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Equine veterinary journal. Supplement1999; (27); 28-29; doi: 10.1111/j.2042-3306.1998.tb05141.x

Characterisation of headshaking syndrome–31 cases.

Abstract: Headshaking is a maturity onset condition with the most commonly reported clinical signs being 'flipping' of the nose, nose rubbing, snorting or sneezing, and acting like a bee is flying up the nostril. A questionnaire was completed by owners of 31 horses with headshaking syndrome. The history, time of onset, clinical presentation and treatment of this condition were reported. Headshaking appeared to be light-stimulated in approximately 60% of the horses. The condition is seasonal and recurring in the majority of horses. Treatment with cyproheptadine produced improvement of symptoms in 76% of cases. The clinical signs are suggested to be compatible with neuropathic pain producing itching, tingling or electric like sensations in the face and muzzle area of affected horses.
Publication Date: 1999-09-15 PubMed ID: 10485000DOI: 10.1111/j.2042-3306.1998.tb05141.xGoogle Scholar: Lookup
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  • Journal Article

Summary

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This research article examines the condition known as headshaking syndrome in horses, highlighting factors such as onset, symptoms, and treatment. The study relies on a survey of owners of 31 horses suffering from this condition and finds that around 60% of headshaking incidents are triggered by light, it is a seasonal and recurring condition, and treatment with cyproheptadine improved symptoms in 76% of cases. The symptoms of this condition suggest the presence of neuropathic pain in the face and muzzle area of the affected horses.

Survey Data and Overview of Headshaking Syndrome

  • The study was based on the responses to a questionnaire completed by owners of 31 horses diagnosed with headshaking syndrome, a state where a horse “flips” their nose, acts like a bee flies up their nostril, and engages in other behaviours such as snorting or sneezing.
  • The intention behind this paper was to draw further attention to the disorder and its common manifestations, with the ultimate goal of improving the understanding, diagnosis, and treatment of headshaking in horses.

Clinical Presentation of Headshaking Syndrome

  • Headshaking syndrome is characterized as a maturity onset condition, indicating that it typically starts to manifest as horses reach a mature age.
  • Clinical signs include the ‘flipping’ of the nose, nose rubbing, snorting or sneezing, and acting as though a bee is flying up the nostril. These symptoms are suggested to be the result of neuropathic pain that produces itching, a tingling sensation, or electric-like sensations in the facial and muzzle area of the affected horses.

Temporal and Environmental Factors linked to Headshaking Syndrome

  • About 60% of the headshaking cases seem to be triggered by light, implying that the disorder may have a photic or light-induced component.
  • Furthermore, the condition is reported to be seasonal and recurring among the majority of the examined horses. However, the paper does not elucidate on which seasons are most likely to precipitate the symptoms.

Treatment of Headshaking Syndrome

  • The findings showed that treatment with the pharmaceutical drug cyproheptadine led to symptom alleviation in approximately 76% of the cases. This implies that cyproheptadine can be effective for reducing or managing the symptoms of headshaking syndrome in horses. However, it is essential to note that this does not suggest the drug can eliminate the condition entirely.

Cite This Article

APA
Madigan JE, Bell SA. (1999). Characterisation of headshaking syndrome–31 cases. Equine Vet J Suppl(27), 28-29. https://doi.org/10.1111/j.2042-3306.1998.tb05141.x

Publication

NlmUniqueID: 9614088
Country: United States
Language: English
Issue: 27
Pages: 28-29

Researcher Affiliations

Madigan, J E
  • Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis 95616, USA.
Bell, S A

    MeSH Terms

    • Animals
    • Antioxidants / pharmacology
    • Antioxidants / therapeutic use
    • Behavior, Animal / drug effects
    • Cyproheptadine / pharmacology
    • Cyproheptadine / therapeutic use
    • Female
    • Horses / psychology
    • Male
    • Melatonin / pharmacology
    • Melatonin / therapeutic use
    • Recurrence
    • Seasons
    • Serotonin Antagonists / pharmacology
    • Serotonin Antagonists / therapeutic use
    • Stereotyped Behavior / drug effects
    • Surveys and Questionnaires
    • Syndrome

