Colicine K: VI. The Immune Response of Horses to a Colicinogenic Strain of Escherichia Coli.
Abstract: 1. The immunization of horses with the colicinogenic bacillus E. coli K235 L + O(m) stimulates antibodies which precipitate and neutralize colicine K and neutralize the heterologous colicine I as well. 2. Unlike rabbits, horses evoke predpitating antibodies for the sialic acid-containing polysaccharide colominic acid.
Publication Date: 1965-10-31 PubMed ID: 19867294PubMed Central: PMC2138113DOI: 10.1084/jem.122.5.891Google Scholar: Lookup
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- Journal Article
Summary
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The research paper discusses the immune response of the horses when immunized with a specific strain of E. coli bacterium that produces a toxin called Colicine K. Following the immunization, horses generate antibodies that neutralize Colicine K and also a different toxin called Colicine I.
Immunization and Antibody Production
- The study evaluated the immune response by immunizing horses with a type of E. coli bacterium – E. coli K235 L + O(m). This particular strain is colicinogenic, meaning it produces a toxin known as colicine.
- Post immunization, horses were found to generate specific antibodies that could precipitate and neutralize colicine K. These antibodies bind to the toxin, rendering it ineffective and signaling other cells of the immune system to eliminate them.
Additional Antibody Response
- Interestingly, the antibodies produced by horses were also capable of neutralizing a different toxin – heterologous colicine I.
- This shows that the immune response initiated by the E. coli K235 L + O(m) strain induces a broad spectrum antibody response that not only targets one specific toxin but also cross-reacts with other similar threats.
Distinct Response in Horses: Recognition of Colominic Acid
- Unlike other mammals, such as rabbits, horses evoked precipitating antibodies for the sialic acid-containing polysaccharide colominic acid. This provides another layer of specificity to the horse’s immune response.
- Colominic acid is a polymer composed of sialic acids, which can be found on the surface of bacteria like E. coli. Bestowing the ability to recognize and react to this acid allows the horses to effectively handle bacterial infections.
Cite This Article
APA
Goebel WF, Staub AM.
(1965).
Colicine K: VI. The Immune Response of Horses to a Colicinogenic Strain of Escherichia Coli.
J Exp Med, 122(5), 891-903.
https://doi.org/10.1084/jem.122.5.891 Publication
Researcher Affiliations
- The Rockefeller University and the Institut Pasteur, Paris.
References
This article includes 12 references
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- Horsfall FL. THE CHARACTERISTICS OF ANTIPNEUMOCOCCUS SERA PRODUCED BY VARIOUS ANIMAL SPECIES.. J Bacteriol 1938 Mar;35(3):207-12.
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- BARRY GT, GOEBEL WF. Colominic acid, a substance of bacterial origin related to sialic acid.. Nature 1957 Jan 26;179(4552):206.
- BARRY GT, TSAI TH, CHEN FP. Chemical and serological relationships of certain bacterial polysaccharides containing sialic acid.. Nature 1960 Feb 27;185:597-8.
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Citations
This article has been cited 1 times.- Hinsdill RD, Goebel WF. Colicine K. VII. The transfer to type K colicinogeny to Shigella sonnei. J Exp Med 1966 May 1;123(5):881-95.
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