Characterisation of the inflammatory reaction in equine idiopathic focal eosinophilic enteritis and diffuse eosinophilic enteritis.
Abstract: Idiopathic focal eosinophilic enteritis (IFEE) and diffuse eosinophilic enteritis (DEE) are primary eosinophilic intestinal conditions without a known cause that are associated with an increasing number of surgical colic cases. Histology may be helpful in defining disease aetiology and pathogenesis. Objective: To characterise further the inflammatory infiltrate in equine IFEE and to compare the condition with DEE. Methods: Twenty-three IFEE cases and 5 DEE cases were examined by light microscopy including immunohistology to identify infiltrating leucocytes. Inflammatory infiltrates in mucosa and submucosa were characterised in IFEE lesions (Group 1), the intestine distant from the lesions in IFEE (Group 2) and DEE (Group 3). Conclusions: IFEE lesions represented an accumulation of leucocytes in submucosa and muscularis, with dominance of eosinophils and macrophages and smaller numbers of lymphocytes, plasma cells and neutrophils. T cells represented the dominant lymphocytes. The mucosa overlying the lesion and both mucosa and submucosa in IFEE nonlesion sites and in DEE exhibited a similar composition, with different prevalence of various cell types. Macrophages were significantly more prevalent in the mucosal and submucosal infiltrates in IFEE nonlesion sites than in DEE, and lymphocytes significantly more prevalent in the mucosa in DEE than in IFEE nonlesion sites. The findings confirm IFEE as a primary eosinophilic intestinal disorder and indicate that IFEE represents a focally exacerbated inflammatory reaction in horses with DEE, possibly due to functional changes in the macrophage and T cell components, with subsequent excessive recruitment of both eosinophils and macrophages.
Publication Date: 2008-05-20 PubMed ID: 18487106DOI: 10.2746/042516408X312112Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research discusses the comparison of two intestinal conditions in horses, Idiopathic focal eosinophilic enteritis (IFEE) and diffuse eosinophilic enteritis (DEE). The study specifically examines the inflammatory responses within these conditions and suggests that IFEE may be an intensified localized response within horses experiencing DEE due to certain cell function changes.
Research Background and Objective
- The focus of the research was two intestinal disorders found in horses – Idiopathic focal eosinophilic enteritis (IFEE) and diffuse eosinophilic enteritis (DEE). Both are due to an abnormal infiltration of eosinophils (a type of white blood cell) in the intestinal walls and are linked to an increased number of surgical colic cases.
- The primary aim of the research was to examine and describe the inflammatory infiltrate or the accumulation of inflammatory cells within IFEE and compare it to DEE.
Methods
- The researchers performed a microscopic examination, specifically light microscopy and immunohistology, on 23 IFEE cases and 5 DEE cases.
- The inflammatory infiltrates were characterized within IFEE lesions, sections of the intestine away from the lesions in IFEE, and in DEE.
Results
- IFEE lesions showed an accumulation of various leukocytes (white blood cells), especially eosinophils and macrophages, as well as smaller numbers of lymphocytes, plasma cells, and neutrophils. Dominant lymphocytes were T cells.
- Similar composition but varying prevalence ratios of various cell types were seen in the mucosa (lining of the intestine) overlying the IFEE lesion, in the mucosa and submucosa of IFEE non-lesion sites, and in DEE.
- Macrophages were significantly more prevalent in IFEE non-lesion sites than in DEE while lymphocytes were notably more prevalent in DEE.
Conclusions
- The findings confirm that IFEE is a primary eosinophilic intestinal disorder.
- The study also indicates that IFEE may represent a focal inflammatory reaction that is intensified in horses with DEE. This could be as a result of functional changes in macrophage and T cell components, leading to an over-recruitment of both eosinophils and macrophages.
Cite This Article
APA
Mäkinen PE, Archer DC, Baptiste KE, Malbon A, Proudman CJ, Kipar A.
(2008).
Characterisation of the inflammatory reaction in equine idiopathic focal eosinophilic enteritis and diffuse eosinophilic enteritis.
Equine Vet J, 40(4), 386-392.
https://doi.org/10.2746/042516408X312112 Publication
Researcher Affiliations
- Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Crown Street, Liverpool, UK.
MeSH Terms
- Animals
- Enteritis / etiology
- Enteritis / immunology
- Enteritis / pathology
- Enteritis / veterinary
- Eosinophilia / etiology
- Eosinophilia / immunology
- Eosinophilia / pathology
- Eosinophilia / veterinary
- Female
- Horse Diseases / etiology
- Horse Diseases / immunology
- Horse Diseases / pathology
- Horses
- Immunohistochemistry / veterinary
- Intestinal Mucosa / immunology
- Intestinal Mucosa / pathology
- Leukocyte Count / veterinary
- Male
Citations
This article has been cited 3 times.- Hostetter JM, Uzal FA. Gastrointestinal biopsy in the horse: overview of collection, interpretation, and applications. J Vet Diagn Invest 2022 May;34(3):376-388.
- Archer DC, Costain DA, Sherlock C. Idiopathic focal eosinophilic enteritis (IFEE), an emerging cause of abdominal pain in horses: the effect of age, time and geographical location on risk. PLoS One 2014;9(12):e112072.
- Fushimi Y, Takagi M, Kawaguchi H, Miyoshi N, Tsuka T, Deguchi E. Three cases of idiopathic eosinophilic enteritis with chronic obstinate diarrhea in Japanese Black fattening cattle. J Vet Med Sci 2015 Mar;77(3):337-40.
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