, Tessaro I, Trovato L, Colombini A, Scala M, Magi A, Toto A, Peretti G, de Girolamo L. Rationale and pre-clinical evidences for the use of autologous cartilage micrografts in cartilage repair.. J Orthop Surg Res 2018 Nov 6;13(1):279.
- Yousefi F, Kim M, Nahri SY, Mauck RL, Pleshko N. Near-Infrared Spectroscopy Predicts Compositional and Mechanical Properties of Hyaluronic Acid-Based Engineered Cartilage Constructs.. Tissue Eng Part A 2018 Jan;24(1-2):106-116.
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