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Tropical animal health and production2007; 40(6); 463-467; doi: 10.1007/s11250-007-9121-2

Comparative efficacy of diminazene diaceturate and diminazene aceturate for the treatment of babesiosis in horses.

Abstract: The present work was conducted to study the comparative efficacy of two anti-protozoan (babesicidal) drugs on the recovery and health of horses. A total of 80 horses, showing typical clinical symptoms of the disease, were selected for this study; the presence of babesiosis was confirmed through blood smear examination. These animals were divided into two groups i.e. A and B. Horses of Group A, were treated with diminazene diaceturate, while horses of Group B were treated with diminazene aceturate. Efficacy of the drugs was determined by the reversal of clinical signs and a negative blood smear examination. The efficacy of diminazene diaceturate was demonstrated to be 80% while diminazene aceturate was found to have 90% efficacy against babesiosis.
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Publication Date: 2007-12-15 PubMed ID: 18575975DOI: 10.1007/s11250-007-9121-2Google Scholar: Lookup
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  • Comparative Study
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research studied the effectiveness of two drugs for treating a disease called babesiosis in horses. The results showed that both drugs helped the horses recover, but one (diminazene aceturate) was slightly more effective than the other (diminazene diaceturate).

Objective of the Study

The main purpose of this study was to compare the efficacy of two anti-protozoan drugs, diminazene diaceturate and diminazene aceturate, on the recovery and overall health of horses suffering from babesiosis. Babesiosis is a disease caused by infection with Babesia parasites, which are typically transmitted via tick bites.

Methodology

  • Eighty horses displaying typical clinical signs of babesiosis were chosen for this study. The presence of the disease in these horses was confirmed through a blood smear examination, a standard method for detecting Babesia parasites.
  • The horses were then divided into two equal groups, A and B. Group A horses were given diminazene diaceturate, and Group B horses were administered diminazene aceturate.

Assessment of Drug Efficacy

  • The effectiveness of the drugs was evaluated based on the reversal of clinical signs (i.e., symptoms of the disease decreased or disappeared) and negative results in subsequent blood smear examinations (i.e., absence of Babesia parasites).

Study Findings

  • The research showed that both drugs were effective against babesiosis. However, there was a difference in their levels of efficacy.
  • The diminazene diaceturate drug was found to be 80% effective, meaning it successfully treated babesiosis in 80% of the horses in Group A.
  • Conversely, the diminazene aceturate drug showed a slightly higher efficacy of 90%, successfully treating 90% of the horses in Group B.

Hence, while both drugs were beneficial in treating babesiosis in horses, diminazene aceturate outperformed diminazene diaceturate in terms of efficacy.

Cite This Article

APA
Rashid HB, Chaudhry M, Rashid H, Pervez K, Khan MA, Mahmood AK. (2007). Comparative efficacy of diminazene diaceturate and diminazene aceturate for the treatment of babesiosis in horses. Trop Anim Health Prod, 40(6), 463-467. https://doi.org/10.1007/s11250-007-9121-2

Publication

Tropical animal health and production
ISSN: 0049-4747
NlmUniqueID: 1277355
Country: United States
Language: English
Volume: 40
Issue: 6
Pages: 463-467

Researcher Affiliations

Rashid, Hamad Bin
  • Faculty of Veterinary Science, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Chaudhry, Mamoona
    Rashid, Haroon
      Pervez, Khalid
        Khan, Muhammad Arif
          Mahmood, Asim Khalid

            MeSH Terms

            • Animals
            • Antiprotozoal Agents / therapeutic use
            • Babesia / growth & development
            • Babesiosis / drug therapy
            • Babesiosis / parasitology
            • Babesiosis / veterinary
            • Diminazene / analogs & derivatives
            • Diminazene / therapeutic use
            • Female
            • Horse Diseases / drug therapy
            • Horse Diseases / parasitology
            • Horses
            • Male

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            This article has been cited 9 times.
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