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Molecular biology reports2012; 39(12); 10957-10970; doi: 10.1007/s11033-012-1997-x

Cathelicidins: family of antimicrobial peptides. A review.

Abstract: Cathelicidins are small, cationic, antimicrobial peptides found in humans and other species, including farm animals (cattle, horses, pigs, sheep, goats, chickens, rabbits and in some species of fish). These proteolytically activated peptides are part of the innate immune system of many vertebrates. These peptides show a broad spectrum of antimicrobial activity against bacteria, enveloped viruses and fungi. Apart from exerting direct antimicrobial effects, cathelicidins can also trigger specific defense responses in the host. Their roles in various pathophysiological conditions have been studied in mice and humans, but there are limited information about their expression sites and activities in livestock. The aim of the present review is to summarize current information about these antimicrobial peptides in farm animals, highlighting peptide expression sites, activities, and future applications for human and veterinary medicine.
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Publication Date: 2012-10-14 PubMed ID: 23065264PubMed Central: PMC3487008DOI: 10.1007/s11033-012-1997-xGoogle Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article is a review focusing on cathelicidins, small antimicrobial peptides that form part of the innate immune system in many vertebrates, highlighting their expression sites, activities, and potential future applications in both human and veterinary medicine.

Introduction to Cathelicidins

  • Cathelicidins are small cationic (positively charged) antimicrobial peptides, found in a variety of species including humans and many types of farm animals.
  • These peptides are part of the innate immune system, the body’s first line of defense against microbial pathogens, for many vertebrates including birds, mammals, and some types of fish.

Antimicrobial Activity of Cathelicidins

  • Cathelicidins show a wide range of antimicrobial activity against various potential pathogens including bacteria, enveloped viruses, and fungi.
  • The wide range of their activity makes them a crucial component of the immune system for many species.

Cathelicidins and Host Defense Responses

  • Beyond their direct antimicrobial effects, cathelicidins can also trigger specific defense responses in the host.
  • This means they also have an immunomodulatory role, helping to coordinate the immune response to infection.

Role of Cathelicidins in Pathophysiological Conditions

  • The role of cathelicidins in various disease conditions has been studied in mice and humans, where aberrant regulation or function of these peptides can contribute to disease pathogenesis.
    • Despite the evidence implicating cathelicidins in various diseases in mice and humans, there is limited information about the expression sites and activities of these peptides in livestock.

    Aim of the Review

    • The aim of the present review is to summarize the current knowledge of these antimicrobial peptides in farm animals.
    • It will highlight where these peptides are expressed, their activities, and potential future uses in human and veterinary medicine.

Cite This Article

APA
Kościuczuk EM, Lisowski P, Jarczak J, Strzałkowska N, Jóźwik A, Horbańczuk J, Krzyżewski J, Zwierzchowski L, Bagnicka E. (2012). Cathelicidins: family of antimicrobial peptides. A review. Mol Biol Rep, 39(12), 10957-10970. https://doi.org/10.1007/s11033-012-1997-x

Publication

Molecular biology reports
ISSN: 1573-4978
NlmUniqueID: 0403234
Country: Netherlands
Language: English
Volume: 39
Issue: 12
Pages: 10957-10970

Researcher Affiliations

Kościuczuk, Ewa M
  • Institute of Genetics and Animal Breeding in Jastrzębiec, Polish Academy of Sciences, 05-552, Magdalenka, Poland.
Lisowski, Paweł
    Jarczak, Justyna
      Strzałkowska, Nina
        Jóźwik, Artur
          Horbańczuk, Jarosław
            Krzyżewski, Józef
              Zwierzchowski, Lech
                Bagnicka, Emilia

                  MeSH Terms

                  • Amino Acid Sequence
                  • Animals
                  • Cathelicidins / chemistry
                  • Cathelicidins / genetics
                  • Cathelicidins / metabolism
                  • Cathelicidins / pharmacology
                  • Genetic Variation
                  • Humans
                  • Molecular Sequence Data

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