Comparative effects of mu and kappa opiate agonists on the cecocolic motility in the pony.
Abstract: The electrical and mechanical activity of the large intestine and its response to administration of opiate mu and kappa agonists were assessed from electrodes and inductograph coils chronically implanted on the cecocolic segment in six ponies given a diet of hay and concentrates. Before the drugs were given, migrating complexes propagating from the cecum into the colon occurred at the rate of 1.5 to 16/hour. During this propulsive activity, the cecocolic sphincter opened and closed allowing the outflow of cecal contents and preventing the backflow of colic contents. Each pony was used as its own control and was given fentanyl (0.01 and 0.05 mg/kg of body weight, IV) and U50488H (0.1 and 0.5 mg/kg, IV) at weekly intervals. The mu agonist fentanyl elicited a marked phase of inhibition of the propulsive activity and a closure of the cecocolic sphincter that lasted one to two hours depending on the dose. The kappa agonist U50488H induced an inhibition of the short spiking activity, i.e. of the resting muscle tone. It did not disturb the occurrence of migrating complexes nor that of the openings of the cecocolic sphincter. These kappa compounds may be drugs of choice to alleviate visceral pain in colic stases without inducing delay of transit unlike mu compounds.
Publication Date: 1994-07-01 PubMed ID: 7954116PubMed Central: PMC1263690
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- Clinical Trial
- Controlled Clinical Trial
- Journal Article
Summary
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The research article discusses a comparative study on the effects of mu and kappa opiate stimulants on the bowel movements in ponies.
Objective of the Research
The research sought to determine the effects of two different stimulants, referred to as mu and kappa opiate agonists, on the movement of food through the large intestine, or the ‘cecolic motility,’ in ponies.
Methodology
- Researchers used electrical devices and flexible springs (inductograph coils) attached to the cecocolic segment of the intestine of six ponies who were on a diet of hay and concentrates.
- It monitored the regular bowel movements, noted as ‘migrating complexes,’ and the activities of the ‘cecolic sphincter,’ the muscle controlling the outflow and backflow of contents in the intestines.
- Ponies were then given two types of agonists, fentanyl (mu agonist) and U50488H (kappa agonist), in different doses and at weekly intervals.
- Each pony served as its own control in the experiment, allowing for a more accurate comparison of the effects of the different drugs.
Findings
- The mu agonist, fentanyl, caused a significant inhibition of the propulsive activity of the intestine and a closure of the cecocolic sphincter. This inhibition lasted one to two hours depending on the dosage.
- The kappa agonist, U50488H, led to an inhibition of the ‘short spiking activity,’ which implies a reduction in the tension of the resting muscle tone without disrupting the occurrence of migrating complexes or the functioning of the cecocolic sphincter.
Ideal Treatment for Colic Stases
The research suggests that kappa compounds, such as U50488H, can be used to alleviate visceral pain in colic stases without inducing delay of transit that is seen in the use of mu compounds like fentanyl.
Cite This Article
APA
Roger T, Bardon T, Ruckebusch Y.
(1994).
Comparative effects of mu and kappa opiate agonists on the cecocolic motility in the pony.
Can J Vet Res, 58(3), 163-166.
Publication
Researcher Affiliations
- Laboratoire d'Anatomie, Ecole Nationale Vétérinaire de Lyon, France.
MeSH Terms
- 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
- Animals
- Catheterization, Central Venous / veterinary
- Cecum / drug effects
- Cecum / physiology
- Colon / drug effects
- Colon / physiology
- Cross-Over Studies
- Fentanyl / administration & dosage
- Gastrointestinal Motility / drug effects
- Horses / physiology
- Pyrrolidines / administration & dosage
- Receptors, Opioid, kappa / agonists
References
This article includes 18 references
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