Cerebrospinal fluid variables in clinically normal foals from birth to 42 days of age.
Abstract: To determine the effects of age on each analyte, CSF variables were evaluated in healthy foals from birth through 42 days of age. Cerebrospinal fluid was collected from 14 clinically normal, naturally delivered cross-bred foals and was analyzed for glucose, sodium, potassium, magnesium, and total protein concentrations, total and differential WBC counts, RBC count, and lactate dehydrogenase, aspartate transaminase, and creatine kinase activities. Samples were collected in 3 foals < 48 hours old, and at 11 to 14 days of age in 4 foals, 21 to 22 days of age in 3 foals, and 31 to 42 days of age in 4 foals. Each foal was tested only once, to avoid any effects of CSF sample collection on subsequent analysis. Regression analysis confirmed age-related effects on CSF glucose, protein, and magnesium concentrations, but did not indicate an effect of age on CSF sodium and potassium concentrations or cell counts. Results indicate that CSF glucose concentration decreases with age; foals < 2 days old had the highest CSF glucose values, 98.8 +/- 12.0 mg/dl (mean +/- 1 SD). In foals 10 to 14 days old, CSF glucose concentration was 67.3 +/- 12.0 mg/dl, was 65.3 +/- 4.5 mg/dl in foals 21 to 22 days old, was 70.0 +/- 5.4 mg/dl in foals 31 to 42 days old, and was 51.1 +/- 2.5 mg/dl in adults.(ABSTRACT TRUNCATED AT 250 WORDS)
Publication Date: 1994-06-01 PubMed ID: 7944014
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- Journal Article
Summary
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The research examined the influence of age on cerebrospinal fluid (CSF) variables in healthy foals (baby horses) from birth until 42 days of age. It was confirmed that age has an impact on CSF glucose, protein, and magnesium concentrations, while sodium, potassium concentrations, or cell counts in CSF remained unaffected.
Objective
- The objective of this study was to understand the effects of age changes on cerebrospinal fluid (CSF) variables in young foals from birth to 42 days.
Methodology
- This study involved examining CSF from 14 healthy naturally delivered cross-bred foals.
- The CSF was analyzed for various factors including glucose, sodium, potassium, magnesium, total protein concentrations, total and differential WBC counts, RBC count, and lactate dehydrogenase, aspartate transaminase, and creatine kinase activities.
- The samples were collected at different age stages for comparison: 3 foals under 48 hours old, 4 foals aged 11 to 14 days, 3 foals aged 21 to 22 days, and 4 foals aged 31 to 42 days. Each foal was only tested once to prevent any potential impact from the CSF sample collection on the subsequent analysis.
Analysis
- The study used a regression analysis to determine the effect of age on the analytes.
Findings
- The analysis demonstrated age-related effects on CSF glucose, protein, and magnesium concentrations.
- Conversely, it was found that age has no influence on CSF sodium and potassium concentrations or cell counts.
- The research established that the CSF glucose concentration decreases as foals age. The highest glucose values were observed in foals under 2 days old, with an average value of 98.8 mg/dl, followed by a gradual decrease in CSF glucose concentration as the foals aged.
Conclusion
- The study’s results indicate that age plays a significant role in shaping CSF glucose, protein and magnesium concentrations in foals up to 42 days old, while the impact on CSF sodium and potassium concentrations or cell counts was not significant.
Cite This Article
APA
Furr MO, Bender H.
(1994).
Cerebrospinal fluid variables in clinically normal foals from birth to 42 days of age.
Am J Vet Res, 55(6), 781-784.
Publication
Researcher Affiliations
- Marion duPont Scott Equine Medical Center, Virginia-Maryland Regional College of Veterinary Medicine, Leesburg 22075.
MeSH Terms
- Age Factors
- Animals
- Animals, Newborn
- Cell Count
- Central Nervous System Diseases / cerebrospinal fluid
- Central Nervous System Diseases / diagnosis
- Central Nervous System Diseases / veterinary
- Cerebrospinal Fluid / cytology
- Cerebrospinal Fluid Proteins / analysis
- Enzymes / cerebrospinal fluid
- Glucose / cerebrospinal fluid
- Horses / cerebrospinal fluid
- Magnesium / cerebrospinal fluid
- Potassium / cerebrospinal fluid
- Reference Values
- Reproducibility of Results
- Sodium / cerebrospinal fluid
Citations
This article has been cited 3 times.- Aleman M, Costa LRR, Crowe C, Kass PH. Presumed Neuroglycopenia Caused by Severe Hypoglycemia in Horses.. J Vet Intern Med 2018 Sep;32(5):1731-1739.
- Galvin N, Collins D. Perinatal asphyxia syndrome in the foal: review and a case report.. Ir Vet J 2004 Dec 1;57(12):707-14.
- Wong DM, Vo DT, Alcott CJ, Stewart AJ, Peterson AD, Sponseller BA, Hsu WH. Adrenocorticotropic hormone stimulation tests in healthy foals from birth to 12 weeks of age.. Can J Vet Res 2009 Jan;73(1):65-72.
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