Clinical observations on the course of oxytocin- or prostaglandin E2/oxytocin-induced parturition in mares.
Abstract: The objective of this study was to compare the course of parturitions induced with sole oxytocin with those induced with the combination of intracervical prostaglandin E2 jelly and oxytocin. For this purpose 13 mares in advanced pregnancy were allocated to the groups pretreated with either intracervical PGE2 (experimental group) or saline (control group) two hours before intravenous oxytocin (5 IU) administration. The mares were compared with respect to cervical dilation diameter (CDD) 20 min. after oxytocin injection. Time intervals from the first oxytocin dose to: the first external signs of parturition, the chorioallantois rupture, the delivery of a foal and time interval from the delivery of a foal to the placenta separation were measured. Cervical dilatation diameter as well as proportion of mares with cervical dilatation > 20 cm were significantly higher in the group of PGE2 treated mares comparing with control group (p = 0.0115 and p = 0.0490, respectively). All time intervals measured were statistically insignificant for both groups of mares, however time intervals from the first oxytocin dose to the first external signs of parturition, to the allantochorion rupture and to the delivery of a foal, were very close to the significance level (alpha = 0.05). To conclude, PGE/oxytocin combination has positive influence on the preparation of the uterine cervix to parturition. Moreover, it seems that PGE2 pretreatment reduced total oxytocin dose for successful parturition induction and shortened time elapsing between the first oxytocin dose and the delivery of a foal what is crucial for foal's safety.
Publication Date: 2014-07-06 PubMed ID: 24988862DOI: 10.2478/pjvs-2014-0047Google Scholar: Lookup
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- Journal Article
Summary
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This research explores the effectiveness of oxytocin alone and a combination of prostaglandin E2 jelly and oxytocin, in inducing labor in pregnant horses, and reveals that combining prostaglandin E2 with oxytocin enhances uterine cervix preparation for delivery and might reduce the overall time from the first oxytocin dose needed to deliver a foal.
Research Objectives and Methodology
- This study aimed at comparing the effects of labor induction in pregnant mares using sole oxytocin and the combination of prostaglandin E2 jelly (intracervical PGE2) and oxytocin.
- 13 pregnant mares were divided into two groups: an experimental group treated with intracervical PGE2 and a control group pretreated with saline, both two hours before oxytocin administration.
- The mares were assessed on cervical dilation diameter (CDD) after 20 minutes of the oxytocin injection.
Measurements and Findings
- The researchers measured time intervals from the oxytocin dose until the first signs of parturition, the rupture of the chorioallantois, and the foal’s delivery.
- The cervical dilation diameter and the ratio of mares with cervical dilatation greater than 20 cm were significantly higher in the PGE2 treated group as compared to the control group.
- Although all the time intervals measured showed no significant statistical difference between the two groups, the time taken from the first oxytocin dose to the onset of parturition and delivery was noticeably shorter in PGE2 pretreated group, indicating a potential advantage.
Conclusion
- The combination of PGE and oxytocin enhances cervix readiness for parturition, making it preferable over the use of oxytocin alone.
- The research suggests that pretreatment with PGE2 may reduce the total concentration of oxytocin needed for successful parturition induction and potentially reduce the time from the first oxytocin dose for the foal’s delivery.
- This reduced time is crucial for ensuring the safety of the foal during the delivery process.
Cite This Article
APA
Witkowski M, Witkowski M, Pawłowski K.
(2014).
Clinical observations on the course of oxytocin- or prostaglandin E2/oxytocin-induced parturition in mares.
Pol J Vet Sci, 17(2), 347-351.
https://doi.org/10.2478/pjvs-2014-0047 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Dinoprostone / administration & dosage
- Dinoprostone / pharmacology
- Drug Therapy, Combination
- Female
- Horses / physiology
- Labor, Induced / veterinary
- Oxytocics / administration & dosage
- Oxytocics / pharmacology
- Oxytocin / administration & dosage
- Oxytocin / pharmacology
- Parturition / drug effects
- Parturition / physiology
- Pregnancy
Citations
This article has been cited 2 times.- Piotrowska-Tomala KK, Jonczyk AW, Szóstek-Mioduchowska AZ, Żebrowska E, Ferreira-Dias G, Skarzynski DJ. The Effects of Prostaglandin E(2) Treatment on the Secretory Function of Mare Corpus Luteum Depends on the Site of Application: An in vivo Study. Front Vet Sci 2021;8:753796.
- Rapacz-Leonard A, Leonard M, Chmielewska-Krzesińska M, Siemieniuch M, Janowski TE. The oxytocin-prostaglandins pathways in the horse (Equus caballus) placenta during pregnancy, physiological parturition, and parturition with fetal membrane retention. Sci Rep 2020 Feb 7;10(1):2089.
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