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Ciba Foundation symposium1989; 143; 265-285; doi: 10.1002/9780470513774.ch16

Clinical uses of hyaluronan.

Abstract: The availability of elastoviscous solutions of highly purified hyaluronan has created two new therapeutic methods in human and veterinary medicine: viscosurgery and viscosupplementation. Viscosurgical tools and implants are widely used in ophthalmology and have been suggested for use in otology. Visco-supplementation of joint fluid using elastoviscous hyaluronan solutions is widely used in the treatment of equine traumatic arthritis. It was also suggested for use in idiopathic osteoarthritis in humans, but this application has not received wide acceptance. Cross-linked forms of hyaluronan have been developed and given the generic name of hylans. Water-insoluble soft gels of hylans are ideally suitable as viscosurgical implants to prevent postoperative adhesions and to control scar formation. Hylan solutions are being used in arthroscopic viscosurgery. Hylan devices in various forms (gels, tubes, membranes) have been used in animal studies for matrix engineering, the purpose of which is to control and direct tissue regeneration and augmentation.
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Publication Date: 1989-01-01 PubMed ID: 2680347DOI: 10.1002/9780470513774.ch16Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research focuses on the clinical uses of highly purified hyaluronan, particularly in viscosurgery and viscosupplementation, fields of human and veterinary medicine. These techniques are prevalent in ophthalmology and equine arthritis treatment, and have potential implementation in other areas.

Hyaluronan and Its Therapeutic Potentials

  • Hyaluronan, a highly purified viscous solution, has seen recent therapeutic use in two major areas: viscosurgery, a type of surgery that uses viscous solutions for surgical procedures, and viscosupplementation, a procedure that increases joint fluidity using viscous solutions.
  • The availability of this highly purified substance has brought forth new possibilities in both human and veterinary medicine. Some of the key areas discussed in this paper include ophthalmology, otology, arthritis treatment, and matrix engineering.

Uses in Ophthalmology and Otology

  • Viscosurgical tools and implants made with hyaluronan solutions are extensively used in ophthalmology. This is because the viscous solutions of hyaluronan prove beneficial in such delicate surgical procedures.
  • The use of hyaluronan is also suggested in otology, though the paper does not detail this application much.

Uses in Arthritis Treatment

  • Viscosupplementation of joint fluid with hyaluronan solutions has found wide acceptance in the treatment of equine traumatic arthritis. This helps to enhance fluidity in the joints, thus benefiting the patients.
  • Whilst this method has been suggested for use in humans with idiopathic osteoarthritis, it hasn’t seen widespread acceptance yet.

Development of Hylans and Their Uses

  • The researchers have developed cross-linked forms of hyaluronan, named as hylans. Hylans are soft, water-insoluble gels ideally suitable for use as implants in viscosurgery.
  • Hylan solutions have found their application in arthroscopic viscosurgery, a minimally invasive surgical procedure on a joint.
  • In animal studies, hylan devices in the form of gels, tubes, and membranes have been used for matrix engineering. The aim is to control and direct tissue regeneration and augmentation, leading to improved healing and recovery.

Cite This Article

APA
Balazs EA, Denlinger JL. (1989). Clinical uses of hyaluronan. Ciba Found Symp, 143, 265-285. https://doi.org/10.1002/9780470513774.ch16

Publication

Ciba Foundation symposium
ISSN: 0300-5208
NlmUniqueID: 0356636
Country: Netherlands
Language: English
Volume: 143
Pages: 265-285

Researcher Affiliations

Balazs, E A
  • Matrix Biology Institute, Ridgefield, NJ 07657.
Denlinger, J L

    MeSH Terms

    • Animals
    • Humans
    • Hyaluronic Acid / therapeutic use
    • Surgical Procedures, Operative / methods

    Citations

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