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Home / Equine Research Bank / Vet Surg / Clinical outcome after intra-articular administration of bon...
Veterinary surgery : VS2014; 43(3); 255-265; doi: 10.1111/j.1532-950X.2014.12100.x

Clinical outcome after intra-articular administration of bone marrow derived mesenchymal stem cells in 33 horses with stifle injury.

Abstract: To report outcome of horses with femorotibial lesions (meniscal, cartilage or ligamentous) treated with surgery and intra-articular administration of autologous bone marrow derived mesenchymal stem cells (BMSCs). Methods: Prospective case series. Methods: Horses (n = 33). Methods: Inclusion criteria included horses that had lameness localized to the stifle by diagnostic anesthesia, exploratory stifle arthroscopy and subsequent intra-articular administration of autologous BMSCs. Case details and follow-up were gathered from medical records, owner, trainer or veterinarian. Outcome was defined as returned to previous level of work, returned to work, or failed to return to work. Results: Follow-up (mean, 24 months) was obtained; 43% of horses returned to previous level of work, 33% returned to work, and 24% failed to return to work. In horses with meniscal damage (n = 24) a higher percentage in the current study (75%) returned to some level of work compared to those in previous reports (60-63%) that were treated with arthroscopy alone, which resulted in a statistically significant difference between studies (P = .038). Joint flare post injection was reported in 3 horses (9.0%); however, no long-term effects were noted. Conclusions: Intra-articular administration of BMSC postoperatively for stifle lesions appeared to be safe, with morbidity being similar to that of other biologic agents. Improvement in ability to return to work may be realized with BMSC treatment compared to surgery alone in horses with stifle injury.
© Copyright 2014 by The American College of Veterinary Surgeons.
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Publication Date: 2014-01-16 PubMed ID: 24433318DOI: 10.1111/j.1532-950X.2014.12100.xGoogle Scholar: Lookup
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  • Journal Article
  • Multicenter Study
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research focuses on the clinical outcomes of administering bone marrow derived mesenchymal stem cells (BMSCs) intra-articularly in horses with stifle joint injuries. The study indicates BMSC treatment, as an adjunct to surgery, may improve the chance of return to work for horses with such kind of injuries.

Objective and Methodology of the Study

  • The study aimed to analyze the effects of using autologous BMSCs, derived from the horses own bone marrow, for treating intra-articular stifle injuries involving meniscus, cartilage, or ligaments.
  • A total of 33 horses, diagnosed with lameness localized to the stifle and were treated with BMSCs postoperatively, were roped in for this prospective case series study.
  • Detailed case information and follow-up data were collected from various sources including medical records, owner, trainer or veterinarian.
  • The success of treatment was measured based on whether the horses returned to previous level of work, returned to work at some level, or failed to return to work.

Results of the Study

  • After an average follow-up period of 24 months, it was found that 43% of the horses returned to their previous level of work, 33% returned to some level of work, while 24% failed to return to work.
  • In the subset of horses with meniscal damage (n = 24), 75% returned to some level of work post-treatment. This outcome was significantly better compared to results from previous reports, which showed a success rate of 60-63% for cases treated with arthroscopy alone.
  • Post injection joint flare was reported in 3 horses (9%), however, there were no observed long-term effects.

Conclusion of the Study

  • The intra-articular administration of BMSCs postoperatively for treating stifle injuries was deemed safe, with the level of morbidity similar to that of other biologic agents.”
  • The researchers concluded that the addition of BMSC treatment could potentially enhance the capacity to return to work for horses with injuries in the stifle joint, in comparison to those undergoing surgical treatment alone.

Cite This Article

APA
Ferris DJ, Frisbie DD, Kisiday JD, McIlwraith CW, Hague BA, Major MD, Schneider RK, Zubrod CJ, Kawcak CE, Goodrich LR. (2014). Clinical outcome after intra-articular administration of bone marrow derived mesenchymal stem cells in 33 horses with stifle injury. Vet Surg, 43(3), 255-265. https://doi.org/10.1111/j.1532-950X.2014.12100.x

Publication

Veterinary surgery : VS
ISSN: 1532-950X
NlmUniqueID: 8113214
Country: United States
Language: English
Volume: 43
Issue: 3
Pages: 255-265

Researcher Affiliations

Ferris, Dora J
  • Equine Orthopaedic Research Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado.
Frisbie, David D
    Kisiday, John D
      McIlwraith, C Wayne
        Hague, Brent A
          Major, Michael D
            Schneider, Robert K
              Zubrod, Chad J
                Kawcak, Christopher E
                  Goodrich, Laurie R

                    MeSH Terms

                    • Animals
                    • Arthroscopy / veterinary
                    • Bone Marrow Cells / physiology
                    • Female
                    • Follow-Up Studies
                    • Horses / injuries
                    • Lameness, Animal / physiopathology
                    • Lameness, Animal / therapy
                    • Male
                    • Mesenchymal Stem Cell Transplantation / veterinary
                    • Mesenchymal Stem Cells / physiology
                    • Postoperative Care / methods
                    • Postoperative Care / standards
                    • Postoperative Care / veterinary
                    • Prospective Studies
                    • Stifle / injuries
                    • Treatment Outcome

                    Citations

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