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Microbes and infection2003; 5(12); 1125-1131; doi: 10.1016/j.micinf.2003.07.004

Characterization of experimental equine glanders.

Abstract: Considerable advances in understanding of the disease caused by Burkholderia mallei have been made employing a combination of tools including genetic techniques and animal infection models. The development of small animal models has allowed us to assess the role of a number of putative virulence determinants in the pathogenesis of disease due to B. mallei. Due to the difficulties in performing active immunization studies in small animals, and due to the fact that the horse is the target mammalian species for glanders, we have initiated experimental studies on glanders in horses. Intratracheal deposition of B. mallei produced clinical glanders with organisms being recovered from tissues of infected horses. The model should prove to be of considerable value in our ongoing studies on the pathogenesis and vaccine development for glanders.
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Publication Date: 2003-10-14 PubMed ID: 14554254DOI: 10.1016/j.micinf.2003.07.004Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't
  • Research Support
  • U.S. Gov't
  • Non-P.H.S.

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article focuses on experimental studies carried out on horses to understand the disease caused by Burkholderia mallei, also known as glanders. The study uses genomic techniques and small animal models to investigate potential virulence factors of the disease, the development of an effective vaccination, and the pathogenesis of the disease.

Studying the Disease Caused by Burkholderia mallei

  • Burkholderia mallei is a bacterium that causes glanders, a disease that primarily affects horses and can be transmitted to humans, causing hazardous, usually fatal, infection.
  • The researchers made significant advancements in understanding the disease through the use of genetic techniques and animal infection models.
  • While small animal models have been used to understand the pathogenicity of B. mallei, they present difficulties when performing active immunization studies.

Experimental Studies on Glanders in Horses

  • Given that glanders primarily affects horses, the researchers initiated experimental studies on this species.
  • B. mallei was introduced into horses through intratracheal deposition, which successfully produced clinical glanders.
  • Following the infection, the bacteria were successfully recovered from tissues of the infected horses, confirming the successful establishment of the disease.

The Importance of this Horse Model for Glanders Research

  • This horse model for glanders research could be a game-changer as it facilitates a deeper understanding of the disease’s pathogenesis and the development of an effective vaccine.
  • Studying the disease in its primary host facilitates more realistic and practical results that can be directly applied to devise efficient control and prevention strategies.

Cite This Article

APA
Lopez J, Copps J, Wilhelmsen C, Moore R, Kubay J, St-Jacques M, Halayko S, Kranendonk C, Toback S, DeShazer D, Fritz DL, Tom M, Woods DE. (2003). Characterization of experimental equine glanders. Microbes Infect, 5(12), 1125-1131. https://doi.org/10.1016/j.micinf.2003.07.004

Publication

Microbes and infection
ISSN: 1286-4579
NlmUniqueID: 100883508
Country: France
Language: English
Volume: 5
Issue: 12
Pages: 1125-1131

Researcher Affiliations

Lopez, Jose
  • National Centre for Foreign Animal Disease, 1015 Arlington St., Suite T2300, Winnipeg, Man., Canada R3E 3M4.
Copps, John
    Wilhelmsen, Catherine
      Moore, Richard
        Kubay, Julie
          St-Jacques, Marcel
            Halayko, Stacey
              Kranendonk, Christiaan
                Toback, Shannon
                  DeShazer, David
                    Fritz, David L
                      Tom, Marina
                        Woods, Donald E

                          MeSH Terms

                          • Animals
                          • Burkholderia / isolation & purification
                          • Disease Transmission, Infectious / veterinary
                          • Glanders / epidemiology
                          • Glanders / microbiology
                          • Horse Diseases / microbiology
                          • Horses

                          Citations

                          This article has been cited 17 times.
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