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Frontiers in veterinary science2024; 11; 1503117; doi: 10.3389/fvets.2024.1503117

Changes in blood physiological and biochemical parameters and intestinal flora in newborn horses and mares with angular limb deformities.

Abstract: Angular limb deformities (ALDs) are a common skeletal development disorder in newborn foals. This condition affects the growth and development of foals and severely impacts their future athletic performance and economic value, causing significant financial losses to the horse industry. Placentitis, metritis, and severe metabolic diseases during mare pregnancy are significant causes of ALDs in newborn foals. It has been established that intestinal flora disorders can easily lead to inflammatory and metabolic diseases in the host. However, the incidence of ALDs in foals in Zhaosu County, Xinjiang, a key production area of China's horse industry, remains unclear. Additionally, the relationship between functional changes in foals with ALDs and their mares and changes in their intestinal flora is not well-understood. Unassigned: This study investigated the status of ALD in newborn foals through clinical observation and imaging examinations. In addition, molecular biological methods were applied to examine the effects of ALDs foals and their mares on physiological and biochemical markers and gut microbiota. Unassigned: The results showed that the incidence of ALD in Zhaosu area of China was 4.13%. In addition, by comparing and correlating the physiological and biochemical indicators and intestinal flora of foals and mares with ALD with those of healthy horses, it was found that foals and mares with ALD may promote the occurrence and development of the disease through the "blood marker changes-intestinal flora-ALDs" axis. In addition, by comparing the physiological and biochemical indicators and intestinal flora of foals and mares with ALD with the intestinal flora of healthy horses, it was found that the physiological and biochemical indicators and intestinal flora structure and metabolic pathways of foals and mares with ALD had significant changes. Unassigned: The diversity, species composition, and function of the intestinal flora of ALDs and their mares were significantly altered. These findings provide a scientific basis for understanding the etiology of ALDs in foals and offer new perspectives for diagnosing and treatment ALDs in newborn foals.
Copyright © 2024 Ma, Liu, Li, Yang and Yao.
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Publication Date: 2024-11-26 PubMed ID: 39660173PubMed Central: PMC11628492DOI: 10.3389/fvets.2024.1503117Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research seeks to investigate the incidence and potential causes of Angular Limb Deformities (ALDs), a common developmental disorder in newborn foals, within the horse industry in Zhaosu County, Xinjiang, China. This study focuses on assessing the correlation between ALDs and changes in the blood markers and gut microbiota of both affected foals and their mares.

Research Approach and Methods

  • The study began by examining the prevalence of Angular Limb Deformities (ALDs) within newborn foals in a concentrated horse production area in China, Zhaosu County, Xinjiang.
  • The researchers utilized clinical observation and imaging examinations to diagnose and identify foals with ALDs.
  • Molecular biological methods were then employed to help determine the physiological and biochemical markers within the blood of the foals, along with the structure, composition and function of the gut microbiota of both the affected foals and their mares.

Conclusions and Findings

  • The study determined that ALDs incidence in the examined area was around 4.13%.
  • By comparing the physiological and biochemical indicators and the gut flora of healthy horses to those of horses with ALDs, significant differences were identified that suggest a potential causal connection. The theory proposed indicates an “blood marker changes-intestinal flora-ALDs” axis, which suggests that foals and mares with ALD might contribute to the presence and progression of ALDs through changes in their blood markers and gut microbiota.
  • The diversity, species composition, and function of the gut microbiota in foals and mares with ALDs demonstrated notable changes when compared to healthy horses.
  • These findings provide valuable insights into understanding the possible origins of ALDs in foals, as well as new perspectives for diagnosing and treating ALDs in newborn foals.

In essence, these findings illuminate the potential role that altered microbiota in newborn foals and their mares might play in the onset and development of ALDs, presenting new avenues for preventative and therapeutic approaches within the horse industry.

Cite This Article

APA
Ma Y, Liu Y, Li H, Yang K, Yao G. (2024). Changes in blood physiological and biochemical parameters and intestinal flora in newborn horses and mares with angular limb deformities. Front Vet Sci, 11, 1503117. https://doi.org/10.3389/fvets.2024.1503117

Publication

Frontiers in veterinary science
ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 11
Pages: 1503117
PII: 1503117

Researcher Affiliations

Ma, Yuhui
  • College of Animal Science and Technology, Xinjiang Agricultural University, Urumqi, China.
  • College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, China.
  • Xinjiang Zhaosu County Xiyu Horse Industry Co., Ltd., Zhaosu, China.
Liu, Yigang
  • College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, China.
Li, Hai
  • College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, China.
Yang, Kailun
  • College of Animal Science and Technology, Xinjiang Agricultural University, Urumqi, China.
Yao, Gang
  • College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, China.

Conflict of Interest Statement

YM was employed by Xinjiang Zhaosu County Xiyu Horse Industry Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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