Clinical safety of intrauterine infusion of a uterine sanitizer in mares.

The research paper presents a study on the clinical safety of using a commercial Uterine Cleaning Sanitizer (UCS) for the treatment of infectious endometritis in mares. It also discusses the efficacy of this method in breeding, compared to traditional therapies and concerns of growing antibiotic resistance.

Objective

• The goal of this study was to examine the safety of intrauterine UCS infusion in healthy mares and its potential as an effective alternative treatment for endometritis.

Methods

• The research was conducted in two experiments. In the first experiment, six healthy mares were treated with two infusions of UCS during their estrus cycle. Their endometrial biopsies were taken three days after the treatment and again after eight and twenty-one days of ovulation.
• In the second experiment, two estrous cycles of eleven reproductive sound mares were randomly assigned to receive either UCS infusions or a placebo treatment. These mares were inseminated 24 hours after the last treatment, and embryo flushes were carried out eight days post-ovulation.

Results

• In the first experiment, a slight change in the endometrial biopsy scores was observed which was primarily due to an increase in the inflammatory infiltrate in the endometrium. Nevertheless, recovery was complete by eight and twenty-one days post-ovulation.
• Findings from the second experiment demonstrated similar embryo recovery rates in the UCS-treated mares (9/11) and those given a placebo (8/11).

Conclusions

• Overall, the study concludes that UCS could be a safe therapy for mares. It could also potentially serve as a promising adjuvant therapy for treating endometritis in mares, alongside conventional therapies.