Ceftiofur Side Effect in a Mare-Case Report.
Abstract: Adverse drug reactions in horses are rare. The antimicrobials are in the list of the most common drugs associated with reaction in horses. The aim of this report is to describe the clinical presentation of an adverse drug reaction after the intramuscular administration of ceftiofur hydrochloride. A 5-year-old crioulo broodmare at one day postpartum presented signs of difficulty to walk, positive pulse in the four limbs, and heart rate of 80 beats per minute (bpm), with a history of fighting with another mare. The clinical suspicions were rhabdomyolysis and laminitis. Initially a dose of flunixin meglumine was administrated intravenous to prevent an endotoxemia. On the same day, the blood collection showed an elevated number of white blood cells, predominantly neutrophils and monocytes. An antimicrobial treatment with ceftiofur hydrochloride at a dose of 2.2 mg/kg intramuscular was applied. At the first day, the mare does not show signs of drug side effect. However, 24 hours later, in the second application, the patient presents incoordination, dizziness, and loss of equilibrium. At the same time, dexamethasone was administrated. The signs were reverted, and the mare was normal after the reaction. The treatment with ceftiofur was changed to enrofloxacin, and the animal had a complete recovery. These drug reactions are not common in the routine of equine clinical practitioners, but they cause a great preoccupation for the owner and the veterinarian.
Copyright © 2020 Elsevier Inc. All rights reserved.
Publication Date: 2020-10-12 PubMed ID: 33276911DOI: 10.1016/j.jevs.2020.103295Google Scholar: Lookup
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Summary
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The research article discusses a rare case of adverse drug reaction observed in a mare post-administration of the antibiotic ceftiofur hydrochloride. The reaction manifested as difficulty in walking, heart rate fluctuations, and incoordination, that were thankfully reversed.
Overview and Purpose of the Study
- The researchers aim to document and describe a peculiar instance of adverse drug reaction in a 5-year-old Crioulo broodmare which had recently given birth.
- Rare but severe side effects of antibiotics in horses serve as a significant concern for caretakers and veterinarians.
Case Description and Initial Symptoms
- The mare showed signs of difficulty in walking and increased pulse and heart rate after fighting with another mare.
- Initial diagnosis pointed towards rhabdomyolysis (a condition where muscle tissue breaks down) and laminitis (inflammation of the tissue inside the hoof).
- As a preventive measure against endotoxemia (presence of toxins in the blood), a dose of flunixin meglumine was administered intravenously.
Prior to Drug Reaction
- Blood results showed high counts of white blood cells, specifically neutrophils and monocytes, indicating possible infection.
- To combat this infection, the mare was treated with ceftiofur hydrochloride, a potent antibiotic usually well-tolerated by horses.
The Drug Reaction
- The first day of treatment passed without any signs of adverse drug reactions. However, upon administering the second dose, the mare manifested signs of incoordination, dizziness, and balance loss.
- The symptoms resolved shortly after administration of dexamethasone, a type of steroid medication.
- Given the reaction to ceftiofur hydrochloride, treatment was shifted to enrofloxacin, another antibiotic, resulting in complete recovery of the mare.
Significance of the Study
- Such incidents, although rare, highlight the importance of monitoring animals post-treatment and adjusting treatment plans if adverse reactions occur.
- This study provides valuable data for veterinarians and horse owners on potential side effects of antibiotics, fostering informed decisions regarding equine health.
Cite This Article
APA
Pradella GD, Taschetto PM, Duarte CA, da Silva Azevedo M, Góss GC.
(2020).
Ceftiofur Side Effect in a Mare-Case Report.
J Equine Vet Sci, 95, 103295.
https://doi.org/10.1016/j.jevs.2020.103295 Publication
Researcher Affiliations
- Universidade Federal do Pampa (UNIPAMPA), Uruguaiana, RS. Electronic address: gabrieladowich@hotmail.com.
- Master's Student at Universidade Federal do Pampa (UNIPAMPA), Uruguaiana, RS.
- Researcher Teacher at Universidade Federal do Pampa (UNIPAMPA), Uruguaiana, RS.
- Researcher Teacher at Universidade Federal do Pampa (UNIPAMPA), Uruguaiana, RS.
- Master's Student at Universidade Federal do Pampa (UNIPAMPA), Uruguaiana, RS.
MeSH Terms
- Animals
- Anti-Bacterial Agents / adverse effects
- Cephalosporins / adverse effects
- Drug-Related Side Effects and Adverse Reactions / veterinary
- Female
- Horse Diseases
- Horses
Citations
This article has been cited 1 times.- Thomson P, García P, Río CD, Castro R, Núñez A, Miranda C. Antimicrobial Resistance and Extended-Spectrum Beta-Lactamase Genes in Enterobacterales, Pseudomonas and Acinetobacter Isolates from the Uterus of Healthy Mares. Pathogens 2023 Sep 8;12(9).
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