Cell-based cartilage repair strategies in the horse.
Abstract: Damage to the articular cartilage surface is common in the equine athlete and, due to the poor intrinsic healing capabilities of cartilage, can lead to osteoarthritis (OA). Joint disease and OA are the leading cause of retirement in equine athletes and currently there are no effective treatments to stop the progression of OA. Several different cell-based strategies have been investigated to bolster the weak regenerative response of chondrocytes. Such techniques aim to restore the articular surface and prevent further joint degradation. Cell-based cartilage repair strategies include enhancement of endogenous repair mechanisms by recruitment of stem cells from the bone marrow following perforation of the subchondral bone plate; osteochondral implantation; implantation of chondrocytes that are maintained in defects by either a membrane cover or scaffold, and transplantation of mesenchymal stem cells into cartilage lesions. More recently, bioengineered cartilage and scaffoldless cartilage have been investigated for enhancing repair. This review article focuses on the multitude of cell-based repair techniques for cartilage repair across several species, with special attention paid to the horse.
Copyright © 2015 Elsevier Ltd. All rights reserved.
Publication Date: 2015-10-23 PubMed ID: 26702950DOI: 10.1016/j.tvjl.2015.10.027Google Scholar: Lookup
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Summary
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This research discusses different cell-based strategies aimed at improving cartilage repair in equine athletes. The article reviews techniques such as bone marrow stem cell recruitment, osteochondral implantation, chondrocyte implantation, and bioengineered cartilage usage as methods to prevent joint degradation and progression of osteoarthritis in horses.
Issues with Equine Cartilage Damage
- The article first addresses the problem of damage to articular cartilage in equine athletes, attributing it as a common issue that can result in osteoarthritis due to the limited healing capabilities of cartilage. The author explains that joint disease and osteoarthritis are primary reasons for retirement in these animals.
- The writer also indicates a gap in current treatments, arguing they lack effectiveness in halting the progression of osteoarthritis.
Cell-Based Cartilage Repair Strategies
- The author offers several cell-based strategies as possible solutions to enhance chondrocytes’ weak regenerative response. The goal of these strategies is to restore the articular surface and prevent further joint deformation.
- The article identifies various strategies including the enhancement of endogenous repair mechanisms. One such approach is the recruitment of stem cells from the bone marrow following the perforation of the subchondral bone plate.
- Other techniques mentioned include osteochondral implantation, chondrocytes’ implantation maintained in defects by either a membrane cover or scaffold, and transplantation of mesenchymal stem cells into cartilage lesions.
- More innovative methods, such as bioengineered and scaffoldless cartilage, are also discussed as potential avenues for enhancing repair.
Focus on Equine Repair Techniques
- This review focuses specifically on the variety of cell-based repair techniques for cartilage repair in several species, with a particular focus on horses, given their high susceptibility to joint disease and osteoarthritis.
- The article aims to provide a comprehensive look at the various strategies available for the enhancement of cartilage repair, raising potential solutions to a significant issue in equine health and performance.
Cite This Article
APA
Ortved KF, Nixon AJ.
(2015).
Cell-based cartilage repair strategies in the horse.
Vet J, 208, 1-12.
https://doi.org/10.1016/j.tvjl.2015.10.027 Publication
Researcher Affiliations
- Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA. Electronic address: ko222@cornell.edu.
- Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA.
MeSH Terms
- Animals
- Cartilage, Articular / physiology
- Chondrocytes / physiology
- Horse Diseases / pathology
- Horse Diseases / therapy
- Horses
- Mesenchymal Stem Cell Transplantation / veterinary
- Osteoarthritis / pathology
- Osteoarthritis / therapy
- Osteoarthritis / veterinary
- Regeneration
Citations
This article has been cited 9 times.- Baker ME, Lee S, Clinton M, Hackl M, Castanheira C, Peffers MJ, Taylor SE. Investigation of MicroRNA Biomarkers in Equine Distal Interphalangeal Joint Osteoarthritis.. Int J Mol Sci 2022 Dec 8;23(24).
- Ząbek T, Witarski W, Szmatoła T, Sawicki S, Mrozowicz J, Samiec M. Trichostatin A-Mediated Epigenetic Modulation Predominantly Triggers Transcriptomic Alterations in the Ex Vivo Expanded Equine Chondrocytes.. Int J Mol Sci 2022 Oct 29;23(21).
- Contentin R, Jammes M, Bourdon B, Cassé F, Bianchi A, Audigié F, Branly T, Velot É, Galéra P. Bone Marrow MSC Secretome Increases Equine Articular Chondrocyte Collagen Accumulation and Their Migratory Capacities.. Int J Mol Sci 2022 May 21;23(10).
- Yue Y, Xu P, Lei Z, Li K, Xu J, Wen J, Wang S, Cheng W, Lin S, Huang Z, Xu H. Preparation and characterization of a novel drug-loaded Bi-layer scaffold for cartilage regeneration.. RSC Adv 2022 Mar 25;12(16):9524-9533.
- Fülber J, Agreste FR, Seidel SRT, Sotelo EDP, Barbosa ÂP, Michelacci YM, Baccarin RYA. Chondrogenic potential of mesenchymal stem cells from horses using a magnetic 3D cell culture system.. World J Stem Cells 2021 Jun 26;13(6):645-658.
- Jiao Y, Li XY, Liu J. A New Approach to Cerebral Palsy Treatment: Discussion of the Effective Components of Umbilical Cord Blood and its Mechanisms of Action.. Cell Transplant 2019 May;28(5):497-509.
- Winter RL, Seeto WJ, Tian Y, Caldwell FJ, Lipke EA, Wooldridge AA. Growth and function of equine endothelial colony forming cells labeled with semiconductor quantum dots.. BMC Vet Res 2018 Aug 23;14(1):247.
- Desancé M, Contentin R, Bertoni L, Gomez-Leduc T, Branly T, Jacquet S, Betsch JM, Batho A, Legendre F, Audigié F, Galéra P, Demoor M. Chondrogenic Differentiation of Defined Equine Mesenchymal Stem Cells Derived from Umbilical Cord Blood for Use in Cartilage Repair Therapy.. Int J Mol Sci 2018 Feb 10;19(2).
- Rakic R, Bourdon B, Hervieu M, Branly T, Legendre F, Saulnier N, Audigié F, Maddens S, Demoor M, Galera P. RNA Interference and BMP-2 Stimulation Allows Equine Chondrocytes Redifferentiation in 3D-Hypoxia Cell Culture Model: Application for Matrix-Induced Autologous Chondrocyte Implantation.. Int J Mol Sci 2017 Aug 24;18(9).
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