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Home / Equine Research Bank / Can Vet J / Clinical and immunophenotypic findings in 4 forms of equine ...
The Canadian veterinary journal = La revue veterinaire canadienne2019; 60(1); 33-40; doi: 10.1111/eve.12850

Clinical and immunophenotypic findings in 4 forms of equine lymphoma.

Abstract: The clinical, histological, and immunophenotypic findings are presented for 4 horses affected by different types of lymphoma. Diagnoses of a monomorphic epitheliotropic intestinal T-cell lymphoma, a diffuse splenic large B-cell lymphoma, a peripheral T-cell lymphoma, and a T-cell rich large B-cell lymphoma of the third eyelid were made. Constatations cliniques et immunophénotypiques pour quatre formes de lymphomes équins. Les constatations cliniques, histologiques et immunophénotypiques sont présentées pour quatre chevaux affectés par différents types de lymphome. Des diagnostics d’un lymphome intestinal épithéliotrope et monomorphe à cellules T, d’un lymphome splénique diffus à grandes cellules B, d’un lymphome périphérique à cellules T et d’un lymphome à grandes cellules B riche en cellules T de la troisième paupière ont été posés.(Traduit par Isabelle Vallières).
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Publication Date: 2019-01-18 PubMed ID: 30651648PubMed Central: PMC6294024DOI: 10.1111/eve.12850Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses about the details of clinical, histological, and immunophenotypic analysis for four horses suffering from different kinds of lymphoma.

Introduction to Equine Lymphoma

  • The study primarily discusses lymphoma, a form of cancer, in horses. Lymphoma leads to the proliferation of lymphocytes, a kind of white blood cell. The different types of lymphomas are typically classified based on the type of cell that is predominantly present.

Types of Lymphomas Studied

  • The research talks about four types of lymphomas – monomorphic epitheliotropic intestinal T-cell lymphoma, diffuse splenic large B-cell lymphoma, peripheral T-cell lymphoma, and T-cell rich large B-cell lymphoma of the third eyelid. To understand this, one needs to know that lymphocytes are divided into T-cells and B-cells, which have different roles within the immune system. The different types of lymphomas mentioned are named based on the cells they majorly constitute.

Clinical, Histological and Immunophenotypic Findings

  • The paper provides detailed findings in three categories for each of the four horses: clinical, histological, and immunophenotypic.
  • The clinical findings involve symptoms and manifestations of the disease in the horses. This can include loss of weight, lethargy, or any other physical signs of illness that could be observed.
  • Histological analysis refers to the microscopic examination of tissue in order to study the manifestations of the disease. Such manifestations may include changes in size, shape, and organization of cells.
  • Immunophenotyping is the process of testing the expression of proteins on the surface of cells to determine the type and stage of cancer. It identifies the different types of cells present in a sample by using special markers that are specific to certain cell types.

Conclusion

  • Through this study, diagnoses of different types of lymphomas were confirmed for each of the horses. The research emphasizes the importance of clinical, histological, and immunophenotypic findings in diagnosing and managing equine lymphoma.

Cite This Article

APA
Miglio A, Morelli C, Gialletti R, Lauteri E, Sforna M, Marenzoni ML, Antognoni MT. (2019). Clinical and immunophenotypic findings in 4 forms of equine lymphoma. Can Vet J, 60(1), 33-40. https://doi.org/10.1111/eve.12850

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 60
Issue: 1
Pages: 33-40

Researcher Affiliations

Miglio, Arianna
  • Department of Veterinary Medicine, University of Perugia, via S. Costanzo 4, 06126 Perugia, Italy.
Morelli, Chiara
  • Department of Veterinary Medicine, University of Perugia, via S. Costanzo 4, 06126 Perugia, Italy.
Gialletti, Rodolfo
  • Department of Veterinary Medicine, University of Perugia, via S. Costanzo 4, 06126 Perugia, Italy.
Lauteri, Eleonora
  • Department of Veterinary Medicine, University of Perugia, via S. Costanzo 4, 06126 Perugia, Italy.
Sforna, Monica
  • Department of Veterinary Medicine, University of Perugia, via S. Costanzo 4, 06126 Perugia, Italy.
Marenzoni, Maria Luisa
  • Department of Veterinary Medicine, University of Perugia, via S. Costanzo 4, 06126 Perugia, Italy.
Antognoni, Maria Teresa
  • Department of Veterinary Medicine, University of Perugia, via S. Costanzo 4, 06126 Perugia, Italy.

