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Home / Equine Research Bank / Can J Vet Res / [Circulatory and respiratory effects of ketamine in horses a...
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire1987; 51(4); 513-516;

[Circulatory and respiratory effects of ketamine in horses anesthetized with halothane].

Abstract: Ketamine (0.3 mg/kg) administered intravenously to 12 halothane anesthetized horses caused a significant respiratory depression during ten minutes when respiration was spontaneous. Significant hemodynamic effects were not observed except for cardiac index. Clinical application was also discussed. Ketamine (0.3 mg/kg) administered intravenously to 12 halothane anesthetized horses caused a significant respiratory depression during ten minutes when respiration was spontaneous. Significant hemodynamic effects were not observed except for cardiac index. Clinical application was also discussed.
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Publication Date: 1987-10-01 PubMed ID: 2968832PubMed Central: PMC1255375
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  • English Abstract
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article investigates the impact of intravenous ketamine administration on the circulatory and respiratory functions of horses sedated with halothane. The main finding was that the use of ketamine caused significant respiratory depression for around ten minutes, without major effects on the circulatory system, except for alterations in the cardiac index.

Research Methodology

  • Researchers undertook an experimental study on 12 horses that were anesthetized using halothane.
  • They administered Ketamine – a powerful anesthetic agent – in a specific dosage of 0.3 mg/kg to these anesthetized horses intravenously.

Respiratory Effects

  • The key focus was to understand the impacts on respiratory functions.
  • The results showed a significant depressive effect on respiration in the horses, lasting about ten minutes when breathing was spontaneous.
  • This indicates that ketamine can potentially slow down the rate of respiration in horses when used along with halothane.

Circulatory Effects

  • The study also examined the circulatory ramifications of administering ketamine to horses under halothane anesthesia.
  • No significant impact was observed in terms of hemodynamics (the study of blood flow or the circulation) apart from changes in the cardiac index – a measure that relates the cardiac output from left ventricle in one minute to the body surface area, expressing the myocardial performance.
  • These changes in the cardiac index suggest the influence of ketamine on heart functioning.

Clinical Implications

  • The authors also discussed the clinical applications of their research findings, which could influence the clinical use of ketamine in anesthetized horses.
  • Understanding how different anesthetic agents interact in animals such as horses is crucial for safe anesthesia in veterinary medicine.

Cite This Article

APA
Serteyn D, Blais D, Abou Madi NA, Coppens P, Mottart E, Philippart C. (1987). [Circulatory and respiratory effects of ketamine in horses anesthetized with halothane]. Can J Vet Res, 51(4), 513-516.

Publication

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire
ISSN: 0830-9000
NlmUniqueID: 8607793
Country: Canada
Language: fre
Volume: 51
Issue: 4
Pages: 513-516

Researcher Affiliations

Serteyn, D
  • Faculte de médecine Vétérinaire, Université de Liège, Service de Chirurgie, Bruxelles, Belgique.
Blais, D
    Abou Madi, N A
      Coppens, P
        Mottart, E
          Philippart, C

            MeSH Terms

            • Anesthesia, General / veterinary
            • Animals
            • Halothane
            • Hemodynamics / drug effects
            • Horses / physiology
            • Injections, Intravenous / veterinary
            • Ketamine / administration & dosage
            • Ketamine / pharmacology
            • Respiration / drug effects
            • Rheology

            References

            This article includes 14 references
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            Citations

            This article has been cited 0 times.
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