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Home / Equine Research Bank / J Clin Microbiol / Cladophialophora bantiana as an Emerging Pathogen in Animals...
Journal of clinical microbiology2015; 53(9); 3047-3053; doi: 10.1128/JCM.00728-15

Cladophialophora bantiana as an Emerging Pathogen in Animals: Case Report of Equine Endometritis and Review of the Literature.

Abstract: We present an unusual equine endometritis case associated with Cladophialophora bantiana in a 15-year-old mare. The mare displayed infertility and uterine fluid accumulation with numerous black, hairy granules. Microscopically, the fluid revealed numerous septate, dark fungal hyphae and conidia in chains. Culture yielded C. bantiana (CBS 138271); the species was confirmed by internal transcribed spacer (ITS) sequencing. Treatment was unsuccessful. C. bantiana causes cerebral phaeohyphomycosis in humans, while animal cases are rare. Animal cases are reviewed.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
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Publication Date: 2015-06-17 PubMed ID: 26085616PubMed Central: PMC4540934DOI: 10.1128/JCM.00728-15Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research involves the investigation of an uncommon case of equine endometritis, an inflammation of the inner lining of the uterus, in a mare. This condition was induced by Cladophialophora bantiana, a fungus often leading to a severe brain infection in humans. Despite treatment, the horse could not be cured successfully. Animal cases resulting from this fungus are quite rare and the article also provides an overview of such cases from other research.

Research Study and Findings

In this study, researchers detail an unusual occurrence of endometritis, a disease occurring in the uterus of a mare, which was incited by a fungus known as Cladophialophora bantiana. Core details of the identified pathogenicity are as follows:

  • The investigated case dealt with a 15-year-old mare suffering from infertility and an accumulation of uterine fluid, which featured multiple black, hairy granules.
  • Examining the uterine fluid microscopically, the researchers identified a considerable number of septate, dark fungal hyphae and conidia (asexual fungal spores).
  • Culturing the microorganisms present in the fluid resulted in the growth of C. bantiana. This categorization was substantiated through Internal Transcribed Spacer (ITS) sequencing – a commonly used DNA-based tool that assists in identifying fungi due to variations in the ITS region.
  • Therapeutic measures taken to counteract this infection were unsuccessful, culminating in the horse’s death.

Historical Context and Review

The researchers stress that instances of C. bantiana causing diseases in animals are quite rare. This fungus is primarily known to induce cerebral phaeohyphomycosis in humans, an infection characterized by the formation of a mass lesion in the brain.

  • The text hints at the potential of C. bantiana as an emerging pathogen in animals, indicating the fungus’s ability to host diseases not just in humans but also in a variety of animal species.
  • The study also incorporates a detailed review of similar rare animal cases attributable to the C. bantiana fungal pathogen. This historical context bolsters the study’s scientific findings and enhances understanding of the fungus’ host range and pathogenic capabilities.

Cite This Article

APA
Rantala M, Attia S, Koukila-Kähkölä P, de Hoog S, Anttila M, Katila T. (2015). Cladophialophora bantiana as an Emerging Pathogen in Animals: Case Report of Equine Endometritis and Review of the Literature. J Clin Microbiol, 53(9), 3047-3053. https://doi.org/10.1128/JCM.00728-15

Publication

Journal of clinical microbiology
ISSN: 1098-660X
NlmUniqueID: 7505564
Country: United States
Language: English
Volume: 53
Issue: 9
Pages: 3047-3053

Researcher Affiliations

Rantala, Merja
  • Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland merja.rantala@helsinki.fi.
Attia, Stella
  • Department of Production Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Saarentaus, Finland.
Koukila-Kähkölä, Pirkko
  • Mycology Unit, Helsinki University Hospital Laboratory HUSLAB, Helsinki, Finland.
de Hoog, Sybren
  • CBS Fungal Biodiversity Centre, Institute of the Royal Netherlands Academy of Arts and Sciences, Utrecht, The Netherlands.
Anttila, Marjukka
  • Pathology Research Unit, Research and Laboratory Department, Finnish Food Safety Authority Evira, Helsinki, Finland.
Katila, Terttu
  • Department of Production Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Saarentaus, Finland.

MeSH Terms

  • Animals
  • Ascomycota / classification
  • Ascomycota / genetics
  • Ascomycota / isolation & purification
  • Cluster Analysis
  • DNA, Fungal / chemistry
  • DNA, Fungal / genetics
  • DNA, Ribosomal Spacer / chemistry
  • DNA, Ribosomal Spacer / genetics
  • Endometritis / microbiology
  • Endometritis / pathology
  • Endometritis / veterinary
  • Exudates and Transudates / microbiology
  • Female
  • Horse Diseases / microbiology
  • Horse Diseases / pathology
  • Horses
  • Microbiological Techniques
  • Microscopy
  • Molecular Sequence Data
  • Mycoses / microbiology
  • Mycoses / pathology
  • Mycoses / veterinary
  • Phylogeny
  • Pregnancy
  • Sequence Analysis, DNA

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Citations

This article has been cited 5 times.
  1. Li J, Zhu Y, Mi J, Zhao Y, Holyoak GR, Yi Z, Wu R, Wang Z, Zeng S. Endometrial and vaginal microbiome in donkeys with and without clinical endometritis. Front Microbiol 2022;13:884574.
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  2. G Rathod P, Mishra B, Thakur A, S Loomba P, Sharma A, Bajaj A, Das M, Bhasin A. Cerebral phaeohyphomycosis due to Cladophialophora bantiana in an immunocompetent individual: A case report and brief review of literature. Curr Med Mycol 2020 Jun;6(2):52-57.
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  4. Headley SA, de Mello Zanim Michelazzo M, Elias B, Viana NE, Pereira YL, Pretto-Giordano LG, da Silva JF, da Silva FES, Vilas-Boas LA, da Costa Flaiban KKM, Alfieri AA, Gomes LA. Disseminated melanized fungal infection due to Cladosporium halotolerans in a dog coinfected with canine adenovirus-1 and canine parvovirus-2. Braz J Microbiol 2019 Jul;50(3):859-870.
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  5. Alonso FH, Fenton H, Muller A, Freeman MA, Becker AAMJ, Rolph K, Abramo N, Rawlins G, Kitson L, Kessel E, Thrall MA. Case report: Disseminated Cladophialophora bantiana phaeohyphomycosis in a dog with hepatic dysfunction, and concurrent ehrlichiosis. Front Vet Sci 2024;11:1451299.
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