Comparative efficacy of diminazene diaceturate and diminazene aceturate for the treatment of babesiosis in horses.
Abstract: The present work was conducted to study the comparative efficacy of two anti-protozoan (babesicidal) drugs on the recovery and health of horses. A total of 80 horses, showing typical clinical symptoms of the disease, were selected for this study; the presence of babesiosis was confirmed through blood smear examination. These animals were divided into two groups i.e. A and B. Horses of Group A, were treated with diminazene diaceturate, while horses of Group B were treated with diminazene aceturate. Efficacy of the drugs was determined by the reversal of clinical signs and a negative blood smear examination. The efficacy of diminazene diaceturate was demonstrated to be 80% while diminazene aceturate was found to have 90% efficacy against babesiosis.
Publication Date: 2007-12-15 PubMed ID: 18575975DOI: 10.1007/s11250-007-9121-2Google Scholar: Lookup
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- Comparative Study
- Journal Article
Summary
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This research studied the effectiveness of two drugs for treating a disease called babesiosis in horses. The results showed that both drugs helped the horses recover, but one (diminazene aceturate) was slightly more effective than the other (diminazene diaceturate).
Objective of the Study
The main purpose of this study was to compare the efficacy of two anti-protozoan drugs, diminazene diaceturate and diminazene aceturate, on the recovery and overall health of horses suffering from babesiosis. Babesiosis is a disease caused by infection with Babesia parasites, which are typically transmitted via tick bites.
Methodology
- Eighty horses displaying typical clinical signs of babesiosis were chosen for this study. The presence of the disease in these horses was confirmed through a blood smear examination, a standard method for detecting Babesia parasites.
- The horses were then divided into two equal groups, A and B. Group A horses were given diminazene diaceturate, and Group B horses were administered diminazene aceturate.
Assessment of Drug Efficacy
- The effectiveness of the drugs was evaluated based on the reversal of clinical signs (i.e., symptoms of the disease decreased or disappeared) and negative results in subsequent blood smear examinations (i.e., absence of Babesia parasites).
Study Findings
- The research showed that both drugs were effective against babesiosis. However, there was a difference in their levels of efficacy.
- The diminazene diaceturate drug was found to be 80% effective, meaning it successfully treated babesiosis in 80% of the horses in Group A.
- Conversely, the diminazene aceturate drug showed a slightly higher efficacy of 90%, successfully treating 90% of the horses in Group B.
Hence, while both drugs were beneficial in treating babesiosis in horses, diminazene aceturate outperformed diminazene diaceturate in terms of efficacy.
Cite This Article
APA
Rashid HB, Chaudhry M, Rashid H, Pervez K, Khan MA, Mahmood AK.
(2007).
Comparative efficacy of diminazene diaceturate and diminazene aceturate for the treatment of babesiosis in horses.
Trop Anim Health Prod, 40(6), 463-467.
https://doi.org/10.1007/s11250-007-9121-2 Publication
Researcher Affiliations
- Faculty of Veterinary Science, University of Veterinary and Animal Sciences, Lahore, Pakistan.
MeSH Terms
- Animals
- Antiprotozoal Agents / therapeutic use
- Babesia / growth & development
- Babesiosis / drug therapy
- Babesiosis / parasitology
- Babesiosis / veterinary
- Diminazene / analogs & derivatives
- Diminazene / therapeutic use
- Female
- Horse Diseases / drug therapy
- Horse Diseases / parasitology
- Horses
- Male
References
This article includes 7 references
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Citations
This article has been cited 9 times.- Khotapat P, Maikaew U, Tipkantha W, Kaewkhunjob E, Kongmakee P, Saedan A, Mahadthai P, Sukmak M, Sripiboon S. Clinical Theileriosis in an Endangered Malayan Tapir Diagnosed Using a Molecular Technique with Successful Treatment and Recovery. Animals (Basel) 2025 Oct 29;15(21).
- Mendoza FJ, Pérez-Écija A, Kappmeyer LS, Suarez CE, Bastos RG. New insights in the diagnosis and treatment of equine piroplasmosis: pitfalls, idiosyncrasies, and myths. Front Vet Sci 2024;11:1459989.
- Teodorowski O, Kalinowski M, Winiarczyk D, Dokuzeylül B, Winiarczyk S, Adaszek Ł. Babesia gibsoni Infection in Dogs-A European Perspective. Animals (Basel) 2022 Mar 14;12(6).
- Raftery AG, Jallow S, Coultous RM, Rodgers J, Sutton DGM. Variation in disease phenotype is marked in equine trypanosomiasis. Parasit Vectors 2020 Mar 21;13(1):148.
- Raftery AG, Jallow S, Rodgers J, Sutton DGM. Safety and efficacy of three trypanocides in confirmed field cases of trypanosomiasis in working equines in The Gambia: a prospective, randomised, non-inferiority trial. PLoS Negl Trop Dis 2019 Mar;13(3):e0007175.
- Pedroni MJ, Vidadala RS, Choi R, Keyloun KR, Reid MC, Murphy RC, Barrett LK, Van Voorhis WC, Maly DJ, Ojo KK, Lau AO. Bumped kinase inhibitor prohibits egression in Babesia bovis. Vet Parasitol 2016 Jan 15;215:22-8.
- Lewis KM, Cohn LA, Marr HS, Birkenheuer AJ. Failure of efficacy and adverse events associated with dose-intense diminazene diaceturate treatment of chronic Cytauxzoon felis infection in five cats. J Feline Med Surg 2014 Feb;16(2):157-63.
- Ribeiro AJ, Cardoso L, Maia JM, Coutinho T, Cotovio M. Prevalence of Theileria equi, Babesia caballi, and Anaplasma phagocytophilum in horses from the north of Portugal. Parasitol Res 2013 Jul;112(7):2611-7.
- Lin MY, Huang HP. Use of a doxycycline-enrofloxacin-metronidazole combination with/without diminazene diaceturate to treat naturally occurring canine babesiosis caused by Babesia gibsoni. Acta Vet Scand 2010 Apr 24;52(1):27.
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