MeSH Terms

  • Animals
  • Colic / etiology
  • Colic / veterinary
  • Diagnosis, Differential
  • Eyelid Neoplasms / diagnosis
  • Eyelid Neoplasms / pathology
  • Eyelid Neoplasms / veterinary
  • Female
  • Horse Diseases / diagnosis
  • Horse Diseases / pathology
  • Horses
  • Ileum
  • Immunophenotyping / veterinary
  • Intestinal Neoplasms / complications
  • Intestinal Neoplasms / diagnosis
  • Intestinal Neoplasms / pathology
  • Intestinal Neoplasms / veterinary
  • Lymphoma, T-Cell / complications
  • Lymphoma, T-Cell / diagnosis
  • Lymphoma, T-Cell / pathology
  • Lymphoma, T-Cell / veterinary
  • Male
  • Nictitating Membrane
  • Splenic Neoplasms / diagnosis
  • Splenic Neoplasms / pathology
  • Splenic Neoplasms / veterinary

References

This article includes 40 references
  1. Marenzoni ML, Coppola G, Maranesi M. Age-dependent prevalence of equid herpesvirus 5 infection.. Vet Res Commun 2010;34:703–708.
    pubmed: 20842426
  2. Swerdlow SS, Campo E, Pileri SA. The 2016 revision of the World Health Organization classification of lymphoid neoplasms.. Blood 2016;127:2375–2390.
    pmc: PMC4874220pubmed: 26980727
  3. Munoz A, Riber C, Trigo P, Castejon F. Hematopoietic neoplasias in horses: Myeloproliferative and lymphoproliferative disorders.. J Equine Sci 2009;20:59–70.
    pmc: PMC4013965pubmed: 24833969
  4. Vander Werf KA, Davis E, Janardhan K, Bawa B, Bolin S, Almes K. Identification of equine herpesvirus 5 in horses with lymphoma.. J Equine Vet Sci 2014;34:738–741.
  5. Meyer J, DeLay J, Bienzle D. Clinical, laboratory, and histopathologic features of equine lymphoma.. Vet Pathol 2006;43:914–924.
    pubmed: 17099148
  6. Schleis S. Equine lymphoma.. Equine Vet Educ 2011;23:205–213.
  7. Rendle DI, Hughes KJ, Farish C, Kessell A. Multicentric T-cell lymphoma presenting as inferior palpebral swelling in a Standardbred mare.. Aust Vet J 2012;90:485–489.
    pubmed: 23186090
  8. Schnoke AT, Brooks DE, Wilkie DA. Extraocular lymphoma in the horse.. Vet Ophthalmol 2013;16:35–42.
    pubmed: 22500697
  9. Durham AC, Pillitteri CA, San Myint M, Valli VE. Two hundred three cases of equine lymphoma classified according to the World Health Organization (WHO) classification criteria.. Vet Pathol 2013;50:86–93.
    pubmed: 22700849
  10. Valli VE. B-cell neoplasm. Veterinary Comparative Hematopathology 1st ed. Ames, Iowa: Blackwell Publishing; 2007. pp. 260–262.
  11. Passamonti F, Veronesi F, Cappelli K. Polysynovitis in a horse due to Borrelia burgdorferi sensu lato infection — Case study.. Ann Agric Environ Med 2015;22:247–250.
    pubmed: 26094517
  12. Foreman JH. Changes in body weight.. Equine Internal Medicine 3rd ed. St Louis, Missouri: Saunders Elsevier; 2010. pp. 96–99.
  13. Taylor SD, Pusterla N, Vaughan B, Whitcomb MB, Wilson WD. Intestinal neoplasia in horses.. J Vet Intern Med 2006;20:1429–1436.
    pubmed: 17186861
  14. Bernard WV, Sweeney CR, Morris F. Primary lymphocytic leukemia in a horse.. Vet Clin North Am Equine Pract 1988;10:24–26.
  15. Yadav C, Ahmad A, D’Souza B. Serum dehydrogenase in non-Hodgkin’s lymphoma: A prognostic indicator.. Ind J Clin Biochem 2016;31:240–242.
    pmc: PMC4820421pubmed: 27069334
  16. Zanatta R, Abate O, D’Angelo A, Miniscalco B, Mannelli A. Diagnostic and prognostic value of serum lactate dehydrogenase (LDH) and LDH isoenzymes in canine lymphoma.. Vet Res Commun 2003;27:449–445.
    pubmed: 14535451
  17. Dabareiner RM, Keneth ES, Goodrich LR. Large colon resection for treatment of lymphosarcoma in two horses.. J Am Vet Med Assoc 1996;208:895–897.
    pubmed: 8617649
  18. Schnabel LV, Bradley LN, Gold JR, Meseck EK. Primary alimentary lymphoma with metastasis to the liver causing encephalopathy in a horse.. J Vet Intern Med 2006;20:204–206.