    Citations

    This article has been cited 14 times.
    1. Franzen V, Gruber NA, Klußmann S, Schoster A, May A. Effect of repetitive transcranial magnetic stimulation on trigeminal-mediated headshaking in 17 horses. J Vet Intern Med 2024 Sep-Oct;38(5):2758-2765.
      doi: 10.1111/jvim.17194pubmed: 39264234google scholar: lookup
    2. Nessler JN, Delarocque J, Kloock T, Twele L, Neudeck S, Meyerhoff N, Riese F, Cavalleri JV, Tipold A, Feige K, Niebuhr T. Sensory nerve conduction stimulus threshold measurements of the infraorbital nerve and its applicability as a diagnostic tool in horses with trigeminal-mediated headshaking. BMC Vet Res 2024 May 16;20(1):201.
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    3. Kloock T, Hellige M, Kloock A, Feige K, Niebuhr T. Application of the HRE-S to 140 horses with trigeminal-mediated headshaking and the association of clinical signs with diagnosis, therapy, and outcome. Front Vet Sci 2024;11:1329054.
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    5. Aleman M, Sheldon SA, Jospin G, Coil D, Stratton-Phelps M, Eisen J. Caecal microbiota in horses with trigeminal-mediated headshaking. Vet Med Sci 2022 May;8(3):1049-1055.
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    6. Roberts VLH, Bailey M, Patel NK. The safety and efficacy of neuromodulation using percutaneous electrical nerve stimulation for the management of trigeminal-mediated headshaking in 168 horses. Equine Vet J 2020 Mar;52(2):238-243.
      doi: 10.1111/evj.13174pubmed: 31461784google scholar: lookup
    7. Sheldon SA, Aleman M, Costa LRR, Weich K, Howey Q, Madigan JE. Effects of magnesium with or without boron on headshaking behavior in horses with trigeminal-mediated headshaking. J Vet Intern Med 2019 May;33(3):1464-1472.
      doi: 10.1111/jvim.15499pubmed: 30990929google scholar: lookup
    8. Sheldon SA, Aleman M, Costa LRR, Santoyo AC, Weich KM, Howey Q, Madigan JE. Luteinizing hormone concentrations in healthy horses and horses with trigeminal-mediated headshaking over an 8-hour period. J Vet Intern Med 2019 Mar;33(2):885-888.
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    9. Sheldon SA, Aleman M, Costa LRR, Santoyo AC, Howey Q, Madigan JE. Intravenous infusion of magnesium sulfate and its effect on horses with trigeminal-mediated headshaking. J Vet Intern Med 2019 Mar;33(2):923-932.
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    10. Bell C, Hnenny L, Torske K. Internal neurolysis of the maxillary branch of the trigeminal nerve for the treatment of equine trigeminal mediated headshaking syndrome. Can Vet J 2018 Jul;59(7):763-769.
      pubmed: 30026624
    11. Sheldon S, Aleman M, Costa L, Santoyo AC, Howey Q, Madigan J. Alterations in Metabolic Status and Headshaking Behavior Following Intravenous Administration of Hypertonic Solutions in Horses with Trigeminal-Mediated Headshaking. Animals (Basel) 2018 Jun 25;8(7).
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    12. Roberts VL, Fews D, McNamara JM, Love S. Trigeminal Nerve Root Demyelination Not Seen in Six Horses Diagnosed with Trigeminal-Mediated Headshaking. Front Vet Sci 2017;4:72.
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    13. Aleman M, Rhodes D, Williams DC, Guedes A, Madigan JE. Sensory evoked potentials of the trigeminal nerve for the diagnosis of idiopathic headshaking in a horse. J Vet Intern Med 2014 Jan-Feb;28(1):250-3.
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    14. Hausberger M, Gautier E, Biquand V, Lunel C, Jégo P. Could work be a source of behavioural disorders? A study in horses. PLoS One 2009 Oct 28;4(10):e7625.
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