    pubmed: 16496943
  19. Sanz MG, Sellon DC, Potter KA. Primary epitheliotropic intestinal T-cell lymphoma as cause of diarrhea in a horse.. Can Vet J 2010;55:522–524.
    pmc: PMC2857434pubmed: 20676297
  20. Smith KM, Clarck CK, Dark MM, Kiupel M, Gary J. T-cell rich B-cell lymphoma in the small colon of a yearling horse.. Equine Vet Educ 2012;25:74–78.
  21. Herraez P, Berridge B, Marsh P, Weeks B, Ramiro-Ibanez F. Small intestine large granular lymphoma in a horse.. Vet Pathol 2001;28:223–226.
    pubmed: 11280380
  22. Pinkerton ME, Bailey KL, Thomas KK, Goetz TE, Valli VE. Primary epitheliotropic intestinal T-cell lymphoma in a horse.. J Vet Diagn Invest 2002;14:150–152.
    pubmed: 11939336
  23. Mitsui I, Jackson LP, Couetil LL, Lin TL, Ramos-Vara JA. Hypertrichosis in a horse with alimentary T-cell lymphoma and pituitary involvement.. J Vet Diagn Invest 2007;19:128–132.
    pubmed: 17459849
  24. Seeling DM, Avery PR, Kisseberth WC, Modiano JF. Hematological neoplasia: T-cell lymphoproliferative disease.. Schalm’s Veterinary Hematology 6th ed. Vol. 2010. Ames, Iowa: Wiley-Blackwell; p. 53.
  25. Tanimoto T, Yamasaki S, Ohtsuki Y. Primary splenic lymphoma in a horse.. J Vet Med Sci 1994;56:767–769.
    pubmed: 7999906
  26. Eberle N, von Babo V, Nolte I, Baumgartner W, Bertz D. Splenic masses in the dog.. Tierarztl Prax K 2012;40:250–260.
    pubmed: 22911256
  27. Kattepur AK, Rohith S, Shivaswamy BS, Babu R, Santhosh CS. Primary splenic lymphoma: A case report.. Indian J Surg Oncol 2013;4:287–290.
    pmc: PMC3771062pubmed: 24426740
  28. Chaffin KM, Schmitz DG, Brumbaugh GW, Hall DG. Ultrasonographic characteristics of splenic and hepatic lymphosarcoma in three horses.. J Am Vet Med Assoc 1992;201:743–747.
    pubmed: 1399778
  29. Roccabianca P, Paltrinieri S, Gallo E, Giuliani A. Hepatosplenic T-cell lymphoma in a mare.. Vet Pathol 2002;39:508–511.
    pubmed: 12126157
  30. Riondato F, Miniscalco B, Poggi A. Analytical and diagnostic validation of flow cytometry strategy to quantify blood and marow infiltration in dogs with large B-cell lymphoma.. Cytometry B Clin Cytom 2016;90:525–530.
    pubmed: 26663674
  31. Ayturk S, Celik M, Mert O. Primary splenic diffuse large B-cell lymphoma after splenectomy: A rare case with literature review.. Am J Med Case Rep 2015;3:265–268.
  32. German SE, Richter M, Schwarzwald C, Wimmershoff J, Spiess BM. Ocular and multicentric lymphoma in a young racehorse.. Vet Ophthalmol 2008;11:51–56.
    pubmed: 19046270
  33. Martabano BB, Brooks DE, Whitley RD. Recurrent adnexal lymphoma in horse.. Equine Vet Educ 2017.
    doi: 10.1111/eve.12850google scholar: lookup
  34. D’agostino J, Brightman H. Bilateral lymphosarcoma of the nictating membrane in a Quarter Horse.. J Equine Vet Sci 2004;24:489–491.
  35. Ackermann MR. Infiammazione cronica e guarigione delle ferite.. Patologia generale veterinaria 4th ed. Milan, Italy: Elsevier Masson; 2007. pp. 155–156.
  36. Lepri E, Beccati F, Miglio A, Passamonti F, Veronesi F, Mandara MT. Pathology in practice.. J Am Vet Med Assoc 2017;251:1153–1156.
    pubmed: 29099246
  37. Tornquist SJ. Bone marrow and lymph node evaluation.. Vet Clin Equine 2008;24:261–283.
    pubmed: 18652955
  38. Moore CP, Grevan VL, Champagne ES, Collins BK, Collier LL. Equine conjunctival pseudotumors.. Vet Ophthalmol 2000;3:57–63.
    pubmed: 11397284
  39. Vander Werf KA, Davis E. Disease remission in a horse with EHV-5 associated lymphoma.. J Vet Intern Med 2013;27:387–389.
    pubmed: 23458852
  40. Bawa B, Vander Werf KV, Beard L, Davis E, Andrews G, Almes K. Equine multinodular pulmonary fibrosis and lymphoma in a horse associated with equine herpesvirus-5.. J Equine Vet Sci 2014;34:694–700.
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